{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:26:47Z","timestamp":1791491207224,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20220129"],"award-info":[{"award-number":["BK20220129"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52475588"],"award-info":[{"award-number":["52475588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008081","name":"Southeast University","doi-asserted-by":"publisher","award":["2242022R40003"],"award-info":[{"award-number":["2242022R40003"]}],"id":[{"id":"10.13039\/501100008081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bios.2025.117496","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T18:56:48Z","timestamp":1745002608000},"page":"117496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Heterojunction nanofluidic memristors based on peptide chain valves for neuromorphic applications"],"prefix":"10.1016","volume":"282","author":[{"given":"Honglin","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9469-1540","authenticated-orcid":false,"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bios.2025.117496_bib1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1002\/elan.202000044","article-title":"Synthesis of cysteine modified MoS2 nanocomposite: a biocompatible electrochemical sensor material and its application to the determination of antidiabetic dapagliflozin","volume":"32","author":"Ate\u015f","year":"2020","journal-title":"Electroanalysis"},{"issue":"5","key":"10.1016\/j.bios.2025.117496_bib2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1039\/D3NH00570D","article-title":"Graphene oxide-DNA\/graphene oxide-PDDA sandwiched membranes with neuromorphic function","volume":"9","author":"Bong","year":"2024","journal-title":"Nanoscale Horiz"},{"issue":"24","key":"10.1016\/j.bios.2025.117496_bib3","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1039\/C9AN01561B","article-title":"A nanofluidic memristor based on ion concentration polarization","volume":"144","author":"Bu","year":"2019","journal-title":"Analyst"},{"issue":"1","key":"10.1016\/j.bios.2025.117496_bib4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1109\/JETCAS.2017.2771529","article-title":"Mitigating asymmetric nonlinear weight update effects in hardware neural network based on analog resistive synapse","volume":"8","author":"Chang","year":"2018","journal-title":"IEEE J. Emerg. Sel. Top. Circ. Syst."},{"issue":"9","key":"10.1016\/j.bios.2025.117496_bib5","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1021\/nn202983n","article-title":"Short-term memory to long-term memory transition in a nanoscale memristor","volume":"5","author":"Chang","year":"2011","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.bios.2025.117496_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/aelm.202000848","article-title":"Nanochannel\u2010based interfacial memristor: electrokinetic analysis of the frequency characteristics","volume":"7","author":"Chen","year":"2021","journal-title":"Adv. Electron Mater."},{"issue":"3","key":"10.1016\/j.bios.2025.117496_bib7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41557-023-01322-x","article-title":"Nanopore DNA sequencing technologies and their applications towards single-molecule proteomics","volume":"16","author":"Dorey","year":"2024","journal-title":"Nat. Chem."},{"issue":"22","key":"10.1016\/j.bios.2025.117496_bib8","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1557\/s43578-022-00590-6","article-title":"Laser-induced graphene-based miniaturized, flexible, non-volatile resistive switching memory devices","volume":"37","author":"Enaganti","year":"2022","journal-title":"J. Mater. Res."},{"issue":"10","key":"10.1016\/j.bios.2025.117496_bib9","doi-asserted-by":"crossref","DOI":"10.1088\/0268-1242\/29\/10\/104012","article-title":"Solid-state memcapacitive device based on memristive switch","volume":"29","author":"Flak","year":"2014","journal-title":"Semicond. Sci. Technol."},{"issue":"12","key":"10.1016\/j.bios.2025.117496_bib10","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/nmat4091","article-title":"Vertical and in-plane heterostructures from WS2\/MoS2 monolayers","volume":"13","author":"Gong","year":"2014","journal-title":"Nat. Mater."},{"issue":"9","key":"10.1016\/j.bios.2025.117496_bib11","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1021\/acs.jpclett.3c03184","article-title":"Artificial neural synapses based on microfluidic memristors prepared by capillary tubes and ionic liquid","volume":"15","author":"Guo","year":"2024","journal-title":"J. Phys. Chem. Lett."},{"issue":"38","key":"10.1016\/j.bios.2025.117496_bib12","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1002\/adma.201301361","article-title":"Towards the development of flexible non-volatile memories","volume":"25","author":"Han","year":"2013","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.bios.2025.117496_bib13","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1039\/C9NR07941F","article-title":"Multi-gate memristive synapses realized with the lateral heterostructure of 2D WSe(2) and WO(3)","volume":"12","author":"He","year":"2020","journal-title":"Nanoscale"},{"issue":"2","key":"10.1016\/j.bios.2025.117496_bib14","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1021\/acsami.2c17228","article-title":"Bipolar resistive switching in TiO(2) artificial synapse mimicking Pavlov's associative learning","volume":"15","author":"Jena","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"18","key":"10.1016\/j.bios.2025.117496_bib15","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2320242121","article-title":"Brain-inspired computing with fluidic iontronic nanochannels","volume":"121","author":"Kamsma","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"38","key":"10.1016\/j.bios.2025.117496_bib16","doi-asserted-by":"crossref","first-page":"13368","DOI":"10.1039\/D0TC03334K","article-title":"Soft ionic liquid based resistive memory characteristics in a two terminal discrete polydimethylsiloxane cylindrical microchannel","volume":"8","author":"Khan","year":"2020","journal-title":"J. Mater. Chem. C"},{"issue":"2","key":"10.1016\/j.bios.2025.117496_bib17","article-title":"Advancement in soft iontronic resistive memory devices and their application for neuromorphic computing","volume":"5","author":"Khan","year":"2023","journal-title":"Adv. Intell. Sys."},{"issue":"2","key":"10.1016\/j.bios.2025.117496_bib18","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1021\/acsaelm.2c01636","article-title":"Liquid-based memory devices for next-generation computing","volume":"5","author":"Kim","year":"2023","journal-title":"ACS Appl. Electron. Mater."},{"issue":"1","key":"10.1016\/j.bios.2025.117496_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41427-020-00243-2","article-title":"Designing artificial sodium ion reservoirs to emulate biological synapses","volume":"12","author":"Kim","year":"2020","journal-title":"NPG Asia Mater."},{"issue":"37","key":"10.1016\/j.bios.2025.117496_bib20","doi-asserted-by":"crossref","first-page":"42308","DOI":"10.1021\/acsami.2c12166","article-title":"Emulating the signal transmission in a neural system using polymer membranes","volume":"14","author":"Kim","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.bios.2025.117496_bib21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1109\/TVLSI.2022.3161847","article-title":"Memristors Enabled Computing Correlation Parameter In-Memory System: a Potential Alternative to Von Neumann Architecture","volume":"30","author":"Kundu","year":"2022","journal-title":"IEEE Trans. Very Large Scale Integr. Syst."},{"issue":"11","key":"10.1016\/j.bios.2025.117496_bib22","first-page":"895","article-title":"MAGIC-Memristor-Aided logic","volume":"61","author":"Kvatinsky","year":"2014","journal-title":"IEEE Trans. Circ. Syst. Ii-Express Brief."},{"key":"10.1016\/j.bios.2025.117496_bib23","article-title":"Three-dimensional crossbar arrays of self-rectifying Si\/SiO(2)\/Si memristors","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"issue":"33","key":"10.1016\/j.bios.2025.117496_bib24","doi-asserted-by":"crossref","first-page":"14035","DOI":"10.1039\/D1NR03356E","article-title":"Achieving complementary resistive switching and multi-bit storage goals by modulating the dual-ion reaction through supercritical fluid-assisted ammoniation","volume":"13","author":"Li","year":"2021","journal-title":"Nanoscale"},{"issue":"20","key":"10.1016\/j.bios.2025.117496_bib25","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.1021\/acs.nanolett.3c05079","article-title":"Artificial funnel nanochannel device emulates synaptic behavior","volume":"24","author":"Li","year":"2024","journal-title":"Nano Lett."},{"issue":"50","key":"10.1016\/j.bios.2025.117496_bib26","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6463\/aade3f","article-title":"Review of memristor devices in neuromorphic computing: materials sciences and device challenges","volume":"51","author":"Li","year":"2018","journal-title":"J. Phys. Appl. Phys."},{"issue":"21","key":"10.1016\/j.bios.2025.117496_bib27","doi-asserted-by":"crossref","first-page":"14558","DOI":"10.1021\/jacs.4c01218","article-title":"Single-pore nanofluidic logic memristor with reconfigurable synaptic functions and designable combinations","volume":"146","author":"Ling","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bios.2025.117496_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fncom.2021.755405","article-title":"Editorial: memristor computing for neuromorphic systems","volume":"15","author":"Min","year":"2021","journal-title":"Front. Comput. Neurosci."},{"issue":"23","key":"10.1016\/j.bios.2025.117496_bib29","doi-asserted-by":"crossref","first-page":"26748","DOI":"10.1021\/acsami.1c04949","article-title":"Inverted ion current rectification-based chemical delivery probes for stimulation of neurons","volume":"13","author":"Oh","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.bios.2025.117496_bib30","doi-asserted-by":"crossref","first-page":"8390","DOI":"10.1038\/s41467-023-44019-y","article-title":"Hydrophobically gated memristive nanopores for neuromorphic applications","volume":"14","author":"Paulo","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bios.2025.117496_bib31","doi-asserted-by":"crossref","DOI":"10.1063\/5.0188940","article-title":"Neuromorphic responses of nanofluidic memristors in symmetric and asymmetric ionic solutions","volume":"160","author":"Ramirez","year":"2024","journal-title":"J. Chem. Phys."},{"issue":"6628","key":"10.1016\/j.bios.2025.117496_bib32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.adc9931","article-title":"Long-term memory and synapse-like dynamics in two-dimensional nanofluidic channels","volume":"379","author":"Robin","year":"2023","journal-title":"Science"},{"issue":"6555","key":"10.1016\/j.bios.2025.117496_bib33","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1126\/science.abf7923","article-title":"Modeling of emergent memory and voltage spiking in ionic transport through angstrom-scale slits","volume":"373","author":"Robin","year":"2021","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.bios.2025.117496_bib34","doi-asserted-by":"crossref","first-page":"11662","DOI":"10.1021\/acs.nanolett.3c03518","article-title":"Ultralow energy consumption angstrom-fluidic memristor","volume":"23","author":"Shi","year":"2023","journal-title":"Nano Lett."},{"issue":"17","key":"10.1016\/j.bios.2025.117496_bib35","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1021\/acs.jpclett.2c00533","article-title":"Navigated delivery of peptide to the nanopore using In-Plane heterostructures of MoS(2) and SnS(2) for protein sequencing","volume":"13","author":"Si","year":"2022","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.bios.2025.117496_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsusc.2020.147738","article-title":"Highly transparent solid-state artificial synapse based on oxide memristor","volume":"536","author":"Singh","year":"2021","journal-title":"Appl. Surf. Sci."},{"issue":"1","key":"10.1016\/j.bios.2025.117496_bib37","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1038\/s41467-022-30432-2","article-title":"Simultaneous emulation of synaptic and intrinsic plasticity using a memristive synapse","volume":"13","author":"Sung","year":"2022","journal-title":"Nat. Commun."},{"issue":"Sm","key":"10.1016\/j.bios.2025.117496_bib38","doi-asserted-by":"crossref","DOI":"10.35848\/1347-4065\/ac64e5","article-title":"Solid state ionics for the development of artificial intelligence components","volume":"61","author":"Terabe","year":"2022","journal-title":"Jpn. J. Appl. Phys."},{"key":"10.1016\/j.bios.2025.117496_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2022.107486","article-title":"A biomimetic afferent nervous system based on the flexible artificial synapse","volume":"100","author":"Wang","year":"2022","journal-title":"Nano Energy"},{"issue":"52","key":"10.1016\/j.bios.2025.117496_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202209907","article-title":"Flexible ZnO nanosheet-based artificial synapses prepared by low-temperature process for high recognition accuracy neuromorphic computing","volume":"32","author":"Wang","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"6628","key":"10.1016\/j.bios.2025.117496_bib41","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1126\/science.adc9150","article-title":"Neuromorphic functions with a polyelectrolyte-confined fluidic memristor","volume":"379","author":"Xiong","year":"2023","journal-title":"Science"},{"issue":"27","key":"10.1016\/j.bios.2025.117496_bib42","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2200845119","article-title":"Nanoparticle-blockage-enabled rapid and reversible nanopore gating with tunable memory","volume":"119","author":"Yazbeck","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.bios.2025.117496_bib43","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1021\/acs.nanolett.9b00525","article-title":"Nanochannel-based transport in an interfacial memristor can emulate the analog weight modulation of synapses","volume":"19","author":"Zhang","year":"2019","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.bios.2025.117496_bib44","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1021\/acsami.4c13818","article-title":"WS(2)\/Graphene\/MoS(2) Sandwich van der Waals Heterojunction for Fast-Response Photodetectors","volume":"17","author":"Zhang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6353","key":"10.1016\/j.bios.2025.117496_bib45","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.aan6814","article-title":"Robust epitaxial growth of two-dimensional heterostructures, multiheterostructures, and superlattices","volume":"357","author":"Zhang","year":"2017","journal-title":"Science"},{"issue":"23","key":"10.1016\/j.bios.2025.117496_bib46","doi-asserted-by":"crossref","first-page":"15025","DOI":"10.1021\/acsnano.4c01730","article-title":"Geometrically scalable iontronic memristors: employing bipolar polyelectrolyte gels for neuromorphic systems","volume":"18","author":"Zhang","year":"2024","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.bios.2025.117496_bib47","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwad216","article-title":"Nanofluidic memristor based on the elastic deformation of nanopores with nanoparticle adsorption","volume":"11","author":"Zhou","year":"2024","journal-title":"Natl. Sci. Rev."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325003707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325003707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:34:56Z","timestamp":1762338896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566325003707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":47,"alternative-id":["S0956566325003707"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2025.117496","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heterojunction nanofluidic memristors based on peptide chain valves for neuromorphic applications","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2025.117496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117496"}}