{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:38:12Z","timestamp":1788316692421,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bios.2026.119018","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:31:26Z","timestamp":1783603886000},"page":"119018","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Ultrasensitive electrochemiluminescence aptasensor for Tau protein based on gold nanoparticle-modified perovskite nanocrystals"],"prefix":"10.1016","volume":"312","author":[{"given":"Fuliang","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haicheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2187-7915","authenticated-orcid":false,"given":"Ziheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bios.2026.119018_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1021\/acsenergylett.6b00592","article-title":"Au\u2013CsPbBr3 hybrid architecture: anchoring gold nanoparticles on cubic perovskite nanocrystals","volume":"2","author":"Balakrishnan","year":"2016","journal-title":"ACS Energy Lett."},{"key":"10.1016\/j.bios.2026.119018_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101874","article-title":"Electrochemiluminescence biosensors for detection of cancer biomarkers in biofluids: principles, opportunities, and challenges","volume":"50","author":"Barhoum","year":"2023","journal-title":"Nano Today"},{"issue":"22","key":"10.1016\/j.bios.2026.119018_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/adom.201901075","article-title":"A facile synthesis of water\u2010resistant CsPbBr3 perovskite quantum dots loaded poly(methyl methacrylate) composite microspheres based on in situ polymerization","volume":"7","author":"Cai","year":"2019","journal-title":"Adv. Opt. Mater."},{"issue":"8","key":"10.1016\/j.bios.2026.119018_bib3","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1021\/acs.analchem.3c05494","article-title":"Hydrogen-bonded organic cocrystal-encapsulated perovskite nanocrystals as coreactant-free electrochemiluminescent luminophore for the detection of uranium","volume":"96","author":"Cai","year":"2024","journal-title":"Anal. Chem."},{"issue":"3","key":"10.1016\/j.bios.2026.119018_bib5","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s12274-017-1760-7","article-title":"Colloidal CsPbBr3 perovskite nanocrystal films as electrochemiluminescence emitters in aqueous solutions","volume":"11","author":"Cai","year":"2018","journal-title":"Nano Res."},{"key":"10.1016\/j.bios.2026.119018_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.629830","article-title":"Recent progress in electrochemiluminescence of halide perovskites","volume":"9","author":"Cao","year":"2021","journal-title":"Front. Chem."},{"issue":"36","key":"10.1016\/j.bios.2026.119018_bib7","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1039\/C8CC01325J","article-title":"Reversible modulation of CsPbBr3 perovskite nanocrystal\/gold nanoparticle heterostructures","volume":"54","author":"Chen","year":"2018","journal-title":"Chem. Commun."},{"issue":"18","key":"10.1016\/j.bios.2026.119018_bib8","doi-asserted-by":"crossref","first-page":"5915","DOI":"10.1002\/anie.201814507","article-title":"Electrochemiluminescence platforms based on small water\u2010insoluble organic molecules for ultrasensitive aqueous\u2010phase detection","volume":"58","author":"Han","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"issue":"9","key":"10.1016\/j.bios.2026.119018_bib9","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1021\/acsenergylett.7b00547","article-title":"Lead halide perovskite nanocrystals in the research spotlight: stability and defect tolerance","volume":"2","author":"Huang","year":"2017","journal-title":"ACS Energy Lett."},{"issue":"44","key":"10.1016\/j.bios.2026.119018_bib10","doi-asserted-by":"crossref","first-page":"18734","DOI":"10.1039\/C6NR06456F","article-title":"Monochromatic and electrochemically switchable electrochemiluminescence of perovskite CsPbBr3 nanocrystals","volume":"8","author":"Huang","year":"2016","journal-title":"Nanoscale"},{"issue":"2","key":"10.1016\/j.bios.2026.119018_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3390\/molecules27020431","article-title":"An electrochemiluminescence biosensor for the detection of Alzheimer's Tau protein based on gold nanostar decorated carbon nitride nanosheets","volume":"27","author":"Jalili","year":"2022","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.bios.2026.119018_bib12","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1007\/s00415-013-7047-3","article-title":"Cerebrospinal fluid biomarkers in Alzheimer's disease, vascular dementia and ischemic stroke patients: a critical analysis","volume":"260","author":"Kaerst","year":"2013","journal-title":"J. Neurol."},{"issue":"10","key":"10.1016\/j.bios.2026.119018_bib13","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20250965","article-title":"ApoE-calypse tau: apoe\u2013tau synergy in Alzheimer's disease","volume":"222","author":"Lennol","year":"2025","journal-title":"J. Exp. Med."},{"issue":"42","key":"10.1016\/j.bios.2026.119018_bib14","doi-asserted-by":"crossref","first-page":"16783","DOI":"10.1021\/acs.analchem.4c03392","article-title":"Stable halide perovskite CsPbBr3 nanocrystals assisted by covalent\u2013organic frameworks for electrochemiluminescence analysis in an aqueous medium","volume":"96","author":"Li","year":"2024","journal-title":"Anal. Chem."},{"issue":"32","key":"10.1016\/j.bios.2026.119018_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201902533","article-title":"Sustainable and self\u2010enhanced electrochemiluminescent ternary suprastructures derived from CsPbBr3 perovskite quantum dots","volume":"29","author":"Li","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bios.2026.119018_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134415","article-title":"An electrochemiluminescence sensor based on Fe\/Zn-BTC@C-dots sensitisation for thiamethoxam detection","volume":"394","author":"Li","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"issue":"8","key":"10.1016\/j.bios.2026.119018_bib17","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1021\/jacs.9b11490","article-title":"Enhanced in vivo blood\u2013brain barrier penetration by circular Tau\u2013transferrin receptor bifunctional aptamer for tauopathy therapy","volume":"142","author":"Li","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"10.1016\/j.bios.2026.119018_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/smm2.70022","article-title":"Design strategies and emerging applications of perovskite\u2010based sensors","volume":"6","author":"Li","year":"2025","journal-title":"SmartMat"},{"issue":"1","key":"10.1016\/j.bios.2026.119018_bib19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1039\/D2TC03690H","article-title":"Enhancing the stability of the polymeric lewis-base-assisted dual-phase 3D CsPbBr3\u2013Cs4PbBr6 perovskite by molecular engineering and self-passivation","volume":"11","author":"Liang","year":"2023","journal-title":"J. Mater. Chem. C"},{"issue":"9","key":"10.1016\/j.bios.2026.119018_bib20","doi-asserted-by":"crossref","first-page":"8823","DOI":"10.1021\/acsanm.1c01497","article-title":"Stable electrochemiluminescence of CsPbBr3 perovskite nanocrystals assisted by graphene oxide for ultrasensitive sensing","volume":"4","author":"Lin","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"issue":"2","key":"10.1016\/j.bios.2026.119018_bib21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"issue":"28","key":"10.1016\/j.bios.2026.119018_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201900682","article-title":"Improving the stability of metal halide perovskite quantum dots by encapsulation","volume":"31","author":"Lv","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bios.2026.119018_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117535","article-title":"Advances in biosensors for diagnosis of Alzheimer's and Parkinson's diseases","volume":"284","author":"Negahdary","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bios.2026.119018_bib24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","article-title":"Global, regional, and national burden of Alzheimer's disease and other dementias, 1990\u20132016: a systematic analysis for the global burden of disease study 2016","volume":"18","author":"Nichols","year":"2019","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.bios.2026.119018_bib25","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1039\/C5AN01790D","article-title":"Biomarker detection technologies and future directions","volume":"141","author":"Nimse","year":"2016","journal-title":"Analyst"},{"issue":"S5","key":"10.1016\/j.bios.2026.119018_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/alz.042629","article-title":"Identification and validation of Alzheimer's disease\u2010related metabolic pattern in patients with pathologically confirmed Alzheimer's disease","volume":"16","author":"Perovnik","year":"2020","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.bios.2026.119018_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.electacta.2025.147267","article-title":"MXene-Derived metal-organic framework heterostructures for ultra-sensitive enzyme-free electrochemiluminescent detection of biomarker of Alzheimer's disease","volume":"540","author":"Song","year":"2025","journal-title":"Electrochim. Acta"},{"issue":"14","key":"10.1016\/j.bios.2026.119018_bib28","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1021\/acs.analchem.4c00951","article-title":"Highly active coreactant-capped and water-stable 3D@2D core\u2013shell perovskite quantum dots as a novel and strong self-enhanced electrochemiluminescence probe","volume":"96","author":"Sun","year":"2024","journal-title":"Anal. Chem."},{"issue":"25","key":"10.1016\/j.bios.2026.119018_bib29","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.1021\/jacs.7b05073","article-title":"Electrochemistry and electrochemiluminescence of organometal halide perovskite nanocrystals in aqueous medium","volume":"139","author":"Tan","year":"2017","journal-title":"J. Am. Chem. Soc."},{"issue":"78","key":"10.1016\/j.bios.2026.119018_bib30","doi-asserted-by":"crossref","first-page":"10962","DOI":"10.1039\/D4CC03979C","article-title":"Long-term stable electrochemiluminescence of perovskite quantum dots in aqueous media","volume":"60","author":"Wang","year":"2024","journal-title":"Chem. Commun."},{"issue":"1","key":"10.1016\/j.bios.2026.119018_bib31","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1039\/C8CS00740C","article-title":"An overview on enhancing the stability of lead halide perovskite quantum dots and their applications in phosphor-converted LEDs","volume":"48","author":"Wei","year":"2019","journal-title":"Chem. Soc. Rev."},{"issue":"41","key":"10.1016\/j.bios.2026.119018_bib32","doi-asserted-by":"crossref","first-page":"35385","DOI":"10.1021\/acsami.8b04236","article-title":"Modifying perovskite films with polyvinylpyrrolidone for ambient-air-stable highly bendable solar cells","volume":"10","author":"Xiong","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.bios.2026.119018_bib33","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1021\/acsami.4c18204","article-title":"Using machine learning to design a FeMOF bidirectional regulator for electrochemiluminescence sensing of Tau protein","volume":"17","author":"Yuan","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bios.2026.119018_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132015","article-title":"A facile and effective immunoassay for sensitive detection of phosphorylated tau: the role of flower-shaped TiO2 in specificity and signal amplification","volume":"366","author":"Zhang","year":"2022","journal-title":"Sensor. Actuator. B Chem."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:32:47Z","timestamp":1786516367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326006500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":34,"alternative-id":["S0956566326006500"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.119018","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrasensitive electrochemiluminescence aptasensor for Tau protein based on gold nanoparticle-modified perovskite nanocrystals","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.119018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119018"}}