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Mol. Diagn."},{"issue":"7\u20138","key":"10.1016\/j.bios.2023.115611_bib182","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/13547500802645905","article-title":"Biosensors for biomarkers in medical diagnostics","volume":"13","author":"Mascini","year":"2008","journal-title":"Biomarkers"},{"issue":"5","key":"10.1016\/j.bios.2023.115611_bib183","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ccell.2014.09.005","article-title":"Cancer exosomes perform cell-independent MicroRNA biogenesis and promote tumorigenesis","volume":"26","author":"Melo","year":"2014","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.bios.2023.115611_bib184","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207039","article-title":"TIMP-1 is a novel serum biomarker for the diagnosis of colorectal cancer: a meta-analysis","volume":"13","author":"Meng","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bios.2023.115611_bib185","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/252361","article-title":"Detection of EpCAM-negative and cytokeratin-negative circulating tumor cells in peripheral blood","author":"Mikolajczyk","year":"2011","journal-title":"J. Oncol."},{"issue":"8","key":"10.1016\/j.bios.2023.115611_bib186","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nbt.3598","article-title":"Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction","volume":"34","author":"Mooijman","year":"2016","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.bios.2023.115611_bib187","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-27884-2","article-title":"Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection","volume":"8","author":"Moreira","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bios.2023.115611_bib188","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/jclinpath-2017-204739","article-title":"Cancer stem cells in colorectal cancer: a review","volume":"71","author":"Munro","year":"2018","journal-title":"J. Clin. 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Coloproctol."},{"issue":"3","key":"10.1016\/j.bios.2023.115611_bib197","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1039\/C5AN01790D","article-title":"Biomarker detection technologies and future directions","volume":"141","author":"Nimse","year":"2016","journal-title":"Analyst"},{"issue":"4","key":"10.1016\/j.bios.2023.115611_bib198","first-page":"2713","article-title":"Changes in the gene mutation profiles of circulating tumor DNA detected using CAPP-Seq in neoadjuvant chemotherapy-treated advanced ovarian cancer","volume":"19","author":"Noguchi","year":"2020","journal-title":"Oncol. Lett."},{"issue":"12","key":"10.1016\/j.bios.2023.115611_bib199","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1039\/C5AN00623F","article-title":"Sensitive and direct electrochemical detection of double-stranded DNA utilizing alkaline phosphatase-labelled zinc finger proteins","volume":"140","author":"Noh","year":"2015","journal-title":"Analyst"},{"issue":"12","key":"10.1016\/j.bios.2023.115611_bib200","doi-asserted-by":"crossref","first-page":"E63","DOI":"10.1093\/nar\/28.12.e63","article-title":"Loop-mediated isothermal amplification of DNA","volume":"28","author":"Notomi","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.bios.2023.115611_bib201","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092921","article-title":"Circulating exosomal microRNAs as biomarkers of colon cancer","volume":"9","author":"Ogata-Kawata","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bios.2023.115611_bib202","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/sj.bjc.6603206","article-title":"Biomarker selection for detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT\u2013PCR","volume":"95","author":"Ohlsson","year":"2006","journal-title":"Br. J. 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