{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:14:34Z","timestamp":1778566474940,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20240813142503006"],"award-info":[{"award-number":["JCYJ20240813142503006"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20220530153811027"],"award-info":[{"award-number":["JCYJ20220530153811027"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["22234006"],"award-info":[{"award-number":["22234006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bios.2025.117157","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T20:03:35Z","timestamp":1737057815000},"page":"117157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Enhancing biosensing of trace tau protein in clinical samples via emergence macroscopic directed aggregation"],"prefix":"10.1016","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-094X","authenticated-orcid":false,"given":"Yong","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-2856","authenticated-orcid":false,"given":"Tailin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.bios.2025.117157_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202201478","volume":"9","author":"Ao","year":"2022","journal-title":"Adv. Sci."},{"issue":"6","key":"10.1016\/j.bios.2025.117157_bib2","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.100.061102","volume":"100","author":"Baasch","year":"2019","journal-title":"Phys. Rev. E"},{"issue":"10","key":"10.1016\/j.bios.2025.117157_bib3","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41567-022-01704-x","volume":"18","author":"Baconnier","year":"2022","journal-title":"Nat. Phys."},{"issue":"6555","key":"10.1016\/j.bios.2025.117157_bib4","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.abi5208","volume":"373","author":"Blennow","year":"2021","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bios.2025.117157_bib5","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1039\/c2lc21068a","volume":"12","author":"Bruus","year":"2012","journal-title":"Lab Chip"},{"issue":"5","key":"10.1016\/j.bios.2025.117157_bib6","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1039\/C6SC05615F","volume":"8","author":"Chan","year":"2017","journal-title":"Chem. Sci."},{"issue":"7","key":"10.1016\/j.bios.2025.117157_bib7","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/s41591-023-02391-8","volume":"29","author":"Chen","year":"2023","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.bios.2025.117157_bib8","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1002\/anie.201905005","volume":"59","author":"Das","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"issue":"19","key":"10.1016\/j.bios.2025.117157_bib9","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1021\/jacs.1c02929","volume":"143","author":"Deng","year":"2021","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"10.1016\/j.bios.2025.117157_bib10","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s10404-014-1380-4","volume":"17","author":"Devendran","year":"2014","journal-title":"Microfluid. Nanofluid."},{"issue":"18","key":"10.1016\/j.bios.2025.117157_bib11","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJMp1912298","volume":"381","author":"Dzau","year":"2019","journal-title":"New Engl. J. Med."},{"issue":"22","key":"10.1016\/j.bios.2025.117157_bib12","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1039\/c2lc40999b","volume":"12","author":"Evander","year":"2012","journal-title":"Lab Chip"},{"issue":"10440","key":"10.1016\/j.bios.2025.117157_bib13","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0140-6736(24)00757-8","volume":"403","author":"Ferrari","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.bios.2025.117157_bib14","author":"Gao","year":"2023","journal-title":"Adv. Sci."},{"issue":"S14","key":"10.1016\/j.bios.2025.117157_bib15","article-title":"Alzheimers","volume":"19","author":"Giangrande","year":"2023","journal-title":"Dement."},{"issue":"8","key":"10.1016\/j.bios.2025.117157_bib16","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","volume":"76","author":"Hanseeuw","year":"2019","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bios.2025.117157_bib17","volume":"210","author":"Hu","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"7","key":"10.1016\/j.bios.2025.117157_bib18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41582-022-00665-2","volume":"18","author":"Karikari","year":"2022","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.bios.2025.117157_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.bios.2025.117157_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13024-024-00741-9","volume":"19","author":"Lantero-Rodriguez","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bios.2025.117157_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114279","volume":"209","author":"Lim","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"23","key":"10.1016\/j.bios.2025.117157_bib22","doi-asserted-by":"crossref","first-page":"24343","DOI":"10.1021\/acsnano.3c10405","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.bios.2025.117157_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00604-022-05199-4","volume":"189","author":"Liu","year":"2022","journal-title":"Microchim. Acta"},{"issue":"10452","key":"10.1016\/j.bios.2025.117157_bib24","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"issue":"44","key":"10.1016\/j.bios.2025.117157_bib25","volume":"17","author":"Lu","year":"2021","journal-title":"Small"},{"issue":"9","key":"10.1016\/j.bios.2025.117157_bib26","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1021\/acssensors.2c01103","volume":"7","author":"Luo","year":"2022","journal-title":"ACS Sens."},{"issue":"2","key":"10.1016\/j.bios.2025.117157_bib27","volume":"13","author":"Masters","year":"2008","journal-title":"J. Biomed. Opt."},{"issue":"10","key":"10.1016\/j.bios.2025.117157_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax3084","volume":"5","author":"Ren","year":"2019","journal-title":"Sci. Adv."},{"issue":"8","key":"10.1016\/j.bios.2025.117157_bib29","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nbt1235","volume":"24","author":"Rifai","year":"2006","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.bios.2025.117157_bib30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3390\/mi11020152","volume":"11","author":"Saeidi","year":"2020","journal-title":"Micromachines"},{"issue":"36","key":"10.1016\/j.bios.2025.117157_bib31","doi-asserted-by":"crossref","first-page":"16310","DOI":"10.1021\/jacs.2c07625","volume":"144","author":"Samanta","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.bios.2025.117157_bib32","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.85.016327","volume":"85","author":"Settnes","year":"2012","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.bios.2025.117157_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115771","volume":"243","author":"Shang","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bios.2025.117157_bib34","volume":"5","author":"Tao","year":"2024","journal-title":"Innovation"},{"issue":"1","key":"10.1016\/j.bios.2025.117157_bib35","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1038\/s41467-021-22913-7","volume":"12","author":"Tian","year":"2021","journal-title":"Nat. Commun."},{"issue":"37","key":"10.1016\/j.bios.2025.117157_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb0494","volume":"6","author":"Tian","year":"2020","journal-title":"Sci. Adv."},{"issue":"27","key":"10.1016\/j.bios.2025.117157_bib37","volume":"16","author":"Wang","year":"2020","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.bios.2025.117157_bib38","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1021\/acsnano.1c05267","volume":"16","author":"Wang","year":"2022","journal-title":"ACS Nano"},{"issue":"19","key":"10.1016\/j.bios.2025.117157_bib39","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1021\/acs.chemrev.0c01140","volume":"121","author":"Wu","year":"2021","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.bios.2025.117157_bib40","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1038\/s41467-024-50053-1","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."},{"issue":"38","key":"10.1016\/j.bios.2025.117157_bib41","volume":"16","author":"Xiaolong","year":"2020","journal-title":"Small"},{"issue":"28","key":"10.1016\/j.bios.2025.117157_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/scirobotics.aav8006","volume":"4","author":"Xie","year":"2019","journal-title":"Sci. Robot."},{"issue":"10","key":"10.1016\/j.bios.2025.117157_bib43","doi-asserted-by":"crossref","first-page":"14367","DOI":"10.1364\/OE.418735","volume":"29","author":"Yazhgur","year":"2021","journal-title":"Opt Express"},{"issue":"15","key":"10.1016\/j.bios.2025.117157_bib44","doi-asserted-by":"crossref","first-page":"7960","DOI":"10.1039\/D4CS00001C","volume":"53","author":"Ye","year":"2024","journal-title":"Chem. Soc. Rev."},{"issue":"24","key":"10.1016\/j.bios.2025.117157_bib45","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1039\/D1LC00628B","volume":"21","author":"Zhang","year":"2021","journal-title":"Lab Chip"},{"issue":"4","key":"10.1016\/j.bios.2025.117157_bib46","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1021\/acs.jproteome.3c00102","volume":"22","author":"Zhao","year":"2023","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.bios.2025.117157_bib47","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1038\/s41467-020-18347-2","volume":"11","author":"Zhichao","year":"2020","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bios.2025.117157_bib48","volume":"5","author":"Zhou","year":"2018","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.bios.2025.117157_bib49","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/clinchem\/39.4.561","volume":"39","author":"Zweig","year":"1993","journal-title":"Clin. Chem."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325000314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325000314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:36:00Z","timestamp":1778564160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566325000314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":49,"alternative-id":["S0956566325000314"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2025.117157","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancing biosensing of trace tau protein in clinical samples via emergence macroscopic directed aggregation","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2025.117157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117157"}}