{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:23:14Z","timestamp":1792516994019,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L241062"],"award-info":[{"award-number":["L241062"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["4244102"],"award-info":[{"award-number":["4244102"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024Z172"],"award-info":[{"award-number":["2024Z172"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["2022PHB333-001"],"award-info":[{"award-number":["2022PHB333-001"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFB4600400"],"award-info":[{"award-number":["2022YFB4600400"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12374339"],"award-info":[{"award-number":["12374339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201988"],"award-info":[{"award-number":["82201988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92374202"],"award-info":[{"award-number":["92374202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014985","name":"European Society of Radiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014985","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003847","name":"Ningbo Municipal Peoples Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20230484468"],"award-info":[{"award-number":["20230484468"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bios.2025.117655","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T19:34:01Z","timestamp":1748892841000},"page":"117655","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Nanohole-in-microsphere array (NiMA): An ultrasensitive digital-SERS tool for serum diagnosis of rheumatoid arthritis"],"prefix":"10.1016","volume":"287","author":[{"given":"Mengyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9709-1532","authenticated-orcid":false,"given":"Xiaolin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-7878","authenticated-orcid":false,"given":"Yinzhou","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2025.117655_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bios.2016.12.014","article-title":"Recent advances in biosensor development for the detection of cancer biomarkers","volume":"91","author":"Aditya Jayanthi","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117655_bib2","article-title":"Digital SERS immunoassay of Interleukin-6 based on au@ Ag-Au nanotags","volume":"270","author":"Ao","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117655_bib3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3390\/bios13030328","article-title":"Recent trends in SERS-Based plasmonic sensors for disease diagnostics, biomolecules detection, and machine learning techniques","volume":"13","author":"Beeram","year":"2023","journal-title":"Biosensors"},{"key":"10.1016\/j.bios.2025.117655_bib4","first-page":"1","article-title":"Digital colloid-enhanced Raman spectroscopy by single-molecule counting","author":"Bi","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bios.2025.117655_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-015-0536-2","article-title":"Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage","volume":"17","author":"Brink","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bios.2025.117655_bib6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3390\/mi12050499","article-title":"2D manufacturing of glass microstructures using femtosecond laser","volume":"12","author":"Butkut\u0117","year":"2021","journal-title":"Micromachines (Basel)"},{"key":"10.1016\/j.bios.2025.117655_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340574","article-title":"Serum-based surface-enhanced Raman spectroscopy combined with PCA-RCKNCN for rapid and accurate identification of lung cancer","volume":"1236","author":"Cao","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bios.2025.117655_bib8","doi-asserted-by":"crossref","first-page":"21830","DOI":"10.1021\/acsami.3c00103","article-title":"LoC-SERS platform integrated with the signal amplification strategy toward parkinson's disease diagnosis","volume":"15","author":"Cao","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"9","key":"10.1016\/j.bios.2025.117655_bib9","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/jrs.1734","article-title":"Reference database of Raman spectra of biological molecules","volume":"38","author":"De Gelder","year":"2007","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.bios.2025.117655_bib10","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"The Lancet"},{"key":"10.1016\/j.bios.2025.117655_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134508","article-title":"Plasmonic internal standard-decorated nitrocellulose membranes for duplex detection of circulating tumor biomarkers","volume":"395","author":"Fan","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2025.117655_bib12","article-title":"Surface\u2010enhanced raman spectroscopy\u2010based optical biosensor for liquid biopsy: toward precision medicine","author":"Fan","year":"2024","journal-title":"Laser Photon. Rev."},{"key":"10.1016\/j.bios.2025.117655_bib13","first-page":"591","article-title":"Global epidemiology of rheumatoid arthritis","volume":"18","author":"Finckh","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bios.2025.117655_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132378","article-title":"Simultaneous SERS-based immunoassay of dual cardiac markers on pump-free hybrid microfluidic chip","volume":"369","author":"Gao","year":"2022","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2025.117655_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0169-4332(98)00002-6","article-title":"Damage threshold dependence on electron-phonon coupling in Au and Ni films","volume":"127","author":"Gudde","year":"1998","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.bios.2025.117655_bib16","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1136\/annrheumdis-2013-205109","article-title":"Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies","volume":"73","author":"Jiang","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bios.2025.117655_bib17","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1021\/acs.analchem.6b01123","article-title":"Instrument-free synthesizable fabrication of label-free optical biosensing paper strips for the early detection of infectious keratoconjunctivitides","volume":"88","author":"Kim","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.117655_bib18","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1021\/acsnano.8b02917","article-title":"Based surface-enhanced Raman spectroscopy for diagnosing prenatal diseases in women","volume":"12","author":"Kim","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2025.117655_bib19","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/lpor.201300043","article-title":"Ultrafast nanoporous silica formation driven by femtosecond laser irradiation","volume":"7","author":"Lancry","year":"2013","journal-title":"Laser Photon. Rev."},{"key":"10.1016\/j.bios.2025.117655_bib20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/acsnano.9b04224","article-title":"Present and future of surface-enhanced Raman scattering","volume":"14","author":"Langer","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2025.117655_bib21","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1364\/OPTICA.433765","article-title":"High speed ultrafast laser anisotropic nanostructuring by energy deposition control via near-field enhancement","volume":"8","author":"Lei","year":"2021","journal-title":"Optica"},{"key":"10.1016\/j.bios.2025.117655_bib22","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1364\/OPEX.13.000526","article-title":"Optical analysis of nanoparticles via enhanced backscattering facilitated by 3-D photonic nanojets","volume":"13","author":"Li","year":"2005","journal-title":"Opt. Express"},{"key":"10.1016\/j.bios.2025.117655_bib23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41377-020-0275-2","article-title":"O-FIB: far-field-induced near-field breakdown for direct nanowriting in an atmospheric environment","volume":"9","author":"Li","year":"2020","journal-title":"Light Sci. Appl."},{"key":"10.1016\/j.bios.2025.117655_bib24","article-title":"Design and synthesis of SERS materials for in vivo molecular imaging and biosensing","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bios.2025.117655_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115273","article-title":"Nondestructive separation\/enrichment and rolling circle amplification-powered sensitive SERS enumeration of circulating tumor cells via aptamer recognition","volume":"231","author":"Li","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117655_bib26","first-page":"1","article-title":"Super-stealth dicing of transparent solids with nanometric precision","author":"Li","year":"2024","journal-title":"Nat. Photonics"},{"key":"10.1016\/j.bios.2025.117655_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115076","article-title":"3D plasmonic coral nanoarchitecture paper for label-free human urine sensing and deep learning-assisted cancer screening","volume":"224","author":"Linh","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117655_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1371\/journal.pmed.0050170","article-title":"Cancer screening: a mathematical model relating secreted blood biomarker levels to tumor sizes","volume":"5","author":"Lutz","year":"2008","journal-title":"PLoS Med."},{"key":"10.1016\/j.bios.2025.117655_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40580-024-00428-3","article-title":"SERS biosensors for liquid biopsy towards cancer diagnosis by detection of various circulating biomarkers: current progress and perspectives","volume":"11","author":"Lyu","year":"2024","journal-title":"Nano Convergence"},{"key":"10.1016\/j.bios.2025.117655_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/admt.201600270","article-title":"Femtosecond laser direct writing of plasmonic Ag\/Pd alloy nanostructures enables flexible integration of robust SERS substrates","volume":"2","author":"Ma","year":"2017","journal-title":"Adv. Mater. Techn."},{"key":"10.1016\/j.bios.2025.117655_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.nano.2022.102577","article-title":"Development of a SERS based cancer diagnosis approach employing cryosectioned thyroid tissue samples on PDMS","volume":"44","author":"Mert","year":"2022","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.bios.2025.117655_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116414","article-title":"Diagnosis of neuropsychiatric systemic lupus erythematosus by label-free serum microsphere-coupled SERS fingerprints with machine learning","volume":"260","author":"Mi","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117655_bib33","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/ard-2023-224014","article-title":"Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis","volume":"83","author":"Moulin","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bios.2025.117655_bib34","doi-asserted-by":"crossref","first-page":"11334","DOI":"10.1021\/acsanm.3c01379","article-title":"Label-free SERS salivary biosensor based on Ni@ Ag core\u2013shell nanoparticles anchored on carbon nanofibers for prediagnosis of lung cancer","volume":"6","author":"Navami","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.bios.2025.117655_bib35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1039\/C7CC05979E","article-title":"Surface-enhanced Raman spectroscopy: bottlenecks and future directions","volume":"54","author":"Panneerselvam","year":"2018","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bios.2025.117655_bib36","series-title":"Seminars in Arthritis and Rheumatism","article-title":"Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: a systematic review","volume":"vol. 59","author":"Peyton","year":"2023"},{"key":"10.1016\/j.bios.2025.117655_bib37","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1002\/smll.201303773","article-title":"Hierarchical 3D SERS substrates fabricated by integrating photolithographic microstructures and self\u2010assembly of silver nanoparticles","volume":"10","author":"Qi","year":"2014","journal-title":"Small"},{"issue":"4","key":"10.1016\/j.bios.2025.117655_bib38","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/annrheumdis-2019-216374","article-title":"Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis","volume":"79","author":"Souto-Carneiro","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bios.2025.117655_bib39","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s00339-020-03516-3","article-title":"Volume photoinscription of glasses: three-dimensional micro-and nanostructuring with ultrashort laser pulses","volume":"126","author":"Stoian","year":"2020","journal-title":"Appl. Phys. A"},{"key":"10.1016\/j.bios.2025.117655_bib40","doi-asserted-by":"crossref","first-page":"37130","DOI":"10.1021\/acsami.3c05039","article-title":"Absolute quantification of serum exosomes in patients with an sers-lateral flow strip biosensor for noninvasive clinical cancer diagnosis","volume":"15","author":"Su","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bios.2025.117655_bib41","article-title":"Wearable label\u2010free optical biodetectors: progress and perspectives","volume":"2","author":"Sundar Dhanabalan","year":"2021","journal-title":"Adv. Photonics Res."},{"key":"10.1016\/j.bios.2025.117655_bib42","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1021\/acsanm.7b00295","article-title":"Fabrication of large-area flexible SERS substrates by nanoimprint lithography","volume":"1","author":"Suresh","year":"2018","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.bios.2025.117655_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/lpor.202000455","article-title":"Ultrafast laser direct writing in glass: thermal accumulation engineering and applications","volume":"15","author":"Tan","year":"2021","journal-title":"Laser Photon. Rev."},{"key":"10.1016\/j.bios.2025.117655_bib44","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Ulrich Scherer","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.bios.2025.117655_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102392","article-title":"An overview of autoantibodies in rheumatoid arthritis","volume":"110","author":"Van Delft","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.bios.2025.117655_bib46","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/ard-2023-224103","article-title":"Immune response to post-translationally modified proteins in rheumatoid arthritis: what makes it special?","volume":"83","author":"van der Woude","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bios.2025.117655_bib47","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.autrev.2017.11.017","article-title":"Pitfalls in the detection of citrullination and carbamylation","volume":"17","author":"Verheul","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.bios.2025.117655_bib48","doi-asserted-by":"crossref","first-page":"32837","DOI":"10.1021\/acsami.1c09388","article-title":"Designed Co-DNA-locker and ratiometric SERS sensing for accurate detection of exosomes based on gold nanorod arrays","volume":"13","author":"Wang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bios.2025.117655_bib49","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/jrs.6351","article-title":"Flexible microsphere\u2010coupled surface\u2010enhanced Raman spectroscopy (McSERS) by dielectric microsphere cavity array with random plasmonic nanoparticles","volume":"53","author":"Wang","year":"2022","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.bios.2025.117655_bib50","article-title":"Laser parallel nanofabrication of Dual\u2010Au\u2010Nanoholes on microsphere\u2010lens\u2010array for polarization\u2010dependent SERS","author":"Wang","year":"2024","journal-title":"Adv. Mater. Techn."},{"key":"10.1016\/j.bios.2025.117655_bib51","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1021\/acs.analchem.3c03515","article-title":"Novel digital SERS-Microfluidic chip for rapid and accurate quantification of microorganisms","volume":"96","author":"Wen","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.117655_bib52","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/imr.12838","article-title":"Immunometabolism in the development of rheumatoid arthritis","volume":"294","author":"Weyand","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bios.2025.117655_bib53","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bios.2025.117655_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cej.2009.02.024","article-title":"Characteristics of pseudo-second-order kinetic model for liquid-phase adsorption: a mini-review","volume":"151","author":"Wu","year":"2009","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bios.2025.117655_bib55","first-page":"87","article-title":"Surface-enhanced Raman spectroscopy","volume":"1","author":"Xiao","year":"2021","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.bios.2025.117655_bib56","doi-asserted-by":"crossref","first-page":"20409","DOI":"10.1021\/acs.jpcc.5b04237","article-title":"Nanoscale hydrophilicity on metal surfaces at room temperature: coupling lattice constants and crystal faces","volume":"119","author":"Xu","year":"2015","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.bios.2025.117655_bib57","article-title":"Metabolomics in rheumatoid arthritis: advances and review","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bios.2025.117655_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.116945","article-title":"Machine learning-assisted optical nano-sensor arrays in microorganism analysis","volume":"159","author":"Yang","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.bios.2025.117655_bib59","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1039\/D4CS00883A","article-title":"Surface-enhanced Raman spectroscopy: a half-century historical perspective","volume":"54","author":"Yi","year":"2025","journal-title":"Chem. Soc.Rev."},{"key":"10.1016\/j.bios.2025.117655_bib60","doi-asserted-by":"crossref","first-page":"11116","DOI":"10.1021\/acs.nanolett.4c03507","article-title":"A statistical route to robust SERS quantitation beyond the single-molecule level","volume":"24","author":"Zhang","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.bios.2025.117655_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112067","article-title":"Rapid and low-cost quantitative detection of creatinine in human urine with a portable Raman spectrometer","volume":"154","author":"Zhu","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.117655_bib62","article-title":"The potential role of synovial cells in the progression and treatment of osteoarthritis","volume":"3","author":"Zou","year":"2023","journal-title":"Explorations"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325005299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325005299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:34:45Z","timestamp":1769834085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566325005299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":62,"alternative-id":["S0956566325005299"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2025.117655","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanohole-in-microsphere array (NiMA): An ultrasensitive digital-SERS tool for serum diagnosis of rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2025.117655","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117655"}}