{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:49:06Z","timestamp":1791319746609,"version":"4.3.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bios.2024.116353","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T14:42:14Z","timestamp":1714488134000},"page":"116353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Development of a thermotaxis and rheotaxis microfluidic device for motile spermatozoa sorting"],"prefix":"10.1016","volume":"258","author":[{"given":"Teng-Kuan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hsien","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-An","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1397-8334","authenticated-orcid":false,"given":"Ching Hung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farn","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1459-9758","authenticated-orcid":false,"given":"Wen-Ju","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Yu Jen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor-Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 4","key":"10.1016\/j.bios.2024.116353_bib1","doi-asserted-by":"crossref","first-page":"S720","DOI":"10.21037\/tau.2017.08.06","article-title":"The Society for Translational Medicine: clinical practice guidelines for sperm DNA fragmentation testing in male infertility","volume":"6","author":"Agarwal","year":"2017","journal-title":"Transl. Androl. Urol."},{"issue":"8","key":"10.1016\/j.bios.2024.116353_bib2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s10815-017-0947-x","article-title":"Volatile organic compounds and good laboratory practices in the in vitro fertilization laboratory: the important parameters for successful outcome in extended culture","volume":"34","author":"Agarwal","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"issue":"1","key":"10.1016\/j.bios.2024.116353_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006691","article-title":"OpenCASA: a new open-source and scalable tool for sperm quality analysis","volume":"15","author":"Alquezar-Baeta","year":"2019","journal-title":"PLoS Comput. Biol."},{"issue":"4","key":"10.1016\/j.bios.2024.116353_bib4","first-page":"343","article-title":"Effect of sperm DNA fragmentation on embryo development: clinical and biological aspects","volume":"21","author":"Alvarez Sedo","year":"2017","journal-title":"JBRA Assist Reprod"},{"issue":"1","key":"10.1016\/j.bios.2024.116353_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12562","article-title":"Swim-up method is superior to density gradient centrifugation for preserving sperm DNA integrity during sperm processing","volume":"23","author":"Amano","year":"2024","journal-title":"Reprod. Med. Biol."},{"issue":"6","key":"10.1016\/j.bios.2024.116353_bib6","doi-asserted-by":"crossref","DOI":"10.1007\/s10404-021-02453-8","article-title":"A microfluidic sperm-sorting device based on rheotaxis effect","volume":"25","author":"Ataei","year":"2021","journal-title":"Microfluid. Nanofluidics"},{"key":"10.1016\/j.bios.2024.116353_bib7","doi-asserted-by":"crossref","DOI":"10.1007\/s43032-024-01483-1","article-title":"Sperm preparation with microfluidic sperm sorting chip may improve intracytoplasmic sperm injection outcomes compared to density gradient centrifugation","author":"Banti","year":"2024","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.bios.2024.116353_bib8","series-title":"Sperm Preparation and Selection Techniques","first-page":"244","author":"Beydola","year":"2013"},{"issue":"2","key":"10.1016\/j.bios.2024.116353_bib9","doi-asserted-by":"crossref","DOI":"10.1063\/1.5023574","article-title":"Chemotactic behavior of spermatozoa captured using a microfluidic chip","volume":"12","author":"Bhagwat","year":"2018","journal-title":"Biomicrofluidics"},{"issue":"8","key":"10.1016\/j.bios.2024.116353_bib10","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.bios.2024.116353_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134356","article-title":"Development of a vertical bubble acoustic microfluidic sputum liquefier for improved cancer cell detection","volume":"394","author":"Chang","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"issue":"2","key":"10.1016\/j.bios.2024.116353_bib12","article-title":"Guidance and self-sorting of active swimmers: 3D periodic arrays increase persistence length of human sperm selecting for the fittest","volume":"5","author":"Chinnasamy","year":"2018","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.bios.2024.116353_bib13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.chempr.2017.01.009","article-title":"Small but perfectly formed? Successes, challenges, and opportunities for microfluidics in the chemical and biological sciences","volume":"2","author":"Chiu","year":"2017","journal-title":"Chem"},{"key":"10.1016\/j.bios.2024.116353_bib14","volume":"39","author":"Cocuzza","year":"2020"},{"issue":"11","key":"10.1016\/j.bios.2024.116353_bib15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ogrm.2008.08.009","article-title":"In-vitro fertilisation","volume":"18","author":"Coughlan","year":"2008","journal-title":"Obstet. Gynaecol. Reprod. Med."},{"issue":"1","key":"10.1016\/j.bios.2024.116353_bib16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aju.2017.12.004","article-title":"Lifestyle causes of male infertility","volume":"16","author":"Durairajanayagam","year":"2018","journal-title":"Arab J Urol"},{"issue":"4","key":"10.1016\/j.bios.2024.116353_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrm1893","article-title":"Sperm guidance in mammals - an unpaved road to the egg","volume":"7","author":"Eisenbach","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bios.2024.116353_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/s19010123","article-title":"Superhydrophobic soot coated quartz crystal microbalances: a novel platform for human spermatozoa quality assessment","volume":"19","author":"Esmeryan","year":"2019","journal-title":"Sensors (Basel)"},{"issue":"22","key":"10.1016\/j.bios.2024.116353_bib19","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1039\/D0LC00457J","article-title":"High DNA integrity sperm selection using surface acoustic waves","volume":"20","author":"Gai","year":"2020","journal-title":"Lab Chip"},{"key":"10.1016\/j.bios.2024.116353_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110954","article-title":"Getting to and away from the egg, an interplay between several sperm transport mechanisms and a complex oviduct physiology","volume":"518","author":"Giojalas","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.bios.2024.116353_bib21","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s41598-023-28315-7","article-title":"A novel microfluidic device with parallel channels for sperm separation using spermatozoa intrinsic behaviors","volume":"13","author":"Heydari","year":"2023","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.bios.2024.116353_bib22","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1007\/s10815-023-02838-4","article-title":"Live motile sperm sorting device for enhanced sperm-fertilization competency: comparative analysis with density-gradient centrifugation and microfluidic sperm sorting","volume":"40","author":"Hsu","year":"2023","journal-title":"J. Assist. Reprod. Genet."},{"issue":"8","key":"10.1016\/j.bios.2024.116353_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107356","article-title":"Design of a gradient-rheotaxis microfluidic chip for sorting of high-quality Sperm with progressive motility","volume":"26","author":"Huang","year":"2023","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.bios.2024.116353_bib24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12958-018-0436-9","article-title":"Lifestyle and fertility: the influence of stress and quality of life on male fertility","volume":"16","author":"Ilacqua","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"6","key":"10.1016\/j.bios.2024.116353_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/chemosensors9060126","article-title":"Recent microfluidic innovations for sperm sorting","volume":"9","author":"Khodamoradi","year":"2021","journal-title":"Chemosensors"},{"issue":"4","key":"10.1016\/j.bios.2024.116353_bib26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tibtech.2015.01.005","article-title":"Microfluidics for sperm research","volume":"33","author":"Knowlton","year":"2015","journal-title":"Trends Biotechnol."},{"issue":"6","key":"10.1016\/j.bios.2024.116353_bib27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1177\/2472630318783948","article-title":"Design, fabrication, and testing of a microfluidic device for thermotaxis and chemotaxis assays of sperm","volume":"23","author":"Ko","year":"2018","journal-title":"SLAS Technol"},{"issue":"5","key":"10.1016\/j.bios.2024.116353_bib28","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1530\/REP-15-0261","article-title":"Genetics of male infertility: from research to clinic","volume":"150","author":"Krausz","year":"2015","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.bios.2024.116353_bib29","doi-asserted-by":"crossref","DOI":"10.1063\/1.4866851","article-title":"The construction of an interfacial valve-based microfluidic chip for thermotaxis evaluation of human sperm","volume":"8","author":"Li","year":"2014","journal-title":"Biomicrofluidics"},{"issue":"1","key":"10.1016\/j.bios.2024.116353_bib30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s43032-020-00269-5","article-title":"A simple, centrifugation-free, sperm-sorting device eliminates the risks of centrifugation in the swim-up method while maintaining functional competence and DNA integrity of selected spermatozoa","volume":"28","author":"Meitei","year":"2021","journal-title":"Reprod. Sci."},{"issue":"14","key":"10.1016\/j.bios.2024.116353_bib31","doi-asserted-by":"crossref","first-page":"E3087","DOI":"10.1073\/pnas.1717974115","article-title":"Live births from artificial insemination of microfluidic-sorted bovine spermatozoa characterized by trajectories correlated with fertility","volume":"115","author":"Nagata","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.bios.2024.116353_bib32","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrurol.2017.175","article-title":"Microfluidics for sperm analysis and selection","volume":"14","author":"Nosrati","year":"2017","journal-title":"Nat. Rev. Urol."},{"issue":"6","key":"10.1016\/j.bios.2024.116353_bib33","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1039\/c3lc51254a","article-title":"Rapid selection of sperm with high DNA integrity","volume":"14","author":"Nosrati","year":"2014","journal-title":"Lab Chip"},{"issue":"8810","key":"10.1016\/j.bios.2024.116353_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0140-6736(92)92425-F","article-title":"Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte","volume":"340","author":"Palermo","year":"1992","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.bios.2024.116353_bib35","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4103\/1008-682X.154308","article-title":"Behavioral mechanisms of mammalian sperm guidance","volume":"17","author":"Perez-Cerezales","year":"2015","journal-title":"Asian J. Androl."},{"issue":"13","key":"10.1016\/j.bios.2024.116353_bib36","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1039\/C9LC00209J","article-title":"Two-dimensional planar swimming selects for high DNA integrity sperm","volume":"19","author":"Riordon","year":"2019","journal-title":"Lab Chip"},{"issue":"4","key":"10.1016\/j.bios.2024.116353_bib37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.rbmo.2017.06.023","article-title":"Paving the way for a gold standard of care for infertility treatment: improving outcomes through standardization of laboratory procedures","volume":"35","author":"Schoolcraft","year":"2017","journal-title":"Reprod. Biomed. Online"},{"issue":"2","key":"10.1016\/j.bios.2024.116353_bib38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.fertnstert.2015.10.023","article-title":"Separation efficiency of a microfluidic sperm sorter to minimize sperm DNA damage","volume":"105","author":"Shirota","year":"2016","journal-title":"Fertil. Steril."},{"issue":"12","key":"10.1016\/j.bios.2024.116353_bib39","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1039\/D0LC01182G","article-title":"Selection of high-quality sperm with thousands of parallel channels","volume":"21","author":"Simchi","year":"2021","journal-title":"Lab Chip"},{"issue":"4","key":"10.1016\/j.bios.2024.116353_bib40","first-page":"227","article-title":"Microfluidic devices for the study of sperm migration","volume":"23","author":"Suarez","year":"2017","journal-title":"Mol. Hum. Reprod."},{"issue":"5","key":"10.1016\/j.bios.2024.116353_bib41","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ncpuro0166","article-title":"Practical approaches to the diagnosis and management of male infertility","volume":"2","author":"Turek","year":"2005","journal-title":"Nat. Clin. Pract. Urol."},{"key":"10.1016\/j.bios.2024.116353_bib42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: definition and epidemiology","volume":"62","author":"Vander Borght","year":"2018","journal-title":"Clin. Biochem."},{"issue":"1","key":"10.1016\/j.bios.2024.116353_bib43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41378-023-00501-7","article-title":"Sperm quality metrics were improved by a biomimetic microfluidic selection platform compared to swim-up methods","volume":"9","author":"Vasilescu","year":"2023","journal-title":"Microsystems & Nanoengineering"},{"issue":"1","key":"10.1016\/j.bios.2024.116353_bib44","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1038\/s41598-021-87046-9","article-title":"A microfluidic approach to rapid sperm recovery from heterogeneous cell suspensions","volume":"11","author":"Vasilescu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bios.2024.116353_bib45","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.chemosphere.2018.10.001","article-title":"Metal\/metalloid levels in urine and seminal plasma in relation to computer-aided sperm analysis motion parameters","volume":"214","author":"Wan","year":"2019","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.bios.2024.116353_bib46","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1039\/C6AN02420C","article-title":"High-throughput flowing upstream sperm sorting in a retarding flow field for human semen analysis","volume":"142","author":"Wu","year":"2017","journal-title":"Analyst"},{"issue":"2","key":"10.1016\/j.bios.2024.116353_bib47","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1039\/D0LC00845A","article-title":"A fully integrated biomimetic microfluidic device for evaluation of sperm response to thermotaxis and chemotaxis","volume":"21","author":"Yan","year":"2021","journal-title":"Lab Chip"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566324003580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566324003580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T16:58:55Z","timestamp":1715965135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566324003580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":47,"alternative-id":["S0956566324003580"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2024.116353","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a thermotaxis and rheotaxis microfluidic device for motile spermatozoa sorting","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2024.116353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116353"}}