{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:33:55Z","timestamp":1791578035181,"version":"4.3.4"},"reference-count":11,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Advances"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.biotechadv.2005.05.005","type":"journal-article","created":{"date-parts":[[2005,7,13]],"date-time":"2005-07-13T22:19:25Z","timestamp":1121293165000},"page":"401-408","source":"Crossref","is-referenced-by-count":45,"title":["Coeliac Disease: Background and biochemical aspects"],"prefix":"10.1016","volume":"23","author":[{"given":"Rob. J.","family":"Hamer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biotechadv.2005.05.005_bib1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.191.4.603","article-title":"The intestinal T cell response to a-Gliadin in adult Celiac disease is focused on a singel deamidated glutamine targeted by tissue transglutaminase","volume":"191","author":"Arentz-Hansen","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1521-6918(02)00147-6","article-title":"Coeliac disease","volume":"17","author":"Ciclitira","year":"2003","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib3","first-page":"566","article-title":"Glutenin polymers: the in vitro to in vivo translation","volume":"44","author":"Kasarda","year":"1999","journal-title":"Cereal Foods World"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib4","series-title":"Food allergy: adverse reactions to foods and food additives","author":"Metcalf","year":"2003"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0300-483X(98)00098-5","article-title":"In vitro screening of food peptides toxic for coeliac and other gluten-sensitive patients","volume":"132","author":"Silano","year":"1999","journal-title":"Toxicology"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-3083.1998.00397.x","article-title":"Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition","volume":"48","author":"Sjostrom","year":"1998","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib7","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1097\/00042737-200106000-00023","article-title":"Analysis and clinical effects of gluten in coeliac disease","volume":"13","author":"Stern","year":"2000","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib8","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0140-6736(94)91837-6","article-title":"Wheat peptide challenge in coeliac disease","volume":"343","author":"Sturgess","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.20012028","article-title":"Specificity of tissue transglutaminase explains cereal toxicity in celiac disease","volume":"195","author":"Vader","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/00365529609004873","article-title":"In vitro hydrolysis of gliadin and casein peptides: secondary defect in coeliac disease shown by organ culture","volume":"31","author":"Walz","year":"1996","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.biotechadv.2005.05.005_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1651-2227.1996.tb14239.x","article-title":"Relation between gliadin structure and coeliac toxicity","volume":"412","author":"Wieser","year":"1996","journal-title":"Acta Paediatr Suppl"}],"container-title":["Biotechnology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975005000698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975005000698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T14:57:24Z","timestamp":1548341844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0734975005000698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0734975005000698"],"URL":"https:\/\/doi.org\/10.1016\/j.biotechadv.2005.05.005","relation":{},"ISSN":["0734-9750"],"issn-type":[{"value":"0734-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}