{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:18:33Z","timestamp":1788531513596,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025A1515012805"],"award-info":[{"award-number":["2025A1515012805"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bios.2026.119123","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:37:19Z","timestamp":1786603039000},"page":"119123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Engineering bubble structures as Cas12a activators for highly sensitive monitoring of WRN helicase function"],"prefix":"10.1016","volume":"313","author":[{"given":"Jiajun","family":"Ke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengrou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1074-8330","authenticated-orcid":false,"given":"Junqiu","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiangang","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.bios.2026.119123_bib1","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1038\/emboj.2010.205","volume":"29","author":"Ammazzalorso","year":"2010","journal-title":"EMBO J."},{"issue":"22","key":"10.1016\/j.bios.2026.119123_bib2","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1093\/nar\/gkm1008","volume":"35","author":"Brosh","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"6387","key":"10.1016\/j.bios.2026.119123_bib3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.aar6245","volume":"360","author":"Chen","year":"2018","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bios.2026.119123_bib4","volume":"25","author":"Chen","year":"2025","journal-title":"Clin. Exp. Med."},{"issue":"33","key":"10.1016\/j.bios.2026.119123_bib5","doi-asserted-by":"crossref","first-page":"34603","DOI":"10.1074\/jbc.M401901200","volume":"279","author":"Choudhary","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bios.2026.119123_bib6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nrc2682","volume":"9","author":"Chu","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"48","key":"10.1016\/j.bios.2026.119123_bib7","doi-asserted-by":"crossref","first-page":"17399","DOI":"10.1002\/anie.201910772","volume":"58","author":"Dai","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"issue":"1","key":"10.1016\/j.bios.2026.119123_bib8","volume":"12","author":"Datta","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bios.2026.119123_bib9","volume":"15","author":"Deng","year":"2024","journal-title":"Nat. Commun."},{"issue":"8011","key":"10.1016\/j.bios.2026.119123_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41586-024-07350-y","volume":"629","author":"Ferretti","year":"2024","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.bios.2026.119123_bib11","doi-asserted-by":"crossref","first-page":"16439","DOI":"10.1074\/jbc.M100253200","volume":"276","author":"Kamath-Loeb","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"46","key":"10.1016\/j.bios.2026.119123_bib12","doi-asserted-by":"crossref","first-page":"13508","DOI":"10.1002\/anie.201504741","volume":"54","author":"Kirchner","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"issue":"4","key":"10.1016\/j.bios.2026.119123_bib13","doi-asserted-by":"crossref","DOI":"10.1593\/tlo.13238","volume":"6","author":"Lao","year":"2013","journal-title":"Transl. Oncol."},{"issue":"9","key":"10.1016\/j.bios.2026.119123_bib14","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1093\/nar\/gky272","volume":"46","author":"Lee","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bios.2026.119123_bib15","volume":"179","author":"Li","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.119123_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116276","volume":"256","author":"Li","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.bios.2026.119123_bib17","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1021\/acssensors.9b02305","volume":"5","author":"Li","year":"2020","journal-title":"ACS Sens."},{"issue":"16","key":"10.1016\/j.bios.2026.119123_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202206105","volume":"19","author":"Lv","year":"2023","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.bios.2026.119123_bib19","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-016-0352-4","volume":"9","author":"Moles","year":"2016","journal-title":"J. Hematol. Oncol."},{"issue":"11","key":"10.1016\/j.bios.2026.119123_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113442","volume":"19","author":"Mukherjee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bios.2026.119123_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.chembiol.2012.10.016","volume":"20","author":"Nguyen","year":"2013","journal-title":"Chem. Biol."},{"issue":"8","key":"10.1016\/j.bios.2026.119123_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202413368","volume":"12","author":"Ning","year":"2024","journal-title":"Adv. Sci."},{"issue":"15","key":"10.1016\/j.bios.2026.119123_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25158300","volume":"25","author":"Orren","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.bios.2026.119123_bib24","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1021\/acs.biochem.2c00599","volume":"62","author":"Parker","year":"2023","journal-title":"Biochemistry"},{"key":"10.1016\/j.bios.2026.119123_bib25","series-title":"Biochem Pharmacol. 239","author":"Peng","year":"2025"},{"issue":"28","key":"10.1016\/j.bios.2026.119123_bib26","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1039\/D0SC03084H","volume":"11","author":"Peng","year":"2020","journal-title":"Chem. Sci."},{"issue":"10","key":"10.1016\/j.bios.2026.119123_bib27","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/sj.onc.1206169","volume":"22","author":"Pichierri","year":"2003","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.bios.2026.119123_bib28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrc.2015.2","volume":"16","author":"Roos","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bios.2026.119123_bib29","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45909","volume":"8","author":"Seol","year":"2019","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.bios.2026.119123_bib30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/nar\/gkac1200","volume":"51","author":"Shin","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.bios.2026.119123_bib31","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.str.2016.06.004","volume":"24","author":"Shin","year":"2016","journal-title":"Structure"},{"issue":"10","key":"10.1016\/j.bios.2026.119123_bib32","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1039\/D2AN01989B","volume":"148","author":"Wang","year":"2023","journal-title":"The Analyst"},{"issue":"9","key":"10.1016\/j.bios.2026.119123_bib33","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1021\/acssensors.1c01061","volume":"6","author":"Xia","year":"2021","journal-title":"ACS Sens."},{"issue":"1","key":"10.1016\/j.bios.2026.119123_bib34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1021\/jacs.9b09211","volume":"142","author":"Xiong","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bios.2026.119123_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.129711","volume":"104","author":"Yuan","year":"2024","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"19","key":"10.1016\/j.bios.2026.119123_bib36","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1021\/acs.analchem.3c01251","volume":"95","author":"Zhai","year":"2023","journal-title":"Anal. Chem."},{"issue":"9","key":"10.1016\/j.bios.2026.119123_bib37","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1021\/acs.analchem.4c03193","volume":"97","author":"Zhai","year":"2025","journal-title":"Anal. Chem."},{"issue":"24","key":"10.1016\/j.bios.2026.119123_bib38","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1021\/acs.analchem.1c05499","volume":"94","author":"Zhang","year":"2022","journal-title":"Anal. Chem."},{"issue":"19","key":"10.1016\/j.bios.2026.119123_bib39","doi-asserted-by":"crossref","first-page":"11884","DOI":"10.1093\/nar\/gkae804","volume":"52","author":"Zuo","year":"2024","journal-title":"Nucleic Acids Res."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326007554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326007554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:31:28Z","timestamp":1788528688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326007554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":39,"alternative-id":["S0956566326007554"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.119123","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering bubble structures as Cas12a activators for highly sensitive monitoring of WRN helicase function","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.119123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119123"}}