{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:55:33Z","timestamp":1791320133815,"version":"4.3.1"},"reference-count":86,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Advances"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.biotechadv.2010.11.006","type":"journal-article","created":{"date-parts":[[2010,12,4]],"date-time":"2010-12-04T04:42:49Z","timestamp":1291437769000},"page":"223-229","source":"Crossref","is-referenced-by-count":141,"title":["Unexpected applications of secondary metabolites"],"prefix":"10.1016","volume":"29","author":[{"given":"Preeti","family":"Vaishnav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold L.","family":"Demain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biotechadv.2010.11.006_bb0005","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1126\/science.320.5879.993c","article-title":"Reliving Iraq","volume":"320","author":"Anonymous","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0010","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1182\/blood.V80.6.1528.1528","article-title":"Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype","volume":"80","author":"Arceci","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0015","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1021\/jm0300882","article-title":"Role of the glycopeptide framework in the antibacterial activity of hydrophobic derivatives of glycopeptide antibiotics","volume":"46","author":"Balzarini","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0020","doi-asserted-by":"crossref","first-page":"14984","DOI":"10.1074\/jbc.M313061200","article-title":"Squalestatin cures prion-infected neurones and protects against prion nerurotoxicity","volume":"279","author":"Bate","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0025","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1042\/bj3340437","article-title":"Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum","volume":"334","author":"Berriman","year":"1998","journal-title":"Biochem J"},{"issue":"33","key":"10.1016\/j.biotechadv.2010.11.006_bb0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1021\/cen-v080n033.p042","article-title":"The competition for academic positions","volume":"80","author":"Borman","year":"2002","journal-title":"Chem Eng News"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0035","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nrd978","article-title":"Multiple sclerosis. A new use for statins?","volume":"1","author":"Brazil","year":"2002","journal-title":"Nat Revs\/Drug Disc"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0040","unstructured":"BRNI Press release, FDA gives clinical trial green light on drug to treat Alzheimer's disease. April 22, 2009."},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0045","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1039\/p19760001165","article-title":"Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum","volume":"1","author":"Brown","year":"1976","journal-title":"J Chem Soc Perkin Trans"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0050","doi-asserted-by":"crossref","first-page":"15113","DOI":"10.1073\/pnas.2436348100","article-title":"Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling","volume":"100","author":"Brown","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0055","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/ajhp\/61.16.1676","article-title":"HMG-CoA reductase inhibitors for lowering elevated levels of C-reactive protein","volume":"61","author":"Chan","year":"2004","journal-title":"Amer J Hlth-Syst Pharm"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0060","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1128\/AAC.47.9.2810-2816.2003","article-title":"Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1","volume":"47","author":"Chen","year":"2003","journal-title":"Antimicrob Ag Chemother"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0065","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1021\/jm051225t","article-title":"Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target","volume":"49","author":"Chong","year":"2006","journal-title":"J Med Chem"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0070","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/4571090a","article-title":"Alzheimer's disease: A prion protein connection","volume":"457","author":"Cisse","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/AAC.44.1.143-149.2000","article-title":"Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin","volume":"44","author":"Cruz","year":"2000","journal-title":"Antimicrob Ag Chemother"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0080","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1128\/JVI.73.4.3511-3513.1999","article-title":"Effectiveness of polyene antibiotics in treatment of transmissible spongiform encephalopathy in transgenic mice expressing Syrian hamster PrP only in neurons","volume":"73","author":"Demaimay","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0085","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0166-6851(99)00010-9","article-title":"Characterization of protein Ser\/Thr phosphatases of the malaria parasite, Plasmodium falciparum: inhibition of the parasitic calcineurin by cyclophilin\u2013cyclosporin complex","volume":"99","author":"Dobson","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0090","doi-asserted-by":"crossref","first-page":"8901","DOI":"10.1021\/jo801312r","article-title":"The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity","volume":"73","author":"Donnelly","year":"2008","journal-title":"J Org Chem"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0095","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1021\/np50101a009","article-title":"Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase","volume":"56","author":"Dufresne","year":"1993","journal-title":"J Nat Prod"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/BA20070115","article-title":"Violacein: properties and biological activities","volume":"48","author":"Dur\u00e1n","year":"2007","journal-title":"Biotechnol Appl Biochem"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0105","first-page":"387","article-title":"Violacein and its beta-cyclodextrin complexes induce apoptosis and differentiation in HL60 cells","volume":"81","author":"Duran","year":"2003","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0110","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1517\/13543784.12.4.647","article-title":"A new class of cyclosporine analogues for the treatment of asthma","volume":"12","author":"Eckstein","year":"2003","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1021\/jm00382a001","article-title":"Compactin (ML236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase","volume":"28","author":"Endo","year":"1985","journal-title":"J Med Chem"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0120","first-page":"17","article-title":"Progress without profits?","volume":"7","author":"Filmore","year":"2004","journal-title":"Mod Drug Discovery"},{"issue":"22","key":"10.1016\/j.biotechadv.2010.11.006_bb0125","first-page":"22","article-title":"Saving statins","volume":"17","author":"Fogarty","year":"2003","journal-title":"The Scientist"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0130","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1073\/pnas.162195499","article-title":"Tetracyclines affect prion infectivity","volume":"99","author":"Forloni","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0135","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1248\/yakushi.128.153","article-title":"Fluvastatin Induces apoptosis on human tongue carcinoma cell line HSC-3","volume":"128","author":"Fujiwara","year":"2008","journal-title":"J Pharm Soc Jp. (Yakugaku Zasshi)"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0140","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1593\/neo.04442","article-title":"Sensitization for anticancer drug-induced apoptosis by betulinic acid","volume":"7","author":"Fulda","year":"2005","journal-title":"Neoplasia"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0145","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijantimicag.2005.09.008","article-title":"Bleomycin has antiviral properties against drug-resistant HIV strains and sensitises virus to currently used antiviral agents","volume":"27","author":"Georgiou","year":"2006","journal-title":"Int J Antimicrob Ag"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0150","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1517\/13543784.9.10.2331","article-title":"Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders","volume":"9","author":"Gold","year":"2000","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0155","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm0202-128","article-title":"Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis. Involvement of vascular endothelial growth factor","volume":"8","author":"Guba","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/08959374980120010501","article-title":"Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms","volume":"12","author":"Golub","year":"1998","journal-title":"Adv Dent Res"},{"issue":"Suppl 3","key":"10.1016\/j.biotechadv.2010.11.006_bb0165","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.2146\/ajhp080089","article-title":"Novel cytotoxic agents: Epothilones","volume":"6","author":"Goodin","year":"2008","journal-title":"Amer J Hlth-Syst Pharm"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0170","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1097\/00007890-199457120-00001","article-title":"The antimicrobial activities of cyclosporine, FK506 and rapamycin","volume":"57","author":"High","year":"1994","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.biotechadv.2010.11.006_bb0175","first-page":"22","article-title":"Statins reduce amyloid-induced inflammation","volume":"19","author":"Hrastar","year":"2005","journal-title":"The Scientist"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0180","doi-asserted-by":"crossref","first-page":"9791","DOI":"10.1073\/pnas.95.17.9791","article-title":"Neomycin inhibits angiogenin-induced angiogenesis","volume":"95","author":"Hu","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0185","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/jac\/dkm496","article-title":"Unexpected antimicrobial effect of statins","volume":"61","author":"Jerwood","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0190","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1164\/ajrccm\/147.1.153","article-title":"A mechanism of erythromycin treatment in patients with diffuse panbronchiolitis","volume":"147","author":"Kadota","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0195","first-page":"121","article-title":"Bacterial metabolism of polychlorinated biphenyls","volume":"14","author":"Kim","year":"2004","journal-title":"J Microbiol Biotechnol"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0200","doi-asserted-by":"crossref","first-page":"12509","DOI":"10.1073\/pnas.0805504105","article-title":"Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C\/EBPb","volume":"105","author":"Komuro","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0205","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1081\/CNV-120025095","article-title":"Bryostatin-1: a novel PKC inhibitor in clinical development","volume":"21","author":"Kortmansky","year":"2003","journal-title":"Cancer Investig"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0210","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.2741\/1420","article-title":"Beta-lactams and their potential use as novel anticancer chemotherapeutics drugs","volume":"9","author":"Kuhn","year":"2004","journal-title":"Frontiers Biosci"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.critrevonc.2004.09.009","article-title":"Rapamycin: An anticancer immunosuppressant?","volume":"56","author":"Law","year":"2005","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0220","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2144\/04374TN01","article-title":"Apoptosis","volume":"37","author":"Lederman","year":"2004","journal-title":"Biotechniques"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0225","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1248\/yakushi.128.1681","article-title":"Shikonin, acetylshikonin, and idobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in Lewis Lung Carcinoma-bearing mice","volume":"128","author":"Lee","year":"2008","journal-title":"J. Pharm Soc Jpn (Yakugaku Zasshi)"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0230","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1128\/AAC.46.8.2315-2320.2002","article-title":"Clindamycin as an antimalarial drug: Review of clinical trials","volume":"46","author":"Lell","year":"2002","journal-title":"Antimicrob Ag Chemother"},{"issue":"1","key":"10.1016\/j.biotechadv.2010.11.006_bb0235","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1465-9921-7-16","article-title":"EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-\u03b2 signaling in lung fibroblasts","volume":"7","author":"Li","year":"2006","journal-title":"Respir Res"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0240","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1128\/JVI.74.7.3135-3140.2000","article-title":"Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures","volume":"74","author":"Mang\u00e9","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0245","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1073\/pnas.0800962105","article-title":"Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies","volume":"105","author":"Merlini","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0250","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1073\/pnas.0400063101","article-title":"Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs","volume":"101","author":"Mohi","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0255","first-page":"132","article-title":"Microbial prescreens for anticancer activity","volume":"58","author":"Newman","year":"2008","journal-title":"SIM News"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0260","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1248\/cpb.45.1665","article-title":"Enhanced cytotoxicity of some tritepenes toward leukemia L1210 cells cultured in low pH media; possibility of a new mode of cell killing","volume":"45","author":"Noda","year":"1997","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0265","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1128\/AAC.47.3.956-964.2003","article-title":"Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors in Candida albicans, Candida glabrata, and Candida krusei","volume":"47","author":"Onyewu","year":"2003","journal-title":"Antimicrob Ag Chemothe."},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0270","first-page":"295","article-title":"Prodigiosins: A novel family of immunosuppressants with anti-cancer activity","volume":"44","author":"Pandey","year":"2007","journal-title":"Ind J Biochem Biophys"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0275","first-page":"1447","article-title":"Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin","volume":"66","author":"P\u00e9reg-Tom\u00e1s","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0280","unstructured":"Petersen F. Natural products and innovative therapeutic concepts. SIM Annual Meeting Program and Abstracts, Abstr. S15, p. 60, Chicago, 2005."},{"issue":"7","key":"10.1016\/j.biotechadv.2010.11.006_bb0285","first-page":"36","article-title":"Strange bedfellows in transplant drug therapy","volume":"16","author":"Pray","year":"2002","journal-title":"The Scientist"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0290","first-page":"1330","article-title":"Pezacki JP Bleomycin is a potent small-molecule inhibitor of hepatitis C virus replication","volume":"7","author":"Rakic","year":"2006","journal-title":"Chem Biochem"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0295","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1124\/jpet.102.034264","article-title":"Genetically engineered analogs of ascomycin for nerve regeneration","volume":"302","author":"Revill","year":"2002","journal-title":"J Pharmacol Exper Ther"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0300","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrd2382","article-title":"Temsirolimus","volume":"6","author":"Rini","year":"2007","journal-title":"Nat Rev.\/Drug Disc"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0305","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1073\/pnas.0710424105","article-title":"Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities","volume":"105","author":"Ruan","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0310","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/1475-2875-7-225","article-title":"Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin\u2013clindamycin in patients with acute unconmplicated falciparum malaria","volume":"7","author":"Ruangweerayut","year":"2008","journal-title":"Malaria J"},{"issue":"11","key":"10.1016\/j.biotechadv.2010.11.006_bb0315","first-page":"7","article-title":"Minirevolutions","volume":"6","author":"Ryan","year":"2003","journal-title":"Mod Drug Discovery"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0320","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/cbic.200600029","article-title":"Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis","volume":"7","author":"S\u00e1nchez","year":"2006","journal-title":"Chembiochem"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0325","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1535-6108(03)00275-7","article-title":"Will mTOR inhibitors make it as cancer drugs?","volume":"4","author":"Sawyers","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0330","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ardp.200700184","article-title":"Antimalarial drugs \u2014 What is in use and what is in the pipeline","volume":"341","author":"Schlitzer","year":"2008","journal-title":"Arch Pharm Chem Life Sci"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0335","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/jac\/dkh309","article-title":"Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae","volume":"54","author":"Schultz","year":"2004","journal-title":"J. Antimicrob. Chemother"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0340","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pharmthera.2007.11.001","article-title":"Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action","volume":"117","author":"Shinkai","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0345","first-page":"2277","article-title":"Artemisinin induces apoptosis in human cancer cells","volume":"24","author":"Singh","year":"2004","journal-title":"Anticancer Res"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0350","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1158\/1078-0432.CCR-06-1863","article-title":"Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2\/neu-dependent breast tumors","volume":"13","author":"Solit","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0355","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ccr.2006.07.013","article-title":"Intracellular signaling in tumor and endothelial cells: The expected and, yet again, the unexpected","volume":"10","author":"Stoeltzing","year":"2006","journal-title":"Cancer Cel"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0360","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1007\/s00018-003-3146-0","article-title":"The potential therapeutic role of statins in central nervous system autoimmune disorders","volume":"60","author":"Stuve","year":"2003","journal-title":"Cell Molec Life Sci"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0365","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7164\/antibiotics.50.58","article-title":"Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. 1. Taxonomy, fermentation, isolation and physico-chemical properties and biological activities","volume":"50","author":"Tanaka","year":"1997","journal-title":"J Antibiot"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0370","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.bbrc.2005.11.062","article-title":"The sterol-binding antibiotic nystatin inhibits entry of non-opsonized Leishmania donovani into macrophages","volume":"339","author":"Tewary","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0375","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00253-007-0988-7","article-title":"Microbial production and application of sophorolipids","volume":"76","author":"Van Bogaert","year":"2007","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0380","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/ajhp\/61.5.449","article-title":"Sirolimus-eluting coronary stent","volume":"61","author":"Vishnevetsky","year":"2004","journal-title":"Am J Health-Syst Pharm"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0385","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/15216540701646484","article-title":"Sirolimus inhibits human pancreatic carcinoma cell proliferation by a mechanism linked to the targeting of mTOR\/HIF-1 alpha\/VEGF signaling","volume":"59","author":"Wang","year":"2007","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0390","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/420039a","article-title":"Tackling multiple sclerosis","volume":"420","author":"Wekerle","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0395","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nrmicro1531","article-title":"The biosynthesis and regulation of bacterial prodigenes","volume":"4","author":"Williamson","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0400","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2202-8-99","article-title":"Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide","volume":"8","author":"Wilson","year":"2007","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0405","series-title":"Microbial Diversity and Bioprospecting","first-page":"356","article-title":"Pharmacologicallly active agents of microbial action","author":"Wrigley","year":"2004"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0410","first-page":"396","article-title":"Synthesis of one dimensional zinc oxide nanostructure and their applications","volume":"33","author":"Wu","year":"2008","journal-title":"Chi J Antibiot"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0415","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2174\/138955708784223558","article-title":"Novel beta-zlactam antibiotic derivatives: their new applications as gene reporters, antitumor prodrugs and enzyme inhibitors","volume":"8","author":"Xing","year":"2008","journal-title":"Mini Rev Med Chem."},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0420","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature01158","article-title":"The potential therapeutic role of statins in central nervous system autoimmune disorders","volume":"420","author":"Youssef","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0425","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00044-005-0133-z","article-title":"Inhibitive effect of prodigiosin on the proliferation of human malignant pancreatic cancer cells","volume":"14","author":"Zhang","year":"2005","journal-title":"Med Chem Res"},{"key":"10.1016\/j.biotechadv.2010.11.006_bb0430","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/0929867033368448","article-title":"Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC","volume":"10","author":"Zotchev","year":"2003","journal-title":"Curr Med Chem"}],"container-title":["Biotechnology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975010001564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975010001564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T05:56:49Z","timestamp":1592114209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0734975010001564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0734975010001564"],"URL":"https:\/\/doi.org\/10.1016\/j.biotechadv.2010.11.006","relation":{},"ISSN":["0734-9750"],"issn-type":[{"value":"0734-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}