{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:28:07Z","timestamp":1786519687278,"version":"build-2736575974"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202645"],"award-info":[{"award-number":["82202645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bios.2026.119027","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:40:21Z","timestamp":1784130021000},"page":"119027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A dual-recognition fluorescence chip utilizing a substrate-borne DNA walker for precision profiling of small extracellular vesicles"],"prefix":"10.1016","volume":"312","author":[{"given":"Xiaoya","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bios.2026.119027_bib1","article-title":"Proximity ligation assay (PLA)","volume":"123","author":"Alam","year":"2018","journal-title":"Curr. Protoc. Im."},{"issue":"15","key":"10.1016\/j.bios.2026.119027_bib2","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1039\/D5AN00359H","article-title":"A proximity cleavage assisted DNAzyme catalyzed loading DNA walker system for accurate and sensitive small extracellular vesicle analysis","volume":"150","author":"Cao","year":"2025","journal-title":"Analyst"},{"issue":"3","key":"10.1016\/j.bios.2026.119027_bib3","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3390\/ijms23031379","article-title":"The role of small extracellular vesicles in the progression of colorectal cancer and its clinical applications","volume":"23","author":"Chang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bios.2026.119027_bib4","article-title":"Small extracellular vesicles (exosomes) and their cargo in pancreatic cancer: key roles in the hallmarks of cancer","volume":"1877","author":"Channon","year":"2022","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"key":"10.1016\/j.bios.2026.119027_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.124158","article-title":"Recent advances in electrochemical proximity ligation assay","volume":"254","author":"Gao","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2026.119027_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.aca.2020.08.036","article-title":"Catalytic hairpin assembly-triggered DNA walker for electrochemical sensing of tumor exosomes sensitized with Ag@C core-shell nanocomposites","volume":"1135","author":"Guo","year":"2020","journal-title":"Anal. Chim. Acta"},{"issue":"3","key":"10.1016\/j.bios.2026.119027_bib7","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1039\/D0NR06995G","article-title":"A CHA-based DNA stochastic walker that traverses on cell membranes","volume":"13","author":"Hu","year":"2021","journal-title":"Nanoscale"},{"issue":"23","key":"10.1016\/j.bios.2026.119027_bib8","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1002\/asia.202000873","article-title":"Recent progress on the isolation and detection methods of exosomes","volume":"15","author":"Jiang","year":"2020","journal-title":"Chem. Asian J."},{"issue":"16","key":"10.1016\/j.bios.2026.119027_bib9","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1039\/D2AN00875K","article-title":"Low-cost electrochemical paper-based device for exosome detection","volume":"147","author":"Kasetsirikul","year":"2022","journal-title":"Analyst"},{"issue":"9","key":"10.1016\/j.bios.2026.119027_bib10","doi-asserted-by":"crossref","first-page":"13943","DOI":"10.1021\/acsnano.1c04327","article-title":"DNAzyme-Based biosensors: immobilization strategies, applications, and future prospective","volume":"15","author":"Khan","year":"2021","journal-title":"ACS Nano"},{"issue":"22","key":"10.1016\/j.bios.2026.119027_bib11","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1039\/D2AN01410F","article-title":"A colorimetric aptasensor based on a hemin\/EpCAM aptamer DNAzyme for sensitive exosome detection","volume":"147","author":"Kuang","year":"2022","journal-title":"Analyst"},{"issue":"6","key":"10.1016\/j.bios.2026.119027_bib12","doi-asserted-by":"crossref","first-page":"L977","DOI":"10.1152\/ajplung.00546.2018","article-title":"Extracellular vesicles in lung health, disease, and therapy","volume":"316","author":"McVey","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"13","key":"10.1016\/j.bios.2026.119027_bib13","doi-asserted-by":"crossref","first-page":"15350","DOI":"10.1021\/acsomega.3c09888","article-title":"Label-free, sensitive, and versatile colorimetric method for molecule detection via the G-Quadruplex-Based signal quenching strategy","volume":"9","author":"Mei","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.bios.2026.119027_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114983","article-title":"Electrochemical DNAzyme-based biosensors for disease diagnosis","volume":"224","author":"Pandey","year":"2023","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.bios.2026.119027_bib15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3390\/cells11040674","article-title":"Proximity ligation mapping of microcephaly associated SMPD4 shows association with components of the nuclear pore membrane","volume":"11","author":"Piet","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bios.2026.119027_bib16","doi-asserted-by":"crossref","first-page":"C29","DOI":"10.1152\/ajpcell.00280.2019","article-title":"Extracellular vesicles as biomarkers and therapeutic targets for cancer","volume":"318","author":"Urabe","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bios.2026.119027_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340432","article-title":"Universal platform for accurately damage-free mapping of sEVs cargo information","volume":"1232","author":"Xu","year":"2022","journal-title":"Anal. Chim. Acta"},{"issue":"42","key":"10.1016\/j.bios.2026.119027_bib18","doi-asserted-by":"crossref","first-page":"15745","DOI":"10.1021\/acs.analchem.3c03239","article-title":"Dual-recognition triggered proximity ligation combined with a rolling circle amplification strategy for analysis of exosomal protein-specific glycosylation","volume":"95","author":"Xu","year":"2023","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.bios.2026.119027_bib19","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1021\/acs.analchem.4c05700","article-title":"Aptamer-proximity ligation coupled with rolling circle amplification strategy for an ultrasensitive analysis of tumor-derived extracellular vesicles PD-L1","volume":"97","author":"Ye","year":"2025","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.bios.2026.119027_bib20","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1021\/acs.analchem.0c00141","article-title":"Aptamer-cholesterol-mediated proximity ligation assay for accurate identification of exosomes","volume":"92","author":"Zhao","year":"2020","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.bios.2026.119027_bib21","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1021\/acssensors.0c00944","article-title":"Allosteric probe-initiated wash-free method for sensitive extracellular vesicle detection through dual cycle-assisted CRISPR-Cas12a","volume":"5","author":"Zhao","year":"2020","journal-title":"ACS Sens."},{"issue":"3","key":"10.1016\/j.bios.2026.119027_bib22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00216-019-02211-4","article-title":"Rapid and sensitive exosome detection with CRISPR\/Cas12a","volume":"412","author":"Zhao","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"issue":"28","key":"10.1016\/j.bios.2026.119027_bib23","doi-asserted-by":"crossref","first-page":"17776","DOI":"10.1021\/acsomega.0c06334","article-title":"Pancreatitis-associated extracellular vesicle identification through an allosteric probe-initiated Cascade amplification system","volume":"6","author":"Zhou","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.bios.2026.119027_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112213","article-title":"Recent advances of aptasensors for exosomes detection","volume":"160","author":"Zhu","year":"2020","journal-title":"Biosens. Bioelectron."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:35:14Z","timestamp":1786516514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326006597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":24,"alternative-id":["S0956566326006597"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.119027","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dual-recognition fluorescence chip utilizing a substrate-borne DNA walker for precision profiling of small extracellular vesicles","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.119027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119027"}}