{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:04:56Z","timestamp":1792548296747,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bios.2023.115808","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T14:11:09Z","timestamp":1698934269000},"page":"115808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Exploration of aminopeptidase N as new biomarker for early diagnosis of thyroid cancer"],"prefix":"10.1016","volume":"244","author":[{"given":"Lanlan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianfeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinyi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4866-1292","authenticated-orcid":false,"given":"Daqian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bios.2023.115808_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/med.20044","volume":"26","author":"Bauvois","year":"2006","journal-title":"Med. Res. Rev."},{"issue":"3","key":"10.1016\/j.bios.2023.115808_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/CEJ.0000000000000699","volume":"31","author":"Boukheris","year":"2022","journal-title":"Eur. J. Cancer Prev."},{"issue":"44","key":"10.1016\/j.bios.2023.115808_bib3","doi-asserted-by":"crossref","first-page":"17966","DOI":"10.1073\/pnas.1210123109","volume":"109","author":"Chen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.bios.2023.115808_bib4","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1021\/acs.analchem.0c00989","volume":"92","author":"Cheng","year":"2020","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.bios.2023.115808_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12885-017-3104-0","volume":"17","author":"Cho","year":"2017","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.bios.2023.115808_bib6","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/ijc.29857","volume":"138","author":"Crump","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"17","key":"10.1016\/j.bios.2023.115808_bib7","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1039\/D2CC05408F","volume":"59","author":"Dominguez","year":"2023","journal-title":"Chem. Commun."},{"issue":"10","key":"10.1016\/j.bios.2023.115808_bib8","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1016\/j.cclet.2021.03.056","volume":"32","author":"Feng","year":"2021","journal-title":"Chin. Chem. Lett."},{"issue":"2","key":"10.1016\/j.bios.2023.115808_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12094-019-02284-8","volume":"22","author":"Gallardo","year":"2020","journal-title":"Clin. Transl. Oncol."},{"issue":"5","key":"10.1016\/j.bios.2023.115808_bib10","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/anie.201509457","volume":"55","author":"Hata","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"issue":"1","key":"10.1016\/j.bios.2023.115808_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"issue":"11","key":"10.1016\/j.bios.2023.115808_bib12","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1002\/anie.201911859","volume":"59","author":"Huang","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"issue":"4","key":"10.1016\/j.bios.2023.115808_bib13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/jnci\/djx210","volume":"110","author":"Kebebew","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bios.2023.115808_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114049","volume":"203","author":"Kumaravel","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"11","key":"10.1016\/j.bios.2023.115808_bib15","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1089\/thy.2019.0368","volume":"30","author":"Lee","year":"2020","journal-title":"Thyroid"},{"issue":"6","key":"10.1016\/j.bios.2023.115808_bib16","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1039\/C8SC04685A","volume":"10","author":"Li","year":"2019","journal-title":"Chem. Sci."},{"issue":"13","key":"10.1016\/j.bios.2023.115808_bib17","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.1021\/jacs.0c01365","volume":"142","author":"Li","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bios.2023.115808_bib18","volume":"363","author":"Liu","year":"2022","journal-title":"Sensor. Actuat. B-Chem."},{"issue":"16","key":"10.1016\/j.bios.2023.115808_bib19","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1021\/acs.analchem.1c00280","volume":"93","author":"Liu","year":"2021","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.bios.2023.115808_bib20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s12885-020-07137-0","volume":"20","author":"Lopez Gavilanez","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bios.2023.115808_bib21","volume":"379","author":"Ma","year":"2023","journal-title":"Sensor. Actuat. B-Chem."},{"issue":"1","key":"10.1016\/j.bios.2023.115808_bib22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1750-3639.2009.00267.x","volume":"20","author":"Mawrin","year":"2010","journal-title":"Brain Pathol."},{"issue":"3","key":"10.1016\/j.bios.2023.115808_bib23","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/jrh.12374","volume":"36","author":"McDow","year":"2020","journal-title":"J. Rural Health"},{"issue":"8","key":"10.1016\/j.bios.2023.115808_bib24","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.molmed.2008.06.003","volume":"14","author":"Mina-Osorio","year":"2008","journal-title":"Trends Mol. Med."},{"issue":"7","key":"10.1016\/j.bios.2023.115808_bib25","first-page":"709","volume":"142","author":"Morris","year":"2016","journal-title":"JAMA Otolaryngol."},{"issue":"4","key":"10.1016\/j.bios.2023.115808_bib26","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1530\/ERC-21-0012","volume":"28","author":"Rosario","year":"2021","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bios.2023.115808_bib27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3390\/genes12020126","volume":"12","author":"Silva","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.bios.2023.115808_bib28","volume":"18","author":"Toro-Wills","year":"2022","journal-title":"Womens Health"},{"issue":"3","key":"10.1016\/j.bios.2023.115808_bib29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1349-7006.2010.01826.x","volume":"102","author":"Wickstrom","year":"2011","journal-title":"Cancer Sci."},{"issue":"5","key":"10.1016\/j.bios.2023.115808_bib30","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1021\/acs.analchem.2c04705","volume":"95","author":"Xu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2023.115808_bib31","volume":"215","author":"Xu","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2023.115808_bib32","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1039\/D3BM00007A","volume":"11","author":"Yang","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bios.2023.115808_bib33","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3390\/diagnostics11112080","volume":"11","author":"Zahra","year":"2021","journal-title":"Diagnostics"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566323007509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566323007509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:47:29Z","timestamp":1760665649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566323007509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":33,"alternative-id":["S0956566323007509"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2023.115808","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration of aminopeptidase N as new biomarker for early diagnosis of thyroid cancer","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2023.115808","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115808"}}