{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:37:46Z","timestamp":1786711066563,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004184","name":"Northeastern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004184","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22274017"],"award-info":[{"award-number":["22274017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22334003"],"award-info":[{"award-number":["22334003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bios.2026.118938","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:36:17Z","timestamp":1781678177000},"page":"118938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Microfluidic capture and spatiotemporal analysis: Chemical mechanisms of tumor exosome-mediated malignant cell transformation"],"prefix":"10.1016","volume":"311","author":[{"given":"Ya-Nan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Jie","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zhuo","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Fei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-9199","authenticated-orcid":false,"given":"Cheng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8536-8864","authenticated-orcid":false,"given":"Ming-Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2026.118938_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116352","article-title":"Emergence of microfluidic devices in sample extraction; an overview of diverse methodologies, principals, and recent advancements","volume":"143","author":"Alidoust","year":"2021","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.bios.2026.118938_bib2","doi-asserted-by":"crossref","DOI":"10.1039\/c4lc00128a","article-title":"Inertial microfluidic physics","volume":"14","author":"Amini","year":"2014","journal-title":"Lab Chip"},{"key":"10.1016\/j.bios.2026.118938_bib3","article-title":"Exosomes derived from M. Bovis BCG infected macrophages activate antigen-specific CD4+ and CD8+ T cells in vitro and in vivo","volume":"3","author":"Bishai","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bios.2026.118938_bib4","doi-asserted-by":"crossref","unstructured":"N. Bresciani, H. Demagny, V. Lemos, F. Pontanari, X. Li, Y. Sun, H. Li, A. Perino, J. Auwerx, K. Schoonjans, The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. J. Hepatol. 77, 1071-1082. doi: 10.1016\/j.jhep.2022.05.040.","DOI":"10.1016\/j.jhep.2022.05.040"},{"key":"10.1016\/j.bios.2026.118938_bib5","doi-asserted-by":"crossref","unstructured":"A. J. Chung, D. R. Gossett, D. Di Carlo, Three dimensional, sheathless, and high-throughput microparticle inertial focusing through GeometryInduced secondary flows. Small 9. doi: 10.1002\/smll.201202413.","DOI":"10.1002\/smll.201202413"},{"key":"10.1016\/j.bios.2026.118938_bib6","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bios.2026.118938_bib7","article-title":"Deep learning-assisted label-free parallel cell sorting with digital microfluidics","volume":"12","author":"Guo","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bios.2026.118938_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bios.2014.07.029","article-title":"Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices","volume":"63","author":"Halldorsson","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.118938_bib9","doi-asserted-by":"crossref","unstructured":"K. Jiang, Y. Chen, K. Wang, L. Yang, S. Sun, J. Yang, X. Li, miR-331-depleted exosomes derived from injured endometrial epithelial cells promote macrophage activation during endometritis. Int. J. Biol. Macromol. 279.doi:10.1016\/j.ijbiomac.2024.134967.","DOI":"10.1016\/j.ijbiomac.2024.134967"},{"key":"10.1016\/j.bios.2026.118938_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.116932","article-title":"Recent advances in droplet microfluidics for single-cell analysis","volume":"159","author":"Jiang","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.bios.2026.118938_bib11","doi-asserted-by":"crossref","first-page":"12176","DOI":"10.1002\/anie.201200460","article-title":"Droplet Microfluidics\u2014A tool for single\u2010cell analysis","volume":"51","author":"Joensson","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118938_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bios.2026.118938_bib13","doi-asserted-by":"crossref","first-page":"11335","DOI":"10.1021\/acsnano.4c00768","article-title":"Microfluidic platform enables shearless aerosolization of lipid nanoparticles for mRNA inhalation","volume":"18","author":"Kim","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2026.118938_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bios.2026.118938_bib15","doi-asserted-by":"crossref","unstructured":"M. T. N. Le, P. Hamar, C. Guo, E. Basar, R. Perdig\u00e3o-Henriques, L. Balaj, J. Lieberman, miR-200\u2013containing extracellular vesicles promote breast cancer cell metastasis. J. Clin. Investig. 124, 5109-5128. doi:10.1172\/JCI75695.","DOI":"10.1172\/JCI75695"},{"key":"10.1016\/j.bios.2026.118938_bib16","article-title":"Paper microfluidics for cell analysis","volume":"8","author":"Ma","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bios.2026.118938_bib17","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.cej.2018.09.030","article-title":"Liquid-liquid extraction of calcium using ionic liquids in spiral microfluidics","volume":"356","author":"Marsousi","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bios.2026.118938_bib18","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ccell.2014.09.005","article-title":"Cancer exosomes perform cell-independent MicroRNA biogenesis and promote tumorigenesis","volume":"26","author":"Melo","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bios.2026.118938_bib19","doi-asserted-by":"crossref","unstructured":"O. Mitxelena-Iribarren, J. Zabalo, S. Arana, M. Mujika, Improved microfluidic platform for simultaneous multiple drug screening towards personalized treatment. Biosens. Bioelectron. 123, 237-243. doi: 10.1016\/j.bios.2018.09.001.","DOI":"10.1016\/j.bios.2018.09.001"},{"key":"10.1016\/j.bios.2026.118938_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"Emt: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bios.2026.118938_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-025-02129-7","article-title":"Molecular principles underlying aggressive cancers","volume":"10","author":"Nussinov","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bios.2026.118938_bib22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","article-title":"Exosomes","volume":"88","author":"Pegtel","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bios.2026.118938_bib23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pharmthera.2017.08.009","article-title":"EMT: mechanisms and therapeutic implications","volume":"182","author":"Singh","year":"2018","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.bios.2026.118938_bib24","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1002\/anie.201809337","article-title":"Bioinspired engineering of a multivalent aptamer\u2010functionalized nanointerface to enhance the capture and release of circulating tumor cells","volume":"58","author":"Song","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118938_bib25","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/jth.12712","article-title":"Exosome poly\u2010ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro\u2010atherothombotic cellular functions","volume":"12","author":"Srikanthan","year":"2014","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.bios.2026.118938_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrc.2016.25","article-title":"Targeting metastasis","volume":"16","author":"Steeg","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bios.2026.118938_bib27","article-title":"RNA and protein delivery by cell\u2010secreted and bioengineered extracellular vesicles","volume":"11","author":"Wang","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bios.2026.118938_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800180","article-title":"Breast cancer\u2010derived exosomes reflect the cell-of-origin phenotype","volume":"19","author":"Wen","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.bios.2026.118938_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116836","article-title":"Recent advances in centrifugal microfluidic chip-based loop-mediated isothermal amplification","volume":"158","author":"Xiao","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.bios.2026.118938_bib30","article-title":"When super\u2010resolution microscopy meets microfluidics: enhanced biological imaging and analysis with unprecedented resolution","volume":"19","author":"Yang","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.bios.2026.118938_bib31","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1038\/nature22816","article-title":"Upholding a role for EMT in breast cancer metastasis","volume":"547","author":"Ye","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bios.2026.118938_bib32","doi-asserted-by":"crossref","unstructured":"Q. Yin, T.-T. Tang, X.-Y. Lu, W.-J. Ni, D. Yin, Y.-L. Zhang, W. Jiang, Y. Zhang, Z.-L. Li, Y. Wen, W.-H. Gan, A.-Q. Zhang, L.-L. Lv, B. Wang, B.-C. Liu, Macrophage-derived exosomes promote telomere fragility and senescence in tubular epithelial cells by delivering miR-155. Cell Commun. Signal. 22. doi: 10.1186\/s12964-024-01708-5.","DOI":"10.1186\/s12964-024-01708-5"},{"key":"10.1016\/j.bios.2026.118938_bib33","doi-asserted-by":"crossref","DOI":"10.1039\/b909900j","article-title":"Fundamentals of microfluidic cell culture in controlled microenvironments","volume":"39","author":"Young","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bios.2026.118938_bib35","doi-asserted-by":"crossref","first-page":"14115","DOI":"10.1002\/anie.202005974","article-title":"DNA nanolithography enables a highly ordered recognition interface in a microfluidic chip for the efficient capture and release of circulating tumor cells","volume":"59","author":"Zhang","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118938_bib34","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.bios.2017.12.017","article-title":"A dual-functional microfluidic chip for on-line detection of interleukin-8 based on rolling circle amplification","volume":"102","author":"Zhang","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.118938_bib36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1021\/acs.accounts.6b00370","article-title":"Hydrogel droplet microfluidics for high-throughput single molecule\/cell analysis","volume":"50","author":"Zhu","year":"2016","journal-title":"Acc. Chem. Res."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326005701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326005701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:02:12Z","timestamp":1786708932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326005701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":36,"alternative-id":["S0956566326005701"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.118938","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microfluidic capture and spatiotemporal analysis: Chemical mechanisms of tumor exosome-mediated malignant cell transformation","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.118938","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118938"}}