{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:25:57Z","timestamp":1787142357672,"version":"build-2736575974"},"reference-count":201,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017526","name":"International Cooperation Project of Ningbo City","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017526","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biotechnology Advances"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.biotechadv.2026.108979","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:46:21Z","timestamp":1783601181000},"page":"108979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nature-derived exosome-like nanoparticles (NELNs) for intracellular transport and targeted RNA delivery"],"prefix":"10.1016","volume":"92","author":[{"given":"Baoyu","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0005","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12081","article-title":"Nanoalgosomes: introducing extracellular vesicles produced by microalgae","volume":"10","author":"Adamo","year":"2021","journal-title":"J Extracell Vesicles"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0010","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/s42003-024-06612-9","article-title":"Extracellular vesicles from the microalga Tetraselmis chuii are biocompatible and exhibit unique bone tropism along with antioxidant and anti-inflammatory properties","volume":"7","author":"Adamo","year":"2024","journal-title":"Communications Biology"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis","volume":"379","author":"Adams","year":"2018","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0020","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal drug delivery systems: from concept to clinical applications","volume":"65","author":"Allen","year":"2013","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174178","article-title":"siRNA: mechanism of action, challenges, and therapeutic approaches","volume":"905","author":"Alshaer","year":"2021","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0030","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.108979_bb0035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev-med-012017-043332","article-title":"Entering the modern era of gene therapy","volume":"70","author":"Anguela","year":"2019","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jconrel.2023.03.016","article-title":"Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors","volume":"357","author":"Anthiya","year":"2023","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114102","article-title":"Ginger exosome-like nanoparticles (GELNs) induced apoptosis, cell cycle arrest, and anti-metastatic effects in triple-negative breast cancer MDA-MB-231 cells","volume":"182","author":"Anusha","year":"2023","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0050","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0055","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11060-013-1235-y","article-title":"Heparin blocks transfer of extracellular vesicles between donor and recipient cells","volume":"115","author":"Atai","year":"2013","journal-title":"J Neurooncol"},{"issue":"12","key":"10.1016\/j.biotechadv.2026.108979_bb0060","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/gt.2011.79","article-title":"Developing therapeutic microRNAs for cancer","volume":"18","author":"Bader","year":"2011","journal-title":"Gene Ther"},{"issue":"7","key":"10.1016\/j.biotechadv.2026.108979_bb0065","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ncb2502","article-title":"Syndecan-syntenin-ALIX regulates the biogenesis of exosomes","volume":"14","author":"Baietti","year":"2012","journal-title":"Nat Cell Biol"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0070","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/10837450.2023.2202242","article-title":"Application of plant-derived exosome-like nanoparticles in drug delivery","volume":"28","author":"Barzin","year":"2023","journal-title":"Pharm Dev Technol"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109249","article-title":"Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue","volume":"113","author":"Bian","year":"2023","journal-title":"J Nutr Biochem"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tcb.2013.10.009","article-title":"ALIX and the multivesicular endosome: ALIX in Wonderland","volume":"24","author":"Bissig","year":"2014","journal-title":"Trends Cell Biol"},{"issue":"15","key":"10.1016\/j.biotechadv.2026.108979_bb0085","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1002\/1873-3468.13472","article-title":"Content release of extracellular vesicles in a cell-free extract","volume":"593","author":"Bonsergent","year":"2019","journal-title":"FEBS Lett"},{"issue":"21","key":"10.1016\/j.biotechadv.2026.108979_bb0090","doi-asserted-by":"crossref","first-page":"11827","DOI":"10.1093\/nar\/gkaa670","article-title":"Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates","volume":"48","author":"Brown","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0095","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s40425-019-0817-4","article-title":"Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth","volume":"7","author":"Cao","year":"2019","journal-title":"J Immunother Cancer"},{"issue":"10","key":"10.1016\/j.biotechadv.2026.108979_bb0100","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1039\/D3MH01030A","article-title":"Plant exosome nanovesicles (PENs): green delivery platforms","volume":"10","author":"Cao","year":"2023","journal-title":"Mater Horiz"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0105","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.addr.2014.05.009","article-title":"In vivo delivery of miRNAs for cancer therapy: challenges and strategies","volume":"81","author":"Chen","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0110","article-title":"An antioxidative sophora exosome-encapsulated hydrogel promotes spinal cord repair by regulating oxidative stress microenvironment","volume":"47","author":"Chen","year":"2023","journal-title":"Nanomedicine"},{"issue":"9","key":"10.1016\/j.biotechadv.2026.108979_bb0115","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.7150\/ijbs.84994","article-title":"The potential role and mechanism of circRNA\/miRNA axis in cholesterol synthesis","volume":"19","author":"Chen","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12951-022-01755-5","article-title":"Tea leaf-derived exosome-like nanotherapeutics retard breast tumor growth by pro-apoptosis and microbiota modulation","volume":"21","author":"Chen","year":"2023","journal-title":"J Nanobiotechnology"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0125","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0304-4157(87)90016-5","article-title":"Biomembrane fusion: a new concept derived from model studies using two interacting planar lipid bilayers","volume":"906","author":"Chernomordik","year":"1987","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"10.1016\/j.biotechadv.2026.108979_bb0130","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41576-024-00693-2","article-title":"Targeting and engineering long non-coding RNAs for cancer therapy","volume":"25","author":"Coan","year":"2024","journal-title":"Nat Rev Genet"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.molmed.2018.01.006","article-title":"Manufacturing exosomes: a promising therapeutic platform","volume":"24","author":"Colao","year":"2018","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0140","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2017.09.019","article-title":"Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis","volume":"266","author":"Costa Verdera","year":"2017","journal-title":"J Control Release"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/nat.2016.0656","article-title":"Molecular mechanisms of antisense oligonucleotides","volume":"27","author":"Crooke","year":"2017","journal-title":"Nucleic Acid Ther"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41477-018-0328-1","article-title":"A whole-cell electron tomography model of vacuole biogenesis in Arabidopsis root cells","volume":"5","author":"Cui","year":"2019","journal-title":"Nat Plants"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0155","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymthe.2020.11.030","article-title":"Plant exosome-like nanovesicles: emerging therapeutics and drug delivery nanoplatforms","volume":"29","author":"Dad","year":"2021","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0160","article-title":"Therapeutic potential of plant-derived extracellular vesicles as nanocarriers for exogenous miRNAs","volume":"198","author":"de Las","year":"2023","journal-title":"Pharmacol Res"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0165","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1261\/rna.079507.122","article-title":"Endosomal escape of RNA therapeutics: How do we solve this rate-limiting problem?","volume":"29","author":"Dowdy","year":"2023","journal-title":"Rna"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0170","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1039\/D0NR07622H","article-title":"Exosome-mediated delivery of gene vectors for gene therapy","volume":"13","author":"Duan","year":"2021","journal-title":"Nanoscale"},{"issue":"9","key":"10.1016\/j.biotechadv.2026.108979_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093387","article-title":"The Interplay between microRNAs and the components of the tumor microenvironment in B-cell malignancies","volume":"21","author":"El-Daly","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0180","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2407-11-108","article-title":"Interaction and uptake of exosomes by ovarian cancer cells","volume":"11","author":"Escrevente","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.addr.2015.03.008","article-title":"Antisense oligonucleotides in therapy for neurodegenerative disorders","volume":"87","author":"Evers","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/cells12060824","article-title":"Anticancer activity of bitter melon-derived vesicles extract against breast cancer","volume":"12","author":"Feng","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0195","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/rr6","article-title":"Size does matter: overcoming the adeno-associated virus packaging limit","volume":"1","author":"Flotte","year":"2000","journal-title":"Respir Res"},{"issue":"22","key":"10.1016\/j.biotechadv.2026.108979_bb0200","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1038\/emboj.2010.255","article-title":"Visualizing the transfer-messenger RNA as the ribosome resumes translation","volume":"29","author":"Fu","year":"2010","journal-title":"Embo J"},{"issue":"12","key":"10.1016\/j.biotechadv.2026.108979_bb0205","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1021\/acs.molpharmaceut.8b00921","article-title":"Apple-derived nanoparticles modulate expression of organic-anion-transporting polypeptide (OATP) 2B1 in Caco-2 cells","volume":"15","author":"Fujita","year":"2018","journal-title":"Mol Pharm"},{"issue":"13","key":"10.1016\/j.biotechadv.2026.108979_bb0210","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa2021712","article-title":"Lumasiran, an RNAi therapeutic for primary hyperoxaluria type 1","volume":"384","author":"Garrelfs","year":"2021","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","article-title":"Regulation of microRNA function in animals","volume":"20","author":"Gebert","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0220","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/s41467-020-14957-y","article-title":"Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping","volume":"11","author":"Gee","year":"2020","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0225","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJMoa2107454","article-title":"CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis","volume":"385","author":"Gillmore","year":"2021","journal-title":"N Engl J Med"},{"issue":"7196","key":"10.1016\/j.biotechadv.2026.108979_bb0230","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature06907","article-title":"The Cl-\/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes","volume":"453","author":"Graves","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0235","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.actbio.2025.07.039","article-title":"Engineered M2 macrophage-derived exosomes: mechanisms and therapeutic potential in inflammation regulation and regenerative medicine","volume":"203","author":"Guan","year":"2025","journal-title":"Acta Biomaterialia"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0240","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12964-021-00730-1","article-title":"The exosome journey: from biogenesis to uptake and intracellular signalling","volume":"19","author":"Gurung","year":"2021","journal-title":"Cell Commun Signal"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039520","article-title":"Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT\/ERK1\/2 inactivation by targeting PTEN","volume":"7","author":"Han","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/pr9020356","article-title":"Overview and update on methods for cargo loading into extracellular vesicles","volume":"9","author":"Han","year":"2021","journal-title":"Processes"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0255","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ymthe.2021.08.028","article-title":"Ginseng-derived nanoparticles potentiate immune checkpoint antibody efficacy by reprogramming the cold tumor microenvironment","volume":"30","author":"Han","year":"2022","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0260","article-title":"Bioactive compounds from microalgae: mechanistic insights into the regulatory and therapeutic potential of the gut microbiota","author":"He","year":"2026","journal-title":"Food Sci. Hum. Wellness"},{"issue":"7","key":"10.1016\/j.biotechadv.2026.108979_bb0265","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41565-021-00931-2","article-title":"Extracellular vesicles as a next-generation drug delivery platform","volume":"16","author":"Herrmann","year":"2021","journal-title":"Nat Nanotechnol"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0270","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1083\/jcb.201506084","article-title":"Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER","volume":"213","author":"Heusermann","year":"2016","journal-title":"J Cell Biol"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11030129","article-title":"Challenges and recent progress in oral drug delivery systems for biopharmaceuticals","volume":"11","author":"Homayun","year":"2019","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0280","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cell.2009.01.019","article-title":"The many pathways of RNA degradation","volume":"136","author":"Houseley","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0285","article-title":"TLyp-1-modified exosome-mediated delivery of circRAPGEF5 ASO inhibits lung adenocarcinoma metastasis via regulating the miR-570-3p\/SPP1 axis","volume":"35","author":"Hu","year":"2025","journal-title":"Mater Today Bio"},{"issue":"10","key":"10.1016\/j.biotechadv.2026.108979_bb0290","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12361","article-title":"Plant exosomes fused with engineered mesenchymal stem cell-derived nanovesicles for synergistic therapy of autoimmune skin disorders","volume":"12","author":"Huang","year":"2023","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0295","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jconrel.2023.01.071","article-title":"Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice","volume":"355","author":"Hwang","year":"2023","journal-title":"J Control Release"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0300","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1038\/s41598-023-30180-3","article-title":"Gene knockdown in HaCaT cells by small interfering RNAs entrapped in grapefruit-derived extracellular vesicles using a microfluidic device","volume":"13","author":"Itakura","year":"2023","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0305","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.molonc.2012.09.006","article-title":"MicroRNA and cancer","volume":"6","author":"Jansson","year":"2012","journal-title":"Mol Oncol"},{"issue":"11","key":"10.1016\/j.biotechadv.2026.108979_bb0310","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70198","article-title":"Nose-to-brain delivery of Chlorella vulgaris extracellular vesicles for antidepressant effects","volume":"14","author":"Jin","year":"2025","journal-title":"J Extracell Vesicles"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0315","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1007\/s10616-016-9952-7","article-title":"Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes","volume":"68","author":"Johnsen","year":"2016","journal-title":"Cytotechnology"},{"issue":"7","key":"10.1016\/j.biotechadv.2026.108979_bb0320","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/mt.2013.64","article-title":"Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis","volume":"21","author":"Ju","year":"2013","journal-title":"Mol Ther"},{"issue":"7659","key":"10.1016\/j.biotechadv.2026.108979_bb0325","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010191","article-title":"Plant-derived extracellular vesicles as therapeutic nanocarriers","volume":"23","author":"Karamanidou","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0335","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41418-024-01377-4","article-title":"The long non-coding RNA ROSALIND protects the mitochondrial translational machinery from oxidative damage","volume":"32","author":"Katopodi","year":"2025","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0340","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12951-022-01478-7","article-title":"Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects","volume":"20","author":"Kiaie","year":"2022","journal-title":"J Nanobiotechnol."},{"issue":"57","key":"10.1016\/j.biotechadv.2026.108979_bb0345","doi-asserted-by":"crossref","first-page":"34501","DOI":"10.1039\/D0RA04978F","article-title":"In vivo and in vitro studies of antisense oligonucleotides - a review","volume":"10","author":"Kilanowska","year":"2020","journal-title":"RSC Adv"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0350","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12040943","article-title":"Potential of plant exosome vesicles from grapefruit (Citrus \u00d7 paradisi) and tomato (Solanum lycopersicum) juices as functional ingredients and targeted drug delivery vehicles","volume":"12","author":"Kilasoniya","year":"2023","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0355","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s13770-021-00367-8","article-title":"The antioxidant effect of small extracellular vesicles derived from aloe vera peels for wound healing","volume":"18","author":"Kim","year":"2021","journal-title":"Tissue Eng Regen Med"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0360","first-page":"53","article-title":"Plant-derived exosome-like nanoparticles and their therapeutic activities","volume":"17","author":"Kim","year":"2022","journal-title":"Asian J Pharm Sci"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0365","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12951-023-02006-x","article-title":"Anti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood-brain-barrier penetration and tumor microenvironment modulation","volume":"21","author":"Kim","year":"2023","journal-title":"J Nanobiotechnology"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0370","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00018-017-2664-0","article-title":"Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons","volume":"75","author":"Laulagnier","year":"2018","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0375","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1261\/rna.5239604","article-title":"In vivo activity of nuclease-resistant siRNAs","volume":"10","author":"Layzer","year":"2004","journal-title":"RNA"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115346","article-title":"Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads","volume":"211","author":"Leandro","year":"2024","journal-title":"Advanced Drug Delivery Reviews"},{"issue":"7951","key":"10.1016\/j.biotechadv.2026.108979_bb0385","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41586-023-05722-4","article-title":"Sequence determinant of small RNA production by DICER","volume":"615","author":"Lee","year":"2023","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102511","article-title":"Lemon exosome-like nanoparticles enhance stress survival of gut bacteria by RNase P-mediated specific tRNA decay","volume":"24","author":"Lei","year":"2021","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0395","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nsmb.1376","article-title":"Structural insights into the dual activity of RNase","volume":"15","author":"Li de la Sierra-Gallay","year":"2008","journal-title":"J. Nat Struct Mol Biol"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0400","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3389\/fpls.2018.00979","article-title":"Biogenesis and function of multivesicular bodies in plant immunity","volume":"9","author":"Li","year":"2018","journal-title":"Front Plant Sci"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0405","article-title":"Arrowtail RNA for ligand display on ginger exosome-like nanovesicles to systemic deliver siRNA for cancer suppression","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0410","doi-asserted-by":"crossref","first-page":"13991","DOI":"10.2147\/IJN.S493434","article-title":"Houttuynia cordata-derived exosome-like nanoparticles mitigate colitis in mice via inhibition of the NLRP3 signaling pathway and modulation of the gut microbiota","volume":"19","author":"Li","year":"2024","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0415","doi-asserted-by":"crossref","unstructured":"Li, Y., Wang, Y., Zhao, H., Pan, Q., & Chen, G. 2024b. Engineering strategies of plant-derived exosome-like nanovesicles: current knowledge and future perspectives. Int J Nanomedicine, 19(0), 12793\u201312815. doi:https:\/\/doi.org\/10.2147\/IJN.S496664.","DOI":"10.2147\/IJN.S496664"},{"issue":"12","key":"10.1016\/j.biotechadv.2026.108979_bb0420","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12283","article-title":"Plant-derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications","volume":"11","author":"Lian","year":"2022","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109997","article-title":"RNA-based pharmacotherapy for tumors: from bench to clinic and back","volume":"125","author":"Liang","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0430","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.ymthe.2022.10.008","article-title":"Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering","volume":"31","author":"Liang","year":"2023","journal-title":"Mol Ther"},{"issue":"8","key":"10.1016\/j.biotechadv.2026.108979_bb0435","doi-asserted-by":"crossref","first-page":"8040","DOI":"10.1021\/acsnano.4c16085","article-title":"Microalgae-derived extracellular vesicles synergize with herbal hydrogel for energy homeostasis in osteoarthritis treatment","volume":"19","author":"Liang","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0440","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1038\/s41467-020-17093-9","article-title":"Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression","volume":"11","author":"Lim","year":"2020","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0445","doi-asserted-by":"crossref","DOI":"10.3390\/nu12020477","article-title":"Protective role of shiitake mushroom-derived exosome-like nanoparticles in D-galactosamine and lipopolysaccharide-induced acute liver injury in mice","volume":"12","author":"Liu","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0450","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejps.2018.05.001","article-title":"Functionalized extracellular vesicles as advanced therapeutic nanodelivery systems","volume":"121","author":"Lu","year":"2018","journal-title":"Eur. J. Pharm. Sci"},{"issue":"22","key":"10.1016\/j.biotechadv.2026.108979_bb0455","doi-asserted-by":"crossref","first-page":"8413","DOI":"10.1021\/acs.jafc.2c07760","article-title":"Celery (Apium graveolens L.) exosome-like nanovesicles as a new-generation chemotherapy drug delivery platform against tumor proliferation","volume":"71","author":"Lu","year":"2023","journal-title":"J Agric Food Chem"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0460","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/aps.2017.12","article-title":"Engineering exosomes as refined biological nanoplatforms for drug delivery","volume":"38","author":"Luan","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0465","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.biomaterials.2016.06.024","article-title":"RNAi delivery by exosome-mimetic nanovesicles - Implications for targeting c-Myc in cancer","volume":"102","author":"Lunavat","year":"2016","journal-title":"Biomaterials"},{"issue":"30","key":"10.1016\/j.biotechadv.2026.108979_bb0470","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202312153","article-title":"Nanoplatform-based in vivo gene delivery systems for cancer therapy","volume":"20","author":"Luo","year":"2024","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0475","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s12951-025-03567-9","article-title":"Prunus mume derived extracellular vesicle-like particles alleviate experimental colitis via disrupting NEK7-NLRP3 interaction and inflammasome activation","volume":"23","author":"Lv","year":"2025","journal-title":"J Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0480","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/JS9.0000000000000789","article-title":"Neutrophil membrane-engineered Panax ginseng root-derived exosomes loaded miRNA 182-5p targets NOX4\/Drp-1\/NLRP3 signal pathway to alleviate acute lung injury in sepsis: experimental studies","volume":"110","author":"Ma","year":"2024","journal-title":"Int J Surg"},{"issue":"9","key":"10.1016\/j.biotechadv.2026.108979_bb0485","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1039\/D3TB02752J","article-title":"Plant-derived exosomes: a green approach for cancer drug delivery","volume":"12","author":"Madhan","year":"2024","journal-title":"J Mater Chem B"},{"issue":"47","key":"10.1016\/j.biotechadv.2026.108979_bb0490","doi-asserted-by":"crossref","first-page":"20157","DOI":"10.1039\/D1NR06015E","article-title":"A biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for high-performance delivery of oral antibodies","volume":"13","author":"Mao","year":"2021","journal-title":"Nanoscale"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0495","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nmeth.4640","article-title":"How to pull the blanket off dormant cancer cells","volume":"15","author":"Marx","year":"2018","journal-title":"Nat Methods"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0500","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jmb.2011.07.048","article-title":"Slow formation of stable complexes during coincubation of minimal rRNA and ribosomal protein S4","volume":"412","author":"Mayerle","year":"2011","journal-title":"J Mol Biol"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0505","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/s12951-025-03352-8","article-title":"Exosome-powered neuropharmaceutics: unlocking the blood-brain barrier for next-gen therapies","volume":"23","author":"Mehdizadeh","year":"2025","journal-title":"J Nanobiotechnology"},{"issue":"7559","key":"10.1016\/j.biotechadv.2026.108979_bb0510","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature14581","article-title":"Glypican-1 identifies cancer exosomes and detects early pancreatic can cer","volume":"523","author":"Melo","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0515","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-physiol-012110-142317","article-title":"Lysosomal acidification mechanisms","volume":"74","author":"Mindell","year":"2012","journal-title":"Annu Rev Physiol"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0520","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1021\/cr800409e","article-title":"Nonviral vectors for gene delivery","volume":"109","author":"Mintzer","year":"2009","journal-title":"Chem Rev"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0525","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood-2011-02-338004","article-title":"Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes","volume":"119","author":"Montecalvo","year":"2012","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.biotechadv.2026.108979_bb0530","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1182\/blood-2004-03-0824","article-title":"Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells","volume":"104","author":"Morelli","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0535","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biomaterials.2016.09.031","article-title":"Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA","volume":"111","author":"Morishita","year":"2016","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.biotechadv.2026.108979_bb0540","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/mnfr.201300729","article-title":"Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles","volume":"58","author":"Mu","year":"2014","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0545","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.2147\/IJN.S420748","article-title":"Plant-derived exosome-like nanovesicles: current progress and prospects","volume":"18","author":"Mu","year":"2023","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0550","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v3.24641","article-title":"Routes and mechanisms of extracellular vesicle uptake","volume":"3","author":"Mulcahy","year":"2014","journal-title":"J Extracell Vesicles"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0555","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1021\/acs.nanolett.1c00094","article-title":"Natural or synthetic RNA delivery: a stoichiometric comparison of extracellular vesicles and synthetic nanoparticles","volume":"21","author":"Murphy","year":"2021","journal-title":"Nano Lett"},{"issue":"9","key":"10.1016\/j.biotechadv.2026.108979_bb0560","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.ymthe.2024.02.025","article-title":"Therapeutic potential of RNA-enriched extracellular vesicles: The next generation in RNA delivery via biogenic nanoparticles","volume":"32","author":"Muskan","year":"2024","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0565","doi-asserted-by":"crossref","DOI":"10.1038\/srep10112","article-title":"Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes","volume":"5","author":"Nakase","year":"2015","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0570","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12964-022-00889-1","article-title":"Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges","volume":"20","author":"Nemati","year":"2022","journal-title":"Cell Commun Signal"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0575","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1021\/acs.nanolett.0c04753","article-title":"A biomimetic drug delivery system by integrating grapefruit extracellular vesicles and doxorubicin-loaded heparin-based nanoparticles for glioma therapy","volume":"21","author":"Niu","year":"2021","journal-title":"Nano Lett"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0580","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1515\/hsz-2020-0329","article-title":"Mtr4 RNA helicase structures and interactions","volume":"402","author":"Olsen","year":"2021","journal-title":"Biol Chem"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0585","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/13543776.2023.2195093","article-title":"Purposing plant-derived exosomes-like nanovesicles for drug delivery: patents and literature review","volume":"33","author":"Orefice","year":"2023","journal-title":"Expert Opin Ther Pat"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0590","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-93876-4","article-title":"Garlic (Allium sativum)-derived SEVs inhibit cancer cell proliferation and induce caspase mediated apoptosis","volume":"11","author":"\u00d6zkan","year":"2021","journal-title":"Sci Rep"},{"issue":"49","key":"10.1016\/j.biotechadv.2026.108979_bb0595","doi-asserted-by":"crossref","first-page":"34211","DOI":"10.1074\/jbc.M109.041152","article-title":"Microenvironmental pH is a key factor for exosome traffic in tumor cells","volume":"284","author":"Parolini","year":"2009","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0600","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41576-021-00439-4","article-title":"Drug delivery systems for RNA therapeutics","volume":"23","author":"Paunovska","year":"2022","journal-title":"Nat Rev Genet"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0605","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/jxb\/erq402","article-title":"The role for the exocyst complex subunits Exo70B2 and Exo70H1 in the plant-pathogen interaction","volume":"62","author":"Pecenkov\u00e1","year":"2011","journal-title":"J Exp Bot"},{"issue":"8","key":"10.1016\/j.biotechadv.2026.108979_bb0610","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1039\/D0BM01696A","article-title":"Isolation of extracellular vesicles from microalgae: towards the production of sustainable and natural nanocarriers of bioactive compounds","volume":"9","author":"Picciotto","year":"2021","journal-title":"Biomater. Sci"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0615","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15030974","article-title":"Plant-derived extracellular vesicles as a delivery platform for RNA-based vaccine: feasibility study of an oral and intranasal SARS-CoV-2 vaccine","volume":"15","author":"Pomatto","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0620","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2144\/000114371","article-title":"A new approach to follow a single extracellular vesicle-cell interaction using optical tweezers","volume":"60","author":"Prada","year":"2016","journal-title":"Biotechniques"},{"issue":"23","key":"10.1016\/j.biotechadv.2026.108979_bb0625","doi-asserted-by":"crossref","first-page":"19514","DOI":"10.18632\/oncotarget.4004","article-title":"Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death","volume":"6","author":"Raimondo","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0630","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11523-020-00717-x","article-title":"MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside","volume":"15","author":"Ratti","year":"2020","journal-title":"Target Oncol"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0635","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-1-0716-1554-6_8","article-title":"The structure and mechanism of drug transporters","volume":"2342","author":"Roberts","year":"2021","journal-title":"Methods Mol Biol"},{"issue":"8","key":"10.1016\/j.biotechadv.2026.108979_bb0640","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.ymthe.2019.05.012","article-title":"mRNA delivery for therapeutic anti-HER2 antibody expression In Vivo","volume":"27","author":"Rybakova","year":"2019","journal-title":"Mol Ther"},{"issue":"7662","key":"10.1016\/j.biotechadv.2026.108979_bb0645","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature23003","article-title":"Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer","volume":"547","author":"Sahin","year":"2017","journal-title":"Nature"},{"issue":"1737","key":"10.1016\/j.biotechadv.2026.108979_bb0650","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2017.0065","article-title":"Cisplatin induces the release of extracellular vesicles from ovarian cancer cells that can induce invasiveness and drug resistance in bystander cells","volume":"373","author":"Samuel","year":"2018","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0655","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s12951-025-03528-2","article-title":"Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges","volume":"23","author":"Sanadgol","year":"2025","journal-title":"J Nanobiotechnology"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0660","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1021\/acsabm.3c01108","article-title":"Herb extracellular vesicle-chitosan-PEGylated graphene oxide conjugate delivers estrogen receptor \u03b1 targeting siRNA to breast cancer cells","volume":"7","author":"Saroj","year":"2024","journal-title":"ACS Appl Bio Mater"},{"issue":"7","key":"10.1016\/j.biotechadv.2026.108979_bb0665","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1073\/pnas.0308698100","article-title":"Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells","volume":"101","author":"Scacheri","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10426","key":"10.1016\/j.biotechadv.2026.108979_bb0670","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0140-6736(23)01952-9","article-title":"A new age of precision gene therapy","volume":"403","author":"Schambach","year":"2024","journal-title":"Lancet"},{"issue":"42","key":"10.1016\/j.biotechadv.2026.108979_bb0675","doi-asserted-by":"crossref","DOI":"10.1002\/advs.72372","article-title":"MicroRNA-enriched plant-derived exosomes alleviate colitis by modulating systemic immunity, metabolic homeostasis, and gut microbiota","volume":"12","author":"Shi","year":"2025","journal-title":"Adv Sci"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0680","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1128\/AAC.48.5.1756-1762.2004","article-title":"Dose-dependent pharmacokinetics of itraconazole after intravenous or oral administration to rats: intestinal first-pass effect","volume":"48","author":"Shin","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0685","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1038\/s41467-017-02066-2","article-title":"RNA degradation by the plant RNA exosome involves both phosphorolytic and hydrolytic activities","volume":"8","author":"Sikorska","year":"2017","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0690","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tibs.2018.02.001","article-title":"Unravelling the mechanisms of RNA helicase regulation","volume":"43","author":"Sloan","year":"2018","journal-title":"Trends Biochem Sci"},{"issue":"7","key":"10.1016\/j.biotechadv.2026.108979_bb0695","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.4161\/rna.24909","article-title":"Ineffective delivery of diet-derived microRNAs to recipient animal organisms","volume":"10","author":"Snow","year":"2013","journal-title":"RNA Biology"},{"issue":"36","key":"10.1016\/j.biotechadv.2026.108979_bb0700","doi-asserted-by":"crossref","first-page":"23118","DOI":"10.1021\/acsomega.0c02893","article-title":"Internalization of garlic-derived nanovesicles on liver cells is triggered by interaction with CD98","volume":"5","author":"Song","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0705","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-1-4939-3804-9_18","article-title":"Isolation of exosome-like vesicles from plants by ultracentrifugation on sucrose\/deuterium oxide (D2O) density cushions","volume":"1459","author":"Stanly","year":"2016","journal-title":"Methods Mol Biol"},{"issue":"24","key":"10.1016\/j.biotechadv.2026.108979_bb0710","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246205","article-title":"Membrane transporters in Citrus clementina fruit juice-derived nanovesicles","volume":"20","author":"Stanly","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.biotechadv.2026.108979_bb0715","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122722","article-title":"Grapefruit-derived micro and nanovesicles show distinct metabolome profiles and anticancer activities in the A375 human melanoma cell line","volume":"9","author":"Stanly","year":"2020","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.biotechadv.2026.108979_bb0720","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1111\/1750-3841.15787","article-title":"Plant-derived exosome-like nanoparticles: A concise review on its extraction methods, content, bioactivities, and potential as functional food ingredient","volume":"86","author":"Suharta","year":"2021","journal-title":"J Food Sci"},{"issue":"13","key":"10.1016\/j.biotechadv.2026.108979_bb0725","doi-asserted-by":"crossref","first-page":"10605","DOI":"10.1021\/acs.jafc.5c12697","article-title":"Fucoxanthin: a comprehensive review on digestion, biotransformation, microbiome interaction, and targeted delivery","volume":"74","author":"Sun","year":"2026","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0730","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2017.1388731","article-title":"Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes","volume":"6","author":"Takov","year":"2017","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0735","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101083","article-title":"pH\/ATP cascade-responsive nano-courier with efficient tumor targeting and siRNA unloading for photothermal-immunotherapy","volume":"37","author":"Tang","year":"2021","journal-title":"Nano Today"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0740","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.chom.2018.10.001","article-title":"Plant-derived exosomal microRNAs shape the gut microbiota","volume":"24","author":"Teng","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"13","key":"10.1016\/j.biotechadv.2026.108979_bb0745","doi-asserted-by":"crossref","first-page":"495","DOI":"10.15585\/mmwr.mm7013e3","volume":"70","author":"Thompson","year":"2021","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"20","key":"10.1016\/j.biotechadv.2026.108979_bb0750","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.15252\/embj.201696003","article-title":"Qualitative differences in T-cell activation by dendritic cell-derived extracellular vesicle subtypes","volume":"36","author":"Tkach","year":"2017","journal-title":"Embo J"},{"issue":"7","key":"10.1016\/j.biotechadv.2026.108979_bb0755","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/jth.12602","article-title":"Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing","volume":"12","author":"van der Pol","year":"2014","journal-title":"J Thromb Haemost"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0760","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0765","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12020102","article-title":"Opportunities and challenges in the delivery of mRNA-based vaccines","volume":"12","author":"Wadhwa","year":"2020","journal-title":"Pharmaceutics"},{"issue":"12","key":"10.1016\/j.biotechadv.2026.108979_bb0770","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1105\/tpc.110.080697","article-title":"EXPO, an exocyst-positive organelle distinct from multivesicular endosomes and autophagosomes, mediates cytosol to cell wall exocytosis in Arabidopsis and tobacco cells","volume":"22","author":"Wang","year":"2010","journal-title":"Plant Cell"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0775","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1038\/ncomms2886","article-title":"Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids","volume":"4","author":"Wang","year":"2013","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0780","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/mt.2013.190","article-title":"Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit","volume":"22","author":"Wang","year":"2014","journal-title":"Mol Ther"},{"issue":"12","key":"10.1016\/j.biotechadv.2026.108979_bb0785","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1158\/0008-5472.CAN-14-3095","article-title":"Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites","volume":"75","author":"Wang","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0790","article-title":"Oral delivery of Dmt1 siRNAs by ginger nanoparticle-derived lipid vectors mitigates iron loading in hepcidin KO mice","volume":"33","author":"Wang","year":"2019","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0795","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ymthe.2019.01.003","article-title":"Oral gavage of ginger nanoparticle-derived lipid vectors carrying Dmt1 siRNA blunts iron loading in murine hereditary hemochromatosis","volume":"27","author":"Wang","year":"2019","journal-title":"Mol Ther"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0800","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2020.03.023","article-title":"Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression","volume":"322","author":"Wang","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0805","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111044","article-title":"Anticancer activities of TCM and their active components against tumor metastasis","volume":"133","author":"Wang","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0810","doi-asserted-by":"crossref","DOI":"10.3390\/nu13051686","article-title":"Oral administration of ginger-derived lipid nanoparticles and Dmt1 siRNA potentiates the effect of dietary iron restriction and mitigates pre-existing iron overload in Hamp KO mice","volume":"13","author":"Wang","year":"2021","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.biotechadv.2026.108979_bb0815","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad249","article-title":"RNA trafficking and subcellular localization-a review of mechanisms, experimental and predictive methodologies","volume":"24","author":"Wang","year":"2023","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0820","first-page":"82","article-title":"Lipidomic analysis of plant-derived extracellular vesicles for guidance of potential anti-cancer therapy","volume":"46","author":"Wang","year":"2025","journal-title":"Bioact Mater"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0825","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11061554","article-title":"Advances in the therapeutic applications of plant-derived exosomes in the treatment of inflammatory diseases","volume":"11","author":"Wei","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0830","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ncrna.2025.08.007","article-title":"Exosome-like nanovesicles from Dunaliella salina efficient sequential co-delivery of anti-PDL1 and miR-375 for enhancing gene\/immune therapy","volume":"14","author":"Wei","year":"2025","journal-title":"Noncoding RNA Res"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0835","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J Extracell Vesicles"},{"issue":"492","key":"10.1016\/j.biotechadv.2026.108979_bb0840","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav8521","article-title":"Advances in therapeutic applications of extracellular vesicles","volume":"11","author":"Wiklander","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0845","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev-biophys-083012-130404","article-title":"Molecular mechanisms of RNA interference","volume":"42","author":"Wilson","year":"2013","journal-title":"Annu Rev Biophys"},{"issue":"8","key":"10.1016\/j.biotechadv.2026.108979_bb0850","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41573-021-00219-z","article-title":"Noncoding RNA therapeutics - challenges and potential solutions","volume":"20","author":"Winkle","year":"2021","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0855","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020357","article-title":"Extracellular vesicles from fresh and dried plants-simultaneous purification and visualization using gel electrophoresis","volume":"20","author":"Woith","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0860","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.bbcan.2017.10.001","article-title":"Extracellular vesicles as emerging targets in cancer: recent development from bench to bedside","volume":"1868","author":"Wu","year":"2017","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0865","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood-brain barrier: structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0870","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.5186","article-title":"Identification of exosome-like nanoparticle-derived microRNAs from 11 edible fruits and vegetables","volume":"6","author":"Xiao","year":"2018","journal-title":"PeerJ"},{"issue":"9","key":"10.1016\/j.biotechadv.2026.108979_bb0875","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201701130","article-title":"Glioma-targeted delivery of a theranostic liposome integrated with quantum dots, superparamagnetic iron oxide, and cilengitide for dual-imaging guiding cancer surgery","volume":"7","author":"Xu","year":"2018","journal-title":"Adv Healthc Mater"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0880","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202105385","article-title":"Restoring oat nanoparticles mediated brain memory function of mice fed alcohol by sorting inflammatory Dectin-1 complex into microglial exosomes","volume":"18","author":"Xu","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0885","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102438","article-title":"Plant-derived exosomes as cell homogeneous nanoplatforms for brain biomacromolecules delivery ameliorate mitochondrial dysfunction against Parkinson\u2019s disease","volume":"58","author":"Xu","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0890","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.139092","article-title":"Inhibition mechanism of leukemia cells HL-60 by exopolysaccharides from Botryococcus braunii in response to high-concentration cobalt","volume":"290","author":"Xu","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0895","article-title":"Utilizing extracellular vesicles from Phaeodactylum tricornutum as a novel approach for protecting the skin from oxidative damage","author":"Xu","year":"2025","journal-title":"ACS Biomater Sci Eng."},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0900","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202512563","article-title":"Folic acid-modified ginger-derived exosome-like nanoparticles co-delivering sunitinib suppress renal cell carcinoma via PI3K-Akt pathway inhibition, P-gp downregulation, and macrophage reprogramming","volume":"13","author":"Xu","year":"2026","journal-title":"Adv Sci"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0905","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J Extracell Vesicles"},{"issue":"2","key":"10.1016\/j.biotechadv.2026.108979_bb0910","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1208\/s12248-016-0015-y","article-title":"Delivery of small interfering RNA to inhibit vascular endothelial growth factor in zebrafish using natural brain endothelia cell-secreted exosome nanovesicles for the treatment of brain cancer","volume":"19","author":"Yang","year":"2017","journal-title":"Aaps J"},{"issue":"9","key":"10.1016\/j.biotechadv.2026.108979_bb0915","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1039\/C7TB03207B","article-title":"Advances in plant-derived edible nanoparticle-based lipid nano-drug delivery systems as therapeutic nanomedicines","volume":"6","author":"Yang","year":"2018","journal-title":"J Mater Chem B"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0925","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s13346-024-01621-x","article-title":"Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment","volume":"15","author":"Yi","year":"2025","journal-title":"Drug Deliv Transl Res"},{"issue":"15","key":"10.1016\/j.biotechadv.2026.108979_bb0930","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1021\/acs.jafc.1c07306","article-title":"Characterization of the microRNA profile of ginger exosome-like nanoparticles and their anti-inflammatory effects in intestinal Caco-2 cells","volume":"70","author":"Yin","year":"2022","journal-title":"J Agric Food Chem"},{"issue":"34","key":"10.1016\/j.biotechadv.2026.108979_bb0935","doi-asserted-by":"crossref","first-page":"29568","DOI":"10.1074\/jbc.M111.262816","article-title":"Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect","volume":"286","author":"Yoon","year":"2011","journal-title":"J Biol Chem"},{"issue":"5711","key":"10.1016\/j.biotechadv.2026.108979_bb0940","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1126\/science.1107130","article-title":"Methylation as a crucial step in plant microRNA biogenesis","volume":"307","author":"Yu","year":"2005","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.biotechadv.2026.108979_bb0945","doi-asserted-by":"crossref","DOI":"10.3390\/cells12101416","article-title":"Current strategies for exosome cargo loading and targeting delivery","volume":"12","author":"Zeng","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb0950","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/cr.2011.158","article-title":"Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA","volume":"22","author":"Zhang","year":"2012","journal-title":"Cell Res"},{"key":"10.1016\/j.biotechadv.2026.108979_bb0955","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.biomaterials.2016.06.018","article-title":"Edible ginger-derived nanoparticles: a novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer","volume":"101","author":"Zhang","year":"2016","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.biotechadv.2026.108979_bb0960","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1038\/mt.2016.159","article-title":"Edible ginger-derived nano-lipids loaded with doxorubicin as a novel drug-delivery approach for colon cancer therapy","volume":"24","author":"Zhang","year":"2016","journal-title":"Mol Ther"},{"issue":"16","key":"10.1016\/j.biotechadv.2026.108979_bb0965","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.2217\/nnm-2017-0196","article-title":"Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis","volume":"12","author":"Zhang","year":"2017","journal-title":"Nanomedicine"},{"issue":"4","key":"10.1016\/j.biotechadv.2026.108979_bb0970","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41582-018-0126-4","article-title":"Exosomes - beyond stem cells for restorative therapy in stroke and neurological injury","volume":"15","author":"Zhang","year":"2019","journal-title":"Nat Rev Neurol"},{"issue":"Pt 2","key":"10.1016\/j.biotechadv.2026.108979_bb0975","article-title":"Lycium ruthenicum Murray derived exosome-like nanovesicles inhibit A\u03b2-induced apoptosis in PC12 cells via MAPK and PI3K\/AKT signaling pathways","volume":"277","author":"Zhang","year":"2024","journal-title":"Int J Biol Macromol"},{"issue":"11","key":"10.1016\/j.biotechadv.2026.108979_bb0980","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1021\/acs.jafc.7b05614","article-title":"Isolation of exosome-like nanoparticles and analysis of microRNAs derived from coconut water based on small RNA high-throughput sequencing","volume":"66","author":"Zhao","year":"2018","journal-title":"J Agric Food Chem"},{"issue":"3","key":"10.1016\/j.biotechadv.2026.108979_bb0985","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41401-021-00681-w","article-title":"Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress","volume":"43","author":"Zhao","year":"2022","journal-title":"Acta Pharmacol Sin"},{"issue":"12","key":"10.1016\/j.biotechadv.2026.108979_bb0990","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.7150\/thno.97096","article-title":"Exosome-like nanoparticles derived from fruits, vegetables, and herbs: innovative strategies of therapeutic and drug delivery","volume":"14","author":"Zhao","year":"2024","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.biotechadv.2026.108979_bb0995","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/wrna.1363","article-title":"Exosome-mediated small RNA delivery for gene therapy","volume":"7","author":"Zhou","year":"2016","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"10.1016\/j.biotechadv.2026.108979_bb1000","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.2147\/IJN.S425173","article-title":"Identifying the potential of miRNAs in houttuynia cordata-derived exosome-like nanoparticles against respiratory RNA viruses","volume":"18","author":"Zhu","year":"2023","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"10.1016\/j.biotechadv.2026.108979_bb1005","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/mt.2015.188","article-title":"Grapefruit-derived nanovectors delivering therapeutic miR17 through an intranasal route inhibit brain tumor progression","volume":"24","author":"Zhuang","year":"2016","journal-title":"Mol Ther"},{"issue":"1-2","key":"10.1016\/j.biotechadv.2026.108979_bb1010","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijpharm.2010.01.019","article-title":"Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells","volume":"389","author":"Zou","year":"2010","journal-title":"Int J Pharm"}],"container-title":["Biotechnology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975026001850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975026001850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:39:26Z","timestamp":1787139566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0734975026001850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":201,"alternative-id":["S0734975026001850"],"URL":"https:\/\/doi.org\/10.1016\/j.biotechadv.2026.108979","relation":{},"ISSN":["0734-9750"],"issn-type":[{"value":"0734-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nature-derived exosome-like nanoparticles (NELNs) for intracellular transport and targeted RNA delivery","name":"articletitle","label":"Article Title"},{"value":"Biotechnology Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biotechadv.2026.108979","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108979"}}