{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:56:57Z","timestamp":1791251817878,"version":"4.1.0"},"reference-count":182,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000149","name":"National Science Foundation Division of Engineering Education and Centers","doi-asserted-by":"publisher","award":["1648451"],"award-info":[{"award-number":["1648451"]}],"id":[{"id":"10.13039\/100000149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Taighde \u00c9ireann \u2013 Research Ireland","doi-asserted-by":"publisher","award":["21\/RC\/10294_P2"],"award-info":[{"award-number":["21\/RC\/10294_P2"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bios.2025.117535","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:39:06Z","timestamp":1746185946000},"page":"117535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Advances in biosensors for diagnosis of Alzheimer's and Parkinson's diseases"],"prefix":"10.1016","volume":"284","author":[{"given":"Masoud","family":"Negahdary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indherjith","family":"Sakthinathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensiyeh","family":"Mirsadoughi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances S.","family":"Ligler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard L.","family":"Cot\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Forster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4926-5467","authenticated-orcid":false,"given":"Samuel","family":"Mabbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bios.2025.117535_bib1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41582-021-00616-3","article-title":"Blood GFAP as an emerging biomarker in brain and spinal cord disorders","volume":"18","author":"Abdelhak","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bios.2025.117535_bib2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.procbio.2023.11.019","article-title":"Cyclic and differential pulse voltammetric measurements on fibrils formation of alpha synuclein in Parkinson's disease by a gold interdigitated tetraelectrodes","volume":"136","author":"Adam","year":"2024","journal-title":"Process Biochem."},{"key":"10.1016\/j.bios.2025.117535_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2024.108800","article-title":"Selective detection of alpha synuclein amyloid fibrils by faradaic and non-faradaic electrochemical impedance spectroscopic approaches","volume":"161","author":"Adam","year":"2025","journal-title":"Bioelectrochemistry"},{"issue":"28","key":"10.1016\/j.bios.2025.117535_bib4","doi-asserted-by":"crossref","first-page":"10492","DOI":"10.1021\/acs.analchem.3c01197","article-title":"Improving multicolor colocalization in single-vesicle flow cytometry with vesicle transit time","volume":"95","author":"Andronico","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.117535_bib5","article-title":"Chitosan\u2010enhanced sensitivity of mercaptoundecanoic acid (MUA)\u2010capped gold nanorod based localized surface plasmon resonance (LSPR) biosensor for detection of alpha\u2010synuclein oligomer biomarker in parkinson's disease","author":"Apayd\u0131n","year":"2024","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.bios.2025.117535_bib6","article-title":"Alzheimer's diagnosis beyond cerebrospinal fluid: probe-free detection of tau proteins using MXene based redox systems and molecularly imprinted polymers","volume":"20","author":"Arjun","year":"2024","journal-title":"Biosens. Bioelectron. X"},{"issue":"3","key":"10.1016\/j.bios.2025.117535_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jamaneurol.2023.5319","article-title":"Diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for alzheimer disease pathology","volume":"81","author":"Ashton","year":"2024","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1021\/acssensors.3c02268","article-title":"Ultrahigh-throughput, real-time flow cytometry for rare cell quantification from whole blood","volume":"9","author":"Aslan","year":"2024","journal-title":"ACS Sens."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13041-024-01118-1","article-title":"The duality of amyloid-\u03b2: its role in normal and Alzheimer's disease states","volume":"17","author":"Azargoonjahromi","year":"2024","journal-title":"Mol. Brain"},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2144\/btn-2022-0003","article-title":"Western blotting: a powerful staple in scientific and biomedical research","volume":"73","author":"Begum","year":"2022","journal-title":"Biotechniques"},{"issue":"4","key":"10.1016\/j.bios.2025.117535_bib11","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/jnc.15516","article-title":"The role of neuroimaging in Parkinson's disease","volume":"159","author":"Bidesi","year":"2021","journal-title":"J. Neurochem."},{"issue":"10291","key":"10.1016\/j.bios.2025.117535_bib12","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.bios.2025.117535_bib13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00702-021-02452-7","article-title":"Dopamine transporter (DAT) imaging in Parkinson's disease and related disorders","volume":"129","author":"Br\u00fccke","year":"2022","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.bios.2025.117535_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105345","article-title":"Clinical value of plasma pTau181 to predict alzheimer's disease pathology in a large real-world cohort of a memory clinic","volume":"108","author":"Cano","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bios.2025.117535_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102739","article-title":"Fluid-based biomarkers for neurodegenerative diseases","volume":"108","author":"Cao","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bios.2025.117535_bib16","series-title":"Computational and Experimental Studies in Alzheimer's disease","first-page":"1","article-title":"Alzheimer's disease: epidemiology, neuropathology, and neurochemistry","author":"Chaudhary","year":"2024"},{"key":"10.1016\/j.bios.2025.117535_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.116931","article-title":"Nucleic acid-assisted CRISPR-cas systems for advanced biosensing and bioimaging","volume":"159","author":"Chen","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13195-023-01246-1","article-title":"Reference intervals for plasma amyloid-\u03b2, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment","volume":"15","author":"Chen","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bios.2025.117535_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116738","article-title":"In-situ nanozyme catalytic amplification coupled with a universal antibody orientation strategy based electrochemical immunosensor for AD-related biomarker","volume":"266","author":"Chen","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"11","key":"10.1016\/j.bios.2025.117535_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/sstr.202400241","article-title":"A bilingual nanobiosensor for cross-category integrated decoding of the beta-site amyloid precursor protein-cleaving enzyme 1\u2013A\u03b2 oligomer signaling pathway","volume":"5","author":"Cheng","year":"2024","journal-title":"Small Struct."},{"issue":"10","key":"10.1016\/j.bios.2025.117535_bib21","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1021\/acssensors.4c02037","article-title":"Plasmonic nanogap-enhanced tunable three-dimensional nanoframes in application to clinical diagnosis of alzheimer's disease","volume":"9","author":"Choi","year":"2024","journal-title":"ACS Sens."},{"issue":"47","key":"10.1016\/j.bios.2025.117535_bib22","doi-asserted-by":"crossref","first-page":"15016","DOI":"10.1021\/acs.nanolett.4c03768","article-title":"Blood-based nanoparticle-enhanced quaking-induced conversion (Nano-QuIC): inhibitor-resistant detection of seeding activity in patients diagnosed with parkinson's disease","volume":"24","author":"Christenson","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.bios.2025.117535_bib23","series-title":"Smart Diagnostics for Neurodegenerative Disorders","first-page":"155","article-title":"Electrochemical biosensor-based detection assays for early diagnosis of neurodegenerative disorders","author":"da Silva","year":"2024"},{"key":"10.1016\/j.bios.2025.117535_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116880","article-title":"\u03b1-Synuclein plastic antibody applied to monitor monomeric structures and discriminate aggregated forms in human CSF","volume":"268","author":"da Silva","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.bios.2025.117535_bib25","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1002\/alz.13737","article-title":"Nanoscale imaging of pT217\u2010tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: evidence of interneuronal trafficking and early\u2010stage neurodegeneration","volume":"20","author":"Datta","year":"2024","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.bios.2025.117535_bib26","doi-asserted-by":"crossref","DOI":"10.4137\/BMI.S2185","article-title":"Immunohistochemistry as an important tool in biomarkers detection and clinical practice","volume":"5","author":"De Matos","year":"2010","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.bios.2025.117535_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125042","article-title":"Electrochemical magneto-immunoassay for detection of ADAM10 Alzheimer's biomarker using gold nanoparticles as label","volume":"266","author":"de Oliveira","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2025.117535_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2022.107959","article-title":"Molecular imprinting synthetic receptor based sensor for determination of parkinson's disease biomarker DJ-1","volume":"183","author":"Dhinesh Kumar","year":"2022","journal-title":"Microchem. J."},{"key":"10.1016\/j.bios.2025.117535_bib29","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jcis.2024.08.201","article-title":"Sensitive colorimetric immunosensor using AuNP-functionalized polymer film for picogram-level detection of tau protein intermediate aggregates","volume":"678","author":"Di","year":"2025","journal-title":"J. Colloid Interface Sci."},{"issue":"6","key":"10.1016\/j.bios.2025.117535_bib30","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S1474-4422(21)00066-1","article-title":"Clinical diagnosis of alzheimer's disease: recommendations of the international working group","volume":"20","author":"Dubois","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bios.2025.117535_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.136183","article-title":"Applications of carbon-based conductive nanomaterials in biosensors","volume":"442","author":"Eivazzadeh-Keihan","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bios.2025.117535_bib32","series-title":"Cottrell & Patel's Neuroanesthesia","first-page":"22","article-title":"Cerebral and spinal cord blood flow","author":"Ellis","year":"2025"},{"key":"10.1016\/j.bios.2025.117535_bib33","series-title":"Artificial Intelligence Enabled Signal Processing Based Models for Neural Information Processing","first-page":"150","article-title":"Detecting dementia using EEG signal processing and machine learning","author":"Ferdowsi","year":"2024"},{"key":"10.1016\/j.bios.2025.117535_bib34","first-page":"1","article-title":"Fluid biomarkers of chronic traumatic brain injury","author":"Friberg","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"21","key":"10.1016\/j.bios.2025.117535_bib35","doi-asserted-by":"crossref","first-page":"2300057","DOI":"10.1002\/smll.202300057","article-title":"Gold nanomaterials\u2010implemented CRISPR\u2010Cas systems for biosensing","volume":"19","author":"Fu","year":"2023","journal-title":"Small"},{"issue":"10","key":"10.1016\/j.bios.2025.117535_bib36","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/14737159.2024.2403073","article-title":"Research advancement in fluid biomarkers for Parkinson's disease","volume":"24","author":"Gaetani","year":"2024","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"14","key":"10.1016\/j.bios.2025.117535_bib37","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1021\/acs.analchem.3c05665","article-title":"Gold nanoparticle-decorated catalytic micromotor-based aptassay for rapid electrochemical label-free Amyloid-\u03b242 oligomer determination in clinical samples from alzheimer's patients","volume":"96","author":"Gallo-Orive","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.117535_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2021.110017","article-title":"Integrated positron emission tomography\/magnetic resonance imaging in clinical diagnosis of Alzheimer's disease","volume":"145","author":"Gao","year":"2021","journal-title":"Eur. J. Radiol."},{"issue":"2","key":"10.1016\/j.bios.2025.117535_bib39","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1039\/D0CS00115E","article-title":"Fluorescent probes for bioimaging of potential biomarkers in parkinson's disease","volume":"50","author":"Gao","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bios.2025.117535_bib40","series-title":"Astrocyte-Neuron Interactions in Health and Disease","first-page":"319","article-title":"The role of astrocytes in parkinson's disease: astrocytes in parkinson's disease","author":"Garcia","year":"2024"},{"key":"10.1016\/j.bios.2025.117535_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125597","article-title":"Label-free electrochemical immunosensing of glial fibrillary acidic protein (GFAP) at synthesized rGO\/MoS2\/AgNPs nanocomposite. Application to the determination in human cerebrospinal fluid","volume":"270","author":"Garc\u00eda-Rodrigo","year":"2024","journal-title":"Talanta"},{"issue":"4","key":"10.1016\/j.bios.2025.117535_bib42","doi-asserted-by":"crossref","DOI":"10.1149\/2754-2726\/ac973e","article-title":"Towards modern-age advanced sensors for the management of neurodegenerative disorders: current status, challenges and prospects","volume":"1","author":"Gautam","year":"2022","journal-title":"ECS Sensors Plus"},{"issue":"5","key":"10.1016\/j.bios.2025.117535_bib43","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/bcpt.14003","article-title":"A review on the new age methodologies for early detection of Alzheimer's and parkinson's disease","volume":"134","author":"Ghosh","year":"2024","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.bios.2025.117535_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2023.120805","article-title":"Plasma p-tau181 as a promising non-invasive biomarker of alzheimer's disease pathology in subjective cognitive decline and mild cognitive impairment","volume":"453","author":"Giacomucci","year":"2023","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bios.2025.117535_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.dscb.2021.100020","article-title":"DJ-1 and parkinson's disease","volume":"3","author":"Gibson","year":"2021","journal-title":"Brain Disorders"},{"key":"10.1016\/j.bios.2025.117535_bib46","article-title":"The GFAP proteoform puzzle: how to advance GFAP as a fluid biomarker in neurological diseases","author":"Gogishvili","year":"2024","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bios.2025.117535_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115988","article-title":"Micromotor-based electrochemical immunoassays for reliable determination of amyloid-\u03b2 (1\u201342) in Alzheimer's diagnosed clinical samples","volume":"249","author":"Gord\u00f3n Pidal","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117535_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136785","article-title":"Dual on-the-move electrochemical immunoassays for the simultaneous determination of amyloid-\u03b2 (1\u221242) and tau in Alzheimer's patient samples","volume":"423","author":"Gord\u00f3n Pidal","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2025.117535_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135456","article-title":"Multiplex paper-based electrochemical immunosensor for the simultaneous monitoring of blood biomarkers in alzheimer's disease","volume":"406","author":"Gu","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2025.117535_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113467","article-title":"Highly sensitive self-healable strain biosensors based on robust transparent conductive nanocellulose nanocomposites: relationship between percolated network and sensing mechanism","volume":"191","author":"Han","year":"2021","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib51","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1039\/C9CS00621D","article-title":"Visible-light and near-infrared fluorescence and surface-enhanced raman scattering point-of-care sensing and bio-imaging: a review","volume":"51","author":"Hang","year":"2022","journal-title":"Chem. Soc. Rev."},{"issue":"6","key":"10.1016\/j.bios.2025.117535_bib52","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41591-021-01382-x","article-title":"Biomarkers for neurodegenerative diseases","volume":"27","author":"Hansson","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.bios.2025.117535_bib53","article-title":"Immunohistochemistry fundamentals","volume":"vol. 1","author":"Hasic","year":"2022"},{"key":"10.1016\/j.bios.2025.117535_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111315","article-title":"Diagnostics of Alzheimer's disease using fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay","volume":"205","author":"Hsiao","year":"2024","journal-title":"Microchem. J."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib55","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/s41467-025-56653-9","article-title":"NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation","volume":"16","author":"Hu","year":"2025","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bios.2025.117535_bib56","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.survophthal.2023.11.003","article-title":"Age-related macular degeneration and neurodegenerative disorders: shared pathways in complex interactions","volume":"69","author":"Jabbehdari","year":"2024","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.bios.2025.117535_bib57","series-title":"The Impact of the Dementia Epidemic. Design for Dementia","first-page":"5","author":"Jain","year":"2024"},{"issue":"46","key":"10.1016\/j.bios.2025.117535_bib58","doi-asserted-by":"crossref","first-page":"24463","DOI":"10.1021\/acs.langmuir.4c03042","article-title":"SERS-based microfluidic bioscreening platform for selective detection of \u03b2-Amyloid peptides","volume":"40","author":"Jaiswal","year":"2024","journal-title":"Langmuir"},{"key":"10.1016\/j.bios.2025.117535_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135991","article-title":"Optimization of CNT growth-upheaved nanofilm for highly sensitive fluorescent detection of Alzheimer's disease","volume":"415","author":"Jang","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2025.117535_bib60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jcis.2024.03.125","article-title":"Strong cathode electroluminescence biosensor based on CeO2 functionalized PCN-222@Ag NPs for sensitive detection of p-Tau-181 protein","volume":"665","author":"Jiang","year":"2024","journal-title":"J. Colloid Interface Sci."},{"issue":"4","key":"10.1016\/j.bios.2025.117535_bib61","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cclet.2015.01.021","article-title":"New developments in Western blot technology","volume":"26","author":"Jin","year":"2015","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bios.2025.117535_bib62","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jconrel.2024.09.012","article-title":"Amyloid-\u03b2-targeting immunotherapies for alzheimer's disease","volume":"375","author":"Jin","year":"2024","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13195-022-01011-w","article-title":"Diagnostic value of serum versus plasma phospho-tau for Alzheimer's disease","volume":"14","author":"Kac","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bios.2025.117535_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114628","article-title":"A novel multi-set differential pulse voltammetry technique for improving precision in electrochemical sensing","volume":"216","author":"Kashyap","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"6","key":"10.1016\/j.bios.2025.117535_bib65","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.4103\/1673-5374.385871","article-title":"Smart electrochemical sensing of amyloid-beta to manage total Alzheimer's diseases","volume":"19","author":"Kaushik","year":"2024","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.bios.2025.117535_bib66","first-page":"1","article-title":"Neurofilaments as biomarkers in neurological disorders\u2014towards clinical application","author":"Khalil","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"22","key":"10.1016\/j.bios.2025.117535_bib67","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1021\/acs.accounts.4c00458","article-title":"Chemical-Driven amyloid clearance for therapeutics and diagnostics of alzheimer's disease","volume":"57","author":"Kim","year":"2024","journal-title":"Accounts Chem. Res."},{"issue":"10","key":"10.1016\/j.bios.2025.117535_bib68","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1021\/acssensors.4c00945","article-title":"Chemically self-assembled monolayer semiconducting single-walled carbon nanotube-based biosensor platform for Amyloid-\u03b2 detection","volume":"9","author":"Kim","year":"2024","journal-title":"ACS Sens."},{"key":"10.1016\/j.bios.2025.117535_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116128","article-title":"Surface-functionalized SERS platform for deep learning-assisted diagnosis of alzheimer's disease","volume":"251","author":"Kim","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117535_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116085","article-title":"Distinct plasma phosphorylated-tau proteins profiling for the differential diagnosis of mild cognitive impairment and Alzheimer's disease by plasmonic asymmetric nanobridge-based biosensor","volume":"250","author":"Kim","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib71","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41531-024-00738-7","article-title":"A skin-specific \u03b1-Synuclein seeding amplification assay for diagnosing Parkinson's disease","volume":"10","author":"Kuang","year":"2024","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.bios.2025.117535_bib72","series-title":"An Issue of Neuroimaging Clinics of North America","article-title":"The subarachnoid space: percutaneous access for diagnosis and image-guided therapies, an issue of neuroimaging clinics of North America: the subarachnoid space: percutaneous access for diagnosis and image-guided therapies","author":"Lanzman","year":"2024"},{"key":"10.1016\/j.bios.2025.117535_bib73","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.cca.2021.08.009","article-title":"Dopamine in Parkinson's disease","volume":"522","author":"Latif","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bios.2025.117535_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135715","article-title":"Regulation of triazine-COF and CoAl-LDH substrates in composites for high-performance neurofilament-light chains electrochemical immunosensors","volume":"411","author":"Li","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"issue":"30","key":"10.1016\/j.bios.2025.117535_bib75","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202401966","article-title":"An ultrasensitive molecularly imprinted point-of-care electrochemical sensor for detection of glial fibrillary acidic protein","volume":"13","author":"Li","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bios.2025.117535_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125229","article-title":"Peptide-antifouling interface for monitoring \u03b2-amyloid based on electrochemiluminescence resonance energy transfer","volume":"267","author":"Li","year":"2024","journal-title":"Talanta"},{"issue":"17","key":"10.1016\/j.bios.2025.117535_bib77","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1021\/acschemneuro.4c00097","article-title":"Fluorescence-based monitoring of early-stage aggregation of Amyloid-\u03b2, amylin peptide, tau, and \u03b1-Synuclein proteins","volume":"15","author":"Li","year":"2024","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib78","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41427-020-00278-5","article-title":"Carbon-based SERS biosensor: from substrate design to sensing and bioapplication","volume":"13","author":"Liang","year":"2021","journal-title":"NPG Asia Mater."},{"key":"10.1016\/j.bios.2025.117535_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.micromeso.2024.113214","article-title":"Improved photoelectrochemical performance of TiO2-in-MIL-101(Cr)@CDs@AgNPs and application for the detection of ultralow level A\u03b2O","volume":"377","author":"Lin","year":"2024","journal-title":"Microporous Mesoporous Mater."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib80","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12974-024-03164-x","article-title":"PARK7\/DJ-1 deficiency impairs microglial activation in response to LPS-Induced inflammation","volume":"21","author":"Lind-Holm Mogensen","year":"2024","journal-title":"J. Neuroinflammation"},{"issue":"15","key":"10.1016\/j.bios.2025.117535_bib81","article-title":"Freestanding nanofiber-assembled aptasensor for precisely and ultrafast electrochemical detection of alzheimer's disease biomarkers","volume":"13","author":"Liu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bios.2025.117535_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116685","article-title":"Confinement-enhanced electrochemiluminescence of copper nanoclusters on 3D layered double hydroxide for ultrasensitive detection of GFAP","volume":"265","author":"Liu","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117535_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126699","article-title":"Covalent organic framework-based ratiometric electrochemical sensing platform for ultrasensitive determination of amyloid-\u03b2 42 oligomer","volume":"280","author":"Liu","year":"2024","journal-title":"Talanta"},{"issue":"3","key":"10.1016\/j.bios.2025.117535_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2024.109814","article-title":"Signal cascade amplification of streptavidin-biotin-modified immunofluorescence nanocapsules for ultrasensitive detection of glial fibrillary acidic protein","volume":"36","author":"Liu","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bios.2025.117535_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125134","article-title":"Ultrasensitive electrochemical detection of amyloid-beta oligomers using double amplification strategy by MXene substrate and covalent organic framework-based probe","volume":"266","author":"Lv","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2025.117535_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116220","article-title":"Ultrathin parylene C-based sensitivity-gain nanoplasmonic sensor integrated on VCSEL for A\u03b242 detection","volume":"254","author":"Lv","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117535_bib87","series-title":"Functional Smart Nanomaterials and their Theranostics Approaches","author":"Madhusudhan","year":"2024"},{"key":"10.1016\/j.bios.2025.117535_bib88","series-title":"Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders","author":"Mansour","year":"2023"},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib89","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41531-024-00823-x","article-title":"Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses","volume":"10","author":"Mantovani","year":"2024","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.bios.2025.117535_bib90","article-title":"Alzheimer's disease diagnosis in the preclinical stage: normal aging or dementia","author":"Marvi","year":"2024","journal-title":"IEEE reviews in biomedical engineering"},{"key":"10.1016\/j.bios.2025.117535_bib91","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1109\/RBME.2024.3376835","article-title":"Alzheimer's disease diagnosis in the preclinical stage: normal aging or dementia","volume":"18","author":"Marvi","year":"2025","journal-title":"IEEE Reviews in Biomedical Engineering"},{"issue":"4","key":"10.1016\/j.bios.2025.117535_bib92","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/bmb.21516","article-title":"Applications of Western blot technique: from bench to bedside","volume":"49","author":"Meftahi","year":"2021","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"10.1016\/j.bios.2025.117535_bib93","article-title":"Alzheimer's forget-me-not latest research explained: understanding memory loss, prevention","author":"Mihail","year":"2023","journal-title":"Diagnosis, and Hopes for Treatment: Adrian Mihail"},{"issue":"11","key":"10.1016\/j.bios.2025.117535_bib94","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/14737175.2024.2400683","article-title":"Cerebrospinal fluid in the differential diagnosis of Alzheimer's disease: an update of the literature","volume":"24","author":"Milos","year":"2024","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bios.2025.117535_bib95","article-title":"Alzheimer's disease: for researchers: neuropathology, biochemistry","author":"Mohammadi","year":"2022","journal-title":"Disease Mechanism: Nobel TM"},{"issue":"6","key":"10.1016\/j.bios.2025.117535_bib96","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1109\/JSEN.2023.3239887","article-title":"Lable-free LSPR-based colorimetric detection of \u03b1-Synuclein, a biomarker of parkinson's disease, in saliva","volume":"23","author":"Mottaghi","year":"2023","journal-title":"IEEE Sens. J."},{"key":"10.1016\/j.bios.2025.117535_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116907","article-title":"Early-stage Alzheimer's disease profiling in blood achieved by multiplexing aptamer-SERS biosensors","volume":"268","author":"Muhammad","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"5","key":"10.1016\/j.bios.2025.117535_bib98","doi-asserted-by":"crossref","first-page":"e596","DOI":"10.1016\/S2214-109X(19)30074-9","article-title":"Population attributable fractions for risk factors for dementia in low-income and middle-income countries: an analysis using cross-sectional survey data","volume":"7","author":"Mukadam","year":"2019","journal-title":"Lancet Global Health"},{"issue":"29","key":"10.1016\/j.bios.2025.117535_bib99","doi-asserted-by":"crossref","first-page":"295502","DOI":"10.1088\/1361-6528\/ad3d65","article-title":"Deformed graphene FET biosensor on textured glass coupled with dielectrophoretic trapping for ultrasensitive detection of GFAP","volume":"35","author":"Mukherjee","year":"2024","journal-title":"Nanotechnology"},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41531-024-00637-x","article-title":"Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson's disease","volume":"10","author":"Murueta-Goyena","year":"2024","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.bios.2025.117535_bib101","doi-asserted-by":"crossref","first-page":"112018","DOI":"10.1016\/j.bios.2020.112018","article-title":"Aptamers in nanostructure-based electrochemical biosensors for cardiac biomarkers and cancer biomarkers: a review","volume":"152","author":"Negahdary","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117535_bib102","doi-asserted-by":"crossref","first-page":"120999","DOI":"10.1016\/j.talanta.2020.120999","article-title":"Electrochemical aptasensors based on the gold nanostructures","volume":"216","author":"Negahdary","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2025.117535_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2022.112689","article-title":"Electrochemical aptamer-based nanobiosensors for diagnosing alzheimer's disease: a review","volume":"135","author":"Negahdary","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.bios.2025.117535_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2022.214565","article-title":"Application of electrochemical biosensors for the detection of microRNAs (miRNAs) related to cancer","volume":"464","author":"Negahdary","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bios.2025.117535_bib105","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.talanta.2019.01.109","article-title":"An ultrasensitive electrochemical aptasensor for early diagnosis of Alzheimer's disease, using a fern leaves-like gold nanostructure","volume":"198","author":"Negahdary","year":"2019","journal-title":"Talanta"},{"issue":"12","key":"10.1016\/j.bios.2025.117535_bib106","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s00604-019-3903-x","article-title":"An electrochemical peptide-based biosensor for the alzheimer biomarker amyloid-\u03b2(1\u201342) using a microporous gold nanostructure","volume":"186","author":"Negahdary","year":"2019","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.bios.2025.117535_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134130","article-title":"Aptasensing of beta-amyloid (A\u03b2(1\u221242)) by a 3D-printed platform integrated with leaf-shaped gold nanodendrites","volume":"393","author":"Negahdary","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"issue":"15","key":"10.1016\/j.bios.2025.117535_bib108","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1039\/C8SC00994E","article-title":"Through tissue imaging of a live breast cancer tumour model using handheld surface enhanced spatially offset resonance raman spectroscopy (SESORRS)","volume":"9","author":"Nicolson","year":"2018","journal-title":"Chem. Sci."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib109","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s44303-024-00011-9","article-title":"In vivo imaging using surface enhanced spatially offset raman spectroscopy (SESORS): balancing sampling frequency to improve overall image acquisition","volume":"2","author":"Nicolson","year":"2024","journal-title":"npj Imaging"},{"key":"10.1016\/j.bios.2025.117535_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101994","article-title":"Neurotransmitter systems in the etiology of major neurological disorders: emerging insights and therapeutic implications","author":"Nimgampalle","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.bios.2025.117535_bib111","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1039\/C5AN01790D","article-title":"Biomarker detection technologies and future directions","volume":"141","author":"Nimse","year":"2016","journal-title":"Analyst."},{"issue":"11","key":"10.1016\/j.bios.2025.117535_bib112","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00604-024-06747-w","article-title":"Parkinson biomarker determination with an Au microflower\u2013enhanced electrochemical immunosensor using non-Faradaic capacitance measurements","volume":"191","author":"Orzari","year":"2024","journal-title":"Microchim. Acta"},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib113","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00604-023-06158-3","article-title":"Lab-made disposable screen-printed electrochemical sensors and immunosensors modified with Pd nanoparticles for Parkinson's disease diagnostics","volume":"191","author":"Orzari","year":"2024","journal-title":"Microchim. Acta"},{"issue":"8","key":"10.1016\/j.bios.2025.117535_bib114","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jamaneurol.2021.1858","article-title":"Accuracy of tau positron emission tomography as a prognostic marker in preclinical and prodromal Alzheimer disease: a head-to-head comparison against amyloid positron emission tomography and magnetic resonance imaging","volume":"78","author":"Ossenkoppele","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bios.2025.117535_bib115","first-page":"1","article-title":"The evaluation of clinical applications for the detection of the alzheimer's disease biomarker GFAP","author":"Ozcelikay-Akyildiz","year":"2024","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.bios.2025.117535_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.tourman.2024.104916","article-title":"Dementia as a global challenge: progress and prospects for creating more dementia-inclusive tourism industries","volume":"104","author":"Page","year":"2024","journal-title":"Tour. Manag."},{"key":"10.1016\/j.bios.2025.117535_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111559","article-title":"A disposable electrochemical sensor for amyloid-\u03b242 protein based on molecular imprinted polymers with nitrogen doped carbon dots-graphene nanohybrid","volume":"206","author":"Pakapongpan","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.bios.2025.117535_bib118","first-page":"1","article-title":"\u03b1-Synuclein pathology as a target in neurodegenerative diseases","author":"Park","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bios.2025.117535_bib119","first-page":"1","article-title":"Cellular and pathological functions of tau","author":"Parra Bravo","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bios.2025.117535_bib120","first-page":"1","article-title":"Neurodegenerative disorders of alzheimer, parkinsonism, amyotrophic lateral sclerosis and multiple sclerosis: an early diagnostic approach for precision treatment","author":"Pathak","year":"2021","journal-title":"Metab. Brain Dis."},{"issue":"17","key":"10.1016\/j.bios.2025.117535_bib121","doi-asserted-by":"crossref","first-page":"12107","DOI":"10.1039\/D4RA00615A","article-title":"Label-free detection of A\u03b2-42: a liquid crystal droplet approach for Alzheimer's disease diagnosis","volume":"14","author":"Pradhan","year":"2024","journal-title":"RSC Adv."},{"issue":"3","key":"10.1016\/j.bios.2025.117535_bib122","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3934\/Neuroscience.2023017","article-title":"Depletion of dopamine in Parkinson's disease and relevant therapeutic options: a review of the literature","volume":"10","author":"Ramesh","year":"2023","journal-title":"AIMS neuroscience"},{"key":"10.1016\/j.bios.2025.117535_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139174","article-title":"Electrochemical cDNA-sensing of miRNA-137 for detection of Alzheimer's disease using CuO and PEI deposited Au-Pd bimetallic nanoparticles","volume":"1318","author":"Rani","year":"2024","journal-title":"J. Mol. Struct."},{"issue":"24","key":"10.1016\/j.bios.2025.117535_bib124","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1021\/acschemneuro.4c00369","article-title":"Ultrasensitive detection of blood-based alzheimer's disease biomarkers: a comprehensive SERS-immunoassay platform enhanced by machine learning","volume":"15","author":"Resmi","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bios.2025.117535_bib125","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1016\/j.wneu.2023.10.040","article-title":"Letter to our colleagues family practitioners, Geriatricians, and radiologists to increase awareness regarding idiopathic normal pressure hydrocephalus","volume":"181","author":"Rigamonti","year":"2024","journal-title":"World Neurosurg."},{"issue":"8","key":"10.1016\/j.bios.2025.117535_bib126","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.4103\/1673-5374.332127","article-title":"Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease","volume":"17","author":"Roda","year":"2022","journal-title":"Neural regeneration research"},{"key":"10.1016\/j.bios.2025.117535_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115898","article-title":"Implementation of an ultra-sensitive microwell-based electrochemical sensor for the detection of Alzheimer's disease","volume":"247","author":"Roy","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"9","key":"10.1016\/j.bios.2025.117535_bib128","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1001\/jamaneurol.2017.0655","article-title":"Comparing plasma phospho tau, total tau, and phospho tau\u2013total tau ratio as acute and chronic traumatic brain injury biomarkers","volume":"74","author":"Rubenstein","year":"2017","journal-title":"JAMA Neurol."},{"issue":"13","key":"10.1016\/j.bios.2025.117535_bib129","doi-asserted-by":"crossref","first-page":"8810","DOI":"10.1039\/D3RA07058A","article-title":"An innovative transportable immune device for the recognition of \u03b1-synuclein using KCC-1-nPr-CS2 modified silver nano-ink: integration of pen-on-paper technology with biosensing toward early-stage diagnosis of parkinson's disease","volume":"14","author":"Saadati","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.bios.2025.117535_bib130","first-page":"1","article-title":"Parkinson's disease and microRNAs: a duel between inhibition and stimulation of apoptosis in neuronal cells","author":"Saadh","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bios.2025.117535_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.ensci.2025.100550","article-title":"The role of neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in MS and AQP4-NMOSD: advancing clinical applications","author":"Samadzadeh","year":"2025","journal-title":"eNeurologicalSci"},{"key":"10.1016\/j.bios.2025.117535_bib132","doi-asserted-by":"crossref","DOI":"10.1177\/11772719231190218","article-title":"The latest developments in using proteomic biomarkers from urine and serum for non-invasive disease diagnosis and prognosis","volume":"18","author":"Shama","year":"2023","journal-title":"Biomark. Insights"},{"issue":"7","key":"10.1016\/j.bios.2025.117535_bib133","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3390\/bios13070742","article-title":"Electrochemical immunosensors developed for amyloid-beta and tau proteins, leading biomarkers of alzheimer's disease","volume":"13","author":"Sharma","year":"2023","journal-title":"Biosensors"},{"issue":"10","key":"10.1016\/j.bios.2025.117535_bib134","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1039\/D0NA00961J","article-title":"Gold nanomaterials for optical biosensing and bioimaging","volume":"3","author":"Si","year":"2021","journal-title":"Nanoscale Adv."},{"issue":"6","key":"10.1016\/j.bios.2025.117535_bib135","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00702-023-02653-2","article-title":"The \u2018\u03b1-synucleinopathy syndicate\u2019: multiple system atrophy and Parkinson's disease","volume":"131","author":"Sian-Hulsmann","year":"2024","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.bios.2025.117535_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134966","article-title":"Early detection of alzheimer's disease by measuring amyloid beta-42 concentration in human serum based on liquid crystals","volume":"401","author":"Sohrabnavi","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"issue":"10","key":"10.1016\/j.bios.2025.117535_bib137","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1177\/00037028231187963","article-title":"Exploring the clinical utility of raman spectroscopy for point-of-care cardiovascular disease biomarker detection","volume":"77","author":"Soliman","year":"2023","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.bios.2025.117535_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116431","article-title":"Oxygen-enriching triphase platform for reliable sensing of femtomolar Alzheimer's neurofilament lights","volume":"260","author":"Song","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117535_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2020.107734","article-title":"A nano-composite based regenerative neuro biosensor sensitive to Parkinsonism-associated protein DJ-1\/Park7 in cerebrospinal fluid and saliva","volume":"138","author":"Sonu\u00e7 Karabo\u011fa","year":"2021","journal-title":"Bioelectrochemistry"},{"issue":"7","key":"10.1016\/j.bios.2025.117535_bib140","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1093\/brain\/awab099","article-title":"Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease","volume":"144","author":"Spina","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.bios.2025.117535_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113320","article-title":"Alzheimer's disease and its treatment by different approaches: a review","volume":"216","author":"Srivastava","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bios.2025.117535_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.116159","article-title":"Recent advances of bimetallic nanomaterials and its nanocomposites for biosensing applications","volume":"135","author":"Stephanie","year":"2021","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.bios.2025.117535_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111541","article-title":"Signal-amplified detection of amyloid-\u03b2 aggregates based on plasmon-enhanced fluorescence","volume":"206","author":"Sun","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.bios.2025.117535_bib144","doi-asserted-by":"crossref","DOI":"10.1109\/LSENS.2024.3497003","article-title":"PPY-fMWCNT nanocomposite-based chemicapacitive biosensor for ultrasensitive detection of TBI-specific GFAP biomarker in human plasma","author":"Supraja","year":"2024","journal-title":"IEEE Sensors Letters"},{"key":"10.1016\/j.bios.2025.117535_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116824","article-title":"A novel cleanroom-free technique for simultaneous electrodeposition of polypyrrole onto array of IDuEs: towards low-cost, stable and accurate point-of-care TBI diagnosis without trained manpower","volume":"267","author":"Supraja","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.bios.2025.117535_bib146","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/cac2.12023","article-title":"Overview of multiplex immunohistochemistry\/immunofluorescence techniques in the era of cancer immunotherapy","volume":"40","author":"Tan","year":"2020","journal-title":"Cancer Commun."},{"key":"10.1016\/j.bios.2025.117535_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2021.153443","article-title":"Recent advances and challenges of RT-PCR tests for the diagnosis of COVID-19","volume":"221","author":"Teymouri","year":"2021","journal-title":"Pathol. Res. Pract."},{"issue":"5","key":"10.1016\/j.bios.2025.117535_bib148","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of parkinson's disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bios.2025.117535_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2022.105358","article-title":"Detection and assessment of alpha-synuclein in parkinson disease","volume":"158","author":"Tsao","year":"2022","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.bios.2025.117535_bib150","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1021\/acsnano.0c02624","article-title":"Diagnosing COVID-19: the disease and tools for detection","volume":"14","author":"Udugama","year":"2020","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib151","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0009-8981(02)00330-3","article-title":"Measurement of glial fibrillary acidic protein in blood: an analytical method","volume":"326","author":"van Geel","year":"2002","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bios.2025.117535_bib152","series-title":"Handbook of Immunoassay Technologies: Approaches, Performances, and Applications","author":"Vashist","year":"2025"},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib153","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s43586-021-00039-w","article-title":"Electrochemical impedance spectroscopy","volume":"1","author":"Wang","year":"2021","journal-title":"Nature Reviews Methods Primers"},{"key":"10.1016\/j.bios.2025.117535_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116565","article-title":"Advanced on-site and in vitro signal amplification biosensors for biomolecule analysis","volume":"149","author":"Wang","year":"2022","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.bios.2025.117535_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2024.108678","article-title":"Magnetic self-assembled label-free electrochemical biosensor based on Fe3O4\/\u03b1-Fe2O3 heterogeneous nanosheets for the detection of tau proteins","volume":"157","author":"Wang","year":"2024","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.bios.2025.117535_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.125656","article-title":"Entropy-driven catalysis-based lateral flow assay for sensitive detection of alzheimer 's-associated MicroRNA","volume":"271","author":"Wang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2025.117535_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107476","article-title":"The origin of esterase activity of parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA","author":"Watanabe","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bios.2025.117535_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsusc.2024.160616","article-title":"Biofunctionalization-optimized MoS2-based FET biosensors for the detection of tau protein","volume":"670","author":"Wen","year":"2024","journal-title":"Appl. Surf. Sci."},{"issue":"22","key":"10.1016\/j.bios.2025.117535_bib159","doi-asserted-by":"crossref","first-page":"14261","DOI":"10.1021\/acs.analchem.9b02248","article-title":"Improving the flow cytometry-based detection of the cellular uptake of gold nanoparticles","volume":"91","author":"Wu","year":"2019","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.bios.2025.117535_bib160","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s44222-023-00032-w","article-title":"Device integration of electrochemical biosensors","volume":"1","author":"Wu","year":"2023","journal-title":"Nature Reviews Bioengineering"},{"issue":"8","key":"10.1016\/j.bios.2025.117535_bib161","doi-asserted-by":"crossref","first-page":"9167","DOI":"10.1021\/acsanm.4c00674","article-title":"Label-free analysis of protein biomarkers using pattern-optimized graphene-nanopyramid SERS for the rapid diagnosis of alzheimer's disease","volume":"7","author":"Wu","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"issue":"13","key":"10.1016\/j.bios.2025.117535_bib162","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1021\/acschemneuro.4c00263","article-title":"\u03b2-Synuclein intermediates \u03b1-Synuclein neurotoxicity in parkinson's disease","volume":"15","author":"Xian","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bios.2025.117535_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.110914","article-title":"A paper-based fluorescence immunosensor based on internal filter effect using the phosphatase-like activity of Au@CeO2 nanorods for Alzheimer's disease detection","volume":"203","author":"Xiao","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.bios.2025.117535_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116901","article-title":"Sensitivity evaluation of an optical microfiber featuring interfaces with various gold nanoparticle morphologies: application to the GFAP detection","volume":"268","author":"Xiao","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117535_bib165","doi-asserted-by":"crossref","DOI":"10.1177\/13872877241307404","article-title":"Insulin signaling and oxidative stress: bridging the gap between type 2 diabetes mellitus and alzheimer's disease","author":"Xu","year":"2025","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.bios.2025.117535_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2020.12.062","article-title":"Recent advances in rolling circle amplification-based biosensing strategies-A review","volume":"1148","author":"Xu","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bios.2025.117535_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.129003","article-title":"A two-photon fluorescent probe for visualizing endoplasmic reticulum peroxynitrite in parkinson's disease models","volume":"328","author":"Yan","year":"2021","journal-title":"Sensor. Actuator. B Chem."},{"issue":"2","key":"10.1016\/j.bios.2025.117535_bib168","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1021\/acsmaterialsau.2c00056","article-title":"Nucleic acid molecular systems for in vitro detection of biomolecules","volume":"3","author":"Yang","year":"2023","journal-title":"ACS Mater. Au"},{"key":"10.1016\/j.bios.2025.117535_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136006","article-title":"High pH stability and detection of \u03b1-synuclein using an EGFET biosensor with an HfO2 gate deposited by high-power pulsed magnetron sputtering","volume":"416","author":"Yang","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"issue":"6","key":"10.1016\/j.bios.2025.117535_bib170","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3390\/bios14060279","article-title":"A simple sandwich electrochemical immunosensor for rapid detection of the alzheimer's disease biomarker tau protein","volume":"14","author":"Yang","year":"2024","journal-title":"Biosensors"},{"key":"10.1016\/j.bios.2025.117535_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125345","article-title":"Halloysite nanotubes-loaded conductive polymer as substrate and label material for sensitive detection of amyloid-\u03b2 protein by electrochemical immunosensor","volume":"268","author":"Ye","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2025.117535_bib172","series-title":"Seminars in Diagnostic Pathology","article-title":"Review of immunohistochemistry techniques: applications, current status, and future perspectives","year":"2024"},{"key":"10.1016\/j.bios.2025.117535_bib173","doi-asserted-by":"crossref","DOI":"10.1002\/ibra.12155","article-title":"Amyloid\u2010\u03b2 in alzheimer's disease: structure, toxicity, distribution, treatment, and prospects","author":"Yu","year":"2024","journal-title":"Ibrain"},{"key":"10.1016\/j.bios.2025.117535_bib174","first-page":"85","article-title":"Advances in blood biomarkers for alzheimer's disease: ultra-sensitive detection technologies and impact on clinical diagnosis","author":"Zhang","year":"2024","journal-title":"Degener. Neurol. Neuromuscul. Dis."},{"issue":"23","key":"10.1016\/j.bios.2025.117535_bib175","doi-asserted-by":"crossref","first-page":"9676","DOI":"10.1021\/acs.analchem.4c01615","article-title":"Surface acoustic wave-driven enhancement of enzyme-linked immunosorbent assays: ELISAW","volume":"96","author":"Zhang","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.117535_bib176","article-title":"Highly sensitive in-situ growth gold dendrite structure electrochemical sensor for early Alzheimer's disease screening","volume":"490","author":"Zhang","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib177","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40035-024-00429-6","article-title":"Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies","volume":"13","author":"Zhang","year":"2024","journal-title":"Transl. Neurodegener."},{"issue":"4","key":"10.1016\/j.bios.2025.117535_bib178","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1021\/acs.analchem.3c04825","article-title":"Combining glial fibrillary acidic protein and neurofilament light chain for the diagnosis of major depressive disorder","volume":"96","author":"Zhang","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.117535_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342407","article-title":"Magnetic photoelectrochemical sensor array utilizing addressing sensing strategy for simultaneous detection of amyloid-\u03b2 42 and microtubule-associated protein tau","volume":"1298","author":"Zhang","year":"2024","journal-title":"Anal. Chim. Acta"},{"issue":"17","key":"10.1016\/j.bios.2025.117535_bib180","doi-asserted-by":"crossref","first-page":"9490","DOI":"10.3390\/ijms25179490","article-title":"A new strategy for ultrasensitive detection based on target microRNA-Triggered rolling circle amplification in the early diagnosis of alzheimer's disease","volume":"25","author":"Zhao","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib181","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40001-023-01631-4","article-title":"Prediction of clinical progression in nervous system diseases: plasma glial fibrillary acidic protein (GFAP)","volume":"29","author":"Zheng","year":"2024","journal-title":"Eur. J. Med. Res."},{"issue":"1","key":"10.1016\/j.bios.2025.117535_bib182","first-page":"1","article-title":"Research progress on the association of insulin resistance with type 2 diabetes mellitus and Alzheimer's disease","volume":"40","author":"Zheng","year":"2025","journal-title":"Metab. Brain Dis."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325004099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325004099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:33:28Z","timestamp":1762338808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566325004099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":182,"alternative-id":["S0956566325004099"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2025.117535","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in biosensors for diagnosis of Alzheimer's and Parkinson's diseases","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2025.117535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117535"}}