{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:52:49Z","timestamp":1792788769209,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019535","name":"Science Fund for Distinguished Young Scholars of Hebei Province","doi-asserted-by":"publisher","award":["2024AFA101"],"award-info":[{"award-number":["2024AFA101"]}],"id":[{"id":"10.13039\/501100019535","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019535","name":"Science Fund for Distinguished Young Scholars of Hebei Province","doi-asserted-by":"publisher","award":["2022020801020326"],"award-info":[{"award-number":["2022020801020326"]}],"id":[{"id":"10.13039\/501100019535","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2100100"],"award-info":[{"award-number":["2021YFC2100100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300517"],"award-info":[{"award-number":["32300517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bios.2024.116400","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:54:48Z","timestamp":1715820888000},"page":"116400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Preamplification-free ultra-fast and ultra-sensitive point-of-care testing via LwaCas13a"],"prefix":"10.1016","volume":"259","author":[{"given":"Wanting","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-9178","authenticated-orcid":false,"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qili","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.bios.2024.116400_bib1","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1001\/jama.2020.4269","volume":"323","author":"Angel","year":"2020","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.bios.2024.116400_bib2","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.1038\/s41467-020-19097-x","volume":"11","author":"Arizti-Sanz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2024.116400_bib3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s41587-020-0513-4","volume":"38","author":"Broughton","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.bios.2024.116400_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1021\/acscentsci.0c00501","volume":"6","author":"Carter","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.bios.2024.116400_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.micinf.2020.01.004","volume":"22","author":"Chen","year":"2020","journal-title":"Microb. Infect."},{"issue":"6387","key":"10.1016\/j.bios.2024.116400_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.aar6245","volume":"360","author":"Chen","year":"2018","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bios.2024.116400_bib8","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045","volume":"25","author":"Corman","year":"2020","journal-title":"Euro Surveill."},{"key":"10.1016\/j.bios.2024.116400_bib10","doi-asserted-by":"crossref","first-page":"20754","DOI":"10.1002\/anie.202005398","volume":"59","author":"Dai","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"issue":"4","key":"10.1016\/j.bios.2024.116400_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00028-20","volume":"33","author":"Dhama","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.bios.2024.116400_bib12","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.1038\/s41598-022-10097-z","volume":"12","author":"Duarte","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bios.2024.116400_bib13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature19802","volume":"538","author":"East-Seletsky","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bios.2024.116400_bib14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13059-019-1742-z","volume":"20","author":"F. Teng","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.bios.2024.116400_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cell.2020.12.001","volume":"184","author":"Fozouni","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bios.2024.116400_bib17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.aam9321","volume":"356","author":"Gootenberg","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bios.2024.116400_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1126\/science.aaq0179","volume":"360","author":"Gootenberg","year":"2017","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bios.2024.116400_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/diagnostics10060399","volume":"10","author":"James","year":"2023","journal-title":"Diagnostics"},{"key":"10.1016\/j.bios.2024.116400_bib20","volume":"128","author":"Jason","year":"2020","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.bios.2024.116400_bib21","volume":"8","author":"Jiang","year":"2019","journal-title":"Adv. Healthcare Mater."},{"issue":"15","key":"10.1016\/j.bios.2024.116400_bib22","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1056\/NEJMc2026172","volume":"383","author":"Joung","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bios.2024.116400_bib23","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1038\/s41596-019-0210-2","volume":"14","author":"Kellner","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bios.2024.116400_bib24","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41563-020-00906-z","volume":"20","author":"Kevadiya","year":"2021","journal-title":"Nat. Mater."},{"issue":"4","key":"10.1016\/j.bios.2024.116400_bib25","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/nar\/gkm1083","volume":"36","author":"Kuznetsov","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bios.2024.116400_bib26","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1021\/acssynbio.9b00209","volume":"8","author":"Li","year":"2019","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.bios.2024.116400_bib27","doi-asserted-by":"crossref","first-page":"10469","DOI":"10.1021\/acs.chemrev.1c00241","volume":"121","author":"Li","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bios.2024.116400_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijsu.2020.04.018","volume":"78","author":"Nicola","year":"2020","journal-title":"Int. J. Surg."},{"issue":"6299","key":"10.1016\/j.bios.2024.116400_bib29","volume":"353","author":"Omar","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bios.2024.116400_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1142578","volume":"13","author":"Petakh","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.bios.2024.116400_bib31","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.matt.2020.06.015","volume":"3","author":"Qin","year":"2023","journal-title":"Matter"},{"issue":"12","key":"10.1016\/j.bios.2024.116400_bib32","first-page":"e1457","volume":"8","author":"Rakotosamimanana","year":"2020","journal-title":"Global health"},{"key":"10.1016\/j.bios.2024.116400_bib33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41421-018-0028-z","volume":"4","author":"S","year":"2018","journal-title":"4. Cell Discov."},{"issue":"7","key":"10.1016\/j.bios.2024.116400_bib34","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.3201\/eid2607.200282","volume":"26","author":"Sanche","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.bios.2024.116400_bib35","volume":"7","author":"Shi","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bios.2024.116400_bib36","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1373\/clinchem.2016.263665","volume":"63","author":"Song","year":"2017","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.bios.2024.116400_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/cid\/ciaa682","volume":"72","author":"Temimek","year":"2020","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.bios.2024.116400_bib38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pathol.2021.10.001","volume":"54","author":"Varadhan","year":"2022","journal-title":"Pathology"},{"key":"10.1016\/j.bios.2024.116400_bib39","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.molcel.2018.02.028","volume":"70","author":"Yan","year":"2018","journal-title":"Mol. Cell."},{"key":"10.1016\/j.bios.2024.116400_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113541","volume":"193","author":"Yin","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2024.116400_bib43","first-page":"1","volume":"11","author":"Yu","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.bios.2024.116400_bib44","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2015.09.038","volume":"163","author":"Zetsche","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bios.2024.116400_bib45","volume":"vol. 8","author":"Zhang","year":"2023"},{"key":"10.1016\/j.bios.2024.116400_bib46","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/22221751.2020.1729071","volume":"9","author":"Zhang","year":"2020","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.bios.2024.116400_bib47","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566324004056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566324004056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T03:43:41Z","timestamp":1731987821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566324004056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":42,"alternative-id":["S0956566324004056"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2024.116400","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preamplification-free ultra-fast and ultra-sensitive point-of-care testing via LwaCas13a","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2024.116400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116400"}}