{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:37:31Z","timestamp":1777952251674,"version":"3.51.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BioSystems"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.biosystems.2026.105713","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:21:43Z","timestamp":1770164503000},"page":"105713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Why are the most lethal pathogens the simplest? Lack of D-amino acid usage, coherent fractal\n                        morphology, and Hz-level biological oscillations prevalent in beneficial pathogens"],"prefix":"10.1016","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5020-9606","authenticated-orcid":false,"given":"Monica M.","family":"Araujo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.biosystems.2026.105713_bib1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/bies.10192","article-title":"What is complexity?","volume":"24","author":"Adami","year":"2002","journal-title":"Bioessays"},{"issue":"2","key":"10.1016\/j.biosystems.2026.105713_bib2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.immuni.2019.01.002","article-title":"A neutrophil timer coordinates immune defense and vascular protection","volume":"50","author":"Adrover","year":"2019","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.biosystems.2026.105713_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1420-9101.2008.01658.x","article-title":"Virulence evolution and the trade-off hypothesis: history, current state of\n                            affairs and the future","volume":"22","author":"Alizon","year":"2009","journal-title":"J. Evol. Biol."},{"issue":"7","key":"10.1016\/j.biosystems.2026.105713_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0966-842X(98)01312-2","article-title":"Reductive evolution of resident genomes","volume":"6","author":"Andersson","year":"1998","journal-title":"Trends Microbiol."},{"issue":"6","key":"10.1016\/j.biosystems.2026.105713_bib5","first-page":"677","article-title":"Administration of a multi-strain probiotic product to women in the perinatal\n                            period differentially affects the breast milk cytokine profile and may have beneficial\n                            effects on neonatal gastrointestinal functional symptoms. A randomized clinical trial","volume":"10","author":"Baldassarre","year":"2018","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.biosystems.2026.105713_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/imm.13166","article-title":"Circadian rhythms in innate immunity and stress responses","volume":"161","author":"Baxter","year":"2020","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.biosystems.2026.105713_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012157","article-title":"Crosstalk between circadian clocks and pathogen niche","volume":"20","author":"Borrmann","year":"2024","journal-title":"PLoS Pathog."},{"issue":"5","key":"10.1016\/j.biosystems.2026.105713_bib8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3390\/v11050404","article-title":"Giant viruses - big surprises","volume":"11","author":"Brandes","year":"2019","journal-title":"Viruses"},{"issue":"16","key":"10.1016\/j.biosystems.2026.105713_bib9","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1016\/j.cell.2021.07.001","article-title":"The microbiota coordinates diurnal rhythms in innate immunity with the circadian\n                            clock","volume":"184","author":"Brooks","year":"2021","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.biosystems.2026.105713_bib10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signaling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.biosystems.2026.105713_bib11","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1128\/IAI.67.8.3703-3713.1999","article-title":"Host-pathogen interactions: redefining the basic concepts of virulence and\n                            pathogenicity","volume":"67","author":"Casadevall","year":"1999","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.biosystems.2026.105713_bib12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00018-010-0571-8","article-title":"Emerging knowledge of regulatory roles of D-amino acids in bacteria","volume":"68","author":"Cava","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biosystems.2026.105713_bib13","series-title":"Global HIV & AIDS Statistics","year":"2023"},{"issue":"3","key":"10.1016\/j.biosystems.2026.105713_bib14","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1073\/pnas.62.3.756","article-title":"D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial\n                            system","volume":"62","author":"Cline","year":"1969","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biosystems.2026.105713_bib63","first-page":"202","article-title":"Yersinia pestis and the three historical pandemic waves of plague","volume":"71","author":"Demeure","year":"2019","journal-title":"Infection, Genetics and Evolution"},{"key":"10.1016\/j.biosystems.2026.105713_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.840245","article-title":"Lactobacillus spp. for gastrointestinal health","volume":"13","author":"Dempsey","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biosystems.2026.105713_bib65","first-page":"184","article-title":"Genome Sequence of Yersinia pestis KIM","author":"Deng","year":"2002","journal-title":"J Bacteriol"},{"issue":"6","key":"10.1016\/j.biosystems.2026.105713_bib16","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S1701-2163(16)34218-9","article-title":"Probiotic safety in pregnancy: a systematic review and meta-analysis of\n                            randomized controlled trials of Lactobacillus, Bifidobacterium, and Saccharomyces spp","volume":"31","author":"Dugoua","year":"2009","journal-title":"J. Obstet. Gynaecol. Can."},{"issue":"36","key":"10.1016\/j.biosystems.2026.105713_bib17","doi-asserted-by":"crossref","first-page":"10085","DOI":"10.1073\/pnas.1601895113","article-title":"Cell autonomous regulation of herpes and influenza virus infection by the\n                            circadian clock","volume":"113","author":"Edgar","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105713_bib18","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1038\/s41598-019-39602-7","article-title":"Prevention of respiratory syncytial virus infection with probiotic lactic acid\n                            bacterium Lactobacillus gasseri SBT2055","volume":"9","author":"Eguchi","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biosystems.2026.105713_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe2086","article-title":"A circadian clock in a nonphotosynthetic prokaryote","volume":"7","author":"Eelderink-Chen","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biosystems.2026.105713_bib20","series-title":"Fractal Geometry, Mathematical Foundations and Applications","author":"Falconer","year":"2003"},{"issue":"11","key":"10.1016\/j.biosystems.2026.105713_bib21","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1073\/pnas.1915773117","article-title":"Circadian control of interferon-sensitive gene expression in murine skin","volume":"117","author":"Greenberg","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"10","key":"10.1016\/j.biosystems.2026.105713_bib22","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1073\/pnas.0709530105","article-title":"Disclosure of the mycobacterial outer membrane: cryo-electron tomography and\n                            vitreous sections reveal the lipid bilayer structure","volume":"105","author":"Hoffmann","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biosystems.2026.105713_bib23","article-title":"Human Y-chromosome gene classification using fractal dimension & Shannon\n                            entropy","author":"Holden","year":"2014","journal-title":"arXiv preprint arXiv:1404.2540v1"},{"issue":"50","key":"10.1016\/j.biosystems.2026.105713_bib24","doi-asserted-by":"crossref","first-page":"21407","DOI":"10.1073\/pnas.0906361106","article-title":"A circadian clock in macrophages controls inflammatory immune responses","volume":"106","author":"Keller","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.biosystems.2026.105713_bib25","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.jaci.2016.09.003","article-title":"D-tryptophan from probiotic bacteria influences the gut microbiome and allergic\n                            airway disease","volume":"139","author":"Kepert","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5978","key":"10.1016\/j.biosystems.2026.105713_bib26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1126\/science.1188628","article-title":"D-amino acids trigger biofilm disassembly","volume":"328","author":"Kolodkin-Gal","year":"2010","journal-title":"Science"},{"issue":"5947","key":"10.1016\/j.biosystems.2026.105713_bib27","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.1178123","article-title":"D-amino acids govern stationary phase cell wall remodeling in bacteria","volume":"325","author":"Lam","year":"2009","journal-title":"Science"},{"issue":"D1","key":"10.1016\/j.biosystems.2026.105713_bib28","doi-asserted-by":"crossref","first-page":"D396","DOI":"10.1093\/nar\/gkv1126","article-title":"EMDataBank unified data resource for 3DEM","volume":"44","author":"Lawson","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.biosystems.2026.105713_bib29","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1128\/MMBR.00017-08","article-title":"Genes and molecules of lactobacilli supporting probiotic action","volume":"72","author":"Lebeer","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"6","key":"10.1016\/j.biosystems.2026.105713_bib30","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1177\/1753425913503386","article-title":"Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa\n                            quorum-sensing molecules require taste signaling components","volume":"20","author":"Lee","year":"2014","journal-title":"Innate Immun."},{"issue":"8","key":"10.1016\/j.biosystems.2026.105713_bib31","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10096-014-2086-y","article-title":"Probiotics in respiratory virus infections","volume":"33","author":"Lehtoranta","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105713_bib32","first-page":"29","article-title":"Fractal geometry in biological systems","volume":"102","author":"Losa","year":"2009","journal-title":"Riv. Biol."},{"key":"10.1016\/j.biosystems.2026.105713_bib33","series-title":"The Fractal Geometry of Nature","author":"Mandelbrot","year":"1982"},{"issue":"12","key":"10.1016\/j.biosystems.2026.105713_bib34","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1016\/j.jmb.2020.01.003","article-title":"Pharmacological interventions to circadian clocks and their molecular bases","volume":"432","author":"Miller","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.biosystems.2026.105713_bib35","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3389\/fmicb.2018.01540","article-title":"Production of d-branched-chain amino acids by lactic acid bacteria carrying\n                            homologs to isoleucine 2-epimerase of Lactobacillus buchneri","volume":"9","author":"Mutaguchi","year":"2018","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.biosystems.2026.105713_bib36","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1128\/IAI.06214-11","article-title":"Protective role of D-amino acid oxidase against Staphylococcus aureus infection","volume":"80","author":"Nakamura","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.biosystems.2026.105713_bib64","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/35097083","article-title":"Genome sequence of Yersinia pestis, the causative agent of plague","volume":"413","author":"Parkhill","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biosystems.2026.105713_bib37","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.isci.2019.09.007","article-title":"Entrainment of the circadian clock of the enteric bacterium Klebsiella aerogenes\n                            by temperature cycles","volume":"19","author":"Paulose","year":"2019","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.biosystems.2026.105713_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/AAC.49.1.21-25.2005","article-title":"Vancomycin resistance in enterococci due to synthesis of precursors terminating\n                            in D-alanyl-D-serine","volume":"49","author":"Reynolds","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105713_bib39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41467-017-02484-2","article-title":"Sleeping sickness is a circadian disorder","volume":"9","author":"Rijo-Ferreira","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biosystems.2026.105713_bib40","article-title":"Trypanosoma brucei metabolism is under circadian control","volume":"2","author":"Rijo-Ferreira","year":"2020","journal-title":"Nat. Microbiol."},{"issue":"6453","key":"10.1016\/j.biosystems.2026.105713_bib42","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.aax7621","article-title":"Dosing time matters","volume":"365","author":"Ruben","year":"2019","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biosystems.2026.105713_bib43","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1073\/pnas.1114639109","article-title":"D-amino acid oxidase controls motoneuron degeneration through D-serine","volume":"109","author":"Sasabe","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biosystems.2026.105713_bib44","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3389\/fmicb.2018.00933","article-title":"Emerging role of D-amino acid metabolism in the innate defense","volume":"9","author":"Sasabe","year":"2018","journal-title":"Front. Microbiol."},{"issue":"7","key":"10.1016\/j.biosystems.2026.105713_bib45","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41577-018-0008-4","article-title":"Clocking in to immunity","volume":"18","author":"Scheiermann","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105713_bib46","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1038\/s41467-019-11400-9","article-title":"Circadian control of lung inflammation in influenza infection","volume":"10","author":"Sengupta","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biosystems.2026.105713_bib47","article-title":"D-serine suppresses one-carbon metabolism by competing with mitochondrial\n                            L-serine transport","volume":"14","author":"Suzuki","year":"2025","journal-title":"eLife"},{"issue":"3","key":"10.1016\/j.biosystems.2026.105713_bib48","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105713_bib60","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3201\/eid1209.05-0979","article-title":"1918 influenza: the mother of all pandemics","volume":"12","author":"Taubenberger","year":"2006","journal-title":"Emerging Infectious Diseases"},{"issue":"5307","key":"10.1016\/j.biosystems.2026.105713_bib61","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1126\/science.275.5307.1793","article-title":"Initial genetic characterization of the 1918 \u00e2\u20ac\u0153Spanish\u00e2\u20ac\u009d influenza virus","volume":"275","author":"Taubenberger","year":"1997","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.biosystems.2026.105713_bib49","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/v3060920","article-title":"Pattern recognition receptors and the innate immune response to viral infection","volume":"3","author":"Thompson","year":"2011","journal-title":"Viruses"},{"key":"10.1016\/j.biosystems.2026.105713_bib50","article-title":"UNAIDS data 2023","year":"2023","journal-title":"Joint United Nations Programme on HIV\/AIDS (UNAIDS)"},{"issue":"2","key":"10.1016\/j.biosystems.2026.105713_bib51","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/v10020076","article-title":"RNA dependent RNA polymerases: insights from structure, function and evolution","volume":"10","author":"Venkataraman","year":"2018","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.biosystems.2026.105713_bib52","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1016\/S0021-9258(19)81624-1","article-title":"Enzymes in the D-alanine branch of bacterial cell wall peptidoglycan assembly","volume":"264","author":"Walsh","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biosystems.2026.105713_bib57","series-title":"WileyEncyclopedia of Biomedical Engineering","article-title":"Complexity, Scaling, andFractals in Biological Signals","author":"West","year":"2006"},{"key":"10.1016\/j.biosystems.2026.105713_bib54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.carres.2013.05.007","article-title":"Structure, biosynthesis, and function of bacterial capsular polysaccharides\n                            synthesized by ABC transporter-dependent pathways","volume":"378","author":"Willis","year":"2013","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.biosystems.2026.105713_bib55","series-title":"HIV Fact Sheet","year":"2023"},{"issue":"21","key":"10.1016\/j.biosystems.2026.105713_bib62","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1128\/JVI.00959-08","article-title":"Structural characterization of the 1918 influenza virus H1N1 neuraminidase","volume":"82","author":"Xu","year":"2008","journal-title":"Journal of Virology"},{"issue":"1","key":"10.1016\/j.biosystems.2026.105713_bib56","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41467-019-08299-7","article-title":"The circadian clock components BMAL1 and REV-ERB\u00ce\u00b1 regulate flavivirus\n                            replication","volume":"10","author":"Zhuang","year":"2019","journal-title":"Nat. Commun."}],"container-title":["BioSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264726000237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264726000237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:50:08Z","timestamp":1777895408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303264726000237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":61,"alternative-id":["S0303264726000237"],"URL":"https:\/\/doi.org\/10.1016\/j.biosystems.2026.105713","relation":{},"ISSN":["0303-2647"],"issn-type":[{"value":"0303-2647","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Why are the most lethal pathogens the\n                            simplest? Lack of D-amino acid usage, coherent fractal morphology, and Hz-level biological\n                            oscillations prevalent in beneficial pathogens","name":"articletitle","label":"Article Title"},{"value":"BioSystems","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biosystems.2026.105713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00c2\u00a9 2026 Elsevier B.V. All rights are reserved,\n                            including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105713"}}