{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:03:31Z","timestamp":1792451011689,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004147","name":"Tsinghua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bios.2026.118569","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:02:51Z","timestamp":1772557371000},"page":"118569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["High affinity and selective DNA aptamers for the detection of tobramycin in eye drops"],"prefix":"10.1016","volume":"303","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-8104","authenticated-orcid":false,"given":"Xiaohan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Hoi Pui","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boya","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-Ying","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-4891","authenticated-orcid":false,"given":"Philip E.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-9336","authenticated-orcid":false,"given":"Juewen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2026.118569_bib1","doi-asserted-by":"crossref","first-page":"gkaf219","DOI":"10.1093\/nar\/gkaf219","volume":"53","author":"Alkhamis","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bios.2026.118569_bib2","doi-asserted-by":"crossref","first-page":"21094","DOI":"10.1021\/acsomega.0c02744","volume":"5","author":"Alkhzem","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.bios.2026.118569_bib3","doi-asserted-by":"crossref","first-page":"12110","DOI":"10.1021\/acs.jpcb.5c05704","volume":"129","author":"Batchelor","year":"2025","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bios.2026.118569_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340240","volume":"1225","author":"Bojescu","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bios.2026.118569_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2020.105658","volume":"160","author":"da Silva Medeiros","year":"2021","journal-title":"Microchem. J."},{"key":"10.1016\/j.bios.2026.118569_bib6","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/cjoc.202400113","volume":"42","author":"Ding","year":"2024","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.bios.2026.118569_bib7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41570-017-0076","volume":"1","author":"Dunn","year":"2017","journal-title":"Nat. Rev. Chem"},{"key":"10.1016\/j.bios.2026.118569_bib8","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1073\/pnas.96.18.10129","volume":"96","author":"Griffey","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bios.2026.118569_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s00604-017-2568-6","volume":"185","author":"Han","year":"2017","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.bios.2026.118569_bib10","doi-asserted-by":"crossref","first-page":"12471","DOI":"10.1021\/acs.chemrev.3c00377","volume":"123","author":"Ji","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bios.2026.118569_bib12","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1007\/s12161-018-1185-2","volume":"11","author":"Jiang","year":"2018","journal-title":"Food Anal. Methods"},{"key":"10.1016\/j.bios.2026.118569_bib11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/1804","volume":"5","author":"Jiang","year":"1998","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.bios.2026.118569_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coesh.2019.09.003","volume":"10","author":"Kim","year":"2019","journal-title":"Current Opinion in Environmental Science & Health"},{"key":"10.1016\/j.bios.2026.118569_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202316678","volume":"63","author":"Leung","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118569_bib15","doi-asserted-by":"crossref","first-page":"17242","DOI":"10.1021\/acs.analchem.5c03765","volume":"97","author":"Li","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.118569_bib16","doi-asserted-by":"crossref","first-page":"8954","DOI":"10.1039\/D1CS00240F","volume":"50","author":"McConnell","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bios.2026.118569_bib17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3389\/fchem.2020.00434","volume":"8","author":"McConnell","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.bios.2026.118569_bib18","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.1021\/acs.analchem.5b02102","volume":"87","author":"McKeague","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.118569_bib19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bios.2018.09.072","volume":"122","author":"Nie","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.118569_bib20","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/anie.200461848","volume":"44","author":"Nutiu","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118569_bib21","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1136\/archdischild-2012-301728.28","volume":"97","author":"Paskin","year":"2012","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.bios.2026.118569_bib22","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1093\/nar\/gkg764","volume":"31","author":"Rajendran","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bios.2026.118569_bib23","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.1021\/ac101491d","volume":"82","author":"Rowe","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.118569_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2022.106778","volume":"195","author":"Schwarz","year":"2022","journal-title":"Respir. Med."},{"key":"10.1016\/j.bios.2026.118569_bib25","doi-asserted-by":"crossref","first-page":"19767","DOI":"10.1021\/acs.analchem.5c03351","volume":"97","author":"Shu","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.118569_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202400116","volume":"25","author":"Slavkovic","year":"2024","journal-title":"Chembiochem"},{"key":"10.1016\/j.bios.2026.118569_bib27","first-page":"326","article-title":"ACS combinatorial","volume":"17","author":"Spiga","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bios.2026.118569_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202401572","volume":"9","author":"Stangherlin","year":"2025","journal-title":"Small Methods"},{"key":"10.1016\/j.bios.2026.118569_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202510518","volume":"64","author":"Stangherlin","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118569_bib30","author":"Wang","year":"2025","journal-title":"CCS Chem."},{"key":"10.1016\/j.bios.2026.118569_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/1074-5521(95)90047-0","volume":"2","author":"Wang","year":"1995","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bios.2026.118569_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2025.115646","volume":"224","author":"Wong","year":"2025","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bios.2026.118569_bib33","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1021\/acschembio.5c00438","volume":"20","author":"Xie","year":"2025","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bios.2026.118569_bib34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ymeth.2016.04.032","volume":"106","author":"Yang","year":"2016","journal-title":"Methods"},{"key":"10.1016\/j.bios.2026.118569_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trac.2018.09.013","volume":"109","author":"Yeasmin Khusbu","year":"2018","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.bios.2026.118569_bib36","doi-asserted-by":"crossref","first-page":"16800","DOI":"10.1002\/anie.202008663","volume":"60","author":"Yu","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118569_bib37","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1039\/D5AY00680E","volume":"17","author":"Zhang","year":"2025","journal-title":"Anal. Methods"},{"key":"10.1016\/j.bios.2026.118569_bib39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11426-020-9864-7","volume":"64","author":"Zhao","year":"2021","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.bios.2026.118569_bib38","volume":"vol. 5","author":"Zhao","year":"2025"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326002010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326002010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:45:45Z","timestamp":1777596345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326002010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":39,"alternative-id":["S0956566326002010"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.118569","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High affinity and selective DNA aptamers for the detection of tobramycin in eye drops","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.118569","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"118569"}}