{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:10:37Z","timestamp":1761988237612},"reference-count":133,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Advances"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.biotechadv.2009.08.003","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T10:31:52Z","timestamp":1251369112000},"page":"17-26","source":"Crossref","is-referenced-by-count":78,"title":["Genetic richness and diversity in Cryptosporidium hominis and C. parvum reveals major knowledge gaps and a need for the application of \u201cnext generation\u201d technologies \u2014 Research review"],"prefix":"10.1016","volume":"28","author":[{"given":"Aaron R.","family":"Jex","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin B.","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biotechadv.2009.08.003_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00436-006-0140-0","article-title":"Subgenotype analysis of Cryptosporidium parvum isolates from humans and animals in Japan using the 60-kDa glycoprotein gene sequences","volume":"99","author":"Abe","year":"2006","journal-title":"Parasitol Res"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1645\/GE-843R.1","article-title":"Subtype analysis of Cryptosporidium isolates from children in Uganda","volume":"92","author":"Akiyoshi","year":"2006","journal-title":"J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1179\/000349803235002470","article-title":"Detection of Cryptosporidium amongst diarrhoeic and asymptomatic children in Jeddah, Saudi Arabia","volume":"97","author":"Al-Braiken","year":"2003","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00436-006-0164-5","article-title":"Distribution of Cryptosporidium subtypes in humans and domestic and wild ruminants in Portugal","volume":"99","author":"Alves","year":"2006","journal-title":"Parasitol Res"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib5","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1128\/JCM.41.6.2744-2747.2003","article-title":"Subgenotype analysis of Cryptosporidium isolates from humans, cattle, and zoo ruminants in Portugal","volume":"41","author":"Alves","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/00005176-200105000-00011","article-title":"Intestinal and systemic infection, HIV, and mortality in Zambian children with persistent diarrhea and malnutrition","volume":"32","author":"Amadi","year":"2001","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib7","series-title":"World Health Report 2004: changing history","author":"Anon","year":"2004"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib8","series-title":"AIDS epidemic update","author":"Anon","year":"2007"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1586\/14787210.1.2.297","article-title":"A review of chemotherapeutic approaches to the treatment of cryptosporidiosis","volume":"1","author":"Armson","year":"2003","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biotechadv.2006.08.003","article-title":"Molecular targets for detection and immunotherapy in Cryptosporidium parvum","volume":"25","author":"Boulter-Bitzer","year":"2007","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.vetpar.2008.02.029","article-title":"Distribution of Cryptosporidium parvum subtypes in calves in Germany","volume":"154","author":"Broglia","year":"2008","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3201\/eid0801.010269","article-title":"Human infection with Cryptosporidium felis: case report and literature review","volume":"8","author":"Cacci\u00f2","year":"2002","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib13","first-page":"185","article-title":"Molecular epidemiology of human cryptosporidiosis","volume":"47","author":"Cacci\u00f2","year":"2005","journal-title":"Parassitologia"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1586\/14787210.4.3.429","article-title":"Advances in the epidemiology, diagnosis and treatment of cryptosporidiosis","volume":"4","author":"Cacci\u00f2","year":"2006","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.pt.2005.06.013","article-title":"Unravelling Cryptosporidium and Giardia epidemiology","volume":"21","author":"Cacci\u00f2","year":"2005","journal-title":"Trends Parasitol"},{"issue":"Suppl 3","key":"10.1016\/j.biotechadv.2009.08.003_bib16","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00002030-200212003-00002","article-title":"Status of the HIV\/AIDS epidemic and methods to monitor it in the Latin America and Caribbean region","volume":"16","author":"Calleja","year":"2002","journal-title":"Aids"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib17","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3201\/eid1206.060015","article-title":"Mixed Cryptosporidium infections and HIV","volume":"12","author":"Cama","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib18","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.3201\/eid1410.071273","article-title":"Cryptosporidium species and subtypes and clinical manifestations in children, Peru","volume":"14","author":"Cama","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib19","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1550-7408.2003.tb00620.x","article-title":"Cryptosporidium species and genotypes in HIV-positive patients in Lima, Peru","volume":"50","author":"Cama","year":"2003","journal-title":"J Eukaryot Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib20","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1086\/519842","article-title":"Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons","volume":"196","author":"Cama","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib21","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3201\/eid0504.990425","article-title":"Chlorine disinfection of recreational water for Cryptosporidium parvum","volume":"5","author":"Carpenter","year":"1999","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1128\/AEM.62.2.712-716.1996","article-title":"Identification of genetic heterogeneity in the Cryptosporidium parvum ribosomal repeat","volume":"62","author":"Carraway","year":"1996","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4269\/ajtmh.2005.73.54","article-title":"Cryptosporidiosis in HIV-infected Venezuelan adults is strongly associated with acute or chronic diarrhea","volume":"73","author":"Certad","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib24","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1128\/IAI.68.9.5167-5175.2000","article-title":"Mediation of Cryptosporidium parvum infection in vitro by mucin-like glycoproteins defined by a neutralizing monoclonal antibody","volume":"68","author":"Cevallos","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1086\/338196","article-title":"Infection with unusual types of Cryptosporidium is not restricted to immunocompromised patients","volume":"185","author":"Chalmers","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ijpara.2005.01.001","article-title":"Direct comparison of selected methods for genetic categorisation of Cryptosporidium parvum and Cryptosporidium hominis species","volume":"35","author":"Chalmers","year":"2005","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3201\/eid1403.071320","article-title":"Geographic Linkage and Variation in Cryptosporidium hominis","volume":"14","author":"Chalmers","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/oxfordjournals.aje.a009086","article-title":"Asymptomatic and symptomatic cryptosporidiosis: their acute effect on weight gain in Peruvian children","volume":"145","author":"Checkley","year":"1997","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib29","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMra013170","article-title":"Cryptosporidiosis","volume":"346","author":"Chen","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1017\/S0950268897007589","article-title":"Cryptosporidiosis in children during a massive waterborne outbreak in Milwaukee, Wisconsin: clinical, laboratory and epidemiologic findings","volume":"119","author":"Cicirello","year":"1997","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1128\/JCM.44.2.589-591.2006","article-title":"Identification of Cpgp40\/15 Type Ib as the predominant allele in isolates of Cryptosporidium spp. from a waterborne outbreak of gastroenteritis in South Burgundy, France","volume":"44","author":"Cohen","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib32","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/oxfordjournals.aje.a009015","article-title":"Cryptosporidiosis among patients infected with human immunodeficiency virus. Factors related to symptomatic infection and survival","volume":"144","author":"Colford","year":"1996","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib33","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3201\/eid0904.020417","article-title":"Cost of illness in the 1993 waterborne Cryptosporidium outbreak, Milwaukee, Wisconsin","volume":"9","author":"Corso","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1645\/0022-3395(2003)089[0399:MINART]2.0.CO;2","article-title":"Morphology is not a reliable tool for delineating species within Cryptosporidium","volume":"89","author":"Fall","year":"2003","journal-title":"J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000060368","article-title":"Clinical aspects of human cryptosporidiosis","volume":"6","author":"Farthing","year":"2000","journal-title":"Contrib Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.vetpar.2004.09.004","article-title":"Cryptosporidium: a water-borne zoonotic parasite","volume":"126","author":"Fayer","year":"2004","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib37","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0020-7519(00)00135-1","article-title":"Epidemiology of Cryptosporidium: transmission, detection and identification","volume":"30","author":"Fayer","year":"2000","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib38","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1128\/JCM.01067-06","article-title":"Evidence supporting zoonotic transmission of Cryptosporidium spp. in Wisconsin","volume":"44","author":"Feltus","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1128\/JCM.01777-08","article-title":"Cryptosporidium genotype and subtype distribution in raw wastewater in Shanghai, China: evidence for possible unique Cryptosporidium hominis transmission","volume":"47","author":"Feng","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2006.10.001","article-title":"Wide geographic distribution of Cryptosporidium bovis and the deer-like genotype in bovines","volume":"144","author":"Feng","year":"2007","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib41","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1128\/AEM.69.5.2719-2730.2003","article-title":"Electrophoretic analysis of genetic variability within Cryptosporidium parvum from imported and autochthonous cases of human cryptosporidiosis in the United Kingdom","volume":"69","author":"Gasser","year":"2003","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.meegid.2006.08.006","article-title":"Multilocus sequence typing and genetic structure of Cryptosporidium hominis from children in Kolkata, India","volume":"7","author":"Gatei","year":"2007","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib43","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1179\/000349802125002202","article-title":"Zoonotic species of Cryptosporidium are as prevalent as the anthroponotic in HIV-infected patients in Thailand","volume":"96","author":"Gatei","year":"2002","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib44","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.vetpar.2008.05.002","article-title":"Prevalence and molecular characterisation of Cryptosporidium and Giardia in lambs and goat kids in Belgium","volume":"155","author":"Geurden","year":"2008","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/vr.164.1.24","article-title":"Cryptosporidium hominis in a goat and sheep in the UK","volume":"164","author":"Giles","year":"2009","journal-title":"Vet Rec"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib46","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/vr.149.17.523","article-title":"Experimental infection of a lamb with Cryptosporidium parvum genotype 1","volume":"149","author":"Giles","year":"2001","journal-title":"Vet Rec"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib47","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3201\/eid0806.010368","article-title":"Three drinking-water-associated cryptosporidiosis outbreaks, Northern Ireland","volume":"8","author":"Glaberman","year":"2002","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib48","doi-asserted-by":"crossref","first-page":"459","DOI":"10.7326\/0003-4819-124-5-199603010-00001","article-title":"Cryptosporidiosis: an outbreak associated with drinking water despite state-of-the-art water treatment","volume":"124","author":"Goldstein","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib49","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s004360100402","article-title":"Chemotherapeutic approaches to protozoa: Coccidiae-current level of knowledge and outlook","volume":"87","author":"Greif","year":"2001","journal-title":"Parasitol Res"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib50","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1128\/JCM.00936-08","article-title":"Genetic diversity and zoonotic potential of Cryptosporidium parvum causing foal diarrhea","volume":"46","author":"Grinberg","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib51","doi-asserted-by":"crossref","first-page":"707","DOI":"10.4269\/ajtmh.1999.61.707","article-title":"Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four-seven years later in a poor urban community in northeast Brazil","volume":"61","author":"Guerrant","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib52","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1128\/JCM.39.10.3472-3480.2001","article-title":"Molecular characterization of Cryptosporidium isolates obtained from humans in France","volume":"39","author":"Guyot","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib53","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1046\/j.1440-1746.2000.02089.x","article-title":"Prevalence of enteric pathogens among community based asymptomatic individuals","volume":"15","author":"Hellard","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib54","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4269\/ajtmh.2005.73.520","article-title":"Short report: asymptomatic Cryptosporidium hominis infection among human immunodeficiency virus-infected patients in Tanzania","volume":"73","author":"Houpt","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/j.spid.2004.07.006","article-title":"Cryptosporidiosis in children","volume":"15","author":"Huang","year":"2004","journal-title":"Semin Pediatr Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib56","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3201\/eid1301.060481","article-title":"Subtypes of Cryptosporidium parvum in humans and disease risk","volume":"13","author":"Hunter","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib57","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3201\/eid1007.030582","article-title":"Sporadic cryptosporidiosis case-control study with genotyping","volume":"10","author":"Hunter","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib58","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.ijpara.2005.07.009","article-title":"The zoonotic transmission of Giardia and Cryptosporidium","volume":"35","author":"Hunter","year":"2005","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib59","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1002\/elps.200800422","article-title":"Analysis of the genetic diversity within Cryptosporidium hominis and Cryptosporidium parvum from imported and autochtonous cases of human cryptosporidiosis by mutation scanning","volume":"29","author":"Jex","year":"2008","journal-title":"Electrophoresis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib60","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1128\/JCM.00116-08","article-title":"Classification of Cryptosporidium species from patients with sporadic cryptosporidiosis by use of sequence-based multilocus analysis following mutation scanning","volume":"46","author":"Jex","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib62","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.biotechadv.2008.02.003","article-title":"Cryptosporidium \u2014 biotechnological advances in the detection, diagnosis and analysis of genetic variation","volume":"26","author":"Jex","year":"2008","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib61","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1002\/elps.200600772","article-title":"Specific and genotypic identification of Cryptosporidium from a broad range of host species by nonisotopic single-strand conformation polymorphism (SSCP) analysis of nuclear ribosomal DNA","volume":"28","author":"Jex","year":"2007","journal-title":"Electrophoresis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib63","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1002\/elps.200700279","article-title":"A practical and cost-effective mutation scanning-based approach for investigating genetic variation in Cryptosporidium","volume":"28","author":"Jex","year":"2007","journal-title":"Electrophoresis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib134","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1002\/elps.200700279","article-title":"A practical and cost-effective mutation scanning-based approach for investigating genetic variation in Cryptosporidium","volume":"28","author":"Jex","year":"2007","journal-title":"Electrophoresis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2166\/wh.2006.002","article-title":"Waterborne transmission of protozoan parasites: a worldwide review of outbreaks and lessons learnt","volume":"5","author":"Karanis","year":"2007","journal-title":"J Water Health"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib65","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1542\/pir.26-1-5","article-title":"Chronic diarrhea","volume":"26","author":"Keating","year":"2005","journal-title":"Pediatr Rev"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib66","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1017\/S0031182006001491","article-title":"Critical processes affecting Cryptosporidium oocyst survival in the environment","volume":"134","author":"King","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib67","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1128\/AEM.56.5.1423-1428.1990","article-title":"Effects of ozone, chlorine dioxide, chlorine, and monochloramine on Cryptosporidium parvum oocyst viability","volume":"56","author":"Korich","year":"1990","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib68","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1473-3099(01)00121-9","article-title":"Cryptosporidiosis: an update","volume":"1","author":"Kosek","year":"2001","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib69","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00436-008-1215-x","article-title":"Molecular characterization of Cryptosporidium isolates from pigs at slaughterhouses in South Bohemia, Czech Republic","volume":"104","author":"Kv\u00e1\u010d","year":"2009","journal-title":"Parasitol Res"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib70","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1128\/IAI.70.7.3881-3890.2002","article-title":"Analysis of sequence diversity at the highly polymorphic Cpgp40\/15 locus among Cryptosporidium isolates from human immunodeficiency virus-infected children in South Africa","volume":"70","author":"Leav","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib71","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1099\/jmm.0.46251-0","article-title":"Genetic analysis of Cryptosporidium from 2414 humans with diarrhoea in England between 1985 and 2000","volume":"55","author":"Leoni","year":"2006","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib72","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1128\/JCM.02536-06","article-title":"Multilocus analysis of Cryptosporidium hominis and Cryptosporidium parvum from sporadic and outbreak-related human cases and C. parvum from sporadic cases in livestock in the UK","volume":"45","author":"Leoni","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib73","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJM199407213310304","article-title":"A massive outbreak in Milwaukee of Cryptosporidium infection transmitted through the public water supply","volume":"331","author":"MacKenzie","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib74","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1017\/S0950268800058714","article-title":"An outbreak of cryptosporidiosis associated with a resort swimming pool","volume":"115","author":"MacKenzie","year":"1995","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib75","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/clinids\/21.1.57","article-title":"Massive outbreak of waterborne Cryptosporidium infection in Milwaukee, Wisconsin: recurrence of illness and risk of secondary transmission","volume":"21","author":"MacKenzie","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib76","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00239-002-2412-3","article-title":"Population structures and the role of genetic exchange in the zoonotic pathogen Cryptosporidium parvum","volume":"56","author":"Mallon","year":"2003","journal-title":"J Mol Evol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib77","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","article-title":"Genome sequencing in microfabricated high-density picolitre reactors","volume":"437","author":"Margulies","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib78","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1368-7646(02)00011-0","article-title":"Cryptosporidiosis and the challenges of chemotherapy","volume":"5","author":"Mead","year":"2002","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib79","author":"Medema","year":"2006"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib80","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.vetpar.2007.03.034","article-title":"Natural infection with zoonotic subtype of Cryptosporidium parvum in Capybara (Hydrochoerus hydrochaeris) from Brazil","volume":"147","author":"Meireles","year":"2007","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib81","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1017\/S0031182006001508","article-title":"Subtype analysis of Cryptosporidium parvum isolates from calves on farms around Belgrade, Serbia and Montenegro, using the 60kDa glycoprotein gene sequences","volume":"134","author":"Misic","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib82","first-page":"42S","article-title":"Which genotypes\/species of Cryptosporidium are humans susceptible to?","volume":"46","author":"Morgan","year":"1999","journal-title":"J Eukaryot Microbiol"},{"issue":"Pt 1","key":"10.1016\/j.biotechadv.2009.08.003_bib83","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1017\/S0031182098003412","article-title":"Sequence and PCR-RFLP analysis of the internal transcribed spacers of the rDNA repeat unit in isolates of Cryptosporidium from different hosts","volume":"118","author":"Morgan","year":"1999","journal-title":"Parasitology"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib84","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2307\/3285678","article-title":"Phylogenetic relationships among isolates of Cryptosporidium: evidence for several new species","volume":"85","author":"Morgan","year":"1999","journal-title":"J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib85","first-page":"1352","article-title":"Detection of the Cryptosporidium parvum \u201chuman\u201d genotype in a dugong (Dugong dugon)","volume":"86","author":"Morgan","year":"2000","journal-title":"J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib86","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1550-7408.2002.tb00224.x","article-title":"Cryptosporidium hominis n. sp. (Apicomplexa: Cryptosporidiidae) from Homo sapiens","volume":"49","author":"Morgan-Ryan","year":"2002","journal-title":"J Eukaryot Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib87","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.vetpar.2008.03.021","article-title":"Distribution of Cryptosporidium species in sheep in the UK","volume":"154","author":"Mueller-Doblies","year":"2008","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib88","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0163-4453(98)90561-8","article-title":"Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya","volume":"37","author":"Mwachari","year":"1998","journal-title":"J Infect"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib89","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.exppara.2008.01.010","article-title":"Evidence supporting zoonotic transmission of Cryptosporidium in rural New South Wales","volume":"119","author":"Ng","year":"2008","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib90","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1002\/elps.200900071","article-title":"Genetic characterization of Cryptosporidium parvum from calves by mutation scanning and targeted sequencing \u2014 zoonotic implication","volume":"30","author":"Nolan","year":"2009","journal-title":"Electrophoresis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib91","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.exppara.2007.05.012","article-title":"Cryptosporidium GP60 genotypes from humans and domesticated animals in Australia, North America and Europe","volume":"118","author":"O'Brien","year":"2008","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib92","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.molbiopara.2007.07.010","article-title":"Cryptosporidium parvum glycoprotein gp40 localizes to the sporozoite surface by association with gp15","volume":"156","author":"O'Connor","year":"2007","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib93","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1128\/AEM.55.6.1519-1522.1989","article-title":"Effect of disinfection of drinking water with ozone or chlorine dioxide on survival of Cryptosporidium parvum oocysts","volume":"55","author":"Peeters","year":"1989","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib94","doi-asserted-by":"crossref","first-page":"28S","DOI":"10.1111\/j.1550-7408.2001.tb00442.x","article-title":"A comparison of Cryptosporidium subgenotypes from several geographic regions","author":"Peng","year":"2001","journal-title":"J Eukaryot Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib95","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1550-7408.2003.tb00628.x","article-title":"Molecular epidemiology of cryptosporidiosis in children in Malawi","volume":"50","author":"Peng","year":"2003","journal-title":"J Eukaryot Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib96","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1136\/bmj.300.6727.774","article-title":"Cryptosporidiosis in England and Wales: prevalence and clinical and epidemiological features. Public Health Laboratory Service Study Group","volume":"300","author":"PHLSSG","year":"1990","journal-title":"BMJ"},{"issue":"Suppl 1","key":"10.1016\/j.biotechadv.2009.08.003_bib97","first-page":"S1","article-title":"AIDS in Africa: the first decade and challenges for the 1990s","volume":"5","author":"Piot","year":"1991","journal-title":"Aids"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib98","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.vetpar.2007.02.030","article-title":"Genotype and subtype analyses of Cryptosporidium isolates from cattle in Hungary","volume":"146","author":"Plutzer","year":"2007","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib99","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4269\/ajtmh.2007.77.583","article-title":"Seropositive human subjects produce interferon gamma after stimulation with recombinant Cryptosporidium hominis gp15","volume":"77","author":"Preidis","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib100","doi-asserted-by":"crossref","first-page":"6026","DOI":"10.1128\/AEM.00606-08","article-title":"Cryptosporidium genotypes and subtypes in lambs and goat kids in Spain","volume":"74","author":"Qu\u00edlez","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib101","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1017\/S0031182008005088","article-title":"Cryptosporidium species and subtype analysis from dairy calves in Spain","volume":"135","author":"Qu\u00edlez","year":"2008","journal-title":"Parasitology"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib102","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0167-7012(02)00007-6","article-title":"Cryptosporidium parvum and Cyclospora cayetanensis: a review of laboratory methods for detection of these waterborne parasites","volume":"49","author":"Quintero-Betancourt","year":"2002","journal-title":"J Microbiol Methods"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib103","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1086\/315279","article-title":"An outbreak of cryptosporidiosis linked to a foodhandler","volume":"181","author":"Quiroz","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib104","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.micinf.2004.02.021","article-title":"A review of the biology and epidemiology of cryptosporidiosis in humans and animals","volume":"6","author":"Ramirez","year":"2004","journal-title":"Microbes Infect"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib105","doi-asserted-by":"crossref","DOI":"10.1038\/nature05444","article-title":"Reducing stunting among children: the potential contribution of diagnostics","author":"Ricci","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib106","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S1286-4579(02)01631-3","article-title":"Recent advances in cryptosporidiosis: the immune response","volume":"4","author":"Riggs","year":"2002","journal-title":"Microbes Infect"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib107","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1128\/JCM.42.7.2944-2951.2004","article-title":"Risk factors for sporadic cryptosporidiosis among immunocompetent persons in the United States from 1999 to 2001","volume":"42","author":"Roy","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib108","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1017\/S0950268803008495","article-title":"Outbreaks of infectious disease associated with private drinking water supplies in England and Wales 1970\u20132000","volume":"130","author":"Said","year":"2003","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib109","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.vetpar.2007.01.010","article-title":"Prevalence and molecular characterization of Cryptosporidium and Giardia species and genotypes in sheep in Maryland","volume":"146","author":"Santin","year":"2007","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vetpar.2008.04.018","article-title":"A longitudinal study of cryptosporidiosis in dairy cattle from birth to 2years of age","volume":"155","author":"Santin","year":"2008","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib111","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.mcp.2005.07.001","article-title":"Capillary electrophoretic analysis of fragment length polymorphism in ribosomal markers of Cryptosporidium from humans","volume":"19","author":"Schindler","year":"2005","journal-title":"Mol Cell Probes"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib112","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/vr.156.22.710","article-title":"Natural Cryptosporidium hominis infections in Scottish cattle","volume":"156","author":"Smith","year":"2005","journal-title":"Vet Rec"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib113","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1128\/IAI.68.7.4117-4134.2000","article-title":"Cloning and sequence analysis of a highly polymorphic Cryptosporidium parvum gene encoding a 60-kilodalton glycoprotein and characterization of its 15- and 45-kilodalton zoite surface antigen products","volume":"68","author":"Strong","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib115","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1128\/JCM.43.6.2805-2809.2005","article-title":"Unique endemicity of cryptosporidiosis in children in Kuwait","volume":"43","author":"Sulaiman","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib116","doi-asserted-by":"crossref","first-page":"24S","DOI":"10.1111\/j.1550-7408.2001.tb00441.x","article-title":"A population genetic study of the Cryptosporidium parvum human genotype parasites","author":"Sulaiman","year":"2001","journal-title":"J Eukaryot Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib117","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00436-006-0305-x","article-title":"Genotypes and subtypes of Cryptosporidium spp. in neonatal calves in Northern Ireland","volume":"100","author":"Thompson","year":"2007","journal-title":"Parasitol Res"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib118","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0065-308X(05)59002-X","article-title":"Cryptosporidium and cryptosporidiosis","volume":"59","author":"Thompson","year":"2005","journal-title":"Adv Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib119","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s00436-006-0157-4","article-title":"Genotype and subtype analyses of Cryptosporidium isolates from dairy calves and humans in Ontario","volume":"99","author":"Trotz-Williams","year":"2006","journal-title":"Parasitol Res"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib120","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S1286-4579(02)01629-5","article-title":"Cryptosporidiosis: biology, pathogenesis and disease","volume":"4","author":"Tzipori","year":"2002","journal-title":"Microbes Infect"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib121","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0065-308X(08)60122-0","article-title":"Genetic heterogeneity and PCR detection of Cryptosporidium parvum","volume":"40","author":"Widmer","year":"1998","journal-title":"Adv Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib122","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ijpara.2007.10.014","article-title":"Molecular epidemiology of Cryptosporidium in humans and cattle in The Netherlands","volume":"38","author":"Wielinga","year":"2008","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib123","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1098\/rstb.2001.0896","article-title":"The epidemiology of human immunodeficiency virus in South Africa","volume":"356","author":"Williams","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib124","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1128\/AEM.69.8.4720-4726.2003","article-title":"Intraspecies polymorphism of Cryptosporidium parvum revealed by PCR-restriction fragment length polymorphism (RFLP) and RFLP-single-strand conformational polymorphism analyses","volume":"69","author":"Wu","year":"2003","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib125","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1086\/318090","article-title":"Identification of 5 types of Cryptosporidium parasites in children in Lima, Peru","volume":"183","author":"Xiao","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib126","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1128\/CMR.17.1.72-97.2004","article-title":"Cryptosporidium taxonomy: recent advances and implications for public health","volume":"17","author":"Xiao","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib127","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1574-695X.2008.00377.x","article-title":"Zoonotic cryptosporidiosis","volume":"52","author":"Xiao","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib128","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/00001432-200410000-00014","article-title":"Cryptosporidiosis: an update in molecular epidemiology","volume":"17","author":"Xiao","year":"2004","journal-title":"Current Opin Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib129","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0020-7519(02)00197-2","article-title":"Host adaptation and host-parastic co-evolution in Cryptosporidium: implications for taxonomy and public health","volume":"32","author":"Xiao","year":"2002","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib130","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00436-006-0337-2","article-title":"Distribution of Cryptosporidium parvum subtypes in calves in eastern United States","volume":"100","author":"Xiao","year":"2007","journal-title":"Parasitol Res"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib131","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000086920","article-title":"Treatment of cryptosporidiosis in immunocompromised hosts","volume":"51","author":"Zardi","year":"2005","journal-title":"Chemotherapy"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib132","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1128\/JCM.41.11.5254-5257.2003","article-title":"Molecular surveillance of Cryptosporidium spp. in raw wastewater in Milwaukee: implications for understanding outbreak occurrence and transmission dynamics","volume":"41","author":"Zhou","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.biotechadv.2009.08.003_bib133","first-page":"1","article-title":"The prevalence of Cryptosporidium species and subtypes in human faecal samples in Ireland","author":"Zintl","year":"2008","journal-title":"Epidemiol Infect"}],"container-title":["Biotechnology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975009001499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975009001499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T20:15:54Z","timestamp":1590092154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0734975009001499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":133,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0734975009001499"],"URL":"https:\/\/doi.org\/10.1016\/j.biotechadv.2009.08.003","relation":{},"ISSN":["0734-9750"],"issn-type":[{"value":"0734-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}