{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:27:40Z","timestamp":1786519660543,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011244","name":"State Key Laboratory of Analytical Chemistry for Life Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011244","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bios.2026.118997","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:19:50Z","timestamp":1783351190000},"page":"118997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nanopipette confined hydrogel-catalyst networks for spatiotemporal monitoring of nanoplastics-induced oxidative stress in single cells"],"prefix":"10.1016","volume":"312","author":[{"given":"Guanxia","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanxiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6138-7470","authenticated-orcid":false,"given":"Wei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2026.118997_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117472","article-title":"A comparative review of organ-on-a-chip technologies for micro- and nanoplastics versus other environmental toxicants","volume":"282","author":"Abdessalam","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.118997_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117254","article-title":"Molecular modulation of aggregation-induced luminescence for improving response sensing of DNA hydrogels","volume":"276","author":"Bai","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.118997_bib3","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1038\/s41467-019-12475-0","article-title":"Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity","volume":"10","author":"Carmona","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bios.2026.118997_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1021\/acs.chemrev.5c00454","article-title":"Nanopipette electrochemistry","volume":"126","author":"Chen","year":"2026","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bios.2026.118997_bib5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.tifs.2022.10.004","article-title":"Recent applications of hydrogels in food safety sensing: role of hydrogels","volume":"129","author":"Cheng","year":"2022","journal-title":"Trends Food Sci. Technol."},{"issue":"15","key":"10.1016\/j.bios.2026.118997_bib6","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1021\/acs.analchem.4c00634","article-title":"The detection of trace metal contaminants in organic products using ion current rectifying quartz nanopipettes","volume":"96","author":"Farrell","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.118997_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.169081","article-title":"Reactive oxygen species activatable nanotherapeutics for evaluating and relieving nanoplastics-induced oxidative stress","volume":"524","author":"Fu","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"51","key":"10.1016\/j.bios.2026.118997_bib8","doi-asserted-by":"crossref","first-page":"42869","DOI":"10.1021\/acsnano.5c15989","article-title":"Nanoplastics in duckweed: Single-cell responses and recovery","volume":"19","author":"Grossart","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2026.118997_bib9","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1038\/s41467-025-60148-y","article-title":"Photoelectrochemical biosensor with single atom sites for norepinephrine sensing and brain region synergy in epilepsy","volume":"16","author":"Gu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.118997_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.165606","article-title":"From oxidative stress to metabolic revival: Pyrite-based constructed wetlands harness S-Fe-N synergy to combat nanoplastics toxicity","volume":"519","author":"Guo","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bios.2026.118997_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.118313","article-title":"Ligand-regulated PEDOT-based nanoelectrochemical sensor for ultrasensitive and in situ detection of dopamine in single living cells","volume":"295","author":"He","year":"2026","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.118997_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122418","article-title":"Impacts of nanoplastics on bivalve: fluorescence tracing of organ accumulation, oxidative stress and damage","volume":"392","author":"Li","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"17","key":"10.1016\/j.bios.2026.118997_bib13","doi-asserted-by":"crossref","first-page":"17468","DOI":"10.1021\/acsnano.3c05825","article-title":"A fast and reversible responsive bionic transmembrane nanochannel for dynamic single-cell quantification of glutathione","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2026.118997_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123778","article-title":"Polystyrene nanoplastic induces oxidative stress, immune defense, and glycometabolism change in Daphnia pulex: application of transcriptome profiling in risk assessment of nanoplastics","volume":"402","author":"Liu","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.bios.2026.118997_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2025.111496","article-title":"Hollow mesoporous Prussian blue nanozymes with intrinsic self-chromogenicity and photothermal amplification as a pH-adaptive dual-modal biosensor for one-step glucose monitoring","volume":"37","author":"Luo","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bios.2026.118997_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.117056","article-title":"Comparing Ag-O coordinated AgMOF-5 and Ag-N coordinated Ag nanosphere catalytic polymers for real time monitoring of H2O2 level in cancer cells","volume":"271","author":"Mohapatra","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"46","key":"10.1016\/j.bios.2026.118997_bib17","doi-asserted-by":"crossref","first-page":"18464","DOI":"10.1021\/acs.analchem.4c03846","article-title":"Multispatially localized dna walker coupling covalent organic framework for dual-mode detection of nucleocapsid protein using the walking-recycling-conversion strategy","volume":"96","author":"Qiu","year":"2024","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.bios.2026.118997_bib18","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1021\/acs.analchem.5c06649","article-title":"Apt-nanogel-kit for real-time quantitative monitoring of the released H2O2 from living cells and point-of-care application","volume":"98","author":"Shao","year":"2026","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.118997_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.163997","article-title":"Chronocoulometry signal amplification using in-situ Prussian blue conductive hydrogel for advanced electrochemical antifouling sensing","volume":"516","author":"Shi","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bios.2026.118997_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117845","article-title":"Optical and electrochemical probes-assisted dual-mode nanosensor for ultrasensitive monitoring of serotonin in single cells","volume":"288","author":"Song","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"40","key":"10.1016\/j.bios.2026.118997_bib21","doi-asserted-by":"crossref","first-page":"13226","DOI":"10.1002\/anie.201808537","article-title":"Ultrasmall nanopipette: toward continuous monitoring of redox metabolism at subcellular level","volume":"57","author":"Song","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118997_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2026.118467","article-title":"Non-destructive surface acoustic wave sensing for real-time material characterisation of GelMA hydrogels","volume":"303","author":"Stamp","year":"2026","journal-title":"Biosens. Bioelectron."},{"issue":"44","key":"10.1016\/j.bios.2026.118997_bib23","doi-asserted-by":"crossref","first-page":"17649","DOI":"10.1021\/acs.analchem.4c03620","article-title":"Metal-organic framework nanochannels within the confined micropipettes: precise construction makes it a universal aptamer-based sensing platform","volume":"96","author":"Tang","year":"2024","journal-title":"Anal. Chem."},{"issue":"29","key":"10.1016\/j.bios.2026.118997_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202504520","article-title":"Dual-interface nanopipette sensor for electrochemical interferent shielding","volume":"64","author":"Tian","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.118997_bib25","article-title":"Nanoplastics in infusion system remains underexplored: evidence from detected nanoplastics in hospital-sourced infusion products","volume":"299","author":"Wang","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"16","key":"10.1016\/j.bios.2026.118997_bib26","doi-asserted-by":"crossref","first-page":"16849","DOI":"10.1021\/jacs.5c23220","article-title":"Enzymatic charge switching in asymmetric dual-barrel nanopipettes for multiplex and label-free bacterial detection","volume":"148","author":"Wang","year":"2026","journal-title":"J. Am. Chem. Soc."},{"issue":"51","key":"10.1016\/j.bios.2026.118997_bib27","doi-asserted-by":"crossref","first-page":"20152","DOI":"10.1021\/acs.analchem.4c03572","article-title":"Efficient electrochemical coupling of aptamer to nanoelectrode for in situ detection of ATP in single cells","volume":"96","author":"Wang","year":"2024","journal-title":"Anal. Chem."},{"issue":"38","key":"10.1016\/j.bios.2026.118997_bib28","doi-asserted-by":"crossref","first-page":"14127","DOI":"10.1021\/acs.est.3c02769","article-title":"Nanoplastic exposure at environmental concentrations disrupts hepatic lipid metabolism through oxidative stress induction and endoplasmic reticulum homeostasis perturbation","volume":"57","author":"Wang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.bios.2026.118997_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143612","article-title":"Development of a colorimetric sensing assay for ascorbic acid and sarcosine utilizing the dual-class enzyme activity of Fe3O4@SiO2@NiCo2S4","volume":"468","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"52","key":"10.1016\/j.bios.2026.118997_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202315681","article-title":"Direct quantification of nanoplastics neurotoxicity by single-vesicle electrochemistry","volume":"62","author":"Wei","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"issue":"8","key":"10.1016\/j.bios.2026.118997_bib31","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.immuni.2025.07.012","article-title":"Mitochondria reactive oxygen species signaling in immune responses","volume":"58","author":"Weinberg","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.bios.2026.118997_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136419","article-title":"A mitochondria-targeted fluorescent probe for revealing H2O2 elevation modulated by basal HClO in HeLa and A549 cells","volume":"419","author":"Yin","year":"2024","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.bios.2026.118997_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2024.101378","article-title":"Water: the soul of hydrogels","volume":"148","author":"Yuan","year":"2025","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.bios.2026.118997_bib34","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s41664-024-00298-y","article-title":"Integrating bimetallic nanoparticles with covalent organic frameworks as multifunctional nanozyme for colorimetric detection of hydrogen peroxide and glutathione","volume":"8","author":"Yuan","year":"2024","journal-title":"J. Anal. Test."},{"key":"10.1016\/j.bios.2026.118997_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102245","article-title":"Resistance to H2O2-induced oxidative stress in human cells of different phenotypes","volume":"50","author":"Zenin","year":"2022","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.bios.2026.118997_bib36","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1021\/acs.analchem.1c05571","article-title":"Highly sensitive glass nanopipette sensor using composite probes of DNA-functionalized metal-organic frameworks","volume":"94","author":"Zhang","year":"2022","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.bios.2026.118997_bib38","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1021\/acs.analchem.5c06980","article-title":"Highly specific detection of miRNA mutants using a combined analysis of functionalized micropipette and hybridization free energy","volume":"98","author":"Zhang","year":"2026","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.118997_bib39","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s41664-025-00396-5","article-title":"Dual-mode self-calibrated strategy based on synergistic amplification effects of in situ rolling circle amplification and hydrophobic inner wall of the nanopores for highly sensitive detection of microRNA","volume":"10","author":"Zhang","year":"2025","journal-title":"J. Anal. Test."},{"key":"10.1016\/j.bios.2026.118997_bib37","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s41664-025-00416-4","article-title":"Special topic: identification and detection of emerging pollutants","volume":"9","author":"Zhang","year":"2025","journal-title":"J. Anal. Test."},{"issue":"8","key":"10.1016\/j.bios.2026.118997_bib40","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1021\/acsnano.3c08851","article-title":"Real-time quantification of nanoplastics-induced oxidative stress in stretching alveolar cells","volume":"18","author":"Zhao","year":"2024","journal-title":"ACS Nano"},{"issue":"13","key":"10.1016\/j.bios.2026.118997_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202307067","article-title":"High-precision single-cell microRNA therapy by a functional nanopipette with sensitive photoelectrochemical feedback","volume":"20","author":"Zheng","year":"2024","journal-title":"Small"},{"issue":"22","key":"10.1016\/j.bios.2026.118997_bib42","doi-asserted-by":"crossref","first-page":"11261","DOI":"10.1021\/acs.est.5c04935","article-title":"Interactions between nanoplastics and antibiotics: implications for nanoplastics aggregation in aquatic environments","volume":"59","author":"Zhou","year":"2025","journal-title":"Environ. Sci. Technol."},{"issue":"11","key":"10.1016\/j.bios.2026.118997_bib43","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1021\/acs.analchem.4c06722","article-title":"Target-Triggered DNA Hydrogel gating with nanoconfinement effect in micropipettes for antibiotic resistance gene detection","volume":"97","author":"Zhou","year":"2025","journal-title":"Anal. Chem."},{"issue":"11","key":"10.1016\/j.bios.2026.118997_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202212458","article-title":"Galvanic redox potentiometry for fouling-free and stable serotonin sensing in a living animal brain","volume":"62","author":"Zhu","year":"2023","journal-title":"Angew. Chem. Int. Ed."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:31:38Z","timestamp":1786516298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326006299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S0956566326006299"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.118997","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanopipette confined hydrogel-catalyst networks for spatiotemporal monitoring of nanoplastics-induced oxidative stress in single cells","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.118997","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118997"}}