{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:36:34Z","timestamp":1786710994034,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bios.2026.118976","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:36:58Z","timestamp":1782715018000},"page":"118976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CRISPR\/Cas12a-based dual-modal signal platform using MIL-101(Fe) for colorimetric and electron spin resonance detection of HPV-16 nucleic acid"],"prefix":"10.1016","volume":"311","author":[{"given":"Yue","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8962-858X","authenticated-orcid":false,"given":"Yujing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bios.2026.118976_bib1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.12788\/jcso.0039","article-title":"Cobas HPV test for first-line screening for cervical cancer","volume":"12","author":"Abraham","year":"2014","journal-title":"J Community Support Oncol"},{"issue":"4","key":"10.1016\/j.bios.2026.118976_bib2","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/j.foodchem.2011.12.060","article-title":"An electron paramagnetic resonance study of antioxidant properties of alcoholic beverages","volume":"132","author":"Bartoszek","year":"2012","journal-title":"Food Chem."},{"issue":"7","key":"10.1016\/j.bios.2026.118976_bib3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s41587-020-0513-4","article-title":"CRISPR\u2013Cas12-based detection of SARS-CoV-2","volume":"38","author":"Broughton","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"46","key":"10.1016\/j.bios.2026.118976_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202403354","article-title":"In situ defect engineering of Fe-MIL for self-enhanced peroxidase-like activity","volume":"20","author":"Cai","year":"2024","journal-title":"Small"},{"issue":"6387","key":"10.1016\/j.bios.2026.118976_bib5","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.aar6245","article-title":"CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity","volume":"360","author":"Chen","year":"2018","journal-title":"Science"},{"issue":"6336","key":"10.1016\/j.bios.2026.118976_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.aam9321","article-title":"Nucleic acid detection with CRISPR-Cas13a\/C2c2","volume":"356","author":"Gootenberg","year":"2017","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bios.2026.118976_bib7","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1071\/SH10020","article-title":"Cancers attributable to human papillomavirus infection","volume":"7","author":"Grulich","year":"2010","journal-title":"Sex. Health"},{"key":"10.1016\/j.bios.2026.118976_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.128021","article-title":"A label-free fluorescence biosensor based on a bifunctional MIL-101(Fe) nanozyme for sensitive detection of choline and acetylcholine at nanomolar level","volume":"312","author":"Guo","year":"2020","journal-title":"Sensor. Actuator. B Chem."},{"issue":"5962","key":"10.1016\/j.bios.2026.118976_bib9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1126\/science.1179555","article-title":"CRISPR\/Cas, the immune system of bacteria and archaea","volume":"327","author":"Horvath","year":"2010","journal-title":"Science"},{"issue":"6333","key":"10.1016\/j.bios.2026.118976_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal5056","article-title":"CRISPR-Cas: adapting to change","volume":"356","author":"Jackson","year":"2017","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.bios.2026.118976_bib11","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3390\/v16050680","article-title":"Human papillomavirus and associated cancers: a review","volume":"16","author":"Jensen","year":"2024","journal-title":"Viruses"},{"issue":"6096","key":"10.1016\/j.bios.2026.118976_bib12","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.1225829","article-title":"A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity","volume":"337","author":"Jinek","year":"2012","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bios.2026.118976_bib13","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1128\/JCM.42.6.2470-2475.2004","article-title":"Human papillomavirus testing with the hybrid capture 2 assay and PCR as screening tools","volume":"42","author":"Kulmala","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.bios.2026.118976_bib14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jcis.2019.07.046","article-title":"Adsorption behavior of arsenicals on MIL-101(Fe): the role of arsenic chemical structures","volume":"554","author":"Li","year":"2019","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"10.1016\/j.bios.2026.118976_bib15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1158\/1940-6207.CAPR-11-0542","article-title":"Reducing HPV-associated cancer globally","volume":"5","author":"Lowy","year":"2012","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.bios.2026.118976_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117153","article-title":"CRISPR analysis based on Pt@MOF dual-modal signal for multichannel fluorescence and visual detection of norovirus","volume":"273","author":"Mao","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"6","key":"10.1016\/j.bios.2026.118976_bib17","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S1386-1425(01)00716-8","article-title":"Novel EPR characterization of the antioxidant activity of tea leaves","volume":"58","author":"Morsy","year":"2002","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bios.2026.118976_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.113447","article-title":"Development of rapid and sensitive RPA-CRISPR-Cas12a assay for HPV16 detection to aid in point-of-care cervical cancer screening","volume":"212","author":"Padavu","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.bios.2026.118976_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.microb.2025.100344","article-title":"CRISPR Cas systems: from bacterial defense mechanisms to revolutionary tools reshaping genetic research and translation therapeutics","volume":"7","author":"Saeed","year":"2025","journal-title":"Microbe"},{"issue":"37","key":"10.1016\/j.bios.2026.118976_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202506539","article-title":"Electron spin resonance at the single-molecule scale","volume":"64","author":"Sellies","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118976_bib22","doi-asserted-by":"crossref","first-page":"8242","DOI":"10.1039\/D4AY01682C","article-title":"A dual-mode sensing platform for electron spin resonance and UV-vis detection of alkaline phosphatase based on Cu-based metal-organic frameworks","volume":"16","author":"Shi","year":"2024","journal-title":"Anal. Methods"},{"key":"10.1016\/j.bios.2026.118976_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136112","article-title":"Ratiometric paramagnetic probe based on ABTS\u2022+ and Mn2+ for detection of glutathione and revelation of the mechanism for MnO2 nanosheet induced oxidation of ABTS","volume":"417","author":"Shi","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2026.118976_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1681779","article-title":"Evolving HPV diagnostics: current practice and future frontiers","volume":"15","author":"Shi","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bios.2026.118976_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2026.118710","article-title":"Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR\/Cas12a signal amplification for bladder cancer detection","volume":"306","author":"Sun","year":"2026","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.118976_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2025.118505","article-title":"Recent advances in CRISPR-based diagnostics for single-nucleotide variant detection TrAC","volume":"194","author":"Wang","year":"2026","journal-title":"Trends Anal. Chem."},{"issue":"29","key":"10.1016\/j.bios.2026.118976_bib26","doi-asserted-by":"crossref","first-page":"9827","DOI":"10.1021\/jacs.7b05633","article-title":"General and direct method for preparing oligonucleotide-functionalized metal-organic framework nanoparticles","volume":"139","author":"Wang","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bios.2026.118976_bib27","series-title":"Spherical Nucleic Acids","first-page":"671","article-title":"General and direct method for preparing oligonucleotide-functionalized metal-organic framework nanoparticles, spherical nucleic acids","author":"Wang","year":"2020"},{"key":"10.1016\/j.bios.2026.118976_bib28","doi-asserted-by":"crossref","first-page":"10105","DOI":"10.1021\/acs.analchem.3c01830","article-title":"Determination of the maximum velocity of a peroxidase-like nanozyme","volume":"95","author":"Wang","year":"2023","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.bios.2026.118976_bib29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ogc.2008.09.006","article-title":"Natural history of human papillomavirus infections, cytologic and histologic abnormalities, and cancer","volume":"35","author":"Wheeler","year":"2008","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"issue":"45","key":"10.1016\/j.bios.2026.118976_bib30","doi-asserted-by":"crossref","first-page":"50534","DOI":"10.1021\/acsami.2c14497","article-title":"MnO(2) nanozyme-mediated CRISPR-Cas12a system for the detection of SARS-CoV-2","volume":"14","author":"Wu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bios.2026.118976_bib31","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1038\/s41467-022-34086-y","article-title":"Microfluidic space coding for multiplexed nucleic acid detection via CRISPR-Cas12a and recombinase polymerase amplification","volume":"13","author":"Xu","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bios.2026.118976_bib32","article-title":"Comprehensive overview of genotype distribution and prevalence of human papillomavirus in cervical lesions","volume":"4","author":"Ye","year":"2024","journal-title":"Gynecol. Obstet. Clin. Med."},{"issue":"1","key":"10.1016\/j.bios.2026.118976_bib33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/mnfr.200700395","article-title":"Application of electron spin resonance (ESR) spectrometry in nutraceutical and food research","volume":"52","author":"Yu","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bios.2026.118976_bib34","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.foodchem.2016.11.036","article-title":"Determination of antioxidant capacity of diverse fruits by electron spin resonance (ESR) and UV-vis spectrometries","volume":"221","author":"Zang","year":"2017","journal-title":"Food Chem."},{"issue":"12","key":"10.1016\/j.bios.2026.118976_bib35","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1007\/s00216-018-0873-5","article-title":"Detection of target DNA with a novel Cas9\/sgRNAs-associated reverse PCR (CARP) technique","volume":"410","author":"Zhang","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"issue":"10","key":"10.1016\/j.bios.2026.118976_bib36","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1039\/D2NJ05856A","article-title":"Efficient degradation of metronidazole wastewater over MIL-101(Fe) Fenton catalysts","volume":"47","author":"Zhang","year":"2023","journal-title":"New J. Chem."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:57:09Z","timestamp":1786708629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326006081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":36,"alternative-id":["S0956566326006081"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.118976","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CRISPR\/Cas12a-based dual-modal signal platform using MIL-101(Fe) for colorimetric and electron spin resonance detection of HPV-16 nucleic acid","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.118976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118976"}}