{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:43:23Z","timestamp":1791549803833,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374056"],"award-info":[{"award-number":["22374056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Jilin Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["20260205025GH"],"award-info":[{"award-number":["20260205025GH"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bios.2026.119044","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:56:11Z","timestamp":1784534171000},"page":"119044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["acDEP-assisted microfluidic chip for ultrasensitive detection of urinary exosomes for non-invasive hepatocellular carcinoma diagnosis"],"prefix":"10.1016","volume":"312","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3225-6871","authenticated-orcid":false,"given":"Yifei","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2185-6544","authenticated-orcid":false,"given":"Wenhan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyu","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1246-6524","authenticated-orcid":false,"given":"Lianghai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-5601","authenticated-orcid":false,"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2026.119044_bib1","first-page":"229","volume":"vol. 74","author":"Bray","year":"2024"},{"key":"10.1016\/j.bios.2026.119044_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12943-024-02101-z","volume":"23","author":"Chan","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bios.2026.119044_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155679","volume":"148","author":"Chen","year":"2023","journal-title":"Metabolism"},{"key":"10.1016\/j.bios.2026.119044_bib4","volume":"vol. 10","author":"Erdbr\u00fcgger","year":"2021"},{"key":"10.1016\/j.bios.2026.119044_bib5","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1021\/acs.analchem.2c04190","volume":"95","author":"Feng","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.119044_bib6","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1021\/acs.jproteome.3c00063","volume":"22","author":"Feng","year":"2023","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bios.2026.119044_bib7","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s41596-024-01082-z","volume":"20","author":"Feng","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bios.2026.119044_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117362","volume":"279","author":"Ge","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.119044_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116380","volume":"259","author":"Guan","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.119044_bib10","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s00216-022-04362-3","volume":"415","author":"Havers","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.bios.2026.119044_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7150\/thno.21945","volume":"8","author":"He","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bios.2026.119044_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s43586-023-00240-z","volume":"3","author":"Hendrix","year":"2023","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.bios.2026.119044_bib13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41575-023-00818-8","volume":"20","author":"Huang","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bios.2026.119044_bib14","doi-asserted-by":"crossref","first-page":"6548","DOI":"10.7150\/thno.74305","volume":"12","author":"Jia","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bios.2026.119044_bib15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/mi11020220","volume":"11","author":"Khan","year":"2020","journal-title":"Micromachines"},{"key":"10.1016\/j.bios.2026.119044_bib16","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/abde70","volume":"16","author":"Le","year":"2021","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.bios.2026.119044_bib17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jhep.2023.11.030","volume":"80","author":"Lehrich","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bios.2026.119044_bib18","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1186\/s12951-025-03768-2","volume":"23","author":"Li","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bios.2026.119044_bib19","volume":"216","author":"Li","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.119044_bib20","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1038\/s41467-025-57633-9","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.119044_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113879","volume":"204","author":"Lu","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.119044_bib22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41392-024-02021-w","volume":"9","author":"Ma","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bios.2026.119044_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115592","volume":"239","author":"Mun","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.119044_bib24","volume":"vol. 6","author":"Musante","year":"2017"},{"key":"10.1016\/j.bios.2026.119044_bib25","doi-asserted-by":"crossref","first-page":"D516","DOI":"10.1093\/nar\/gky1029","volume":"47","author":"Pathan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bios.2026.119044_bib26","volume":"322","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bios.2026.119044_bib27","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.1038\/ncomms7999","volume":"6","author":"Shao","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.119044_bib28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jhep.2022.01.023","volume":"77","author":"Singal","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bios.2026.119044_bib29","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.bios.2026.119044_bib30","volume":"2021","author":"Wei","year":"2021","journal-title":"Canad. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bios.2026.119044_bib31","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1039\/D2LC00837H","volume":"23","author":"Xie","year":"2023","journal-title":"Lab Chip"},{"key":"10.1016\/j.bios.2026.119044_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12943-022-01509-9","volume":"21","author":"Yu","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bios.2026.119044_bib33","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1038\/s41467-020-16630-w","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.119044_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13206-020-4207-2","volume":"14","author":"Zhang","year":"2020","journal-title":"Biochip J."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:30:16Z","timestamp":1786516216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326006767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":34,"alternative-id":["S0956566326006767"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.119044","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"acDEP-assisted microfluidic chip for ultrasensitive detection of urinary exosomes for non-invasive hepatocellular carcinoma diagnosis","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.119044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119044"}}