{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:18:02Z","timestamp":1787771882628,"version":"build-2784847793"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302344"],"award-info":[{"award-number":["82302344"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12374405"],"award-info":[{"award-number":["12374405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009696","name":"Minjiang University","doi-asserted-by":"publisher","award":["MJY23019"],"award-info":[{"award-number":["MJY23019"]}],"id":[{"id":"10.13039\/501100009696","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019533","name":"Science Fund for Distinguished Young Scholars of Fujian Province","doi-asserted-by":"publisher","award":["2024J010024"],"award-info":[{"award-number":["2024J010024"]}],"id":[{"id":"10.13039\/501100019533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J05246"],"award-info":[{"award-number":["2023J05246"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bios.2026.119047","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:01:21Z","timestamp":1784530881000},"page":"119047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Label-free detection of glioma radioresistance using exosomal SERS spectra and machine learning"],"prefix":"10.1016","volume":"312","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5836-3755","authenticated-orcid":false,"given":"Qiong","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanzun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youliang","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7800","key":"10.1016\/j.bios.2026.119047_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/d41586-020-00844-5","article-title":"The future of liquid biopsy","volume":"579","author":"Alix-Panabieres","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bios.2026.119047_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-019-1210-z","article-title":"Isolation and characterization of extracellular vesicles from broncho-alveolar lavage fluid: a review and comparison of different methods","volume":"20","author":"Carnino","year":"2019","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.bios.2026.119047_bib3","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/cancers13030542","article-title":"The role of hypoxia in glioblastoma radiotherapy resistance","volume":"13","author":"Chedeville","year":"2021","journal-title":"Cancers"},{"issue":"Pt A","key":"10.1016\/j.bios.2026.119047_bib4","article-title":"Surface-enhanced Raman spectroscopy for exosome profiling: methodology and application","volume":"298","author":"Cheng","year":"2025","journal-title":"Talanta"},{"issue":"105","key":"10.1016\/j.bios.2026.119047_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/physci241020a0","article-title":"Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions","volume":"241","author":"Frens","year":"1973","journal-title":"Nature Phys. Sci."},{"issue":"5","key":"10.1016\/j.bios.2026.119047_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41571-020-00457-x","article-title":"Liquid biopsy enters the clinic\u2014Implementation issues and future challenges","volume":"18","author":"Ignatiadis","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.bios.2026.119047_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-0728(77)80224-6","article-title":"Surface Raman spectroelectrochemistry: part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode","volume":"84","author":"Jeanmaire","year":"1977","journal-title":"J. Electroanal. Chem. Interfacial Electrochem."},{"key":"10.1016\/j.bios.2026.119047_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114782","article-title":"A review of the role of tumor-derived exosomes in cancers treatment and progression","volume":"157","author":"Khidr","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"14","key":"10.1016\/j.bios.2026.119047_bib9","doi-asserted-by":"crossref","first-page":"13565","DOI":"10.1364\/OE.19.013565","article-title":"Colorectal cancer detection by gold nanoparticle based surface-enhanced Raman spectroscopy of blood serum and statistical analysis","volume":"19","author":"Lin","year":"2011","journal-title":"Opt. Express"},{"key":"10.1016\/j.bios.2026.119047_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2026.127472","article-title":"SERS-based deep learning approach for early detection of gestational diabetes mellitus","volume":"351","author":"Lin","year":"2026","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"9","key":"10.1016\/j.bios.2026.119047_bib11","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1021\/acs.jpclett.0c01116","article-title":"Marangoni effect-driven transfer and compression at three-phase interfaces for highly reproducible nanoparticle monolayers","volume":"11","author":"Lin","year":"2020","journal-title":"J. Phys. Chem. Lett."},{"issue":"1","key":"10.1016\/j.bios.2026.119047_bib12","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s41467-019-08921-8","article-title":"Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.119047_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113824","article-title":"Machine learning-based exosome profiling of multi-receptor SERS sensors for differentiating adenocarcinoma in situ from early-stage invasive adenocarcinoma","volume":"236","author":"Lu","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"1","key":"10.1016\/j.bios.2026.119047_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-022-01305-4","article-title":"Emerging role of exosomes in cancer progression and tumor microenvironment remodeling","volume":"15","author":"Paskeh","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"5","key":"10.1016\/j.bios.2026.119047_bib15","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1021\/acsnano.9b09119","article-title":"Early-stage lung cancer diagnosis by deep learning-based spectroscopic analysis of circulating exosomes","volume":"14","author":"Shin","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2026.119047_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.117253","article-title":"Advances of surface-enhanced Raman spectroscopy in exosomal biomarkers analysis","volume":"167","author":"Tan","year":"2023","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.bios.2026.119047_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.mee.2012.03.022","article-title":"SERS analysis on exosomes using super-hydrophobic surfaces","volume":"97","author":"Tirinato","year":"2012","journal-title":"Microelectron. Eng."},{"issue":"13","key":"10.1016\/j.bios.2026.119047_bib18","doi-asserted-by":"crossref","first-page":"7289","DOI":"10.1021\/acs.analchem.4c06966","article-title":"Cancer cell line classification using Raman spectroscopy of cancer-derived exosomes and machine learning","volume":"97","author":"Villazon","year":"2025","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.bios.2026.119047_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/stem.261","article-title":"Notch promotes radioresistance of glioma stem cells","volume":"28","author":"Wang","year":"2010","journal-title":"Stem Cell."},{"issue":"19","key":"10.1016\/j.bios.2026.119047_bib20","doi-asserted-by":"crossref","first-page":"9053","DOI":"10.1039\/C7NR09162A","article-title":"Screening and multiple detection of cancer exosomes using an SERS-based method","volume":"10","author":"Wang","year":"2018","journal-title":"Nanoscale"},{"issue":"8","key":"10.1016\/j.bios.2026.119047_bib21","article-title":"Profiling of tumor cell\u2010delivered exosome by surface enhanced raman spectroscopy\u2010based biosensor for evaluation of nasopharyngeal cancer radioresistance","volume":"12","author":"Wu","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"2","key":"10.1016\/j.bios.2026.119047_bib22","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1166\/jbn.2020.2887","article-title":"Combined detection of exosome concentration and tumor markers in gastric cancer","volume":"16","author":"Xia","year":"2020","journal-title":"J. Biomed. Nanotechnol."},{"issue":"6","key":"10.1016\/j.bios.2026.119047_bib23","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3390\/cancers15061752","article-title":"A handheld visible resonance raman Analyzer used in intraoperative detection of human glioma","volume":"15","author":"Zhang","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.bios.2026.119047_bib24","article-title":"Raman spectroscopy: a prospective intraoperative visualization technique for gliomas","volume":"12","author":"Zhang","year":"2023","journal-title":"Front. Oncol."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326006792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:35:58Z","timestamp":1786516558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326006792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":24,"alternative-id":["S0956566326006792"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.119047","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Label-free detection of glioma radioresistance using exosomal SERS spectra and machine learning","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.119047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119047"}}