{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:04:50Z","timestamp":1781273090157,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["132950"],"award-info":[{"award-number":["132950"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["134361"],"award-info":[{"award-number":["134361"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024256","name":"Toronto Metropolitan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bios.2023.115782","type":"journal-article","created":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T09:49:09Z","timestamp":1697968149000},"page":"115782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Detection of lung cancer metastasis from blood using L-MISC nanosensor: Targeting circulating metastatic cues for improved diagnosis"],"prefix":"10.1016","volume":"243","author":[{"given":"Srilakshmi","family":"Premachandran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Dhinakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunit","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnan","family":"Venkatakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0289-8962","authenticated-orcid":false,"given":"Mansi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2023.115782_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083651","article-title":"Niche-dependent gene expression profile of intratumoral heterogeneous ovarian cancer stem cell populations","volume":"8","author":"Abelson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bios.2023.115782_bib2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3390\/cancers11030345","article-title":"Conversion of stem cells to cancer stem cells: undercurrent of cancer initiation","volume":"11","author":"Afify","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.bios.2023.115782_bib3","article-title":"Stem cells in cancer initiation and progression","volume":"219","author":"Bajaj","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bios.2023.115782_bib4","first-page":"109","article-title":"Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations","volume":"2","author":"Barriere","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bios.2023.115782_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13073-020-00728-3","article-title":"Tracking cancer progression: from circulating tumor cells to metastasis","volume":"12","author":"Castro-Giner","year":"2020","journal-title":"Genome Med."},{"key":"10.1016\/j.bios.2023.115782_bib6","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1101\/gad.277681.116","article-title":"Distinctive properties of metastasis-initiating cells","volume":"30","author":"Celi\u00e0-Terrassa","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.bios.2023.115782_bib34","first-page":"16","article-title":"Cancer stem cells in small cell lung cancer","volume":"5","author":"Codony-Servat","year":"2016","journal-title":"Transl. Lung Cancer Res."},{"issue":"505\u2013512","key":"10.1016\/j.bios.2023.115782_bib7","first-page":"W176","article-title":"Cumulative incidence of false-positive test results in lung cancer screening: a randomized trial","volume":"152","author":"Croswell","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bios.2023.115782_bib8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ccm.2011.09.001","article-title":"Lung cancer: epidemiology, etiology, and prevention","volume":"32","author":"Dela Cruz","year":"2011","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.bios.2023.115782_bib9","first-page":"96","article-title":"Heterogeneity in lung cancer","volume":"85","author":"de Sousa","year":"2018","journal-title":"PAT"},{"key":"10.1016\/j.bios.2023.115782_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.02168","article-title":"CXCR4 inhibition counteracts immunosuppressive properties of metastatic NSCLC stem cells","volume":"11","author":"Fortunato","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bios.2023.115782_bib11","doi-asserted-by":"crossref","DOI":"10.21037\/tlcr.2017.05.07","article-title":"Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer","volume":"6","author":"Gallo","year":"2017","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.bios.2023.115782_bib12","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/onco.13858","article-title":"Liquid biopsy in glioblastoma management: from current research to future perspectives","volume":"26","author":"Gatto","year":"2021","journal-title":"Oncol."},{"key":"10.1016\/j.bios.2023.115782_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-1898-1","article-title":"Lung tumorspheres reveal cancer stem cell-like properties and a score with prognostic impact in resected non-small-cell lung cancer","volume":"10","author":"Herreros-Pomares","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bios.2023.115782_bib14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.21037\/tlcr.2016.08.06","article-title":"Pros: can tissue biopsy be replaced by liquid biopsy?","volume":"5","author":"Ili\u00e9","year":"2016","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.bios.2023.115782_bib15","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0151-2022","article-title":"Circulating tumour cells in patients with lung cancer universally indicate poor prognosis","volume":"31","author":"Jin","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.bios.2023.115782_bib16","doi-asserted-by":"crossref","DOI":"10.1109\/LED.2015.2508479","article-title":"Selective fabrication of SiC\/Si diodes by excimer laser under ambient conditions","volume":"37","author":"Kaur","year":"2016","journal-title":"IEEE Electron. Device Lett."},{"key":"10.1016\/j.bios.2023.115782_bib17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/cr.2008.50","article-title":"Prostate cancer and metastasis initiating stem cells","volume":"18","author":"Kelly","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.bios.2023.115782_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-01566-0","article-title":"Targeting therapy-resistant lung cancer stem cells via disruption of the AKT\/TSPYL5\/PTEN positive-feedback loop","volume":"4","author":"Kim","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bios.2023.115782_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2019.00582","article-title":"Study of chemical enhancement mechanism in non-plasmonic surface enhanced Raman spectroscopy (SERS)","volume":"7","author":"Kim","year":"2019","journal-title":"Front. Chem."},{"key":"10.1016\/j.bios.2023.115782_bib20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3390\/coatings8120431","article-title":"Growth without postannealing of monoclinic VO 2 thin film by atomic layer deposition using VCl 4 as precursor","volume":"8","author":"Lee","year":"2018","journal-title":"Coatings"},{"key":"10.1016\/j.bios.2023.115782_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012533","article-title":"Lipid droplets in lung cancers are crucial for the cell growth and starvation survival","volume":"23","author":"Lung","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bios.2023.115782_bib22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/jcmm.12004","article-title":"Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells","volume":"17","author":"Mimeault","year":"2013","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bios.2023.115782_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.omto.2021.05.005","article-title":"Progress and application of circulating tumor cells in non-small cell lung cancer","volume":"22","author":"Qian","year":"2021","journal-title":"Molecular Therapy - Oncolytics"},{"key":"10.1016\/j.bios.2023.115782_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","article-title":"A molecular signature of metastasis in primary solid tumors","volume":"33","author":"Ramaswamy","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bios.2023.115782_bib25","first-page":"49","article-title":"Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors","volume":"27","author":"Rao","year":"2005","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bios.2023.115782_bib26","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1063\/1.349160","article-title":"Removal of native silicon oxide with low\u2010energy argon ions","volume":"70","author":"Salimian","year":"1991","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.bios.2023.115782_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41388-019-0959-3","article-title":"TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment","volume":"39","author":"Sirkisoon","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.bios.2023.115782_bib28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s40425-019-0649-2","article-title":"Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors","volume":"7","author":"Tamminga","year":"2019","journal-title":"Journal for ImmunoTherapy of Cancer"},{"key":"10.1016\/j.bios.2023.115782_bib29","doi-asserted-by":"crossref","first-page":"6980","DOI":"10.1158\/1078-0432.CCR-09-1095","article-title":"Circulating tumor cell as a diagnostic marker in primary lung cancer","volume":"15","author":"Tanaka","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bios.2023.115782_bib30","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.2147\/OTT.S142149","article-title":"Biomarkers for early diagnosis, prognosis, prediction, and recurrence monitoring of non-small cell lung cancer","volume":"10","author":"Tang","year":"2017","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.bios.2023.115782_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042086","article-title":"Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer","volume":"7","author":"Valles","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bios.2023.115782_bib32","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1364\/OE.26.006507","article-title":"Enhanced Raman scattering in porous silicon grating","volume":"26","author":"Wang","year":"2018","journal-title":"Opt. Express, OE"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566323007248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566323007248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:47:39Z","timestamp":1760665659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566323007248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":33,"alternative-id":["S0956566323007248"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2023.115782","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection of lung cancer metastasis from blood using L-MISC nanosensor: Targeting circulating metastatic cues for improved diagnosis","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2023.115782","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115782"}}