{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:14:24Z","timestamp":1774793664205,"version":"3.50.1"},"reference-count":137,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Advances"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.biotechadv.2009.11.006","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T19:41:10Z","timestamp":1258659670000},"page":"184-196","source":"Crossref","is-referenced-by-count":36,"title":["Prevention of bubonic and pneumonic plague using plant-derived vaccines"],"prefix":"10.1016","volume":"28","author":[{"given":"M. Lucrecia","family":"Alvarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy A.","family":"Cardineau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biotechadv.2009.11.006_bib1","series-title":"Biohazard: the chilling true story of the largest covert biological weapons program in the world \u2014 told from inside by the man who ran it","author":"Alibek","year":"2000"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib2","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.vaccine.2005.12.057","article-title":"Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice","volume":"24","author":"Alvarez","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11103-008-9352-2","article-title":"P19-dependent and P19-independent reversion of F1\u2013V gene silencing in tomato","volume":"68","author":"Alvarez","year":"2008","journal-title":"Plant Mol Biol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib4","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1128\/IAI.64.11.4580-4585.1996","article-title":"Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis","volume":"64","author":"Anderson","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib5","doi-asserted-by":"crossref","first-page":"793","DOI":"10.4269\/ajtmh.1998.58.793","article-title":"Short- and long-term efficacy of single dose subunit vaccines against Yersinia pestis in mice","volume":"58","author":"Anderson","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib6","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1128\/IAI.64.6.2180-2187.1996","article-title":"Fraction 1 capsular antigen (F1) purification from Yersinia pestis CO92 and from an Escherichia coli recombinant strain and efficacy against lethal plague challenge","volume":"64","author":"Andrews","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib7","first-page":"19","article-title":"Madagascar: public health situation on the \u201cBig Island\u201d at the beginning of the 21st century","volume":"67","author":"Andrianarisoa","year":"2007","journal-title":"Med Trop"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib8","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1128\/IAI.00050-08","article-title":"Effective plague vaccination via oral delivery of plant cells expressing F1\u2013V antigens in chloroplasts","volume":"78","author":"Arlen","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10123-002-0084-x","article-title":"Responding to the threat of bioterrorism: a microbial ecology perspective \u2014 the case of anthrax","volume":"5","author":"Atlas","year":"2002","journal-title":"Int Microbiol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4049\/jimmunol.68.2.131","article-title":"Studies on immunization against plague: I. The isolation and characterization of the soluble antigen of Pasteurella pestis","volume":"68","author":"Baker","year":"1952","journal-title":"J Immunol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib11","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/milmed\/138.11.720","article-title":"Clinical and serological responses to plague vaccine U.S.P.","volume":"138","author":"Bartelloni","year":"1973","journal-title":"Milit Med"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0264-410X(99)00317-5","article-title":"Gene gun mediated vaccination is superior to manual delivery for immunization with DNA vaccines expressing protective antigens from Yersinia pestis or Venezuelan Equine Encephalitis virus","volume":"18","author":"Bennett","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib13","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3201\/eid1310.070284","article-title":"Plague reappearance in Algeria after 50years, 2003","volume":"13","author":"Bertherat","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib14","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.addr.2005.01.010","article-title":"H. Particulate delivery systems for biodefense subunit vaccines","volume":"57","author":"Bramwell","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/978-0-387-72124-8_36","article-title":"Oral vaccination with different antigens from Yersinia pestis KIM delivered by live attenuated Salmonella typhimurium elicits a protective immune response against plague","volume":"603","author":"Branger","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib16","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1128\/JB.98.3.1404-1406.1969","article-title":"Mutation rate to non pigmentation in Pasteurella pestis","volume":"98","author":"Brubaker","year":"1969","journal-title":"J Bacteriol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib17","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1128\/CVI.00137-07","article-title":"Yersinia pestis CO92 delta yopH is a potent live, attenuated plague vaccine","volume":"14","author":"Bubeck","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib18","first-page":"92","article-title":"Salmonella-based plague vaccines for bioterrorism","volume":"39","author":"Calhoun","year":"2006","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib19","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1093\/infdis\/129.Supplement_1.S37","article-title":"Plague immunization. V. Indirect evidence for the efficacy of plague vaccine","volume":"129","author":"Cavanaugh","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib20","series-title":"Student Material. September 21\u201323","article-title":"Biological Warfare and Terrorism: The Military and Public Health Response Satellite Broadcast","year":"1999"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib22","unstructured":"CDC \u2014 Center for Disease Control and Prevention. The history of bioterrorism: plague, 1999b. Four minutes video available for download from: URL: http:\/\/emergency.cdc.gov\/training\/historyofbt\/03plague.asp."},{"key":"10.1016\/j.biotechadv.2009.11.006_bib133","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1016\/j.vaccine.2009.01.050","article-title":"A single component two-valent LcrV-F1 vaccine protects non-human primates against pneumonic plague","volume":"27","author":"Chichester","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1001\/jama.1997.03550050074036","article-title":"Biological warfare: a historical perspective","volume":"278","author":"Christopher","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.200205077","article-title":"Yersinia type III secretion: send in the effectors","volume":"158","author":"Cornelis","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib26","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1128\/IAI.00699-08","article-title":"Immunization with recombinant V10 protects Cynomolgus Macaques from lethal pneumonic plague","volume":"76","author":"Cornelius","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib27","series-title":"World Patent Application","article-title":"Oral immunization by transgenic plants","author":"Curtis","year":"1990"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib28","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/biot.200600145","article-title":"Production of biopharmaceuticals and vaccines in plants via the chloroplast genome","volume":"10","author":"Daniell","year":"2006","journal-title":"Biotechnol J"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib29","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.vaccine.2004.11.004","article-title":"Chloroplast-derived vaccine antigens and other therapeutic proteins","volume":"23","author":"Daniell","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib30","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0958-1669(97)80041-9","article-title":"Plasmid DNA expression systems for the purpose of immunisation","volume":"8","author":"Davis","year":"1997","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/83559","article-title":"Overexpression of the Bt cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals","volume":"19","author":"De Cosa","year":"2001","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/039463200902200115","article-title":"Plant-derived recombinant F1, V, and F1\u2013V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system","volume":"22","author":"Del Prete","year":"2009","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib33","unstructured":"Dennis, DT, Gage, KI, Gratz, N, Poland, JD, Tikhomirov, E. Plague Manual: Epidemiology, Distribution, Surveillance and Control. Geneva, World Health Organization, Communicable Disease Surveillance and Response, 1997. Available for download from: URL: www.who.int\/csr\/resources\/publications\/plague\/WHO_CDS_CSR_EDC_99_2_EN\/en\/."},{"key":"10.1016\/j.biotechadv.2009.11.006_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1001\/jama.1966.03100140113030","article-title":"DeMussis and the great plague of 1348","volume":"196","author":"Derbes","year":"1966","journal-title":"JAMA"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.20506\/rst.25.1.1646","article-title":"Achievements of the soviet biological weapons programme and implications for the future","volume":"25","author":"Domaradskij","year":"2006","journal-title":"Rev Sci Tech"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib36","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1128\/IAI.70.3.1453-1460.2002","article-title":"Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis","volume":"70","author":"Du","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib37","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1016\/j.vaccine.2005.12.016","article-title":"Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine","volume":"24","author":"Elvin","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib138","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/S0264-410X(98)00089-9","article-title":"Analysis of local and systemic immunological responses after intra-tracheal, intra-nasal and intra-muscular administration of microsphere co-encapsulated Yersinia pestis sub-unit vaccines","volume":"16","author":"Eyles","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib38","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1128\/IAI.67.10.5395-5408.1999","article-title":"Virulence role of V antigen of Yersinia pestis at the bacterial surface","volume":"67","author":"Fields","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib39","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1128\/IAI.72.2.908-915.2004","article-title":"Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates","volume":"72","author":"Flashner","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib40","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1093\/clinids\/21.Supplement_2.S178","article-title":"Relationship between virulence and immunity as revealed in recent studies of the F1 capsule of Yersinia pestis","volume":"21","author":"Friedlander","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib41","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0264-410X(99)00505-8","article-title":"Mucosal vaccination and immune responses in the elderly","volume":"18","author":"Fujihashi","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib42","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1056\/NEJM199709043371004","article-title":"Multidrug resistance in Yersinia pestis mediated by transferable plasmid","volume":"337","author":"Galimand","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-0556-1-2","article-title":"DNA vaccines: improving expression of antigens","volume":"1","author":"Garmory","year":"2003","journal-title":"Genet Vaccines Ther"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib44","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1016\/S0264-410X(03)00112-9","article-title":"Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague","volume":"21","author":"Garmory","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib134","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.vaccine.2003.09.020","article-title":"Protection against plague afforded by immunization with DNA vaccines optimized for expression of the Yersinina pestis V antigen","volume":"22","author":"Garmory","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib135","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.vaccine.2005.01.006","article-title":"Magnifection \u2014 a new platform for expressing recombinant vaccines in plants","volume":"23","author":"Gleba","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib45","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.vaccine.2004.10.025","article-title":"Effect of homologous and heterologous prime\u2013boost on the immune response to recombinant plague antigens","volume":"23","author":"Glynn","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib46","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/qjmed\/hch121","article-title":"Biopharmaceuticals derived from genetically modified plants","volume":"97","author":"Goldstein","year":"2004","journal-title":"QJM"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib47","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1128\/IAI.71.1.374-383.2003","article-title":"Effective protective immunity to Yersinia pestis infection conferred by DNA vaccine coding for derivatives of the F1 capsular antigen","volume":"71","author":"Grosfeld","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3201\/eid0701.010106","article-title":"Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis","volume":"7","author":"Guiyoule","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib49","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1146\/annurev.immunol.18.1.927","article-title":"DNA vaccines: immunology, application, and optimization","volume":"18","author":"Gurunathan","year":"2000","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib50","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1136\/bmj.1.1902.1461","article-title":"Remarks on the plague prophylactic fluid","volume":"1","author":"Haffkine","year":"1897","journal-title":"Br Med J"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib51","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1749-6632.1992.tb38021.x","article-title":"Japanese biological warfare research on humans: a case study of microbiology and ethics","volume":"555","author":"Harris","year":"1992","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib52","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0264-410X(98)80110-2","article-title":"Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1\u2013V antigen fusion protein vaccine","volume":"16","author":"Heath","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib53","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.0966-0879.2005.00452.x","article-title":"Emerging and re-emerging infectious diseases from plague and cholera to Ebola and AIDS: a potential for international spread that transcends the defenses of any single country","volume":"13","author":"Heymann","year":"2005","journal-title":"J Contig Crisis Manag"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib54","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1365-2958.2002.03159.x","article-title":"High-frequency conjugative transfer of antibiotic resistance genes to Yersinia pestis in the flea midgut","volume":"46","author":"Hinnebusch","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib55","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1001\/jama.283.17.2281","article-title":"Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense","volume":"283","author":"Inglesby","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib56","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0264-410X(00)00108-0","article-title":"Protection conferred by a fully recombinant sub-unit vaccine against Yersinia pestis in male and female mice of four inbred strains","volume":"19","author":"Jones","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib57","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-59745-427-8_8","article-title":"Transient transformation of plants","volume":"513","author":"Jones","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biotechadv.2009.11.006_bib58","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/jama.1997.03550050011005","article-title":"Biological weapons control. Prospects and implications for the future","volume":"278","author":"Kadlec","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib59","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1096\/fasebj.13.13.1796","article-title":"A plant-derived edible vaccine against hepatitis B virus","volume":"13","author":"Kapusta","year":"1999","journal-title":"Faseb J"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib60","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2249.2007.03452.x","article-title":"The fraction 1 and V protein antigens of Yersinia pestis activate dendritic cells to induce primary T cell responses","volume":"149","author":"Kingston","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.biotechadv.2009.11.006_bib61","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/327070a0","article-title":"High velocity micro-projectiles for delivery of nucleic acid into living cells","volume":"327","author":"Klein","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib62","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/scientificamerican0900-66","article-title":"Edible vaccines","volume":"283","author":"Langridge","year":"2000","journal-title":"Sci Am"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib63","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1128\/IAI.63.8.2854-2858.1995","article-title":"Active immunization with recombinant V antigen from Yersinia pestis protects mice against plague","volume":"63","author":"Leary","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib64","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/mpat.1997.0141","article-title":"Expression of an F1\/V fusion protein in attenuated Salmonella typhimurium and protection of mice against plague","volume":"23","author":"Leary","year":"1997","journal-title":"Microb Pathog"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/j.spid.2006.07.002","article-title":"Plague: a review of its history and potential as a biological weapon","volume":"17","author":"Ligo","year":"2006","journal-title":"Semin Pediatr Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib66","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/nrg1177","article-title":"The production of recombinant pharmaceutical proteins in plants","volume":"4","author":"Ma","year":"2003","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib67","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.arplant.55.031903.141633","article-title":"Plastid transformation in higher plants","volume":"55","author":"Maliga","year":"2004","journal-title":"Annu Rev Plant Biol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib68","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.1073\/pnas.0400149101","article-title":"In planta engineering of viral RNA replicons: efficient assembly by recombination of DNA modules delivered by Agrobacterium","volume":"101","author":"Marillonnet","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib69","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nbt1094","article-title":"Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants","volume":"23","author":"Marillonnet","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib70","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1093\/infdis\/129.Supplement_1.S19","article-title":"Plague immunization. II. Relation of adverse clinical reactions to multiple immunizations with killed vaccines","volume":"129","author":"Marshall","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib71","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S1471-4914(02)02360-2","article-title":"Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine","volume":"8","author":"Mason","year":"2002","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib72","doi-asserted-by":"crossref","first-page":"10131","DOI":"10.1073\/pnas.0803636105","article-title":"Plant-produced idiotype vaccines for the treatment of non-Hodgkin's lymphoma: safety and immunogenicity in a phase I clinical study","volume":"105","author":"McCormick","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib73","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1574-695X.2000.tb01444.x","article-title":"Modulation of immune responses following antigen administration by mucosal route","volume":"27","author":"Medina","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib74","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1016\/j.vaccine.2007.01.017","article-title":"A plant-produced plague vaccine candidate confers protection to monkeys","volume":"25","author":"Mett","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib75","first-page":"653","article-title":"Effectiveness of live or killed plague vaccines in man","volume":"42","author":"Meyer","year":"1970","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib76","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1093\/infdis\/129.Supplement_1.S13","article-title":"Plague immunization I. Past and present trends","volume":"129","author":"Meyer","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib77","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1093\/infdis\/129.Supplement_1.S30","article-title":"Plague immunization. IV. Clinical reactions and serologic response to inoculations of Haffekine and freeze-dried plague vaccine","volume":"129","author":"Meyer","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib78","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1093\/infdis\/129.Supplement_1.S85","article-title":"Live, attenuated Yersinia pestis vaccine: virulent in nonhuman primates, harmless to guinea pigs","volume":"129","author":"Meyer","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib79","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1574-695X.1998.tb01168.x","article-title":"Macromolecular organization of recombinant Yersinia pestis F1 antigen and the effect of structure on immunogenicity","volume":"21","author":"Miller","year":"1998","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib80","series-title":"New generation vaccines","first-page":"305","article-title":"Plants as a production and delivery vehicle for orally delivered subunit vaccines","author":"Mor","year":"2004"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib81","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.vaccine.2004.01.007","article-title":"A Salmonella enterica serovar Typhi vaccine expressing Yersinia pestis F1 antigen on its surface provides protection against plague in mice","volume":"22","author":"Morton","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib82","first-page":"19","article-title":"A launch vector for the production of vaccines in plants","volume":"1","author":"Musiymuck","year":"2006","journal-title":"Influenza Other Respi Viruses"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib83","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1128\/CMR.14.2.430-445.2001","article-title":"Vaccination strategies for mucosal immune responses","volume":"14","author":"Ogra","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib84","unstructured":"Pearson, G.S. The threat of deliberate disease in the 21st century. Henry L. Stimson Centre Report No. 24, Biological Weapons Proliferation: Reasons for Concern, Courses of Action, 1998. Available from URL: http:\/\/www.brad.ac.uk\/acad\/sbtwc\/other\/disease.htm."},{"key":"10.1016\/j.biotechadv.2009.11.006_bib85","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia pestis \u2014 etiologic agent of plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib86","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1021\/bp050098r","article-title":"Design and testing for a nontagged F1\u2013V fusion protein as vaccine antigen against bubonic and pneumonic plague","volume":"21","author":"Powell","year":"2005","journal-title":"Biotechnol Prog"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib87","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(07)60566-2","article-title":"Plague","volume":"369","author":"Prentice","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib88","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1188\/08.CJON.295-302","article-title":"Bioterrorism: class A agents and their potential presentation in immuno-compromised patients","volume":"12","author":"Richard","year":"2008","journal-title":"Clin J Oncol Nurs"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib89","first-page":"400","article-title":"Biological warfare and bioterrorism: a historical review","volume":"17","author":"Riedel","year":"2004","journal-title":"BUMC Proc"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib90","first-page":"116","article-title":"Plague: from natural disease to bioterrorism","volume":"18","author":"Riedel","year":"2005","journal-title":"BUMC Proc"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib91","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1440-1711.2005.01336.x","article-title":"Expression systems and developments in plant-made vaccines","volume":"83","author":"Rigano","year":"2005","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib92","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0264-410X(02)00604-7","article-title":"Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites","volume":"21","author":"Rigano","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib93","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.virusres.2004.01.020","article-title":"Plant viral suppressors of RNA silencing","volume":"102","author":"Roth","year":"2004","journal-title":"Virus Res"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib94","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/0264-410X(95)00090-N","article-title":"A comparison of plague vaccine, USP and EV76 vaccine induced protection against Yersinia pestis in a murine model","volume":"13","author":"Russell","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib95","first-page":"223","article-title":"Optimizing the biolistic process for different biological applications","volume":"6","author":"Sanford","year":"1992","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib96","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1073\/pnas.0510014103","article-title":"Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system","volume":"103","author":"Santi","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib97","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1056\/NEJM199907223410410","article-title":"DNA vaccines \u2014 designer vaccines for the 21st century","volume":"341","author":"Seder","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib98","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1467-7652.2006.00209.x","article-title":"Agrobacterium-mediated transformation of cereals: a promising approach crossing barriers","volume":"4","author":"Shrawat","year":"2006","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib99","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1586\/14760584.7.2.209","article-title":"Current challenges in the development of vaccines for pneumonic plague","volume":"7","author":"Smiley","year":"2008","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib100","doi-asserted-by":"crossref","first-page":"13110","DOI":"10.1073\/pnas.0602447103","article-title":"Plague dynamics are driven by climate variation","volume":"103","author":"Stenseth","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib101","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1371\/journal.pmed.0050003","article-title":"Plague: past, present and future","volume":"5","author":"Stenseth","year":"2008","journal-title":"PLoS Med"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib102","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1517\/17425247.2.4.719","article-title":"Delivery of plant-derived vaccines","volume":"2","author":"Streatfield","year":"2005","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib103","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ymeth.2005.09.013","article-title":"Mucosal immunization using recombinant plant-based oral vaccines","volume":"38","author":"Streatfield","year":"2006","journal-title":"Methods"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib104","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0020-7519(03)00052-3","article-title":"Plant-based vaccines","volume":"33","author":"Streatfield","year":"2003","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib105","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1073\/pnas.90.3.913","article-title":"High-frequency plastid transformation in tobacco by selection for a chimeric aadA gene","volume":"90","author":"Svab","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib106","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nm0598-607","article-title":"Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato","volume":"4","author":"Tacket","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib107","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1086\/315653","article-title":"Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes","volume":"182","author":"Tacket","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib108","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1016\/j.vaccine.2004.01.073","article-title":"Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn","volume":"22","author":"Tacket","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib109","unstructured":"Telegraph Newspaper. Al-Qaeda cell killed by Black Death \u2018was developing biological weapons\u2019. January 20th, 2009. Available online at http:\/\/www.telegraph.co.uk."},{"key":"10.1016\/j.biotechadv.2009.11.006_bib136","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1073\/pnas.0409899102","article-title":"Immunogenicity in humans of an edible vaccine for hepatitis B","volume":"102","author":"Thanavala","year":"2005","journal-title":"Proc Natl Acad U S A"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib137","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1586\/14760584.5.2.249","article-title":"Plant-derived vaccines: a look back at the highlights and a view to the challenges on the road ahead","volume":"5","author":"Thanavala","year":"2006","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib110","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1016\/S0264-410X(01)00163-3","article-title":"Vaccination against bubonic and pneumonic plague","volume":"19","author":"Titball","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib111","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1517\/14712598.4.6.965","article-title":"Yersinia pestis (plague) vaccines","volume":"4","author":"Titball","year":"2004","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib112","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.biotechadv.2009.03.006","article-title":"Plants as bioreactors for the production of vaccine antigens","volume":"27","author":"Tiwari","year":"2009","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib113","unstructured":"USDA News Release. USDA issues license for plant-cell-produced Newcastle disease vaccine for chickens. January, 2006. Available from URL: http:\/www.aphis.usda.gov\/newsroom\/content\/2006\/01\/ndvaccine.shtml)."},{"key":"10.1016\/j.biotechadv.2009.11.006_bib114","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nprot.2007.522","article-title":"A protocol for expression of foreign genes in chloroplasts","volume":"3","author":"Verma","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib115","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrg1555","article-title":"Induction and suppression of RNA silencing: insights from viral infections","volume":"6","author":"Voinnet","year":"2005","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib116","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1016\/S0264-410X(02)00119-6","article-title":"Determination of the virulence of the pigmentation-deficient and pigmentation-\/plasminogen activator-deficient strains of Yersinia pestis in non-human primate and mouse models of pneumonic plague","volume":"20","author":"Welkos","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib117","series-title":"Health aspects of chemical and biological weapons","first-page":"98","year":"1970"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib118","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1365-2672.2001.01497.x","article-title":"Plague vaccine research and development","volume":"91","author":"Williamson","year":"2001","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib119","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1574-695X.1995.tb00196.x","article-title":"A new improved sub-unit vaccine for plague: the basis of protection","volume":"12","author":"Williamson","year":"1995","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib120","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0264-410X(96)00303-9","article-title":"A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague","volume":"15","author":"Williamson","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib121","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2249.1999.00859.x","article-title":"An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model","volume":"116","author":"Williamson","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib122","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1016\/S0264-410X(02)00232-3","article-title":"Co-immunisation with a plasmid DNA cocktail primes mice against anthrax and plague","volume":"20","author":"Williamson","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib123","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1128\/IAI.73.6.3598-3608.2005","article-title":"Human immune response to a plague vaccine comprising recombinant F1 and V antigens","volume":"73","author":"Williamson","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib124","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.vaccine.2006.09.052","article-title":"Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague","volume":"25","author":"Williamson","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib125","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.it.2003.11.009","article-title":"Jump-starting the immune system: prime-boosting comes of age","volume":"25","author":"Woodland","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib126","first-page":"301","article-title":"Human plague in 2002 and 2003","volume":"79","year":"2004","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib127","first-page":"65","article-title":"Outbreak news: plague. Democratic Republic of Congo","volume":"80","year":"2005","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib128","unstructured":"World Health Organization. Suspected plague in the Democratic Republic of the Congo. Epidemic and Pandemic Alert Response, 2006. Available from: URL: http:\/\/www.who.int\/csr\/don\/2006_11_07\/en\/index.html."},{"key":"10.1016\/j.biotechadv.2009.11.006_bib21","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1128\/IAI.00581-08","volume":"76","author":"Yamanaka","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib129","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.4049\/jimmunol.178.2.1059","article-title":"Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague","volume":"178","author":"Yang","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib130","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1586\/14760584.7.8.1173","article-title":"Recent progress in the development of plant derived vaccines","volume":"7","author":"Yusibov","year":"2008","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib131","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1016\/S0264-410X(02)00260-8","article-title":"Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine","volume":"20","author":"Yusibov","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2009.11.006_bib132","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2165\/00126839-200607040-00001","article-title":"The potential of plant virus vectors for vaccine production","volume":"7","author":"Yusibov","year":"2006","journal-title":"Drugs R. D."}],"container-title":["Biotechnology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975009001918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975009001918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T16:22:19Z","timestamp":1685204539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0734975009001918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":137,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0734975009001918"],"URL":"https:\/\/doi.org\/10.1016\/j.biotechadv.2009.11.006","relation":{},"ISSN":["0734-9750"],"issn-type":[{"value":"0734-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}