{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:49:16Z","timestamp":1789714156070,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"am","delay-in-days":315,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1552782"],"award-info":[{"award-number":["1552782"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL137695"],"award-info":[{"award-number":["R01HL137695"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["OT2HL152643"],"award-info":[{"award-number":["OT2HL152643"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL133574"],"award-info":[{"award-number":["R01HL133574"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R42HL160384"],"award-info":[{"award-number":["R42HL160384"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL117659"],"award-info":[{"award-number":["U01HL117659"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL134622"],"award-info":[{"award-number":["T32HL134622"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K25HL159358"],"award-info":[{"award-number":["K25HL159358"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bios.2022.114921","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T11:26:51Z","timestamp":1669289211000},"page":"114921","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["A microfluidic device for assessment of E-selectin-mediated neutrophil recruitment to inflamed endothelium and prediction of therapeutic response in sickle cell disease"],"prefix":"10.1016","volume":"222","author":[{"given":"Yuncheng","family":"Man","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Kucukal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-0120","authenticated-orcid":false,"given":"Ran","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utku","family":"Goreke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Wulftange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Sekyonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Manwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evi X.","family":"Stavrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-9960","authenticated-orcid":false,"given":"Umut A.","family":"Gurkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2022.114921_bib1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.trsl.2016.03.008","article-title":"Sickle cell disease biochip: a functional red blood cell adhesion assay for monitoring sickle cell disease","volume":"173","author":"Alapan","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.bios.2022.114921_bib2","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1038\/srep07173","article-title":"Heterogeneous red blood cell adhesion and deformability in sickle cell disease","volume":"4","author":"Alapan","year":"2014","journal-title":"Sci. Rep."},{"issue":"5 Pt 1","key":"10.1016\/j.bios.2022.114921_bib3","doi-asserted-by":"crossref","first-page":"C1102","DOI":"10.1152\/ajpcell.1993.264.5.C1102","article-title":"Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18\/CD11b, and ICAM-1","volume":"264","author":"Arnould","year":"1993","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.bios.2022.114921_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89761","article-title":"Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli","volume":"2","author":"Bennewitz","year":"2017","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bios.2022.114921_bib5","first-page":"17","article-title":"Hypoxemia in sickle cell disease: significance and management","volume":"15","author":"Caboot","year":"2014","journal-title":"Paediatr. Respir. Rev."},{"issue":"2","key":"10.1016\/j.bios.2022.114921_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.blre.2015.08.005","article-title":"The role of blood rheology in sickle cell disease","volume":"30","author":"Connes","year":"2016","journal-title":"Blood Rev."},{"issue":"5","key":"10.1016\/j.bios.2022.114921_bib7","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","article-title":"HIF-1\u03b1 is essential for myeloid cell-mediated inflammation","volume":"112","author":"Cramer","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bios.2022.114921_bib8","article-title":"A randomized clinical trial of the efficacy and safety of Rivipansel for sickle cell vaso-occlusive crisis (VOC)","author":"Dampier","year":"2022","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.bios.2022.114921_bib9","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.3324\/haematol.2014.108555","article-title":"Prominent role of platelets in the formation of circulating neutrophil-red cell heterocellular aggregates in sickle cell anemia","volume":"99","author":"Dominical","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.bios.2022.114921_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2053646","article-title":"The response of macrophages and neutrophils to hypoxia in the context of cancer and other inflammatory diseases","volume":"2016","author":"Egners","year":"2016","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.bios.2022.114921_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2249.2000.01082.x","article-title":"Increased serum levels of soluble L-selectin (CD62L) in patients with active systemic lupus erythematosus (SLE)","volume":"119","author":"Font","year":"2000","journal-title":"Clin. Exp. Immunol."},{"issue":"4","key":"10.1016\/j.bios.2022.114921_bib12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/ard.59.4.297","article-title":"Circulating concentrations of soluble L-selectin (CD62L) in patients with primary Sjogren's syndrome","volume":"59","author":"Garcia-Carrasco","year":"2000","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.bios.2022.114921_bib13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.189.6.939","article-title":"Relevance of L-selectin shedding for leukocyte rolling in vivo","volume":"189","author":"Hafezi-Moghadam","year":"1999","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.bios.2022.114921_bib14","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.injury.2015.03.028","article-title":"N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1\/2 and P38 MAP kinase signalling pathways","volume":"46","author":"Hazeldine","year":"2015","journal-title":"Injury"},{"issue":"4","key":"10.1016\/j.bios.2022.114921_bib15","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nm.1939","article-title":"Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury","volume":"15","author":"Hidalgo","year":"2009","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bios.2022.114921_bib16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.immuni.2007.03.011","article-title":"Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44","volume":"26","author":"Hidalgo","year":"2007","journal-title":"Immunity"},{"issue":"26","key":"10.1016\/j.bios.2022.114921_bib17","doi-asserted-by":"crossref","first-page":"15519","DOI":"10.1039\/D1RA01948A","article-title":"Quantifying the influences of radiation therapy on deformability of human red blood cells by dual-beam optical tweezers","volume":"11","author":"Inanc","year":"2021","journal-title":"RSC Adv."},{"issue":"2","key":"10.1016\/j.bios.2022.114921_bib18","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1365-2141.2000.02353.x","article-title":"Platelet and leucocyte activation in childhood sickle cell disease: association with nocturnal hypoxaemia","volume":"111","author":"Inwald","year":"2000","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.bios.2022.114921_bib19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00441-017-2774-x","article-title":"A head-to-tail view of L-selectin and its impact on neutrophil behaviour","volume":"371","author":"Ivetic","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bios.2022.114921_bib20","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3389\/fimmu.2019.01068","article-title":"L-selectin: a major regulator of leukocyte adhesion, migration and signaling","volume":"10","author":"Ivetic","year":"2019","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.bios.2022.114921_bib21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/ajh.21475","article-title":"Vasculopathy in sickle cell disease: biology, pathophysiology, genetics, translational medicine, and new research directions","volume":"84","author":"Kato","year":"2009","journal-title":"Am. J. Hematol."},{"issue":"2","key":"10.1016\/j.bios.2022.114921_bib22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1042\/BJ20091611","article-title":"The cytoplasmic domains of TNFalpha-converting enzyme (TACE\/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding","volume":"428","author":"Killock","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.bios.2022.114921_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12374","article-title":"Hypoxia-enhanced adhesion of red blood cells in microscale flow","volume":"24","author":"Kim","year":"2017","journal-title":"Microcirculation"},{"issue":"4923","key":"10.1016\/j.bios.2022.114921_bib24","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1126\/science.2551036","article-title":"Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors","volume":"245","author":"Kishimoto","year":"1989","journal-title":"Science"},{"issue":"28","key":"10.1016\/j.bios.2022.114921_bib25","doi-asserted-by":"crossref","first-page":"10440","DOI":"10.1073\/pnas.0401339101","article-title":"Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta 2 integrin gene expression","volume":"101","author":"Kong","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bios.2022.114921_bib26","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/ajh.25159","article-title":"Red blood cell adhesion to heme-activated endothelial cells reflects clinical phenotype in sickle cell disease","volume":"93","author":"Kucukal","year":"2018","journal-title":"Am. J. Hematol."},{"issue":"9","key":"10.1016\/j.bios.2022.114921_bib27","doi-asserted-by":"crossref","DOI":"10.1115\/1.4050647","article-title":"Blood flow velocimetry in a microchannel during coagulation using particle image velocimetry and wavelet-based optical flow velocimetry","volume":"143","author":"Kucukal","year":"2021","journal-title":"J. Biomech. Eng."},{"issue":"11","key":"10.1016\/j.bios.2022.114921_bib28","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/ajh.25933","article-title":"Whole blood viscosity and red blood cell adhesion: potential biomarkers for targeted and curative therapies in sickle cell disease","volume":"95","author":"Kucukal","year":"2020","journal-title":"Am. J. Hematol."},{"issue":"15","key":"10.1016\/j.bios.2022.114921_bib29","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1182\/bloodadvances.2020001656","article-title":"Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease","volume":"4","author":"Kucukal","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.bios.2022.114921_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/B978-0-12-813456-6.00016-3","article-title":"Interactions between platelets, leukocytes, and the endothelium","author":"Li","year":"2019","journal-title":"Platelets"},{"issue":"4","key":"10.1016\/j.bios.2022.114921_bib31","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2141.2005.05432.x","article-title":"Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension","volume":"129","author":"Machado","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bios.2022.114921_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.954106","article-title":"OcclusionChip: a functional microcapillary occlusion assay complementary to ektacytometry for detection of small-fraction red blood cells with abnormal deformability","volume":"13","author":"Man","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bios.2022.114921_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcmd.2020.102424","article-title":"Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: a standardized microfluidic assessment","volume":"83","author":"Man","year":"2020","journal-title":"Blood Cells Mol. Dis."},{"issue":"2","key":"10.1016\/j.bios.2022.114921_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12662","article-title":"Standardized microfluidic assessment of red blood cell mediated microcapillary occlusion: association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease","volume":"28","author":"Man","year":"2020","journal-title":"Microcirculation"},{"issue":"12","key":"10.1016\/j.bios.2022.114921_bib35","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1039\/D0LC00112K","article-title":"Microfluidic assessment of red blood cell mediated microvascular occlusion","volume":"20","author":"Man","year":"2020","journal-title":"Lab Chip"},{"issue":"6","key":"10.1016\/j.bios.2022.114921_bib36","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1039\/D0LC01133A","article-title":"Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion","volume":"21","author":"Man","year":"2021","journal-title":"Lab Chip"},{"issue":"24","key":"10.1016\/j.bios.2022.114921_bib37","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1182\/blood-2013-05-498311","article-title":"Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies","volume":"122","author":"Manwani","year":"2013","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bios.2022.114921_bib38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/cvr\/cvv154","article-title":"Selectins: initiators of leucocyte adhesion and signalling at the vascular wall","volume":"107","author":"McEver","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bios.2022.114921_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.663886","article-title":"Targeting neutrophil adhesive events to address vaso-occlusive crisis in sickle cell patients","volume":"12","author":"Morikis","year":"2021","journal-title":"Front. Immunol."},{"issue":"20","key":"10.1016\/j.bios.2022.114921_bib40","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1182\/bloodadvances.2019000193","article-title":"Role of the coagulation system in the pathogenesis of sickle cell disease","volume":"3","author":"Nasimuzzaman","year":"2019","journal-title":"Blood Adv."},{"issue":"4","key":"10.1016\/j.bios.2022.114921_bib41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/bjh.16671","article-title":"Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease","volume":"190","author":"Noomuna","year":"2020","journal-title":"Br. J. Haematol."},{"issue":"38","key":"10.1016\/j.bios.2022.114921_bib42","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1073\/pnas.1807405115","article-title":"Simultaneous polymerization and adhesion under hypoxia in sickle cell disease","volume":"115","author":"Papageorgiou","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bios.2022.114921_bib43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41573-018-0003-2","article-title":"Therapeutic strategies for sickle cell disease: towards a multi-agent approach","volume":"18","author":"Telen","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.bios.2022.114921_bib44","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.4049\/jimmunol.157.9.3995","article-title":"L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity","volume":"157","author":"Tu","year":"1996","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.bios.2022.114921_bib45","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.052522799","article-title":"Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm","volume":"99","author":"Turhan","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bios.2022.114921_bib46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20040624","article-title":"Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity","volume":"201","author":"Walmsley","year":"2005","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.bios.2022.114921_bib47","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.it.2011.06.009","article-title":"Emerging mechanisms of neutrophil recruitment across endothelium","volume":"32","author":"Williams","year":"2011","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.bios.2022.114921_bib48","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.4049\/jimmunol.0903244","article-title":"Acute hypoxia induces HIF-independent monocyte adhesion to endothelial cells through increased intercellular adhesion molecule-1 expression: the role of hypoxic inhibition of prolyl hydroxylase activity for the induction of NF-kappa B","volume":"185","author":"Winning","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bios.2022.114921_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2353\/ajpath.2008.070502","article-title":"Mechanisms and consequences of neutrophil interaction with the endothelium","volume":"172","author":"Zarbock","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.bios.2022.114921_bib50","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1182\/blood-2015-09-618538","article-title":"Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology","volume":"127","author":"Zhang","year":"2016","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bios.2022.114921_bib51","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1083\/jcb.136.3.707","article-title":"L-selectin from human, but not from mouse neutrophils binds directly to E-selectin","volume":"136","author":"Z\u00f6llner","year":"1997","journal-title":"J. Cell Biol."},{"issue":"14","key":"10.1016\/j.bios.2022.114921_bib52","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1073\/pnas.93.14.7075","article-title":"Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells","volume":"93","author":"Zund","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566322009617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566322009617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:33:56Z","timestamp":1778564036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566322009617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":52,"alternative-id":["S0956566322009617"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2022.114921","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A microfluidic device for assessment of E-selectin-mediated neutrophil recruitment to inflamed endothelium and prediction of therapeutic response in sickle cell disease","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2022.114921","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114921"}}