{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:27:24Z","timestamp":1786519644098,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bios.2026.119000","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:08:04Z","timestamp":1783379284000},"page":"119000","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["3D-printed MOF\u2013hydrogel microarray for multiplexed miRNA detection and early herb-induced liver injury warning"],"prefix":"10.1016","volume":"312","author":[{"given":"Yuzhi","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-5556","authenticated-orcid":false,"given":"Dong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2026.119000_bib1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/jcp.30908","article-title":"MicroRNAs: small molecules with big impacts in liver injury","volume":"238","author":"Abdel Halim","year":"2023","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bios.2026.119000_bib2","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1002\/hep.25873","article-title":"Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases","volume":"56","author":"Bala","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.bios.2026.119000_bib3","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.12998\/wjcc.v9.i20.5490","article-title":"Herb-induced liver injury: systematic review and meta-analysis","volume":"9","author":"Ballotin","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.bios.2026.119000_bib4","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1038\/s41467-021-23497-y","article-title":"Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum","volume":"12","author":"Cai","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.119000_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.130864","article-title":"\"Two-in-one\" dual-function luminescent MOF hydrogel for onsite ultra-sensitive detection and efficient enrichment of radioactive uranium in water","volume":"448","author":"Cui","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.bios.2026.119000_bib6","doi-asserted-by":"crossref","first-page":"24860","DOI":"10.1021\/acsnano.4c05081","article-title":"Multiplex profiling of miR-122 for preclinical and clinical evaluation of drug-induced liver injury by a full-scale platform","volume":"18","author":"Dong","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2026.119000_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.125854","article-title":"Metal-organic framework (MOF)-based biosensors for miRNA detection","volume":"273","author":"Gorgani","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2026.119000_bib8","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1021\/acs.analchem.2c05640","article-title":"Well-Ordered Au Nanoarray for Sensitive and Reproducible Detection of Hepatocellular Carcinoma-Associated miRNA via CHA-Assisted SERS\/Fluorescence Dual-Mode Sensing","volume":"95","author":"Huang","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.119000_bib9","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/bjc.2011.588","article-title":"Detection of gastric cancer-associated microRNAs on microRNA microarray comparing pre- and post-operative plasma","volume":"106","author":"Konishi","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bios.2026.119000_bib10","article-title":"3D-Printed metal organic frameworks-based supramolecular hydrogel as biological materials","volume":"4","author":"Kumi","year":"2025","journal-title":"Supramol. Mater."},{"key":"10.1016\/j.bios.2026.119000_bib11","doi-asserted-by":"crossref","first-page":"7482","DOI":"10.1039\/C5NR00518C","article-title":"Metal\u2013organic framework composites: from fundamentals to applications","volume":"7","author":"Li","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.bios.2026.119000_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202107449","article-title":"Ratiometric FRET Encoded Hierarchical ZrMOF @ Au Cluster for Ultrasensitive Quantifying MicroRNA In Vivo","volume":"34","author":"Liang","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bios.2026.119000_bib13","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1039\/D2BM01906J","article-title":"Biomedically-relevant metal organic framework-hydrogel composites","volume":"11","author":"Lim","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bios.2026.119000_bib14","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/s41388-024-03076-3","article-title":"MicroRNAs: circulating biomarkers for the early detection of imperceptible cancers via biosensor and machine-learning advances","volume":"43","author":"Metcalf","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.bios.2026.119000_bib15","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.3389\/fphar.2019.01500","article-title":"Non-Exosomal and exosomal circulatory MicroRNAs: which are more valid as biomarkers?","volume":"10","author":"Nik Mohamed Kamal","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bios.2026.119000_bib16","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/healthcare10020278","article-title":"Herb-induced liver injury\u2014A challenging diagnosis","volume":"10","author":"Nunes","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.bios.2026.119000_bib17","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1021\/acs.analchem.8b05909","article-title":"MicroRNA detection specificity: recent advances and future perspective","volume":"91","author":"Ouyang","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.119000_bib18","doi-asserted-by":"crossref","first-page":"13799","DOI":"10.1021\/acs.analchem.5c00346","article-title":"Rare Earth ion-induced functionalized fluorescent MOF hydrogel patches for monitoring lysozyme in tears","volume":"97","author":"Pan","year":"2025","journal-title":"Anal. Chem."},{"issue":"10","key":"10.1016\/j.bios.2026.119000_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202206872","article-title":"CRISPR-enhanced hydrogel microparticles for multiplexed detection of nucleic acids","volume":"10","author":"Roh","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bios.2026.119000_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139455","article-title":"Independent and combined associations of urinary metals exposure with markers of liver injury: results from the NHANES 2013-2016","volume":"338","author":"Tang","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.bios.2026.119000_bib21","doi-asserted-by":"crossref","DOI":"10.21037\/tgh-20-149","article-title":"Herb-induced liver injury (HILI) with 12,068 worldwide cases published with causality assessments by Roussel Uclaf Causality Assessment Method (RUCAM): an overview","volume":"6","author":"Teschke","year":"2021","journal-title":"Translat. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bios.2026.119000_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.21037\/tgh-20-149","article-title":"Herb-induced liver injury (HILI) with 12,068 worldwide cases published with causality assessments by Roussel Uclaf Causality Assessment Method (RUCAM): an overview","volume":"6","author":"Teschke","year":"2021","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bios.2026.119000_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135296","article-title":"Fluorescent oligonucleotide indicators for ratiometric microRNA sensing on metal-organic frameworks","volume":"437","author":"Wang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bios.2026.119000_bib24","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.biopha.2017.04.003","article-title":"Toxicity of triptolide and the molecular mechanisms involved","volume":"90","author":"Xi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bios.2026.119000_bib25","doi-asserted-by":"crossref","first-page":"11455","DOI":"10.1021\/acs.analchem.4c01839","article-title":"Programmable lanthanide metal\u2013organic framework for ultra-efficient nucleic acids extraction and interaction analysis","volume":"96","author":"Yu","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.119000_bib26","doi-asserted-by":"crossref","first-page":"16553","DOI":"10.1021\/acsnano.3c02148","article-title":"The Dual-Response\u2013single-amplification fluorescent nanomachine for tumor imaging and gastric cancer diagnosis","volume":"17","author":"Zhang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2026.119000_bib27","article-title":"Diagnostic value of a plasma microRNA signature in gastric cancer: a microRNA expression analysis","volume":"5","author":"Zhou","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:29:55Z","timestamp":1786516195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326006329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":27,"alternative-id":["S0956566326006329"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.119000","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3D-printed MOF\u2013hydrogel microarray for multiplexed miRNA detection and early herb-induced liver injury warning","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.119000","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119000"}}