{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:33:05Z","timestamp":1787509985979,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosystems"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.biosystems.2012.01.006","type":"journal-article","created":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T14:15:59Z","timestamp":1327155359000},"page":"45-51","source":"Crossref","is-referenced-by-count":5,"title":["Death wins against life in a spatially extended model of the caspase-3\/8 feedback loop"],"prefix":"10.1016","volume":"108","author":[{"given":"M.","family":"Daub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Waldherr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Allg\u00f6wer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Scheurich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biosystems.2012.01.006_bib0005","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1083\/jcb.200404158","article-title":"Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis","volume":"166","author":"Bentele","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0010","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1137\/0133023","article-title":"Stability properties of solutions to systems of reaction\u2013diffusion equations","volume":"33","author":"Casten","year":"1977","journal-title":"SIAM J. Appl. Math."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.biosystems.2012.01.006_bib0025","doi-asserted-by":"crossref","first-page":"36892","DOI":"10.1074\/jbc.M404893200","article-title":"Bistability analyses of a caspase activation model for receptor-induced apoptosis","volume":"279","author":"Eissing","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0030","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.biosystems.2007.01.003","article-title":"Steady state and (bi-)stability evaluation of simple protease signalling networks","volume":"90","author":"Eissing","year":"2007","journal-title":"BioSystems"},{"key":"10.1016\/j.biosystems.2012.01.006_bib0035","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/81208","article-title":"A mathematical model of caspase function in apoptosis","volume":"18","author":"Fussenegger","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0040","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.biosystems.2012.01.006_bib0045","series-title":"Geometric Theory of Semilinear Parabolic Equations. Volume 840 of Lecture Notes in Mathematics","author":"Henry","year":"1981"},{"key":"10.1016\/j.biosystems.2012.01.006_bib0050","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1137\/0715077","article-title":"Stability and convergence of finite difference methods for systems of nonlinear reaction\u2013diffusion equations","volume":"15","author":"Hoff","year":"1978","journal-title":"SIAM J. Numer. Anal."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1752-0509-4-9","article-title":"Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death","volume":"4","author":"Huber","year":"2010","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0060","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/713803693","article-title":"Caspase-8 in apoptosis: the beginning of \u201cthe end\u201d?","volume":"50","author":"Kruidering","year":"2000","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biosystems.2012.01.006_bib0065","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/sj.cdd.4402047","article-title":"Caspases in cell survival, proliferation and differentiation","volume":"14","author":"Lamkanfi","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0070","doi-asserted-by":"crossref","DOI":"10.1038\/msb4100108","article-title":"Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades","volume":"2","author":"Markevich","year":"2006","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0075","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S1043-4666(05)80004-3","article-title":"Development of resistance to tumour necrosis factor (tnf [alpha]) in kym-1 cells involves both tnf receptors","volume":"5","author":"Meager","year":"1993","journal-title":"Cytokine"},{"key":"10.1016\/j.biosystems.2012.01.006_bib0080","series-title":"Mathematical Biology I: An Introduction","author":"Murray","year":"2002"},{"key":"10.1016\/j.biosystems.2012.01.006_bib0085","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1038\/sj.emboj.7601295","article-title":"Systems analysis of effector caspase activation and its control by x-linked inhibitor of apoptosis protein","volume":"25","author":"Rehm","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0090","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/cdd.2008.187","article-title":"Dynamics of outer mitochondrial membrane permeabilization during apoptosis","volume":"16","author":"Rehm","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0095","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nrm1496","article-title":"Molecular mechanisms of caspase regulation during apoptosis","volume":"5","author":"Riedl","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biosystems.2012.01.006_bib0100","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1097-2765(02)00482-3","article-title":"Mechanisms of caspase activation and inhibition during apoptosis","volume":"9","author":"Shi","year":"2002","journal-title":"Mol. Cell"}],"container-title":["Biosystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264712000196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264712000196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T18:53:48Z","timestamp":1543258428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303264712000196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":20,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0303264712000196"],"URL":"https:\/\/doi.org\/10.1016\/j.biosystems.2012.01.006","relation":{},"ISSN":["0303-2647"],"issn-type":[{"value":"0303-2647","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}