{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:20:03Z","timestamp":1792750803693,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62301325"],"award-info":[{"award-number":["62301325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015622","name":"Ministerul Cercet\u0103rii \u015fi Inov\u0103rii","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016391","name":"Societat Catalana de Digestologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bios.2025.118074","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:34:50Z","timestamp":1759797290000},"page":"118074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Robust detection of femtogram-level Alzheimer's biomarkers using machine learning-enhanced graphene biosensors"],"prefix":"10.1016","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-0824","authenticated-orcid":false,"given":"Qingzhou","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunhua","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-2856","authenticated-orcid":false,"given":"Tailin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2025.118074_bib1","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3389\/fnagi.2021.624330","volume":"13","author":"Bao","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bios.2025.118074_bib2","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3389\/fmolb.2021.651232","volume":"8","author":"Bungon","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bios.2025.118074_bib3","doi-asserted-by":"crossref","first-page":"5340","DOI":"10.1021\/acs.analchem.4c00776","volume":"96","author":"Cao","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.118074_bib4","doi-asserted-by":"crossref","first-page":"19567","DOI":"10.1021\/acsnano.2c10240","volume":"16","author":"Capman","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2025.118074_bib5","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/alz.12724","volume":"19","author":"Chatterjee","year":"2023","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.bios.2025.118074_bib6","doi-asserted-by":"crossref","first-page":"21873","DOI":"10.1021\/acsnano.4c01937","volume":"18","author":"Chen","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2025.118074_bib7","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1021\/acssensors.2c00967","volume":"7","author":"Chen","year":"2022","journal-title":"ACS Sens."},{"key":"10.1016\/j.bios.2025.118074_bib8","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1126\/science.1062711","volume":"293","author":"Cui","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bios.2025.118074_bib9","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1038\/s41467-021-23746-0","volume":"12","author":"Cullen","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2025.118074_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116459","volume":"145","author":"Debus","year":"2021","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.bios.2025.118074_bib11","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S1474-4422(21)00066-1","volume":"20","author":"Dubois","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bios.2025.118074_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13195-023-01314-6","volume":"15","author":"Dubois","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bios.2025.118074_bib13","volume":"29","author":"Fu","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bios.2025.118074_bib14","volume":"1\u20139","author":"Grande","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.bios.2025.118074_bib15","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s43587-023-00403-3","volume":"3","author":"Hansson","year":"2023","journal-title":"Nature Aging"},{"key":"10.1016\/j.bios.2025.118074_bib16","volume":"4","author":"Huang","year":"2022","journal-title":"Adv. Intell. Syst."},{"key":"10.1016\/j.bios.2025.118074_bib17","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/s41467-020-15330-9","volume":"11","author":"Hwang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2025.118074_bib18","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","volume":"20","author":"Jack Jr","year":"2024","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.bios.2025.118074_bib19","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1021\/acs.analchem.2c03399","volume":"95","author":"Krishnan","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.118074_bib20","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.pmatsci.2012.03.002","volume":"57","author":"Kuila","year":"2012","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.bios.2025.118074_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113519","volume":"192","author":"Kwon","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2025.118074_bib22","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.1021\/acs.analchem.2c05751","volume":"95","author":"Li","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.118074_bib23","volume":"21","author":"Li","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.bios.2025.118074_bib24","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1021\/acssensors.4c03396","volume":"10","author":"Ma","year":"2025","journal-title":"ACS Sens."},{"key":"10.1016\/j.bios.2025.118074_bib25","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","volume":"7","author":"Nichols","year":"2022","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.bios.2025.118074_bib26","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s41586-024-08003-w","volume":"634","author":"Pannone","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bios.2025.118074_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202201691","volume":"34","author":"Pasadas","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bios.2025.118074_bib28","doi-asserted-by":"crossref","first-page":"21984","DOI":"10.1021\/acsnano.3c08499","volume":"17","author":"Peng","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2025.118074_bib29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.14283\/jpad.2021.23","volume":"8","author":"Porsteinsson","year":"2021","journal-title":"J. Prev. Alzheim. Dis"},{"key":"10.1016\/j.bios.2025.118074_bib30","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bios.2025.118074_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101503","volume":"72","author":"Song","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bios.2025.118074_bib32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature05498","volume":"445","author":"Stern","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bios.2025.118074_bib33","volume":"283","author":"Sun","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2025.118074_bib34","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1021\/acs.analchem.1c05174","volume":"94","author":"Sun","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2025.118074_bib35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1021\/acssensors.0c02335","volume":"6","author":"Sun","year":"2021","journal-title":"ACS Sens."},{"key":"10.1016\/j.bios.2025.118074_bib36","volume":"34","author":"Sun","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bios.2025.118074_bib37","volume":"34","author":"Sun","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bios.2025.118074_bib38","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s40120-022-00338-8","volume":"11","author":"Tahami Monfared","year":"2022","journal-title":"Neurology and Therapy"},{"key":"10.1016\/j.bios.2025.118074_bib39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1474-4422(21)00361-6","volume":"21","author":"Teunissen","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bios.2025.118074_bib40","author":"Wang","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.bios.2025.118074_bib41","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/acsnano.3c09311","volume":"18","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2025.118074_bib42","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/acsnano.3c09311","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.bios.2025.118074_bib43","volume":"21","author":"Yaqoob","year":"2021","journal-title":"Periodical"},{"key":"10.1016\/j.bios.2025.118074_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/sstr.202470061","volume":"5","author":"Zhang","year":"2024","journal-title":"Small Struct."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325009509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566325009509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:31:19Z","timestamp":1773153079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566325009509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"alternative-id":["S0956566325009509"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2025.118074","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Robust detection of femtogram-level Alzheimer's biomarkers using machine learning-enhanced graphene biosensors","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2025.118074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118074"}}