{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:23:37Z","timestamp":1791217417175,"version":"4.1.0"},"reference-count":263,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006469","name":"Macao Science and Technology Development Fund","doi-asserted-by":"crossref","award":["062\/2013\/A2"],"award-info":[{"award-number":["062\/2013\/A2"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004733","name":"Research Fund of the University of Macau","doi-asserted-by":"crossref","award":["MYRG2014-00051-ICMS-QRCM"],"award-info":[{"award-number":["MYRG2014-00051-ICMS-QRCM"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004733","name":"Research Fund of the University of Macau","doi-asserted-by":"crossref","award":["MRG004\/CMW\/2014\/ICMS"],"award-info":[{"award-number":["MRG004\/CMW\/2014\/ICMS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004733","name":"Research Fund of the University of Macau","doi-asserted-by":"crossref","award":["MYRG2014-00033-ICMS-QRCM"],"award-info":[{"award-number":["MYRG2014-00033-ICMS-QRCM"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Chinese National Natural Science Foundation","doi-asserted-by":"crossref","award":["31271444"],"award-info":[{"award-number":["31271444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Chinese National Natural Science Foundation","doi-asserted-by":"crossref","award":["81201726"],"award-info":[{"award-number":["81201726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Foundation for Doctoral Discipline of Higher Education","award":["20124401120007"],"award-info":[{"award-number":["20124401120007"]}]},{"name":"Science and Technology Program of Guangzhou","award":["2014J4100009"],"award-info":[{"award-number":["2014J4100009"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biotechnology Advances"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.biotechadv.2014.10.011","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T20:08:31Z","timestamp":1414786111000},"page":"224-241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer"],"prefix":"10.1016","volume":"33","author":[{"given":"Shengpeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiange","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiwan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biotechadv.2014.10.011_bb0010","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijpharm.2014.01.009","article-title":"Polyethylene glycol-phosphatidylethanolamine (PEG-PE)\/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer","volume":"464","author":"Abouzeid","year":"2014","journal-title":"Int J Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0005","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1007\/s11095-013-1295-x","article-title":"Transferrin-targeted polymeric micelles co-loaded with curcumin and paclitaxel: efficient killing of paclitaxel-resistant cancer cells","volume":"31","author":"Abouzeid","year":"2014","journal-title":"Pharm Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0015","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The Bcl-2 protein family: arbiters of cell survival","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0020","doi-asserted-by":"crossref","first-page":"17450","DOI":"10.1073\/pnas.1114518108","article-title":"Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma","volume":"108","author":"Agemy","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0025","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ccr.2007.11.014","article-title":"The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel","volume":"12","author":"Ahmed","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0030","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1158\/0008-5472.CAN-11-0025","article-title":"Modulating microtubule stability enhances the cytotoxic response of cancer cells to paclitaxel","volume":"71","author":"Ahmed","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0035","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1158\/1535-7163.MCT-11-0787","article-title":"XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells","volume":"11","author":"Allensworth","year":"2012","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrc968","article-title":"Validating survivin as a cancer therapeutic target","volume":"3","author":"Altieri","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0045","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nm0897-917","article-title":"A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma","volume":"3","author":"Ambrosini","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0050","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.pharmtox.39.1.361","article-title":"Biochemical, cellular, and pharmacological aspects of the multidrug transporter","volume":"39","author":"Ambudkar","year":"1999","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0055","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.drup.2012.02.002","article-title":"Targeting MDR in breast and lung cancer: discriminating its potential importance from the failure of drug resistance reversal studies","volume":"15","author":"Amiri-Kordestani","year":"2012","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0060","first-page":"2798","article-title":"Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma","volume":"5","author":"Arts","year":"1999","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0065","doi-asserted-by":"crossref","first-page":"17498","DOI":"10.1073\/pnas.1313839110","article-title":"Oral delivery system prolongs blood circulation of docetaxel nanocapsules via lymphatic absorption","volume":"110","author":"Attili-Qadri","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0070","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.2042-7158.2012.01578.x","article-title":"2-Hydroxypropyl-beta-cyclodextrin-modified SLN of paclitaxel for overcoming p-glycoprotein function in multidrug-resistant breast cancer cells","volume":"65","author":"Baek","year":"2013","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0075","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1016\/j.biomaterials.2013.04.062","article-title":"Nanoparticle-mediated drug delivery to tumor neovasculature to combat P-gp expressing multidrug resistant cancer","volume":"34","author":"Bai","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0080","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.drudis.2009.07.010","article-title":"Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation","volume":"14","author":"Bansal","year":"2009","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0085","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1023\/A:1026179132599","article-title":"Sensitization of cells overexpressing multidrug-resistant proteins by Pluronic P85","volume":"20","author":"Batrakova","year":"2003","journal-title":"Pharm Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrd2781","article-title":"Is NF-kappa B a good target for cancer therapy? Hopes and pitfalls","volume":"8","author":"Baud","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0095","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrc2442","article-title":"Modes of resistance to anti-angiogenic therapy","volume":"8","author":"Bergers","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0100","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S1470-2045(04)01411-1","article-title":"Do beta-tubulin mutations have a role in resistance to chemotherapy?","volume":"5","author":"Berrieman","year":"2004","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0105","first-page":"465","article-title":"Characterization of a human myeloid leukemia cell line highly resistant to taxol","volume":"8","author":"Bhalla","year":"1994","journal-title":"Leukemia"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12645-010-0004-2","article-title":"Evaluating the potential of polymer nanoparticles for oral delivery of paclitaxel in drug-resistant cancer","volume":"1","author":"Bhardwaj","year":"2010","journal-title":"Cancer Nanotechnol."},{"issue":"Pt. 13","key":"10.1016\/j.biotechadv.2014.10.011_bb0115","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1242\/jcs.112.13.2213","article-title":"Overexpression of class I, II or IVb beta-tubulin isotypes in CHO cells is insufficient to confer resistance to paclitaxel","volume":"112","author":"Blade","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1535-6108(03)00336-2","article-title":"Antiangiogenic therapy and tumor progression","volume":"5","author":"Blagosklonny","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0125","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/sj.onc.1202314","article-title":"Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy","volume":"18","author":"Blandino","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0130","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1388-1981(02)00338-4","article-title":"Glucosylceramide synthase and apoptosis","volume":"1585","author":"Bleicher","year":"2002","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0135","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10456-013-9334-0","article-title":"The pharmacological bases of the antiangiogenic activity of paclitaxel","volume":"16","author":"Bocci","year":"2013","journal-title":"Angiogenesis"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0140","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/emboj\/20.5.998","article-title":"Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes","volume":"20","author":"Bratton","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0145","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrc1367","article-title":"Exploiting tumour hypoxia in cancer treatment","volume":"4","author":"Brown","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0150","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.chembiol.2011.12.008","article-title":"RNA-based therapeutics: current progress and future prospects","volume":"19","author":"Burnett","year":"2012","journal-title":"Chem Biol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0155","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/1097-0215(20010601)92:5<738::AID-IJC1249>3.0.CO;2-2","article-title":"A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes","volume":"92","author":"Cassinelli","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0160","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4161\/cc.5.9.2726","article-title":"BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance","volume":"5","author":"Chabalier","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0165","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s002800000265","article-title":"Taxol-induced ceramide generation and apoptosis in human breast cancer cells","volume":"47","author":"Charles","year":"2001","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb9000","first-page":"73","article-title":"Pluronic P105\/F127 mixed micelles for the delivery of docetaxel against Taxol-resistant non-small cell lung cancer: optimization and in vitro, in vivo evaluation","volume":"8","author":"Chen","year":"2013","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0170","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1126\/science.1226338","article-title":"Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities","volume":"338","author":"Cheng","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0175","first-page":"4160","article-title":"Taxol resistance mediated by transfection of the liver-specific sister gene of P-glycoprotein","volume":"58","author":"Childs","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb9005","doi-asserted-by":"crossref","first-page":"7181","DOI":"10.1016\/j.biomaterials.2011.06.028","article-title":"Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic (R) for tumor-targeted delivery of docetaxel","volume":"32","author":"Cho","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0180","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/nm.3388","article-title":"The quest to overcome resistance to EGFR-targeted therapies in cancer","volume":"19","author":"Chong","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0185","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1021\/bm301719b","article-title":"Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action","volume":"14","author":"Cline","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0190","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nantod.2012.06.013","article-title":"Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance","volume":"7","author":"Creixell","year":"2012","journal-title":"Nano Today"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0200","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0168-3659(03)00242-6","article-title":"VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies","volume":"91","author":"Dagar","year":"2003","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0210","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jconrel.2009.08.011","article-title":"Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel","volume":"140","author":"Danhier","year":"2009","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0205","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2010.08.027","article-title":"To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery","volume":"148","author":"Danhier","year":"2010","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0215","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1101\/gr.GR-1649R","article-title":"The human ATP-binding cassette (ABC) transporter superfamily","volume":"11","author":"Dean","year":"2001","journal-title":"Genome Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0220","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.3892\/or.2013.2362","article-title":"Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10)","volume":"29","author":"Deng","year":"2013","journal-title":"Oncol Rep"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0230","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00280-006-0287-5","article-title":"Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model","volume":"59","author":"Devalapally","year":"2007","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0225","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1158\/1078-0432.CCR-07-4973","article-title":"Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles","volume":"14","author":"Devalapally","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0235","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11912-007-0006-3","article-title":"Drug distribution in tumors: mechanisms, role in drug resistance, and methods for modification","volume":"9","author":"Di Paolo","year":"2007","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0240","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1158\/0008-5472.CAN-08-2747","article-title":"Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting p-glycoprotein and depleting ATP","volume":"69","author":"Dong","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0195","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/10611860802228855","article-title":"Nanocarrier-assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel","volume":"16","author":"D'Souza","year":"2008","journal-title":"J Drug Target"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0245","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/cyto.2001.1008","article-title":"Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells","volume":"17","author":"Duan","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0250","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3253","article-title":"Microtubule-binding agents: a dynamic field of cancer therapeutics","volume":"9","author":"Dumontet","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0255","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/1097-0215(20010720)95:4<255::AID-IJC1043>3.0.CO;2-O","article-title":"Decreased expression of BRCA2 mRNA predicts favorable response to docetaxel in breast cancer","volume":"95","author":"Egawa","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0260","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1016\/j.biomaterials.2011.01.073","article-title":"Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel","volume":"32","author":"Eldar-Boock","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0265","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jconrel.2013.09.013","article-title":"Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles","volume":"172","author":"Ernsting","year":"2013","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0275","first-page":"837","article-title":"Taxanes: promising anti-cancer drugs","volume":"12","author":"Fauzee","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0280","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1016\/j.biomaterials.2014.03.012","article-title":"Synergistic inhibition of breast cancer by co-delivery of VEGF siRNA and paclitaxel via vapreotide-modified core-shell nanoparticles","volume":"35","author":"Feng","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0285","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/0959-8049(96)00091-3","article-title":"Clinical trials of P-glycoprotein reversal in solid tumours","volume":"32A","author":"Ferry","year":"1996","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0290","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chembiol.2013.01.014","article-title":"The binding sites of microtubule-stabilizing agents","volume":"20","author":"Field","year":"2013","journal-title":"Chem Biol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0295","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrc2789","article-title":"ABC transporters in cancer: more than just drug efflux pumps","volume":"10","author":"Fletcher","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0300","doi-asserted-by":"crossref","first-page":"13092","DOI":"10.1073\/pnas.0702387104","article-title":"Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer","volume":"104","author":"Franovic","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0305","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1089\/ars.2011.4078","article-title":"Mitochondria as therapeutic targets for the treatment of malignant disease","volume":"15","author":"Fulda","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0310","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrd3627","article-title":"Targeting IAP proteins for therapeutic intervention in cancer","volume":"11","author":"Fulda","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0315","doi-asserted-by":"crossref","first-page":"9356","DOI":"10.1158\/0008-5472.CAN-07-0509","article-title":"Class III beta-tubulin mediates sensitivity to chemotherapeutic drugs in non small cell lung cancer","volume":"67","author":"Gan","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0320","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1021\/mp800240j","article-title":"Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells","volume":"6","author":"Ganta","year":"2009","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0325","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1016\/j.biomaterials.2013.11.076","article-title":"Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment","volume":"35","author":"Gao","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0330","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(94)90754-4","article-title":"The taxoids: paclitaxel and docetaxel","volume":"344","author":"Gelmon","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0335","doi-asserted-by":"crossref","first-page":"17118","DOI":"10.1074\/jbc.272.27.17118","article-title":"Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization","volume":"272","author":"Giannakakou","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0340","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejps.2012.02.010","article-title":"Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines","volume":"46","author":"Gill","year":"2012","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0345","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2174\/156800909788166600","article-title":"Overcoming drug resistance by enhancing apoptosis of tumor cells","volume":"9","author":"Gimenez-Bonafe","year":"2009","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0350","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1080\/01635581.2010.509835","article-title":"Curcumin, the golden spice from Indian Saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs","volume":"62","author":"Goel","year":"2010","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0355","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.drup.2012.07.002","article-title":"Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance","volume":"15","author":"Gonen","year":"2012","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0360","doi-asserted-by":"crossref","first-page":"31269","DOI":"10.1074\/jbc.270.52.31269","article-title":"Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistance","volume":"270","author":"Haber","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0365","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/(SICI)1098-1128(199603)16:2<207::AID-MED4>3.0.CO;2-4","article-title":"Antimitotic natural products and their interactions with tubulin","volume":"16","author":"Hamel","year":"1996","journal-title":"Med Res Rev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0375","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/cm.10132","article-title":"Expression of class III beta-tubulin reduces microtubule assembly and confers resistance to paclitaxel","volume":"56","author":"Hari","year":"2003","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0370","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1158\/1535-7163.MCT-05-0190","article-title":"Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules","volume":"5","author":"Hari","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0380","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1056\/NEJM199310283291807","article-title":"Clinical implications of the p53 tumor-suppressor gene","volume":"329","author":"Harris","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0385","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1016\/j.biomaterials.2013.03.068","article-title":"Cyclodextrin-derived pH-responsive nanoparticles for delivery of paclitaxel","volume":"34","author":"He","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0390","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/jcs.115.1.3","article-title":"Microtubule dynamics","volume":"115","author":"Heald","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0395","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.cb.08.110192.000435","article-title":"ABC transporters: from microorganisms to man","volume":"8","author":"Higgins","year":"1992","journal-title":"Annu Rev Cell Biol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0400","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1023\/A:1011379307472","article-title":"XIAP: apoptotic brake and promising therapeutic target","volume":"6","author":"Holcik","year":"2001","journal-title":"Apoptosis"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0405","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1126\/science.1905840","article-title":"P53 mutations in human cancers","volume":"253","author":"Hollstein","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0410","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"Holohan","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0415","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1158\/0008-5472.CAN-03-3111","article-title":"Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel","volume":"64","author":"Hopper-Borge","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0420","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1158\/0008-5472.CAN-10-3623","article-title":"Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-\/-) mice","volume":"71","author":"Hopper-Borge","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0425","doi-asserted-by":"crossref","first-page":"9496","DOI":"10.1016\/j.biomaterials.2013.09.001","article-title":"CGKRK-modified nanoparticles for dual-targeting drug delivery to tumor cells and angiogenic blood vessels","volume":"34","author":"Hu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0430","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1021\/bc3000468","article-title":"PEG-derivatized embelin as a dual functional carrier for the delivery of paclitaxel","volume":"23","author":"Huang","year":"2012","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0435","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/ijc.21013","article-title":"MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid","volume":"116","author":"Huisman","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0440","first-page":"1109","article-title":"Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells","volume":"57","author":"Ibrado","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0445","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1002\/ijc.23867","article-title":"Intraperitoneal administration of a small interfering RNA targeting nuclear factor-kappa B with paclitaxel successfully prolongs the survival of xenograft model mice with peritoneal metastasis of gastric cancer","volume":"123","author":"Inoue","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0450","first-page":"415","article-title":"Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia","volume":"9","author":"Itoh","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0455","first-page":"6146","article-title":"Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model","volume":"62","author":"Janssen","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0460","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.1038\/onc.2010.379","article-title":"Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition","volume":"29","author":"Ji","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0465","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ijpharm.2011.10.003","article-title":"Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance","volume":"422","author":"Ji","year":"2012","journal-title":"Int J Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0470","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1007\/s11095-009-9889-z","article-title":"Cytotoxicity of paclitaxel incorporated in PLGA nanoparticles on hypoxic human tumor cells","volume":"26","author":"Jin","year":"2009","journal-title":"Pharm Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0475","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1021\/mp400340k","article-title":"Paclitaxel-loaded N-octyl-O-sulfate chitosan micelles for superior cancer therapeutic efficacy and overcoming drug resistance","volume":"11","author":"Jin","year":"2014","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0480","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.biomaterials.2011.11.067","article-title":"Liposomal formulations of etoposide and docetaxel for p53 mediated enhanced cytotoxicity in lung cancer cell lines","volume":"33","author":"Jinturkar","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0485","doi-asserted-by":"crossref","first-page":"9552","DOI":"10.1073\/pnas.90.20.9552","article-title":"Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations","volume":"90","author":"Jordan","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0490","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1021\/bm400406x","article-title":"Carboxymethyl-chitosan-tethered lipid vesicles: hybrid nanoblanket for oral delivery of paclitaxel","volume":"14","author":"Joshi","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0495","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrc2618","article-title":"Microenvironmental regulation of metastasis","volume":"9","author":"Joyce","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0500","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0169-409X(02)00047-9","article-title":"Pluronic((R)) block copolymers for overcoming drug resistance in cancer","volume":"54","author":"Kabanov","year":"2002","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0505","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1158\/1078-0432.CCR-10-1664","article-title":"X-linked inhibitor of apoptosis: a chemoresistance factor or a hollow promise","volume":"16","author":"Kashkar","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0510","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/ijc.21677","article-title":"Fibronectin as target for tumor therapy","volume":"118","author":"Kaspar","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0515","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0009-9120(99)00026-0","article-title":"Increased bcl-2 expression is associated with primary resistance to chemotherapy in human epithelial ovarian cancer","volume":"32","author":"Kassim","year":"1999","journal-title":"Clin Biochem"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0520","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nrc2803","article-title":"Microtubules and resistance to tubulin-binding agents","volume":"10","author":"Kavallaris","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0535","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1172\/JCI119642","article-title":"Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes","volume":"100","author":"Kavallaris","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0530","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/sj.bjc.6690507","article-title":"Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol","volume":"80","author":"Kavallaris","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0525","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1053\/j.seminoncol.2008.01.006","article-title":"Potential mechanisms of resistance to microtubule inhibitors","volume":"35","author":"Kavallaris","year":"2008","journal-title":"Semin Oncol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0540","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1388-1981(02)00301-3","article-title":"Increase of ceramide in adriamycin-induced HL-60 cell apoptosis: detection by a novel anti-ceramide antibody","volume":"1584","author":"Kawase","year":"2002","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0545","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.addr.2013.09.001","article-title":"Exploiting nanotechnology to overcome tumor drug resistance: challenges and opportunities","volume":"65","author":"Kirtane","year":"2013","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0550","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jconrel.2006.03.001","article-title":"In-vivo efficacy of novel paclitaxel nanoparticles in paclitaxel-resistant human colorectal tumors","volume":"112","author":"Koziara","year":"2006","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0555","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bcp.2009.08.021","article-title":"Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance","volume":"79","author":"Kuang","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0560","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1756-9966-27-37","article-title":"Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145","volume":"27","author":"Kucukzeybek","year":"2008","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0565","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1158\/1078-0432.CCR-06-1352","article-title":"Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics","volume":"12","author":"Lagas","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0570","doi-asserted-by":"crossref","first-page":"19530","DOI":"10.1074\/jbc.271.32.19530","article-title":"Accumulation of glucosylceramides in multidrug-resistant cancer cells","volume":"271","author":"Lavie","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0575","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0092-8674(87)90456-9","article-title":"Free intermingling of mammalian beta-tubulin isotypes among functionally distinct microtubules","volume":"49","author":"Lewis","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0585","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1007\/s11095-010-0147-1","article-title":"Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously","volume":"27","author":"Li","year":"2010","journal-title":"Pharm Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0580","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jconrel.2013.04.010","article-title":"Recent advances in delivery of drug-nucleic acid combinations for cancer treatment","volume":"172","author":"Li","year":"2013","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0590","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ctrv.2013.11.009","article-title":"Antiangiogenesis beyond VEGF inhibition: a journey from antiangiogenic single-target to broad-spectrum agents","volume":"40","author":"Limaverde-Sousa","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0610","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1096\/fj.00-0223com","article-title":"Ceramide glycosylation potentiates cellular multidrug resistance","volume":"15","author":"Liu","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0595","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jconrel.2009.08.013","article-title":"Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel","volume":"140","author":"Liu","year":"2009","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0605","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1021\/mp100012s","article-title":"Paclitaxel nanocrystals for overcoming multidrug resistance in cancer","volume":"7","author":"Liu","year":"2010","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0600","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11095-013-1176-3","article-title":"Tumor-specific delivery and therapy by double-targeted DTX-CMCS-PEG-NGR conjugates","volume":"31","author":"Liu","year":"2014","journal-title":"Pharm Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0620","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2007.05.006","article-title":"XIAP induces NF-kappaB activation via the BIR1\/TAB1 interaction and BIR1 dimerization","volume":"26","author":"Lu","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0615","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.biomaterials.2012.10.073","article-title":"PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers","volume":"34","author":"Lu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0630","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.biomaterials.2012.10.029","article-title":"Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel","volume":"34","author":"Luo","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0625","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jconrel.2013.12.030","article-title":"Emerging integrated nanohybrid drug delivery systems to facilitate the intravenous-to-oral switch in cancer chemotherapy","volume":"176","author":"Luo","year":"2014","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0635","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1158\/1078-0432.CCR-04-0958","article-title":"Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models","volume":"10","author":"Mabuchi","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0640","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.drudis.2012.06.004","article-title":"Improving drug penetration to curb tumor drug resistance","volume":"17","author":"Marcucci","year":"2012","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0645","doi-asserted-by":"crossref","first-page":"8838","DOI":"10.1158\/0008-5472.CAN-06-0699","article-title":"Farnesyltransferase inhibitors reverse taxane resistance","volume":"66","author":"Marcus","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0650","doi-asserted-by":"crossref","first-page":"16288","DOI":"10.1073\/pnas.1210096109","article-title":"Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics","volume":"109","author":"Marrache","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0655","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.drudis.2012.08.007","article-title":"Oral delivery of anticancer drugs III: formulation using drug delivery systems","volume":"18","author":"Mazzaferro","year":"2013","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0660","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1007\/s11671-009-9431-6","article-title":"A novel docetaxel-loaded poly (epsilon-Caprolactone)\/Pluronic F68 nanoparticle overcoming multidrug resistance for breast cancer treatment","volume":"4","author":"Mei","year":"2009","journal-title":"Nanoscale Res Lett"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0665","first-page":"1106","article-title":"Multicompartimental nanoparticles for co-encapsulation and multimodal drug delivery to tumor cells and neovasculature","volume":"31","author":"Mendes","year":"2014","journal-title":"Pharm Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0670","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.colsurfb.2013.03.037","article-title":"Drug resistance reversal activity of anticancer drug loaded solid lipid nanoparticles in multi-drug resistant cancer cells","volume":"110","author":"Miao","year":"2013","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0675","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1161\/CIRCULATIONAHA.108.775163","article-title":"Mitochondrial medicine\u2014a new era in medicine opens new windows and brings new challenges","volume":"117","author":"Michelakis","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0680","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrd4088","article-title":"Therapeutic modulators of STAT signalling for human diseases","volume":"12","author":"Miklossy","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0685","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1021\/mp1002653","article-title":"Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel\/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells","volume":"8","author":"Milane","year":"2011","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0690","doi-asserted-by":"crossref","first-page":"e24075","DOI":"10.1371\/journal.pone.0024075","article-title":"Therapeutic efficacy and safety of paclitaxel\/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer","volume":"6","author":"Milane","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0695","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.nano.2010.12.009","article-title":"Pharmacokinetics and biodistribution of lonidamine\/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer","volume":"7","author":"Milane","year":"2011","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0700","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrc1893","article-title":"Drug penetration in solid tumours","volume":"6","author":"Minchinton","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0705","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1016\/j.biomaterials.2011.03.005","article-title":"The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles","volume":"32","author":"Mo","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0710","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrc3398","article-title":"Ceramide-orchestrated signalling in cancer cells","volume":"13","author":"Morad","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0715","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1016\/j.biomaterials.2009.11.102","article-title":"The effects of mixed MPEG-PLA\/Pluronic (R) copolymer micelles on the bioavailability and multidrug resistance of docetaxel","volume":"31","author":"Mu","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0720","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.ctrv.2012.02.011","article-title":"Taxane resistance in breast cancer: mechanisms, predictive biomarkers and circumvention strategies","volume":"38","author":"Murray","year":"2012","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0730","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3109\/10611860903508804","article-title":"In vitro cytotoxic activity of cationic paclitaxel nanoparticles on MDR-3T3 cells","volume":"18","author":"Niu","year":"2010","journal-title":"J Drug Target"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0735","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.biophys.30.1.397","article-title":"Structural insight into microtubule function","volume":"30","author":"Nogales","year":"2001","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0740","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1038\/srep04057","article-title":"Nuclear factor-\u0138B plays a critical role in both intrinsic and acquired resistance against endocrine therapy in human breast cancer cells","volume":"4","author":"Oida","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0745","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.canlet.2008.09.041","article-title":"Nanomicellar paclitaxel increases cytotoxicity of multidrug resistant breast cancer cells","volume":"274","author":"Onyuksel","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0750","doi-asserted-by":"crossref","first-page":"11358","DOI":"10.1073\/pnas.91.24.11358","article-title":"Microtubule dynamics in vitro are regulated by the tubulin isotype composition","volume":"91","author":"Panda","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0755","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0006-2952(97)83383-7","article-title":"Acquisition of taxol resistance via P-glycoprotein- and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells","volume":"53","author":"Parekh","year":"1997","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0760","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1083\/jcb.91.2.479","article-title":"Taxol binds to polymerized tubulin in vitro","volume":"91","author":"Parness","year":"1981","journal-title":"J Cell Biol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0770","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijpharm.2011.05.082","article-title":"Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes","volume":"416","author":"Patel","year":"2011","journal-title":"Int J Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0765","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.addr.2013.08.004","article-title":"Nanopreparations to overcome multidrug resistance in cancer","volume":"65","author":"Patel","year":"2013","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0775","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jconrel.2009.01.021","article-title":"Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance","volume":"136","author":"Patil","year":"2009","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0780","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.biomaterials.2009.09.048","article-title":"The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance","volume":"31","author":"Patil","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0785","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0305-7372(93)90010-O","article-title":"The taxoids: paclitaxel (Taxol\u00ae) and docetaxel (Taxotere\u00ae)","volume":"19","author":"Pazdur","year":"1993","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0790","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1073\/pnas.0511219103","article-title":"Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds","volume":"103","author":"Pilch","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0795","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1182\/blood-2004-01-0065","article-title":"Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event","volume":"104","author":"Plenchette","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0800","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s10456-013-9347-8","article-title":"Tumour vasculature targeting agents in hybrid\/conjugate drugs","volume":"16","author":"Prokopiou","year":"2013","journal-title":"Angiogenesis"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0805","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1230582","article-title":"Molecular mechanism of action of microtubule-stabilizing anticancer agents","volume":"339","author":"Prota","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0810","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/bjc.1998.91","article-title":"Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells","volume":"77","author":"Ranganathan","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0815","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.bcp.2013.02.017","article-title":"Molecular aspects of cancer cell resistance to chemotherapy","volume":"85","author":"Rebucci","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0820","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3109\/07357900009032828","article-title":"Multidrug resistance phenotype and paclitaxel (Taxol) sensitivity in human renal carcinoma cell lines of different histologic types","volume":"18","author":"Reinecke","year":"2000","journal-title":"Cancer Invest"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0825","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s11095-010-0346-9","article-title":"Paclitaxel-loaded poly(n-butylcyanoacrylate) nanoparticle delivery system to overcome multidrug resistance in ovarian cancer","volume":"28","author":"Ren","year":"2011","journal-title":"Pharm Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0830","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-13-476","article-title":"Chemotherapy-induced hyaluronan production: a novel chemoresistance mechanism in ovarian cancer","volume":"13","author":"Ricciardelli","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0835","first-page":"1195","article-title":"Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin","volume":"32","author":"Riehm","year":"1972","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0840","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/jnci\/83.4.288","article-title":"Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol","volume":"83","author":"Ringel","year":"1991","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0845","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1046\/j.1365-2362.1999.00495.x","article-title":"Multidrug resistance in oncology: diagnostic and therapeutic approaches","volume":"29","author":"Robert","year":"1999","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0850","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.med.48.1.353","article-title":"The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents","volume":"48","author":"Rowinsky","year":"1997","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0855","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1042\/BSR20130067","article-title":"Multidrug resistance in chronic myeloid leukaemia: how much can we learn from MDR-CML cell lines?","volume":"33","author":"Rumjanek","year":"2013","journal-title":"Biosci Rep"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0860","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.canlet.2013.09.037","article-title":"Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: a promising strategy to overcome drug resistance in cancer","volume":"343","author":"Salzano","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0865","first-page":"119","article-title":"Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: preparation, in vitro and ex vivo evaluation","volume":"6","author":"Saremi","year":"2011","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb9020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/10717544.2012.674163","article-title":"PEG-PE-based micelles co-loaded with paclitaxel and cyclosporine A or loaded with paclitaxel and targeted by anticancer antibody overcome drug resistance in cancer cells","volume":"19","author":"Sarisozen","year":"2012","journal-title":"Drug Deliv"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0870","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3109\/10717544.2012.724473","article-title":"Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance","volume":"19","author":"Sarisozen","year":"2012","journal-title":"Drug Deliv"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0875","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1365-2559.2004.01899.x","article-title":"Increased cell size and Akt activation in HER-2\/neu-overexpressing invasive ductal carcinoma of the breast","volume":"45","author":"Sastre-Garau","year":"2004","journal-title":"Histopathology"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0880","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1073\/pnas.94.8.4028","article-title":"Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins","volume":"94","author":"Schinkel","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0885","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.drup.2011.01.003","article-title":"Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance","volume":"14","author":"Shapira","year":"2011","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0890","first-page":"5877","article-title":"Antitumor Effect of Taxol-Containing Liposomes in a Taxol-Resistant Murine Tumor-Model","volume":"53","author":"Sharma","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0895","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s002800000155","article-title":"Multiple factors other than p53 influence colon cancer sensitivity to paclitaxel","volume":"46","author":"Sharma","year":"2000","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0900","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1124\/jpet.107.127704","article-title":"Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells","volume":"324","author":"Shen","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0910","doi-asserted-by":"crossref","first-page":"8613","DOI":"10.1016\/j.biomaterials.2012.08.007","article-title":"Co-delivery of paclitaxel and survivin shRNA by Pluronic P85-PEI\/TPGS complex nanoparticles to overcome drug resistance in lung cancer","volume":"33","author":"Shen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0915","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jconrel.2012.05.013","article-title":"Multifunctional drug delivery system for targeting tumor and its acidic microenvironment","volume":"161","author":"Shen","year":"2012","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0905","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1021\/mp400576f","article-title":"iRGD conjugated TPGS mediates codelivery of paclitaxel and survivin shRNA for the reversal of lung cancer resistance","volume":"11","author":"Shen","year":"2014","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0920","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/mp0500420","article-title":"Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations","volume":"2","author":"Shenoy","year":"2005","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0925","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s11095-005-8343-0","article-title":"Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: Part 2. In vivo distribution and tumor localization studies","volume":"22","author":"Shenoy","year":"2005","journal-title":"Pharm Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0935","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4161\/cbt.5.1.2236","article-title":"Reversal of MDR1\/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo","volume":"5","author":"Shi","year":"2006","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0930","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1349-7006.2007.00554.x","article-title":"Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells","volume":"98","author":"Shi","year":"2007","journal-title":"Cancer Sci"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0940","doi-asserted-by":"crossref","first-page":"11012","DOI":"10.1158\/0008-5472.CAN-07-2686","article-title":"Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance","volume":"67","author":"Shi","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0945","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.bcp.2008.11.007","article-title":"Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478","volume":"77","author":"Shi","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0950","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1158\/0008-5472.CAN-10-3820","article-title":"Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance","volume":"71","author":"Shi","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0955","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s10549-012-2196-0","article-title":"Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production","volume":"135","author":"Shi","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0960","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/jps.20017","article-title":"Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes","volume":"93","author":"Shono","year":"2004","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0965","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.leukres.2013.06.014","article-title":"XIAP and P-glycoprotein co-expression is related to imatinib resistance in chronic myeloid leukemia cells","volume":"37","author":"Silva","year":"2013","journal-title":"Leuk Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0970","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.addr.2003.10.038","article-title":"On the formulation of pH-sensitive liposomes with long circulation times","volume":"56","author":"Simoes","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb9015","doi-asserted-by":"crossref","first-page":"e26803","DOI":"10.1371\/journal.pone.0026803","article-title":"Long circulating lectin conjugated paclitaxel loaded magnetic nanoparticles: a new theranostic avenue for leukemia therapy","volume":"6","author":"Singh","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0975","first-page":"136","article-title":"Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors","volume":"2014","author":"Siveen","year":"1845","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0985","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1073\/pnas.0931245100","article-title":"Delivery of bioactive molecules to mitochondria in vivo","volume":"100","author":"Smith","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0980","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/annonc\/mdq430","article-title":"First-line bevacizumab plus taxane-based chemotherapy for locally recurrent or metastatic breast cancer: safety and efficacy in an open-label study in 2251 patients","volume":"22","author":"Smith","year":"2011","journal-title":"Ann Oncol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0990","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.mito.2012.10.013","article-title":"In Vitro assessment of the utility of stearyl triphenyl phosphonium modified liposomes in overcoming the resistance of ovarian carcinoma Ovcar-3 cells to paclitaxel","volume":"13","author":"Solomon","year":"2013","journal-title":"Mitochondrion"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb0995","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.biomaterials.2009.11.067","article-title":"Anti-HIF-1alpha antibody-conjugated Pluronic triblock copolymers encapsulated with Paclitaxel for tumor targeting therapy","volume":"31","author":"Song","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1000","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1038\/onc.2011.23","article-title":"Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer","volume":"30","author":"Sreekanth","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1005","first-page":"95","article-title":"Cellular mechanisms of multidrug resistance of tumor cells","volume":"65","author":"Stavrovskaya","year":"2000","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1010","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.2147\/IJN.S33666","article-title":"PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells","volume":"7","author":"Su","year":"2012","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1015","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1158\/0008-5472.CAN-03-2013","article-title":"Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint","volume":"64","author":"Sudo","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1020","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.1183057","article-title":"Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs","volume":"328","author":"Sugahara","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1025","doi-asserted-by":"crossref","first-page":"e55576","DOI":"10.1371\/journal.pone.0055576","article-title":"Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1030","doi-asserted-by":"crossref","first-page":"7299","DOI":"10.1158\/1078-0432.CCR-09-1745","article-title":"Targeted Drug and Gene Delivery Systems for Lung Cancer Therapy","volume":"15","author":"Sundaram","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1035","first-page":"2121","article-title":"In vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene","volume":"59","author":"Tai","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1040","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1158\/1535-7163.MCT-04-0282","article-title":"Cyclin A-associated kinase activity is needed for paclitaxel sensitivity","volume":"4","author":"Takahashi","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1045","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jconrel.2012.06.019","article-title":"Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy","volume":"162","author":"Takara","year":"2012","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1050","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1021\/bm301661w","article-title":"Key structure of Brij for overcoming multidrug resistance in cancer","volume":"14","author":"Tang","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1055","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1038\/sj.onc.1206940","article-title":"The role of glutathione-S-transferase in anti-cancer drug resistance","volume":"22","author":"Townsend","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1060","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/jnci\/djm135","article-title":"Drug resistance and the solid tumor microenvironment","volume":"99","author":"Tredan","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1070","first-page":"4730","article-title":"Increased accumulation of vincristine and adriamycin in drug-resistant P388-tumor cells following incubation with calcium-antagonists and calmodulin inhibitors","volume":"42","author":"Tsuruo","year":"1982","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1080","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1158\/0008-5472.CAN-06-1648","article-title":"Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer","volume":"67","author":"van Vlerken","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1075","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1021\/mp800030k","article-title":"Biodistribution and pharmacokinetic analysis of Paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model","volume":"5","author":"van Vlerken","year":"2008","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1085","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0891-5849(01)00616-5","article-title":"Direct effect of Taxol on free radical formation and mitochondrial permeability transition","volume":"31","author":"Varbiro","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1090","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/S0026-895X(25)09612-9","article-title":"Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance","volume":"50","author":"Vasey","year":"1996","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1100","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.semradonc.2004.04.008","article-title":"Tumor microenvironmental physiology and its implications for radiation oncology","volume":"14","author":"Vaupel","year":"2004","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb9030","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.nano.2011.10.014","article-title":"Lapatinib\/Paclitaxel polyelectrolyte nanocapsules for overcoming multidrug resistance in ovarian cancer","volume":"8","author":"Vergara","year":"2012","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1105","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1158\/1535-7163.MCT-05-0086","article-title":"Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C-6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein","volume":"4","author":"Voelkel-Johnson","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1110","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/bjc.1997.201","article-title":"Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan","volume":"75","author":"Vukovic","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1145","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nmat1737","article-title":"Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer","volume":"5","author":"Wang","year":"2006","journal-title":"Nat Mater"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1135","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1021\/nn900649v","article-title":"HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors","volume":"3","author":"Wang","year":"2009","journal-title":"ACS Nano"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1120","doi-asserted-by":"crossref","first-page":"9444","DOI":"10.1016\/j.biomaterials.2011.08.041","article-title":"Synergistic effect of folate-mediated targeting and verapamil-mediated P-gp inhibition with paclitaxel -polymer micelles to overcome multi-drug resistance","volume":"32","author":"Wang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1130","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1021\/nn200739q","article-title":"A folate receptor-targeting nanoparticle minimizes drug resistance in a human cancer model","volume":"5","author":"Wang","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1140","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/030089161109700209","article-title":"AKT signaling pathway in invasive ductal carcinoma of the breast: correlation with ERa, ERbeta and HER-2 expression","volume":"97","author":"Wang","year":"2011","journal-title":"Tumori"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1150","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1016\/j.biomaterials.2012.03.013","article-title":"Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors","volume":"33","author":"Wang","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1115","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1021\/mp400022h","article-title":"Multifunctional nanoparticles based on a single-molecule modification for the treatment of drug-resistant cancer","volume":"10","author":"Wang","year":"2013","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1125","doi-asserted-by":"crossref","first-page":"e86369","DOI":"10.1371\/journal.pone.0086369","article-title":"Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1155","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1021\/ja00738a045","article-title":"Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia","volume":"93","author":"Wani","year":"1971","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1160","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ejpb.2010.04.017","article-title":"Enhanced antitumor efficacy by Paclitaxel-loaded Pluronic P123\/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance","volume":"75","author":"Wei","year":"2010","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1165","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jconrel.2005.11.011","article-title":"Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine","volume":"111","author":"Werle","year":"2006","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1170","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1021\/jm100509v","article-title":"Folate-targeted therapies for cancer","volume":"53","author":"Xia","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1175","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1016\/j.biomaterials.2011.03.071","article-title":"Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles","volume":"32","author":"Xiao","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1180","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00280-008-0790-y","article-title":"Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells","volume":"63","author":"Yadav","year":"2009","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2007.08.021","article-title":"Effect of excipients on breast cancer resistance protein substrate uptake activity","volume":"124","author":"Yamagata","year":"2007","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1190","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.1016\/j.biomaterials.2013.05.036","article-title":"The use of HA oligosaccharide-loaded nanoparticles to breach the endogenous hyaluronan glycocalyx for breast cancer therapy","volume":"34","author":"Yang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1195","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1016\/j.biomaterials.2011.01.038","article-title":"The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery","volume":"32","author":"Yao","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1200","first-page":"1733","article-title":"Increased hyaluronan at sites of attachment to mesentery by CD44-positive mouse ovarian and breast tumor cells","volume":"148","author":"Yeo","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1205","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1016\/j.biomaterials.2013.06.058","article-title":"Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours","volume":"34","author":"Yim","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1210","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/18\/49\/495101","article-title":"High cytotoxicity and resistant-cell reversal of novel paclitaxel loaded micelles by enhancing the molecular-target delivery of the drug","volume":"18","author":"You","year":"2007","journal-title":"Nanotechnology"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1220","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1182\/blood-2012-01-407742","article-title":"Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia","volume":"121","author":"Yu","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1225","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10555-012-9402-8","article-title":"Reversal of ATP-binding cassette drug transporter activity to modulate chemoresistance: why has it failed to provide clinical benefit?","volume":"32","author":"Yu","year":"2013","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb9035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/mabi.201300282","article-title":"Reversal of Lung Cancer Multidrug Resistance by pH-Responsive Micelleplexes Mediating Co-Delivery of siRNA and Paclitaxel","volume":"14","author":"Yu","year":"2014","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1568009033333754","article-title":"Paclitaxel resistance: molecular mechanisms and pharmacologic manipulation","volume":"3","author":"Yusuf","year":"2003","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb9040","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1021\/mp100323z","article-title":"Combination Drug Delivery Strategy for the Treatment of Multidrug Resistant Ovarian Cancer","volume":"8","author":"Zahedi","year":"2011","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1235","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1021\/mp7001347","article-title":"P-glycoprotein efflux inhibition by amphiphilic diblock copolymers: relationship between copolymer concentration and substrate hydrophobicity","volume":"5","author":"Zastre","year":"2008","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1245","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1158\/1541-7786.MCR-08-0410","article-title":"Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo","volume":"7","author":"Zhang","year":"2009","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb9050","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.actbio.2009.11.035","article-title":"A novel paclitaxel-loaded poly(epsilon-caprolactone)\/Poloxamer 188 blend nanoparticle overcoming multidrug resistance for cancer treatment","volume":"6","author":"Zhang","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1250","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1016\/j.biomaterials.2010.12.039","article-title":"Multifunctional Pluronic P123\/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors","volume":"32","author":"Zhang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1255","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1016\/j.biomaterials.2012.03.046","article-title":"Vitamin E TPGS as a molecular biomaterial for drug delivery","volume":"33","author":"Zhang","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1240","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1016\/j.biomaterials.2014.01.046","article-title":"Targeting fibronectins of glioma extracellular matrix by CLT1 peptide-conjugated nanoparticles","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1265","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1021\/bm301718f","article-title":"Folic acid modified cationic gamma-cyclodextrin-oligoethylenimine star polymer with bioreducible disulfide linker for efficient targeted gene delivery","volume":"14","author":"Zhao","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1260","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.biomaterials.2013.10.044","article-title":"Supramolecular self-assembly forming a multifunctional synergistic system for targeted co-delivery of gene and drug","volume":"35","author":"Zhao","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1270","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1006\/bbrc.2001.4268","article-title":"Study of multi-drug resistant mechanisms in a taxol-resistant hepatocellular carcinoma QGY-TR 50 cell line","volume":"280","author":"Zhou","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1285","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bcp.2008.12.005","article-title":"Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance","volume":"77","author":"Zhou","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1280","first-page":"721","article-title":"Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma","volume":"38","author":"Zhou","year":"2011","journal-title":"Int J Oncol"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1275","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1016\/j.biomaterials.2013.01.078","article-title":"The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer","volume":"34","author":"Zhou","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1290","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/j.biomaterials.2009.11.077","article-title":"Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA-PCL-PDMAEMA triblock copolymers","volume":"31","author":"Zhu","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2014.10.011_bb1295","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.biomaterials.2013.11.086","article-title":"Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance","volume":"35","author":"Zhu","year":"2014","journal-title":"Biomaterials"}],"container-title":["Biotechnology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975014001608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975014001608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T01:15:49Z","timestamp":1746494149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0734975014001608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":263,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0734975014001608"],"URL":"https:\/\/doi.org\/10.1016\/j.biotechadv.2014.10.011","relation":{},"ISSN":["0734-9750"],"issn-type":[{"value":"0734-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer","name":"articletitle","label":"Article Title"},{"value":"Biotechnology Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biotechadv.2014.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}