{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:05:14Z","timestamp":1793419514837,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20220737"],"award-info":[{"award-number":["BK20220737"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M721404"],"award-info":[{"award-number":["2022M721404"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017534","name":"333 Project of Jiangsu Province","doi-asserted-by":"publisher","award":["BRA2018086"],"award-info":[{"award-number":["BRA2018086"]}],"id":[{"id":"10.13039\/501100017534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bios.2026.118545","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:01:52Z","timestamp":1771516912000},"page":"118545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["High-throughput screening of bladder cancer exosome biomarkers by barcodes integrated herringbone microfluidics"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-505X","authenticated-orcid":false,"given":"Xiaowei","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yile","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2026.118545_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejca.2021.01.001","article-title":"A multimodal molecular imaging approach targeting urokinase plasminogen activator receptor for the diagnosis, resection and surveillance of urothelial cell carcinoma","volume":"146","author":"Baart","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bios.2026.118545_bib2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s43018-023-00539-6","article-title":"Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer","volume":"4","author":"Bakht","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.bios.2026.118545_bib3","article-title":"Emerging multiplexed biosensing technologies for exosome analysis","volume":"11","author":"Choi","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bios.2026.118545_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20230040","article-title":"Role of pretty nanoflowers as novel versatile analytical tools for sensing in biomedical and bioanalytical applications","volume":"3","author":"Dadi","year":"2024","journal-title":"Smart Med"},{"key":"10.1016\/j.bios.2026.118545_bib5","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1126\/science.adl2733","article-title":"Diamond-lattice photonic crystals assembled from DNA origami","volume":"384","author":"Gregor","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.bios.2026.118545_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/febs.15453","article-title":"Rab family of small GTPases: an updated view on their regulation and functions","volume":"288","author":"Homma","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.bios.2026.118545_bib7","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.07.009","article-title":"Extracellular vesicle and particle biomarkers define multiple human cancers","volume":"182","author":"Hoshino","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bios.2026.118545_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2024.103089","article-title":"Smart colloidal photonic crystal sensors","volume":"324","author":"Hu","year":"2024","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.bios.2026.118545_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20240005","article-title":"Engineering strategies for apoptotic bodies","volume":"3","author":"Hu","year":"2024","journal-title":"Smart Med"},{"key":"10.1016\/j.bios.2026.118545_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110156","article-title":"Roles of S100 family members in drug resistance in tumors: status and prospects","volume":"127","author":"Hua","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bios.2026.118545_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bios.2026.118545_bib12","first-page":"112","article-title":"Extracellular vesicles in cancer pathogenesis and diagnostics","volume":"43","author":"Kasi\u0144ski","year":"2025","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.bios.2026.118545_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/9781394268238.ch9","article-title":"Recent advancements in optical biosensors for cancer detection","volume":"197","author":"Kaur","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.118545_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s40001-024-01814-7","article-title":"Functional analysis and validation of oncodrive gene AP3S1 in ovarian cancer through filtering of mutation data from whole-exome sequencing","volume":"29","author":"Kong","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.bios.2026.118545_bib15","doi-asserted-by":"crossref","first-page":"16113","DOI":"10.1021\/acsnano.4c00280","article-title":"Choline phosphate-grafted nanozymes as universal extracellular vesicle probes for bladder cancer detection","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2026.118545_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12943-022-01543-7","article-title":"Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments","volume":"21","author":"Lone","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bios.2026.118545_bib17","article-title":"Microfluidic approaches for microactuators: from fabrication, actuation, to functionalization","volume":"19","author":"Ma","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.bios.2026.118545_bib18","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41585-023-00773-8","article-title":"Urine biomarkers in bladder cancer-current status and future perspectives","volume":"20","author":"Maas","year":"2023","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.bios.2026.118545_bib19","first-page":"3456","article-title":"Molecular heterogeneity and evolution in bladder cancer subtypes","volume":"16","author":"Prip","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.118545_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20240056","article-title":"Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration","volume":"3","author":"Ren","year":"2024","journal-title":"Smart Med"},{"key":"10.1016\/j.bios.2026.118545_bib21","first-page":"1234","article-title":"Microfluidic platforms for high-throughput exosome analysis in oncology","volume":"25","author":"Skubal","year":"2025","journal-title":"Lab Chip"},{"key":"10.1016\/j.bios.2026.118545_bib22","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/s41467-023-36932-z","article-title":"Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact","volume":"14","author":"Spitzberg","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.118545_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20240009","article-title":"Developing organs-on-chips for biomedical applications","volume":"3","author":"Sun","year":"2024","journal-title":"Smart Med"},{"key":"10.1016\/j.bios.2026.118545_bib24","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.scib.2023.04.010","article-title":"Bioinspired optical and electrical dual-responsive heart-on-a-chip for hormone testing","volume":"68","author":"Sun","year":"2023","journal-title":"Sci. Bull."},{"key":"10.1016\/j.bios.2026.118545_bib25","article-title":"Urinary exosomes as promising diagnostic biomarkers for bladder cancer","volume":"208","author":"Sun","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.118545_bib26","doi-asserted-by":"crossref","first-page":"17802","DOI":"10.1021\/acsnano.2c08774","article-title":"Exosomes horizontal line nature's lipid nanoparticles, a rising star in drug delivery and diagnostics","volume":"16","author":"Tenchov","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2026.118545_bib27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41568-020-00313-1","article-title":"Advances in bladder cancer biology and therapy","volume":"21","author":"Tran","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bios.2026.118545_bib28","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1515\/nanoph-2022-0063","article-title":"Structural color generation: from layered thin films to optical metasurfaces","volume":"12","author":"Wang","year":"2023","journal-title":"Nanophotonics"},{"key":"10.1016\/j.bios.2026.118545_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.101066","article-title":"Towards microfluidic-based exosome isolation and detection for tumor therapy","volume":"37","author":"Wang","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.bios.2026.118545_bib30","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41419-023-06050-1","article-title":"Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment","volume":"14","author":"Yang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bios.2026.118545_bib31","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.ymthe.2022.01.022","article-title":"Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments","volume":"30","author":"Yang","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bios.2026.118545_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12943-022-01509-9","article-title":"Exosomes as a new frontier of cancer liquid biopsy","volume":"21","author":"Yu","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bios.2026.118545_bib33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41377-022-00937-y","article-title":"Liquid crystal-based structural color actuators","volume":"11","author":"Zhang","year":"2022","journal-title":"Light Sci. Appl."},{"key":"10.1016\/j.bios.2026.118545_bib34","article-title":"Structural color colloidal photonic crystals for biomedical applications","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bios.2026.118545_bib35","article-title":"Spatial tumor biopsy with fluorescence PCR microneedle array","volume":"5","author":"Zhang","year":"2024","journal-title":"Innovation"},{"key":"10.1016\/j.bios.2026.118545_bib36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41698-024-00675-x","article-title":"M2 macrophage-derived lncRNA NORAD in EVs promotes NSCLC progression via miR-520g-3p\/SMIM22\/GALE axis","volume":"8","author":"Zhao","year":"2024","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.bios.2026.118545_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20230047","article-title":"Photothermal-enhanced in situ supramolecular hydrogel promotes bacteria-infected wound healing in diabetes","volume":"3","author":"Zheng","year":"2024","journal-title":"Smart Med"},{"key":"10.1016\/j.bios.2026.118545_bib38","article-title":"Rolling stone gathers moss: rolling microneedles generate Meta Microfluidic Microneedles (MMM)","volume":"34","author":"Zhou","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bios.2026.118545_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113836","article-title":"Construction of an enzyme-based all-fiber spr biosensor for detection of enantiomers","volume":"198","author":"Zhou","year":"2022","journal-title":"Biosens. Bioelectron."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326001776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326001776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:46:37Z","timestamp":1777596397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326001776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":39,"alternative-id":["S0956566326001776"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.118545","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-throughput screening of bladder cancer exosome biomarkers by barcodes integrated herringbone microfluidics","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.118545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118545"}}