{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:05:22Z","timestamp":1789027522067,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572690"],"award-info":[{"award-number":["82572690"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025J08167 2025J01756"],"award-info":[{"award-number":["2025J08167 2025J01756"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2022QH2212"],"award-info":[{"award-number":["2022QH2212"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2021QH1333"],"award-info":[{"award-number":["2021QH1333"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bios.2026.118442","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:34:38Z","timestamp":1769560478000},"page":"118442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["An ultrasensitive FEN1-aided LCR-electrochemical biosensor enables detection of BCR\/ABL1 fusion transcripts in clinical samples for early diagnosis and minimal residual monitoring of CML"],"prefix":"10.1016","volume":"299","author":[{"given":"Liang-Yong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Hui","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ru","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Long","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Liu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Fang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Hua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-9892","authenticated-orcid":false,"given":"Jin-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bios.2026.118442_bib1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/nar\/23.4.675","article-title":"Detection of point mutations with a modified ligase chain reaction (Gap-LCR)","volume":"23","author":"Abravaya","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bios.2026.118442_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jcv.2019.03.015","article-title":"Amplification chemistries in clinical virology","volume":"115","author":"Dunbar","year":"2019","journal-title":"J. Clin. Virol."},{"issue":"22","key":"10.1016\/j.bios.2026.118442_bib3","doi-asserted-by":"crossref","first-page":"20765","DOI":"10.1021\/acsnano.5c02859","article-title":"Monitoring abundance and activity of electrochemically inactive protein in a single cell by an atomically precise metal cluster-based electrochemical sensor","volume":"19","author":"Han","year":"2025","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.bios.2026.118442_bib4","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1158\/1078-0432.CCR-03-0405","article-title":"Real-time gap ligase chain reaction: a rapid semiquantitative assay for detecting p53 mutation at low levels in surgical margins and lymph nodes from resected lung and head and neck tumors","volume":"10","author":"Harden","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bios.2026.118442_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.aca.2020.02.062","article-title":"Ferrocene-labeled and purification-free electrochemical biosensor based on ligase chain reaction for ultrasensitive single nucleotide polymorphism detection","volume":"1109","author":"Hu","year":"2020","journal-title":"Anal. Chim. Acta"},{"issue":"18","key":"10.1016\/j.bios.2026.118442_bib6","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1001\/jama.2025.0220","article-title":"Chronic myeloid leukemia: a review","volume":"333","author":"Jabbour","year":"2025","journal-title":"JAMA"},{"issue":"9048","key":"10.1016\/j.bios.2026.118442_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0140-6736(05)62829-2","article-title":"Sensitivity of ligase chain reaction assay of urine from pregnant women for Chlamydia trachomatis","volume":"349","author":"Jensen","year":"1997","journal-title":"Lancet"},{"issue":"14","key":"10.1016\/j.bios.2026.118442_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.35953","article-title":"Management of chronic myeloid leukemia in 2025","volume":"131","author":"Kantarjian","year":"2025","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.bios.2026.118442_bib9","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1021\/acs.analchem.0c05275","article-title":"Signal-amplified detection of the tumor biomarker FEN1 based on cleavage-induced ligation of a dumbbell DNA probe and rolling circle amplification","volume":"93","author":"Li","year":"2021","journal-title":"Anal. Chem."},{"issue":"26","key":"10.1016\/j.bios.2026.118442_bib10","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1039\/D0AY00820F","article-title":"Colorimetric detection of class A soybean saponins by coupling DNAzyme with the gap ligase chain reaction","volume":"12","author":"Li","year":"2020","journal-title":"Anal. Methods"},{"issue":"1","key":"10.1016\/j.bios.2026.118442_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00216-020-02997-8","article-title":"Integration of magnetic separation and real-time ligation chain reaction for detection of uracil-DNA glycosylase","volume":"413","author":"Liu","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"issue":"6","key":"10.1016\/j.bios.2026.118442_bib12","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1039\/C7SC04210H","article-title":"Controllable extension of hairpin-structured flaps to allow low-background cascade invasive reaction for a sensitive DNA logic sensor for mutation detection","volume":"9","author":"Liu","year":"2018","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bios.2026.118442_bib13","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.bios.2016.12.015","article-title":"Visualized detection of single-base difference in multiplexed loop-mediated isothermal amplification amplicons by invasive reaction coupled with oligonucleotide probe-modified gold nanoparticles","volume":"90","author":"Lu","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bios.2026.118442_bib14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/acs.analchem.3c03326","article-title":"Ultrafast and highly specific detection of one-base mutated cell-free DNA at a very low abundance","volume":"96","author":"Ma","year":"2024","journal-title":"Anal. Chem."},{"issue":"42","key":"10.1016\/j.bios.2026.118442_bib15","doi-asserted-by":"crossref","first-page":"14725","DOI":"10.1021\/acs.analchem.2c03143","article-title":"Flap endonuclease-induced steric hindrance change enables the construction of multiplex and versatile lateral flow strips for DNA detection","volume":"94","author":"Ma","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.118442_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115456","article-title":"FEN1-aided recombinase polymerase amplification (FARPA) for one-pot and multiplex detection of nucleic acids with an ultra-high specificity and sensitivity","volume":"237","author":"Ma","year":"2023","journal-title":"Biosens. Bioelectron."},{"issue":"8","key":"10.1016\/j.bios.2026.118442_bib17","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41551-022-00919-w","article-title":"A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma","volume":"6","author":"Najjar","year":"2022","journal-title":"Nat. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.bios.2026.118442_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1574-6968.2004.tb09657.x","article-title":"Characterization of a thermophilic DNA ligase from the archaeon Thermococcus fumicolans","volume":"236","author":"Rolland","year":"2004","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett."},{"issue":"36","key":"10.1016\/j.bios.2026.118442_bib19","doi-asserted-by":"crossref","first-page":"14678","DOI":"10.1021\/ja306265n","article-title":"Gold nanoparticle-enabled real-time ligation chain reaction for ultrasensitive detection of DNA","volume":"134","author":"Shen","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bios.2026.118442_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1198784","article-title":"Thermostable DNA ligases from hyperthermophiles in biotechnology","volume":"14","author":"Shi","year":"2023","journal-title":"Front. Microbiol."},{"issue":"7","key":"10.1016\/j.bios.2026.118442_bib21","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/smll.201202242","article-title":"Single quantum dot analysis enables multiplexed point mutation detection by gap ligase chain reaction","volume":"9","author":"Song","year":"2013","journal-title":"Small"},{"key":"10.1016\/j.bios.2026.118442_bib22","doi-asserted-by":"crossref","unstructured":"Sun, Y., Jenkins, L.M., El Touny, L.H., Zhu, L., Yang, X., Jo, U., Escobedo, L., Maity, T.K., Saha, L.K., Uribe, I., Saha, S., Takeda, S., Leung, A.K.L., Cheng, K., Pommier, Y., Flap endonuclease 1 repairs DNA-protein cross-links via ADP-ribosylation\u2013dependent mechanisms. Sci. Adv. 11(2), eads2919. doi: 10.1126\/sciadv.ads2919.","DOI":"10.1126\/sciadv.ads2919"},{"issue":"4","key":"10.1016\/j.bios.2026.118442_bib23","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1373\/clinchem.2016.263996","article-title":"Closed-tube PCR with nested serial invasion probe visualization using gold nanoparticles","volume":"63","author":"Wang","year":"2017","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bios.2026.118442_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124426","article-title":"Simultaneous quantification of multiple single nucleotide variants in PIK3CA ctDNA using mass-tagged LCR probe sets","volume":"258","author":"Wang","year":"2023","journal-title":"Talanta"},{"issue":"52","key":"10.1016\/j.bios.2026.118442_bib25","doi-asserted-by":"crossref","first-page":"20587","DOI":"10.1021\/acs.analchem.4c05189","article-title":"Advanced ligase chain reaction strategy to generate a circular DNA walker for electrochemiluminescent detection of single nucleotide polymorphism","volume":"96","author":"Yan","year":"2024","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.bios.2026.118442_bib26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1021\/acs.analchem.3c04417","article-title":"Ligation-based high-performance mimetic enzyme sensing platform for nucleic acid detection","volume":"96","author":"Yan","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.118442_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116677","article-title":"Rapid and simultaneous detection of common childhood diarrhea viruses by microfluidic-FEN1-assisted isothermal amplification with ultra-high specificity and sensitivity","volume":"264","author":"Ye","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"6726","key":"10.1016\/j.bios.2026.118442_bib28","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1126\/science.adn2600","article-title":"Active-reset protein sensors enable continuous in vivo monitoring of inflammation","volume":"386","author":"Zargartalebi","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.bios.2026.118442_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bios.2013.01.061","article-title":"DNAzyme based gap-LCR detection of single-nucleotide polymorphism","volume":"45","author":"Zhou","year":"2013","journal-title":"Biosens. Bioelectron."},{"issue":"19","key":"10.1016\/j.bios.2026.118442_bib30","doi-asserted-by":"crossref","first-page":"11884","DOI":"10.1093\/nar\/gkae804","article-title":"FRAME: flap endonuclease 1-engineered PAM module for precise and sensitive modulation of CRISPR\/Cas12a trans-cleavage activity","volume":"52","author":"Zuo","year":"2024","journal-title":"Nucleic Acids Res."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326000746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326000746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T07:16:49Z","timestamp":1773991009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326000746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"alternative-id":["S0956566326000746"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.118442","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An ultrasensitive FEN1-aided LCR-electrochemical biosensor enables detection of BCR\/ABL1 fusion transcripts in clinical samples for early diagnosis and minimal residual monitoring of CML","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.118442","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118442"}}