{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:07:32Z","timestamp":1759601252067},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"IBOP, DAE, Government of India"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosystems"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.biosystems.2016.08.012","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T04:05:38Z","timestamp":1473393938000},"page":"46-51","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Systemic study of a natural feedback loop in Huntington\u2019s disease at the onset of neurodegeneration"],"prefix":"10.1016","volume":"150","author":[{"given":"Shounak","family":"Baksi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangram","family":"Bagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandip","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debashis","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biosystems.2016.08.012_bib0005","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0010","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1093\/hmg\/ddm217","article-title":"Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity","volume":"16","author":"Atwal","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0015","doi-asserted-by":"crossref","first-page":"e76792","DOI":"10.1371\/journal.pone.0076792","article-title":"Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin","volume":"8","author":"Baksi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neures.2014.06.009","article-title":"Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth factor receptor binding protein 2 (Grb2)","volume":"87","author":"Baksi","year":"2014","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0025","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1242\/jcs.03272","article-title":"Dynamic regulation of ERK2 nuclear translocation and mobility in living cells","volume":"119","author":"Costa","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0030","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/00019052-199612000-00017","article-title":"Neurotoxicity of beta-amyloid and prion peptides","volume":"9","author":"Forloni","year":"1996","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0035","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1478-5382(03)02370-9","article-title":"CellDesigner: a process diagram editor for gene-regulatory and biochemical networks","volume":"1","author":"Funahashi","year":"2003","journal-title":"BIOSILICO"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0040","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1109\/JPROC.2008.925458","article-title":"CellDesigner 3.5: a versatile modeling tool for biochemical networks","volume":"96","author":"Funahashi","year":"2008","journal-title":"Proc. IEEE"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0045","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.1124514","article-title":"Progressive disruption of cellular protein folding in models of polyglutamine diseases","volume":"311","author":"Gidalevitz","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0050","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.neurobiolaging.2005.04.017","article-title":"Common mechanisms of amyloid oligomer pathogenesis in degenerative disease","volume":"27","author":"Glabe","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0060","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0968-0004(03)00168-3","article-title":"The hunt for huntingtin function: interaction partners tell many different stories","volume":"28","author":"Harjes","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/neur.1995.0003","article-title":"Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide","volume":"4","author":"Howlett","year":"1995","journal-title":"Neurodegeneration"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0070","series-title":"System Modelling in Cellular Biology","first-page":"269","article-title":"Synthetic gene regulatory systems","author":"Kaern","year":"2006"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0075","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1158\/1541-7786.MCR-10-0454","article-title":"FOXD3 regulates migration properties and Rnd3 expression in melanoma cells","volume":"9","author":"Katiyar","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0080","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nbt1111","article-title":"Using process diagrams for the graphical representation of biological networks","volume":"23","author":"Kitano","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0085","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1007\/s00018-008-8170-7","article-title":"The complexity of mitogen-activated protein kinases (MAPKs) made simple","volume":"65","author":"Krishna","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0090","doi-asserted-by":"crossref","first-page":"e15245","DOI":"10.1371\/journal.pone.0015245","article-title":"Formation and toxicity of soluble polyglutamine oligomers in living cells","volume":"5","author":"Lajoie","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0095","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1083\/jcb.122.5.1079","article-title":"Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts","volume":"122","author":"Lenormand","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0100","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1137\/0111030","article-title":"An algorithm for least-square estimation of nonlinear parameters","volume":"11","author":"Marquardt","year":"1963","journal-title":"SIAM J. Appl. Math."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0105","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.abb.2009.12.011","article-title":"Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control","volume":"494","author":"McDonald","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0110","doi-asserted-by":"crossref","first-page":"10541","DOI":"10.1523\/JNEUROSCI.0146-10.2010","article-title":"Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington\u2019s disease molecular pathogenesis","volume":"30","author":"Miller","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0115","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0896-6273(00)80405-5","article-title":"Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?","volume":"19","author":"Ross","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0120","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1111\/j.1742-4658.2008.06562.x","article-title":"Huntington's disease: degradation of mutant huntingtin by autophagy","volume":"275","author":"Sarkar","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molcel.2004.06.029","article-title":"Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation","volume":"15","author":"Schaffar","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.nbd.2011.07.001","article-title":"What have we learned from gene expression profiles in Huntington\u2019s disease?","volume":"45","author":"Seredenina","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0135","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"The Huntington\u2019s Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.biosystems.2016.08.012_bib0140","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cellsig.2005.11.003","article-title":"Regulation of cellular functions by the ERK5 signalling pathway","volume":"18","author":"Wang","year":"2006","journal-title":"Cell. Signal."},{"key":"10.1016\/j.biosystems.2016.08.012_bib0145","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1073\/pnas.0606398104","article-title":"A synthetic time-delay circuit in mammalian cells and mice","volume":"104","author":"Weber","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biosystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264716301940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264716301940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T13:59:10Z","timestamp":1536415150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303264716301940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":29,"alternative-id":["S0303264716301940"],"URL":"https:\/\/doi.org\/10.1016\/j.biosystems.2016.08.012","relation":{},"ISSN":["0303-2647"],"issn-type":[{"value":"0303-2647","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic study of a natural feedback loop in Huntington\u2019s disease at the onset of neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Biosystems","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biosystems.2016.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}