{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:19:18Z","timestamp":1788531558575,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0909100"],"award-info":[{"award-number":["2020YFA0909100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22104128"],"award-info":[{"award-number":["22104128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2025C02124"],"award-info":[{"award-number":["2025C02124"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bios.2026.119144","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:52:21Z","timestamp":1787388741000},"page":"119144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Click-chemistry-mediated modulation of CRISPR-Cas12a activity through activator modification"],"prefix":"10.1016","volume":"313","author":[{"given":"Ruijie","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjie","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-3460","authenticated-orcid":false,"given":"Yunlei","family":"Xianyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2026.119144_bib1","volume":"63","author":"Bagheri","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.119144_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.aar6245","volume":"360","author":"Chen","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.bios.2026.119144_bib3","volume":"261","author":"Chen","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2026.119144_bib4","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1039\/D1SC05558E","volume":"13","author":"Chen","year":"2022","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bios.2026.119144_bib5","doi-asserted-by":"crossref","first-page":"8342","DOI":"10.1038\/s41467-024-52691-x","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.119144_bib6","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nature17944","volume":"532","author":"Dong","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bios.2026.119144_bib7","doi-asserted-by":"crossref","first-page":"12169","DOI":"10.1021\/acs.analchem.3c02471","volume":"95","author":"Fei","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.119144_bib8","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nbt.3900","volume":"35","author":"Gao","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bios.2026.119144_bib9","volume":"119","author":"Hu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bios.2026.119144_bib10","doi-asserted-by":"crossref","first-page":"11148","DOI":"10.1093\/nar\/gkae766","volume":"52","author":"Huang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bios.2026.119144_bib11","doi-asserted-by":"crossref","first-page":"9826","DOI":"10.1021\/acs.analchem.2c01670","volume":"94","author":"Huyke","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.119144_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nmeth.4104","volume":"14","author":"Kim","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bios.2026.119144_bib13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41587-018-0011-0","volume":"37","author":"Kleinstiver","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bios.2026.119144_bib15","doi-asserted-by":"crossref","first-page":"8879","DOI":"10.1021\/acs.analchem.3c00414","volume":"23","author":"Li","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.119144_bib14","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1021\/acs.analchem.3c05497","volume":"96","author":"Li","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.119144_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41422-018-0022-x","volume":"28","author":"Li","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.bios.2026.119144_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41421-018-0028-z","volume":"4","author":"Li","year":"2018","journal-title":"Cell Discov."},{"key":"10.1016\/j.bios.2026.119144_bib18","volume":"63","author":"Liu","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bios.2026.119144_bib19","volume":"3","author":"Liu","year":"2022","journal-title":"Cell Rep. Phys. Sci."},{"key":"10.1016\/j.bios.2026.119144_bib20","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1021\/acsnano.3c12499","volume":"18","author":"Liu","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2026.119144_bib21","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1021\/acs.analchem.2c01401","volume":"94","author":"Ma","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2026.119144_bib22","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.1038\/s41467-023-43389-7","volume":"14","author":"Moon","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.119144_bib23","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1038\/s41467-020-18615-1","volume":"11","author":"Nguyen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.119144_bib24","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1038\/s41467-023-41006-1","volume":"14","author":"Rananaware","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bios.2026.119144_bib25","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/nar\/gkab1227","volume":"50","author":"Shebanova","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bios.2026.119144_bib26","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.cell.2018.10.045","volume":"175","author":"Stella","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bios.2026.119144_bib27","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.molcel.2018.11.021","volume":"73","author":"Swarts","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bios.2026.119144_bib28","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1021\/cr200409f","volume":"113","author":"Thirumurugan","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bios.2026.119144_bib29","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.cell.2016.04.003","volume":"165","author":"Yamano","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bios.2026.119144_bib30","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.molcel.2017.06.035","volume":"67","author":"Yamano","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bios.2026.119144_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116239","volume":"255","author":"Yang","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2026.119144_bib32","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2015.09.038","volume":"163","author":"Zetsche","year":"2015","journal-title":"Cell"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326007761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566326007761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:34:14Z","timestamp":1788528854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566326007761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":32,"alternative-id":["S0956566326007761"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2026.119144","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Click-chemistry-mediated modulation of CRISPR-Cas12a activity through activator modification","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2026.119144","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119144"}}