{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:02:20Z","timestamp":1791511340608,"version":"4.3.4"},"reference-count":223,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["MOE 108QR001I5"],"award-info":[{"award-number":["MOE 108QR001I5"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG310181"],"award-info":[{"award-number":["CMRPG310181"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3F1113"],"award-info":[{"award-number":["CMRPG3F1113"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2923-E-007-002-MY3"],"award-info":[{"award-number":["105-2923-E-007-002-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2221-E-007-046-MY3"],"award-info":[{"award-number":["107-2221-E-007-046-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2622-8-007-015"],"award-info":[{"award-number":["107-2622-8-007-015"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-3017-F-007-002"],"award-info":[{"award-number":["107-3017-F-007-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108-3017-F-007-003"],"award-info":[{"award-number":["108-3017-F-007-003"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biotechnology Advances"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.biotechadv.2019.107447","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T11:17:36Z","timestamp":1568027856000},"page":"107447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["CRISPR technologies for stem cell engineering and regenerative medicine"],"prefix":"10.1016","volume":"37","author":[{"given":"Mu-Nung","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Han","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Anh","family":"Truong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Liang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u1ecb Kieu Nuong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-4467","authenticated-orcid":false,"given":"Yu-Chen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biotechadv.2019.107447_bb0005","doi-asserted-by":"crossref","first-page":"aaf5573","DOI":"10.1126\/science.aaf5573","article-title":"C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector","volume":"353","author":"Abudayyeh","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0010","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/stem.2931","article-title":"Step-wise chondrogenesis of human induced pluripotent stem cells and purification via a reporter allele generated by CRISPR-Cas9 genome editing","volume":"37","author":"Adkar","year":"2019","journal-title":"Stem Cells"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0015","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/mt.2012.286","article-title":"Baculovirus: an insect-derived vector for diverse gene transfer applications","volume":"21","author":"Airenne","year":"2013","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0020","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.aau1549","article-title":"Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy","volume":"362","author":"Amoasii","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0025","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nprot.2017.143","article-title":"CRISPR\/Cas9 genome editing in human hematopoietic stem cells","volume":"13","author":"Bak","year":"2018","journal-title":"Nat Protoc"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0030","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/mt.2015.220","article-title":"In vivo CRISPR\/Cas9 gene editing corrects retinal dystrophy in the S334ter-3 rat model of autosomal dominant retinitis pigmentosa","volume":"24","author":"Bakondi","year":"2016","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0035","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.stemcr.2015.08.001","article-title":"Conditionally stabilized dCas9 activator for controlling gene expression in human cell reprogramming and differentiation","volume":"5","author":"Balboa","year":"2015","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2147\/IJN.S95077","article-title":"Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics","volume":"10","author":"Bayarsaikhan","year":"2016","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0045","article-title":"Muscle-specific CRISPR\/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy","volume":"8","author":"Bengtsson","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0050","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1073\/pnas.0408742102","article-title":"Regulation of osteoblastogenesis and bone mass by Wnt10b","volume":"102","author":"Bennett","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0055","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2018.03.052","article-title":"An integrated genome-wide CRISPRa approach to functionalize lncRNAs in drug resistance","volume":"173","author":"Bester","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0060","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.stem.2016.07.001","article-title":"Targeted epigenetic remodeling of endogenous loci by CRISPR\/Cas9-based transcriptional activators directly converts fibroblasts to neuronal cells","volume":"19","author":"Black Joshua","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0065","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ymthe.2019.03.007","article-title":"Clinically relevant correction of recessive dystrophic epidermolysis bullosa by dual sgRNA CRISPR\/Cas9-mediated gene editing","volume":"27","author":"Bonafont","year":"2019","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0070","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biotechadv.2014.12.006","article-title":"The CRISPR\/Cas9 system for plant genome editing and beyond","volume":"33","author":"Bortesi","year":"2015","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0075","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/art.39982","article-title":"CRISPR\/Cas9 editing of murine induced pluripotent stem cells for engineering inflammation-resistant tissues","volume":"69","author":"Brunger","year":"2017","journal-title":"Arthrit Rheum"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0080","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.coph.2018.07.003","article-title":"Will iPSC-cardiomyocytes revolutionize the discovery of drugs for heart disease?","volume":"42","author":"Bruyneel","year":"2018","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0085","first-page":"e149","article-title":"An easy and efficient inducible CRISPR\/Cas9 platform with improved specificity for multiple gene targeting","volume":"44","author":"Cao","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01875-9","article-title":"Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editing","volume":"8","author":"Carlson-Stevermer","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0095","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.stemcr.2014.09.013","article-title":"A CRISPR\/Cas9-based system for reprogramming cell lineage specification","volume":"3","author":"Chakraborty","year":"2014","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0100","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/stem.2915","article-title":"SOX2 activation using CRISPR\/dCas9 promotes wound healing in corneal endothelial cells","volume":"36","author":"Chang","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41591-018-0326-x","article-title":"Identification of preexisting adaptive immunity to Cas9 proteins in humans","volume":"25","author":"Charlesworth","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0110","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nmeth.3312","article-title":"Highly efficient Cas9-mediated transcriptional programming","volume":"12","author":"Chavez","year":"2015","journal-title":"Nat Meth"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0115","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nmeth.3871","article-title":"Comparison of Cas9 activators in multiple species","volume":"13","author":"Chavez","year":"2016","journal-title":"Nat Meth"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0120","doi-asserted-by":"crossref","first-page":"10548","DOI":"10.1128\/JVI.01250-09","article-title":"Baculovirus transduction of mesenchymal stem cells triggers the toll-like receptor 3 (TLR3) pathway","volume":"83","author":"Chen","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0125","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.biotechadv.2011.04.004","article-title":"Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications","volume":"29","author":"Chen","year":"2011","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0130","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/mp100368d","article-title":"Biosafety assessment of human mesenchymal stem cells engineered by hybrid baculovirus vectors","volume":"8","author":"Chen","year":"2011","journal-title":"Mol Pharmaceut"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1408","article-title":"Immunity to CRISPR Cas9 and Cas12a therapeutics","volume":"10","author":"Chew","year":"2018","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0140","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nmeth.3993","article-title":"A multifunctional AAV\u2013CRISPR\u2013Cas9 and its host response","volume":"13","author":"Chew","year":"2016","journal-title":"Nat Meth"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.omtn.2017.04.001","article-title":"CRISPR\/Cas9: Transcending the reality of genome editing","volume":"7","author":"Chira","year":"2017","journal-title":"Mol Ther-Nucleic Acids"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0150","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nbt.2507","article-title":"Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease","volume":"31","author":"Cho","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0155","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/mt.2009.30","article-title":"Baculovirus transduction of mesenchymal stem cells: In vitro responses and in vivo immune responses after cell transplantation","volume":"17","author":"Chuang","year":"2009","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0160","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/bit.26056","article-title":"Enhanced integration of large DNA into E. coli chromosome by CRISPR\/Cas9","volume":"114","author":"Chung","year":"2017","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0165","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0170","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1126\/science.aaq0180","article-title":"RNA editing with CRISPR-Cas13","volume":"358","author":"Cox","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0175","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12934-016-0623-3","article-title":"CRISPRi-mediated metabolic engineering of E. coli for O-methylated anthocyanin production","volume":"16","author":"Cress","year":"2017","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0180","article-title":"CRISPR\/Cas9-mediated editing for dominant genetic disorders: efficient excision of trinucleotide repeat expansion in myotonic dystrophy","volume":"28","author":"Dastidar","year":"2017","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0185","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature20134","article-title":"CRISPR\/Cas9 \u03b2-globin gene targeting in human haematopoietic stem cells","volume":"539","author":"Dever","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0190","doi-asserted-by":"crossref","first-page":"360ra134","DOI":"10.1126\/scitranslmed.aaf9336","article-title":"Selection-free genome editing of the sickle mutation in human adult hematopoietic stem\/progenitor cells","volume":"8","author":"DeWitt","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0195","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nbt.3155","article-title":"Inducible in vivo genome editing with CRISPR-Cas9","volume":"33","author":"Dow","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0200","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nmeth.4286","article-title":"Genetic interaction mapping in mammalian cells using CRISPR interference","volume":"14","author":"Du","year":"2017","journal-title":"Nat Meth"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17180-w","article-title":"CRISPR\/Cas9 delivery with one single adenoviral vector devoid of all viral genes","volume":"7","author":"Ehrke-Schulz","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0210","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.biotechadv.2019.02.006","article-title":"The application of the CRISPR-Cas9 genome editing machinery in food and agricultural science: current status, future perspectives, and associated challenges","volume":"37","author":"E\u015f","year":"2019","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0215","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nmeth.2681","article-title":"Orthogonal Cas9 proteins for RNA-guided gene regulation and editing","volume":"10","author":"Esvelt","year":"2013","journal-title":"Nat Meth"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0220","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1089\/ten.tea.2016.0441","article-title":"CRISPR-based epigenome editing of cytokine receptors for the promotion of cell survival and tissue deposition in inflammatory environments","volume":"23","author":"Farhang","year":"2017","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0225","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nbt.2623","article-title":"High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells","volume":"31","author":"Fu","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0230","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nbt.2808","article-title":"Improving CRISPR-Cas nuclease specificity using truncated guide RNAs","volume":"32","author":"Fu","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0235","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1053\/j.gastro.2018.11.048","article-title":"Modeling human digestive diseases with CRISPR-Cas9\u2013modified organoids","volume":"156","author":"Fujii","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0240","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1021\/acssynbio.7b00246","article-title":"Control of adipogenic differentiation in mesenchymal stem cells via endogenous gene activation using CRISPR-Cas9","volume":"6","author":"Furuhata","year":"2017","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0245","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tibtech.2013.04.004","article-title":"ZFN, TALEN, and CRISPR\/Cas-based methods for genome engineering","volume":"31","author":"Gaj","year":"2013","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0250","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.omtn.2018.12.008","article-title":"Viral vector-based delivery of CRISPR\/Cas9 and donor DNA for homology-directed repair in an in vitro model for canine hemophilia B","volume":"14","author":"Gao","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0255","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature24644","article-title":"Programmable base editing of A\u2022T to G\u2022C in genomic DNA without DNA cleavage","volume":"551","author":"Gaudelli","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0260","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/hmg\/ddx438","article-title":"Cas9\/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery","volume":"27","author":"Giannelli","year":"2018","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0265","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cell.2013.06.044","article-title":"CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes","volume":"154","author":"Gilbert","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0270","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cell.2014.09.029","article-title":"Genome-scale CRISPR-mediated control of gene repression and activation","volume":"159","author":"Gilbert","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0275","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cobme.2018.08.005","article-title":"CRISPR\/dCas9-mediated cell differentiation","volume":"7","author":"Gong","year":"2018","journal-title":"Curr Opin Biomed Eng"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0280","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.stem.2014.05.018","article-title":"An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells","volume":"15","author":"Gonzalez","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0285","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/698256","article-title":"Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies","volume":"2014","author":"Grinsell","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0290","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41591-018-0049-z","article-title":"CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response","volume":"24","author":"Haapaniemi","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0295","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.2951","article-title":"Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing","volume":"32","author":"Heckl","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0300","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nbt.3199","article-title":"Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers","volume":"33","author":"Hilton","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0305","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/sj.gt.3302796","article-title":"Baculovirus transduction of human mesenchymal stem cell-derived progenitor cells: variation of transgene expression with cellular differentiation states","volume":"13","author":"Ho","year":"2006","journal-title":"Gene Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0310","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/nar\/gky1191","article-title":"A tightly regulated and adjustable CRISPR-dCas9 based AND gate in yeast","volume":"47","author":"Hofmann","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0315","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41551-019-0354-y","article-title":"Local magnetic activation of CRISPR","volume":"3","author":"Hsu","year":"2019","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0320","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2014.05.010","article-title":"Development and applications of CRISPR-Cas9 for genome engineering","volume":"157","author":"Hsu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0325","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.biomaterials.2017.05.004","article-title":"Adipose-derived stem cell sheets functionalized by hybrid baculovirus for prolonged GDNF expression and improved nerve regeneration","volume":"140","author":"Hsu","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0330","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.7150\/thno.36790","article-title":"CRISPR-based activation of endogenous neurotrophic genes in adipose stem cell sheets to stimulate peripheral nerve regeneration","volume":"9","author":"Hsu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0335","doi-asserted-by":"crossref","first-page":"111847","DOI":"10.18632\/oncotarget.22915","article-title":"CRISPR\/Cas9-mediated reversibly immortalized mouse bone marrow stromal stem cells (BMSCs) retain multipotent features of mesenchymal stem cells (MSCs)","volume":"8","author":"Hu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0340","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00439-017-1801-z","article-title":"CRISPR\/Cas9-mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice","volume":"136","author":"Huai","year":"2017","journal-title":"Hum Genet"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0345","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/s41591-018-0050-6","article-title":"p53 inhibits CRISPR\u2013Cas9 engineering in human pluripotent stem cells","volume":"24","author":"Ihry","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0350","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41598-017-18568-4","article-title":"Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells","volume":"8","author":"Ishida","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0355","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2015.58","article-title":"Efficient restoration of the dystrophin gene reading frame and protein structure in DMD myoblasts using the CinDel method","volume":"5","author":"Iyombe-Engembe","year":"2016","journal-title":"Mol Ther-Nucleic Acids"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0360","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012740","article-title":"Repair of strand breaks by homologous recombination","volume":"5","author":"Jasin","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0365","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.aaw7166","article-title":"Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice","volume":"364","author":"Jin","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0370","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.1225829","article-title":"A programmable dual-RNA\u2013guided DNA endonuclease in adaptive bacterial immunity","volume":"337","author":"Jinek","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0375","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1161\/CIRCRESAHA.116.310370","article-title":"Postnatal cardiac gene editing using CRISPR\/Cas9 With AAV9-mediated delivery of short guide RNAs results in mosaic gene disruption","volume":"121","author":"Johansen","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0380","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molcel.2017.09.012","article-title":"Combined CRISPRi\/a-based chemical genetic screens reveal that Rigosertib is a microtubule-destabilizing agent","volume":"68","author":"Jost","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0385","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature23451","article-title":"Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood","volume":"548","author":"Joung","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0390","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41477-018-0178-x","article-title":"Precision genome engineering through adenine base editing in plants","volume":"4","author":"Kang","year":"2018","journal-title":"Nat Plants"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0395","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nrg2971","article-title":"State-of-the-art gene-based therapies: the road ahead","volume":"12","author":"Kay","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0400","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1242\/dev.103341","article-title":"Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells","volume":"141","author":"Kearns","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0405","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tig.2004.12.001","article-title":"Light in retinitis pigmentosa","volume":"21","author":"Kennan","year":"2005","journal-title":"Trends Genet"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0410","article-title":"In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni","volume":"8","author":"Kim","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0415","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1101\/gr.231936.117","article-title":"CRISPR RNAs trigger innate immune responses in human cells","volume":"28","author":"Kim","year":"2018","journal-title":"Genome Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0420","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nature16526","article-title":"High-fidelity CRISPR\u2013Cas9 nucleases with no detectable genome-wide off-target effects","volume":"529","author":"Kleinstiver","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0425","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nbt.3620","article-title":"Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells","volume":"34","author":"Kleinstiver","year":"2016","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0430","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41587-018-0011-0","article-title":"Engineered CRISPR\u2013Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing","volume":"37","author":"Kleinstiver","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0435","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41587-019-0095-1","article-title":"Increasing the specificity of CRISPR systems with engineered RNA secondary structures","volume":"37","author":"Kocak","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0440","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature17946","article-title":"Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage","volume":"533","author":"Komor","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0445","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2016.10.044","article-title":"CRISPR-based technologies for the manipulation of eukaryotic genomes","volume":"168","author":"Komor","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0450","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature14136","article-title":"Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex","volume":"517","author":"Konermann","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0455","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2018.02.033","article-title":"Transcriptome engineering with RNA-targeting type VI-D CRISPR effectors","volume":"173","author":"Konermann","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0460","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1128\/MCB.00512-15","article-title":"The new state of the art: Cas9 for gene activation and repression","volume":"35","author":"La Russa","year":"2015","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0465","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.tibtech.2018.11.003","article-title":"New technologies to enhance in vivo reprogramming for regenerative medicine","volume":"37","author":"Larouche","year":"2018","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0470","doi-asserted-by":"crossref","first-page":"e389","DOI":"10.1038\/mtna.2016.92","article-title":"In vivo editing of the human mutant rhodopsin gene by electroporation of plasmid-based CRISPR\/Cas9 in the mouse retina","volume":"5","author":"Latella","year":"2016","journal-title":"Mol Ther-Nucleic Acids"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0475","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2016.98","article-title":"Restoring ureagenesis in hepatocytes by CRISPR\/Cas9-mediated genomic addition to arginase-deficient induced pluripotent stem cells","volume":"5","author":"Lee","year":"2016","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0480","doi-asserted-by":"crossref","first-page":"114","DOI":"10.15283\/ijsc18110","article-title":"CRISPR\/Cas9 edited sRAGE-MSCs protect neuronal death in Parkinson's disease model","volume":"12","author":"Lee","year":"2019","journal-title":"Int J Stem Cells"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0485","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.stemcr.2014.10.013","article-title":"Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9","volume":"4","author":"Li","year":"2015","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0490","article-title":"Novel HDAd\/EBV reprogramming vector and highly efficient Ad\/CRISPR-Cas sickle cell disease gene correction","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0495","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ymben.2016.09.006","article-title":"CRISPR-Cas9 for the genome engineering of cyanobacteria and succinate production","volume":"38","author":"Li","year":"2016","journal-title":"Metab Eng"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0500","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.biomaterials.2015.09.046","article-title":"Healing of osteoporotic bone defects by baculovirus-engineered bone marrow-derived MSCs expressing microRNA sponges","volume":"74","author":"Li","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0505","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.omtn.2017.06.007","article-title":"One-step piggyBac transposon-based CRISPR\/Cas9 activation of multiple genes","volume":"8","author":"Li","year":"2017","journal-title":"Mol Ther-Nucleic Acids"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0510","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.biomaterials.2018.04.031","article-title":"Non-viral delivery systems for CRISPR\/Cas9-based genome editing: Challenges and opportunities","volume":"171","author":"Li","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0515","doi-asserted-by":"crossref","first-page":"10195","DOI":"10.1093\/nar\/gky804","article-title":"Highly efficient genome editing via CRISPR-Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression","volume":"46","author":"Li","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0520","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ymben.2018.05.010","article-title":"Metabolic engineering of Escherichia coli for the production of L-malate from xylose","volume":"48","author":"Li","year":"2018","journal-title":"Metab Eng"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0525","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.cell.2017.10.025","article-title":"In vivo target gene activation via CRISPR\/Cas9-mediated trans-epigenetic modulation","volume":"171","author":"Liao","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0530","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36045","article-title":"Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference","volume":"7","author":"Libby","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0535","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1016\/j.biomaterials.2011.05.059","article-title":"The role of adipose-derived stem cells engineered with the persistently expressing hybrid baculovirus in the healing of massive bone defects","volume":"32","author":"Lin","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0540","doi-asserted-by":"crossref","first-page":"9401","DOI":"10.1016\/j.biomaterials.2013.08.051","article-title":"The use of ASCs engineered to express BMP2 or TGF-\u03b23 within scaffold constructs to promote calvarial bone repair","volume":"34","author":"Lin","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0545","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biomaterials.2015.01.052","article-title":"Healing of massive segmental femoral bone defects in minipigs by allogenic ASCs engineered with FLPo\/Frt-based baculovirus vectors","volume":"50","author":"Lin","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0550","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nchembio.2179","article-title":"A chemical-inducible CRISPR\u2013Cas9 system for rapid control of genome editing","volume":"12","author":"Liu","year":"2016","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0555","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cell.2016.08.056","article-title":"Editing DNA methylation in the mammalian genome","volume":"167","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0560","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jconrel.2017.09.012","article-title":"Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications","volume":"266","author":"Liu","year":"2017","journal-title":"J Con Release"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0565","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1038\/s41467-017-02265-x","article-title":"Engineering cell signaling using tunable CRISPR-Cpf1-based transcription factors","volume":"8","author":"Liu","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0570","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.stem.2017.12.001","article-title":"CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency","volume":"22","author":"Liu","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2018.09.003","article-title":"CRISPR activation screens systematically identify factors that drive neuronal fate and reprogramming","volume":"23","author":"Liu","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0580","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/mt.2009.13","article-title":"Development of a hybrid baculoviral vector for sustained transgene expression","volume":"17","author":"Lo","year":"2009","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0585","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.01.033","article-title":"Enhanced critical-size calvarial bone healing by ASCs engineered with Cre\/loxP-based hybrid baculovirus","volume":"124","author":"Lo","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0590","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/stem.2935","article-title":"Improving gene editing outcomes in human hematopoietic stem and progenitor cells by temporal control of DNA repair","volume":"37","author":"Lomova","year":"2019","journal-title":"Stem Cells"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0595","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.aad5725","article-title":"Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy","volume":"351","author":"Long","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0600","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.biotechadv.2013.08.015","article-title":"Recent progresses in gene delivery-based bone tissue engineering","volume":"31","author":"Lu","year":"2013","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0605","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/mt.2013.165","article-title":"Regenerating cartilages by engineered ASCs: Prolonged TGF-\u03b23\/BMP-6 expression improved articular cartilage formation and restored zonal structure","volume":"22","author":"Lu","year":"2014","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0610","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1093\/nar\/gkx1222","article-title":"Multimode drug inducible CRISPR\/Cas9 devices for transcriptional activation and genome editing","volume":"46","author":"Lu","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0615","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1093\/nar\/gkz093","article-title":"Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing","volume":"47","author":"Lu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0620","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.molmet.2017.07.001","article-title":"Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA","volume":"6","author":"Lundh","year":"2017","journal-title":"Mol Metab"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0625","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/gt.2011.129","article-title":"Development of the hybrid Sleeping Beauty-baculovirus vector for sustained gene expression and cancer therapy","volume":"19","author":"Luo","year":"2012","journal-title":"Gene Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0630","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1128\/JVI.03510-12","article-title":"Adaptive immune responses elicited by baculovirus and impacts on subsequent transgene expression in vivo","volume":"87","author":"Luo","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0635","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/s41467-018-03760-5","article-title":"Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells","volume":"9","author":"Ma","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0640","doi-asserted-by":"crossref","first-page":"9068","DOI":"10.1073\/pnas.1705836114","article-title":"CRISPR-Cas9 vectors for genome editing and host engineering in the baculovirus\u2013insect cell system","volume":"114","author":"Mabashi-Asazuma","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0645","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ymthe.2017.11.019","article-title":"Triple vectors expand AAV transfer capacity in the retina","volume":"26","author":"Maddalena","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0650","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nmeth.2598","article-title":"CRISPR RNA\u2013guided activation of endogenous human genes","volume":"10","author":"Maeder","year":"2013","journal-title":"Nat Meth"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0655","doi-asserted-by":"crossref","DOI":"10.1038\/srep37051","article-title":"Adenoviral vectors encoding CRISPR\/Cas9 multiplexes rescue dystrophin synthesis in unselected populations of DMD muscle cells","volume":"6","author":"Maggio","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0660","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.biotechadv.2017.11.008","article-title":"Harnessing CRISPR\/Cas systems for programmable transcriptional and post-transcriptional regulation","volume":"36","author":"Mahas","year":"2018","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0665","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1232033","article-title":"RNA-guided human genome engineering via Cas9","volume":"339","author":"Mali","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0670","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.stem.2016.01.022","article-title":"CRISPR interference efficiently induces specific and reversible gene silencing in human iPSCs","volume":"18","author":"Mandegar","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0675","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41467-018-07845-z","article-title":"Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins","volume":"10","author":"Mangeot","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0680","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11529","article-title":"Highly efficient baculovirus-mediated multigene delivery in primary cells","volume":"7","author":"Mansouri","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0685","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.plasmid.2017.01.003","article-title":"Baculovirus-based genome editing in primary cells","volume":"90","author":"Mansouri","year":"2017","journal-title":"Plasmid"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0690","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2217\/17460751.3.1.1","article-title":"A brief definition of regenerative medicine","volume":"3","author":"Mason","year":"2008","journal-title":"Reg Med"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0695","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.vaccine.2009.10.145","article-title":"International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials","volume":"28","author":"Mast","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0700","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.ymthe.2018.04.017","article-title":"In situ gene therapy via AAV-CRISPR-Cas9-mediated targeted gene regulation","volume":"26","author":"Moreno","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0705","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nbt.4048","article-title":"Orthologous CRISPR\u2013Cas9 enzymes for combinatorial genetic screens","volume":"36","author":"Najm","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0710","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.aad5143","article-title":"In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy","volume":"351","author":"Nelson","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0715","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nbt.3245","article-title":"Photoactivatable CRISPR-Cas9 for optogenetic genome editing","volume":"33","author":"Nihongaki","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0720","doi-asserted-by":"crossref","first-page":"aaf8729","DOI":"10.1126\/science.aaf8729","article-title":"Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems","volume":"353","author":"Nishida","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0725","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1126\/science.aas9129","article-title":"Engineered CRISPR-Cas9 nuclease with expanded targeting space","volume":"361","author":"Nishimasu","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0730","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1038\/s41598-017-04625-5","article-title":"CRISPR\/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice","volume":"7","author":"Ohmori","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0735","doi-asserted-by":"crossref","first-page":"7955","DOI":"10.1093\/nar\/gkz475","article-title":"Highly efficient editing of the beta-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease","volume":"47","author":"Park","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0740","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","article-title":"Concise review: mesenchymal stem\/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views","volume":"25","author":"Phinney","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0745","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1128\/AEM.01248-15","article-title":"Coupling the CRISPR\/Cas9 System with Lambda Red recombineering enables simplified chromosomal gene replacement in Escherichia coli","volume":"81","author":"Pyne","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0750","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1021\/acschembio.7b00800","article-title":"Diverse class 2 CRISPR-Cas effector proteins for genome engineering applications","volume":"13","author":"Pyzocha","year":"2018","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0755","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.cell.2013.02.022","article-title":"Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression","volume":"152","author":"Qi","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0760","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.cell.2013.08.021","article-title":"Double nicking by RNA-Guided CRISPR Cas9 for enhanced genome editing specificity","volume":"154","author":"Ran","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0765","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature14299","article-title":"In vivo genome editing using Staphylococcus aureus Cas9","volume":"520","author":"Ran","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0770","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1056\/NEJMoa1609677","article-title":"Gene therapy in a patient with sickle cell disease","volume":"376","author":"Ribeil","year":"2017","journal-title":"New Eng J Med"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0775","first-page":"632","article-title":"CRISPR therapy shows promise in Duchenne muscular dystrophy","volume":"14","author":"Ridler","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0780","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2018.11.022","article-title":"Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks","volume":"176","author":"Rubin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0785","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/nar\/gkx1199","article-title":"Improving CRISPR\u2013Cas specificity with chemical modifications in single-guide RNAs","volume":"46","author":"Ryan","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0790","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nchembio.273","article-title":"Synthetic translational regulation by an L7Ae\u2013kink-turn RNP switch","volume":"6","author":"Saito","year":"2010","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0795","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0495-18.2019","article-title":"A neuron-optimized CRISPR\/dCas9 activation system for robust and specific gene regulation","volume":"6","author":"Savell","year":"2019","journal-title":"eNeuro"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0800","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.omtn.2018.05.006","article-title":"One-vector system for multiplexed CRISPR\/Cas9 against hepatitis B virus cccDNA utilizing high-capacity adenoviral vectors","volume":"12","author":"Schiwon","year":"2018","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0805","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1073\/pnas.1512503112","article-title":"Generation of knock-in primary human T cells using Cas9 ribonucleoproteins","volume":"112","author":"Schumann","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0810","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.stem.2013.11.002","article-title":"Functional repair of CFTR by CRISPR\/Cas9 in intestinal stem cell organoids of cystic fibrosis patients","volume":"13","author":"Schwank","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0815","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1247005","article-title":"Genome-scale CRISPR-Cas9 knockout screening in human cells","volume":"343","author":"Shalem","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0820","doi-asserted-by":"crossref","first-page":"E6722","DOI":"10.1073\/pnas.1802448115","article-title":"Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation","volume":"115","author":"Shao","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0825","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nmeth.2857","article-title":"Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects","volume":"11","author":"Shen","year":"2014","journal-title":"Nat Meth"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0830","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1021\/acssynbio.7b00020","article-title":"Enhancing protein production yield from CHO Cells by CRISPR interference (CRISPRi)","volume":"6","author":"Shen","year":"2017","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0835","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1093\/nar\/gky1165","article-title":"Synthetic switch to minimize CRISPR off-target effects by self-restricting Cas9 transcription and translation","volume":"47","author":"Shen","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0840","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1701620","article-title":"Disabling Cas9 by an anti-CRISPR DNA mimic","volume":"3","author":"Shin","year":"2017","journal-title":"Sci Adv"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0845","doi-asserted-by":"crossref","first-page":"5676","DOI":"10.1073\/pnas.1512028113","article-title":"Site-specific genome editing for correction of induced pluripotent stem cells derived from dominant dystrophic epidermolysis bullosa","volume":"113","author":"Shinkuma","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0850","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.omtm.2018.06.006","article-title":"Prevalence of pre-existing antibodies to CRISPR-associated nuclease Cas9 in the USA population","volume":"10","author":"Simhadri","year":"2018","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0855","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.ymthe.2018.02.023","article-title":"Efficient In vivo liver-directed gene editing using CRISPR\/Cas9","volume":"26","author":"Singh","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0860","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.aad5227","article-title":"Rationally engineered Cas9 nucleases with improved specificity","volume":"351","author":"Slaymaker","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0865","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.coviro.2016.08.003","article-title":"In vivo tissue-tropism of adeno-associated viral vectors","volume":"21","author":"Srivastava","year":"2016","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0870","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nbt.3806","article-title":"Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes","volume":"35","author":"Staahl","year":"2017","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0875","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/nar\/gkw1112","article-title":"Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase","volume":"45","author":"Stepper","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0880","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1016\/j.ymthe.2017.06.010","article-title":"CRISPR epigenome editing of AKAP150 in DRG neurons abolishes degenerative IVD-Induced neuronal activation","volume":"25","author":"Stover","year":"2017","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0885","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-017-0758-0","article-title":"Targeting ectodysplasin promotor by CRISPR\/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells","volume":"9","author":"Sun","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0890","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1093\/nar\/gkt442","article-title":"Enhanced and prolonged baculovirus-mediated expression by incorporating recombinase system and in cis elements: a comparative study","volume":"41","author":"Sung","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0895","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1038\/nprot.2014.130","article-title":"Efficient gene delivery into cell lines and stem cells using baculovirus","volume":"9","author":"Sung","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0900","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/bit.26915","article-title":"Combining orthogonal CRISPR and CRISPRi systems for genome engineering and metabolic pathway modulation in Escherichia coli","volume":"116","author":"Sung","year":"2019","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0905","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41598-018-36740-2","article-title":"CRISPR\/Cas9-mediated one step bi-allelic change of genomic DNA in iPSCs and human RPE cells in vitro with dual antibiotic selection","volume":"9","author":"Supharattanasitthi","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0910","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s10038-017-0352-4","article-title":"In vivo genome editing via the HITI method as a tool for gene therapy","volume":"63","author":"Suzuki","year":"2018","journal-title":"J Hum Genet"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0915","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nature20565","article-title":"In vivo genome editing via CRISPR\/Cas9 mediated homology-independent targeted integration","volume":"540","author":"Suzuki","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0920","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.aad5177","article-title":"In vivo gene editing in dystrophic mouse muscle and muscle stem cells","volume":"351","author":"Tabebordbar","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0925","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2014.09.039","article-title":"A protein-tagging system for signal amplification in gene expression and fluorescence imaging","volume":"159","author":"Tanenbaum","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0930","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/nmeth.3630","article-title":"Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements","volume":"12","author":"Thakore","year":"2015","journal-title":"Nat Meth"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0935","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1093\/nar\/gkv601","article-title":"Development of an intein-mediated split\u2013Cas9 system for gene therapy","volume":"43","author":"Truong","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0940","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1093\/nar\/gkz267","article-title":"CRISPRai for simultaneous gene activation and inhibition to promote stem cell chondrogenesis and calvarial bone regeneration","volume":"47","author":"Truong","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0945","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nrg.2016.28","article-title":"Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases","volume":"17","author":"Tsai","year":"2016","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0950","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/s41591-018-0137-0","article-title":"A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells","volume":"24","author":"Vakulskas","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0955","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/s41591-018-0209-1","article-title":"Treatment of a metabolic liver disease by in vivo genome base editing in adult mice","volume":"24","author":"Villiger","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0960","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1093\/nar\/gkw159","article-title":"Repurposing the CRISPR-Cas9 system for targeted DNA methylation","volume":"44","author":"Vojta","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0965","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.cell.2013.04.025","article-title":"One-step generation of mice carrying mutations in multiple genes by CRISPR\/Cas-mediated genome engineering","volume":"153","author":"Wang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0970","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.1246981","article-title":"Genetic screens in human cells using the CRISPR-Cas9 system","volume":"343","author":"Wang","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0975","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.biotechadv.2019.03.016","article-title":"Advances in CRISPR-Cas systems for RNA targeting, tracking and editing","volume":"37","author":"Wang","year":"2019","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0980","article-title":"Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators","volume":"6","author":"Wei","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0985","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1038\/s41467-018-05067-x","article-title":"Human pluripotent reprogramming with CRISPR activators","volume":"9","author":"Weltner","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0990","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1128\/AEM.01159-16","article-title":"Development of a CRISPR-Cas9 tool kit for comprehensive engineering of Bacillus subtilis","volume":"82","author":"Westbrook","year":"2016","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb0995","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1002\/bit.26789","article-title":"Metabolic engineering of Bacillus subtilis for l-valine overproduction","volume":"115","author":"Westbrook","year":"2018","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1000","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.aav9023","article-title":"Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq","volume":"364","author":"Wienert","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2015.12.035","article-title":"Biology and applications of CRISPR systems: harnessing nature's toolbox for genome engineering","volume":"164","author":"Wright","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1010","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1021\/acssynbio.7b00251","article-title":"Combining CRISPR and CRISPRi systems for metabolic engineering of E. coli and 1,4-BDO biosynthesis","volume":"6","author":"Wu","year":"2017","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1015","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/v11010028","article-title":"Viral delivery systems for CRISPR","volume":"11","author":"Xu","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1020","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nbt.3469","article-title":"A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice","volume":"34","author":"Yang","year":"2016","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1025","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biomaterials.2013.09.080","article-title":"Baculovirus-transduced, VEGF-expressing adipose-derived stem cell sheet for the treatment of myocardium infarction","volume":"35","author":"Yeh","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1030","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nbt.3471","article-title":"Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo","volume":"34","author":"Yin","year":"2016","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1035","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd.2016.280","article-title":"Delivery technologies for genome editing","volume":"16","author":"Yin","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1040","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nchembio.2559","article-title":"Partial DNA-guided Cas9 enables genome editing with reduced off-target activity","volume":"14","author":"Yin","year":"2018","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1045","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11010-013-1851-z","article-title":"Foxc2 over-expression in bone marrow mesenchymal stem cells stimulates osteogenic differentiation and inhibits adipogenic differentiation","volume":"386","author":"You","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1050","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.stem.2016.01.021","article-title":"A single CRISPR-Cas9 deletion strategy that targets the majority of DMD patients restores dystrophin function in hiPSC-derived muscle cells","volume":"18","author":"Young","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1055","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14716","article-title":"Nrl knockdown by AAV-delivered CRISPR\/Cas9 prevents retinal degeneration in mice","volume":"8","author":"Yu","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1060","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cell.2014.11.052","article-title":"Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds","volume":"160","author":"Zalatan Jesse","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1065","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2015.09.038","article-title":"Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system","volume":"163","author":"Zetsche","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1070","article-title":"Efficient and transgene-free genome editing in wheat through transient expression of CRISPR\/Cas9 DNA or RNA","volume":"7","author":"Zhang","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1075","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/annrheumdis-2018-214724","article-title":"Exploration of CRISPR\/Cas9-based gene editing as therapy for osteoarthritis","volume":"78","author":"Zhao","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1080","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/PRS.0000000000005316","article-title":"CRISPR\/Cas9-mediated BRCA1 knockdown adipose stem cells promote breast cancer progression","volume":"143","author":"Zhao","year":"2019","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1085","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41593-018-0077-5","article-title":"CRISPR interference-based specific and efficient gene inactivation in the brain","volume":"21","author":"Zheng","year":"2018","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1090","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1021\/acschembio.7b00603","article-title":"A single-chain photoswitchable CRISPR-Cas9 architecture for light-inducible gene editing and transcription","volume":"13","author":"Zhou","year":"2018","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1095","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/cr.2017.57","article-title":"Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors","volume":"27","author":"Zhu","year":"2017","journal-title":"Cell Res"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1100","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41551-018-0318-7","article-title":"Spatial control of in vivo CRISPR\u2013Cas9 genome editing via nanomagnets","volume":"3","author":"Zhu","year":"2019","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biotechadv.2016.12.003","article-title":"Detection of on-target and off-target mutations generated by CRISPR\/Cas9 and other sequence-specific nucleases","volume":"35","author":"Zischewski","year":"2017","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1126\/science.aav9973","article-title":"Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos","volume":"364","author":"Zuo","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2019.107447_bb1115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nbt.3081","article-title":"Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo","volume":"33","author":"Zuris","year":"2014","journal-title":"Nat Biotechnol"}],"container-title":["Biotechnology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975019301478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975019301478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:44:49Z","timestamp":1760010289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0734975019301478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":223,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0734975019301478"],"URL":"https:\/\/doi.org\/10.1016\/j.biotechadv.2019.107447","relation":{},"ISSN":["0734-9750"],"issn-type":[{"value":"0734-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CRISPR technologies for stem cell engineering and regenerative medicine","name":"articletitle","label":"Article Title"},{"value":"Biotechnology Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biotechadv.2019.107447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107447"}}