{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:49:32Z","timestamp":1786985372380,"version":"build-2736575974"},"reference-count":78,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biotechnology Advances"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.biotechadv.2015.08.006","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T22:13:24Z","timestamp":1441318404000},"page":"1641-1652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Rules for biocatalyst and reaction engineering to implement effective, NAD(P)H-dependent, whole cell bioreductions"],"prefix":"10.1016","volume":"33","author":[{"given":"Regina","family":"Kratzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Woodley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Nidetzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biotechadv.2015.08.006_bb0005","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0167-7799(03)00144-6","article-title":"Towards large-scale synthetic applications of Baeyer\u2013Villiger monooxygenases","volume":"21","author":"Alphand","year":"2003","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0010","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1021\/op800046t","article-title":"The first 200-L scale asymmetric Baeyer\u2013Villiger oxidation using a whole-cell biocatalyst","volume":"12","author":"Baldwin","year":"2008","journal-title":"Org. Process. Res. Dev."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0015","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/nbt1029","article-title":"Recombinant protein folding and misfolding in Escherichia coli","volume":"22","author":"Baneyx","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0020","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/bit.21837","article-title":"Metabolic capacity estimation of Escherichia coli as a platform for redox biocatalysis: constraint-based modeling and experimental verification","volume":"100","author":"Blank","year":"2008","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0025","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1039\/b111064k","article-title":"Screening of yeast species for the stereo-selective reduction of bicyclo[2.2.2]octane-2,6-dione","volume":"1","author":"Botes","year":"2002","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0030","author":"Brown"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00253-006-0378-6","article-title":"In situ product recovery (ISPR) by crystallization: basic principles, design, and potential applications in whole-cell biocatalysis","volume":"71","author":"Buque-Taboada","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0040","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1007\/s00253-006-0811-x","article-title":"Permeability issues in whole-cell bioprocesses and cellular membrane engineering","volume":"74","author":"Chen","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0045","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.ces.2005.03.031","article-title":"Production of recombinant proteins by high cell density culture of Escherichia coli","volume":"61","author":"Choi","year":"2006","journal-title":"Chem. Eng. Sci."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0050","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00449-002-0281-1","article-title":"Scale-down studies on the hydrodynamics of two-liquid phase biocatalytic reactors","volume":"25","author":"Cull","year":"2002","journal-title":"Bioprocess Biosyst. Eng."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0055","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/ja00783a034","article-title":"Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and \u0251-methoxy-\u0251-trifluoromethylphenylacetate (MTPA) esters","volume":"95","author":"Dale","year":"1973","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0060","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1128\/AAC.44.11.2969-2978.2000","article-title":"Stages of polymyxin B interaction with the Escherichia coli cell envelope","volume":"44","author":"Daugelavi\u010dius","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0065","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0167-7799(98)01234-7","article-title":"Solvent-tolerant bacteria in biocatalysis","volume":"16","author":"De Bont","year":"1998","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0070","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1021\/bp0200954","article-title":"Reactor operation and scale-up of whole cell Baeyer\u2013Villiger catalyzed lactone synthesis","volume":"18","author":"Doig","year":"2002","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0075","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/bit.24896","article-title":"Scale-up and intensification of (S)-1-(2-chlorophenyl)ethanol bioproduction: economic evaluation of whole cell-catalyzed reduction of o-chloroacetophenone","volume":"110","author":"Eixelsberger","year":"2013","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0080","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1002\/adsc.200800292","article-title":"Highly efficient chemoenzymatic synthesis of methyl (R)-o-chloromandelate, a key intermediate for clopidogrel, via asymmetric reduction with recombinant Escherichia coli","volume":"350","author":"Ema","year":"2008","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0085","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.drudis.2006.09.012","article-title":"In search of sustainability: process R&D in light of current pharmaceutical industry challenges","volume":"11","author":"Federsel","year":"2006","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0090","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00253-007-1005-x","article-title":"Biocatalytic ketone reduction - a powerful tool for the production of chiral alcohols-part II: whole-cell reductions","volume":"76","author":"Goldberg","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0095","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1002\/anie.200503394","article-title":"Enantioselective reduction of ketones with \u201cdesigner cells\u201d at high substrate concentrations: highly efficient access to functionalized optically active alcohols","volume":"45","author":"Gr\u00f6ger","year":"2006","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0100","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/biot.201200322","article-title":"Harnessing Candida tenuis and Pichia stipitis in whole-cell bioreductions of o-chloroacetophenone: stereoselectivity, cell activity, in situ substrate supply and product removal","volume":"8","author":"Gruber","year":"2013","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0105","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1515\/BC.1999.179","article-title":"Xylose utilisation: cloning and characterisation of the xylose reductase from Candida tenuis","volume":"380","author":"H\u00e4cker","year":"1999","journal-title":"Biol. Chem."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0110","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1016\/j.tetasy.2006.11.018","article-title":"Asymmetric whole-cell bioreduction of an \u03b1, \u03b2-unsaturated aldehyde (citral): competing prim-alcohol dehydrogenase and C-C lyase activities","volume":"17","author":"Hall","year":"2006","journal-title":"Tetrahedron Asymmetry"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0115","first-page":"4","article-title":"New coexpression vectors for expanded compatibilities in E. coli","volume":"18","author":"Held","year":"2003","journal-title":"Novagen InNovations Newsletter"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0120","unstructured":"Held D, Yaeger K, Novy R. pCOLADuet\u2122-1, a lower-copy, KanR vector option for coexpression in E. coli. Novagen InNovations Newsletter 2004;19:17\u201319."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0125","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.tet.2003.10.123","article-title":"Rapid identification of enantioselective ketone reductions using targeted microbial libraries","volume":"60","author":"Homann","year":"2004","journal-title":"Tetrahedron"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0130","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/bit.21697","article-title":"Scale-up of Escherichia coli growth and recombinant protein expression conditions from microwell to laboratory and pilot scale based on matched kLa","volume":"99","author":"Islam","year":"2008","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0135","series-title":"Enzyme Assays","first-page":"77","article-title":"High-throughput screening methods developed for oxidoreductases","author":"Johannes","year":"2006"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0140","doi-asserted-by":"crossref","first-page":"12827","DOI":"10.1021\/ja0469479","article-title":"Systematic investigation of Saccharomyces cerevisiae enzymes catalyzing carbonyl reductions","volume":"126","author":"Kaluzna","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0145","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s002530051118","article-title":"Enzymatic production of ethyl (R)-4-chloro-3-hydroxybutanoate: asymmetric reduction of ethyl 4-chloro-3-oxobutanoate by an Escherichia coli transformant expressing the aldehyde reductase gene from yeast","volume":"48","author":"Kataoka","year":"1997","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00253-003-1347-y","article-title":"Novel bioreduction system for the production of chiral alcohols","volume":"62","author":"Kataoka","year":"2003","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0155","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00253-003-1470-9","article-title":"Metabolic engineering of Escherichia coli: construction of an efficient biocatalyst for d-mannitol formation in a whole-cell biotransformation","volume":"64","author":"Kaup","year":"2004","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0160","first-page":"237","article-title":"Membrane transporter engineering in industrial biotechnology and whole cell","volume":"33","author":"Kell","year":"2015","journal-title":"Biocatalysis"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0165","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1389-1723(00)87085-1","article-title":"Diversity of 4-chloroacetoacetate ethyl ester-reducing enzymes in yeasts and their application to chiral alcohol synthesis","volume":"88","author":"Kita","year":"1999","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0170","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s002530100599","article-title":"Synthesis of optically pure ethyl (S)-4-chloro-3-hydroxybutanoate by Escherichia coli transformant cells coexpressing the carbonyl reductase and glucose dehydrogenase genes","volume":"55","author":"Kizaki","year":"2001","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0175","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1039\/B616475G","article-title":"Identification of Candida tenuis xylosereductase as highly selective biocatalyst for the synthesis ofchiral \u03b1-hydroxy esters and improvement of its efficiency by protein engineering","volume":"10","author":"Kratzer","year":"2007","journal-title":"Chem. Commun."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1475-2859-7-37","article-title":"Whole-cell bioreduction of aromatic \u03b1-keto esters using Candida tenuis xylose reductase and Candida boidinii formate dehydrogenase co-expressed in Escherichia coli","volume":"7","author":"Kratzer","year":"2008","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0185","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/bit.23002","article-title":"Enzyme identification and development of a whole-cell biotransformation for asymmetric reduction of o-chloroacetophenone","volume":"108","author":"Kratzer","year":"2011","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0190","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0195","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1007\/BF00758518","article-title":"Stability in aqueous solutions and acidic properties of carbenicillin","volume":"10","author":"Lapidus","year":"1976","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0200","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/cssc.200800032","article-title":"An exceptionally DMSO-tolerant alcohol dehydrogenase for the stereoselective reduction of ketones","volume":"1","author":"Lavandera","year":"2008","journal-title":"ChemSusChem"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0205","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1126\/science.1199098","article-title":"pH-Dependent gating in a FocA formate channel","volume":"332","author":"L\u00fc","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2859-11-7","article-title":"Host cell and expression engineering for development of an E. coli ketoreductase catalyst: enhancement of formate dehydrogenase activity for regeneration of NADH","volume":"11","author":"M\u00e4dje","year":"2012","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0215","series-title":"Advanced Organic Chemistry: Reactions, Mechanisms and Structure","first-page":"910","author":"March","year":"1992"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0220","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tetasy.2008.12.035","article-title":"Recent progress in biocatalysis for asymmetric oxidation and reduction","volume":"20","author":"Matsuda","year":"2009","journal-title":"Tetrahedron Asymmetry"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0225","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1021\/ar700167a","article-title":"Advances in the enzymatic reduction of ketones","volume":"40","author":"Moore","year":"2007","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0230","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/cctc.200900033","article-title":"A single point mutation reverses the enantiopreference of Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase","volume":"1","author":"Musa","year":"2009","journal-title":"ChemCatChem"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0235","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/(SICI)1097-0290(19981105)60:3<277::AID-BIT2>3.0.CO;2-E","article-title":"A pH-controlled fed-batch process can overcome inhibition by formate in NADH-dependent enzymatic reductions using formate dehydrogenase-catalyzed coenzyme regeneration","volume":"60","author":"Neuhauser","year":"1998","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0240","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00253-010-2941-4","article-title":"Biocatalytic properties of a recombinant aldo-keto reductase with broad substrate spectrum and excellent stereoselectivity","volume":"89","author":"Ni","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0245","series-title":"The 10 Best Selling Pharmaceutical Drugs in History","author":"Nixon","year":"2013"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0250","first-page":"2","article-title":"Coexpression of multiple target proteins in E. coli","volume":"15","author":"Novy","year":"2002","journal-title":"Novagen InNovations Newsletter"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0255","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/BJ20040363","article-title":"The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography","volume":"385","author":"Petschacher","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0260","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tibtech.2006.12.005","article-title":"Biocatalysis for pharmaceutical intermediates: the future is now","volume":"25","author":"Pollard","year":"2007","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0265","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1111\/j.1365-2958.1991.tb01989.x","article-title":"Mechanism of regulation of the formate-hydrogenlyase pathway by oxygen, nitrate, and pH: definition of the formate regulon","volume":"5","author":"Rossmann","year":"1991","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0270","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jbiotec.2011.09.029","article-title":"Coupling of permeabilized cells of Gluconobacter oxydans and Ralstonia eutropha for asymmetric ketone reduction using H2 as reductant","volume":"157","author":"Rundb\u00e4ck","year":"2012","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0275","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1016\/j.bmcl.2009.06.084","article-title":"Imidazopyridine derivatives as potent and selective polo-like kinase (PLK) inhibitors","volume":"19","author":"Sato","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0280","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1042\/BST0330042","article-title":"Formate and its role in hydrogen production in Escherichia coli","volume":"33","author":"Sawers","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0285","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1021\/bi9723055","article-title":"Mutagenesis of 3\u0251-hydroxysteroid dehydrogenase reveals a \u201cpush-pull\u201d mechanism for proton transfer in aldo-keto reductases","volume":"37","author":"Schlegel","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0290","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/35051736","article-title":"Industrial biocatalysis today and tomorrow","volume":"409","author":"Schmid","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0295","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.biortech.2012.01.009","article-title":"Bioprocess design guided by in situ substrate supply and product removal: process intensification for synthesis of (S)-1-(2-chlorophenyl)ethanol","volume":"108","author":"Schm\u00f6lzer","year":"2012","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0300","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jbiotec.2007.08.003","article-title":"Continuous asymmetric ketone reduction processes with recombinant Escherichia coli","volume":"132","author":"Schroer","year":"2007","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0305","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biotechadv.2005.04.004","article-title":"Growing E. coli to high cell density \u2014 a historical perspective on method development","volume":"23","author":"Shiloach","year":"2005","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0310","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1128\/AEM.56.8.2374-2377.1990","article-title":"Stereoselective reduction of ethyl 4-chloro-3-oxobutanoate by a microbial aldehyde reductase in a solvent-water diphasic system","volume":"56","author":"Shimizu","year":"1990","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0315","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1016\/S0021-9258(17)37154-5","article-title":"Interactions of cyclic hydrocarbons with biological membranes","volume":"269","author":"Sikkema","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0320","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jbiotec.2004.08.004","article-title":"Advanced genetic strategies for recombinant protein expression in Escherichia coli","volume":"115","author":"S\u00f8rensen","year":"2005","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0325","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/adsc.200303210","article-title":"Simple biocatalytic access to enantiopure (S)-1-heteroarylethanols employing a microbial hydrogen transfer reaction","volume":"346","author":"Stampfer","year":"2004","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0330","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1038\/ncomms5150","article-title":"Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations","volume":"5","author":"Steinkellner","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0335","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0958-1669(02)00360-9","article-title":"The production of fine chemicals by biotransformations","volume":"13","author":"Straathof","year":"2002","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0340","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1021\/cen-v084n033.p026","article-title":"Competitors want to get a piece of Lipitor","volume":"84","author":"Thayer","year":"2006","journal-title":"Chem. Eng. News"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0345","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bioeng.2006.02.003","article-title":"Protein engineering of formate dehydrogenase","volume":"23","author":"Tishkov","year":"2006","journal-title":"Biomol. Eng."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0350","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nmeth0106-55","article-title":"Strategies for protein coexpression in Escherichia coli","volume":"3","author":"Tolia","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0355","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.1962206","article-title":"The atom economy - a search for synthetic efficiency","volume":"254","author":"Trost","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0360","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/bit.23154","article-title":"Process considerations for the asymmetric synthesis of chiral amines using transaminases","volume":"108","author":"Tufvesson","year":"2011","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0365","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0141-0229(96)00177-9","article-title":"Large-scale stereoselective enzymatic ketone reduction with in situ product removal via polymeric adsorbent resins","volume":"20","author":"Vicenzi","year":"1997","journal-title":"Enzym. Microb. Technol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0370","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/jctb.1761","article-title":"Interfacing biocatalysis and organic synthesis","volume":"82","author":"Wohlgemuth","year":"2007","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0375","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1021\/bp0600583","article-title":"Asymmetric reduction of o-chloroacetophenone with Candida pseudotropicalis 104","volume":"22","author":"Xie","year":"2006","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0380","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s002530051433","article-title":"Glucose overflow metabolism and mixed-acid fermentation in aerobic large-scale fed-batch processes with Escherichia coli","volume":"51","author":"Xu","year":"1999","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0385","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s002530051472","article-title":"Synthesis of optically active ethyl 4-chloro-3-hydroxybutanoate by microbial reduction","volume":"51","author":"Yasohara","year":"1999","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biotechadv.2015.08.006_bb0390","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1128\/AEM.02519-08","article-title":"Ser67Asp and His68Asp substitutions in Candida parapsilosis carbonyl reductase alter the coenzyme specificity and enantioselectivity of ketone reduction","volume":"75","author":"Zhang","year":"2009","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Biotechnology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073497501530032X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073497501530032X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T07:09:06Z","timestamp":1653116946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073497501530032X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":78,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S073497501530032X"],"URL":"https:\/\/doi.org\/10.1016\/j.biotechadv.2015.08.006","relation":{},"ISSN":["0734-9750"],"issn-type":[{"value":"0734-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rules for biocatalyst and reaction engineering to implement effective, NAD(P)H-dependent, whole cell bioreductions","name":"articletitle","label":"Article Title"},{"value":"Biotechnology Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biotechadv.2015.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}