{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:00:17Z","timestamp":1790701217273,"version":"4.1.0"},"reference-count":207,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572135"],"award-info":[{"award-number":["82572135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2025NSFTD0030"],"award-info":[{"award-number":["2025NSFTD0030"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024NSFTD0029"],"award-info":[{"award-number":["2024NSFTD0029"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403200"],"award-info":[{"award-number":["2023YFC3403200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20241163"],"award-info":[{"award-number":["GZC20241163"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M762207"],"award-info":[{"award-number":["2024M762207"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0500500"],"award-info":[{"award-number":["2023ZD0500500"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biotechnology Advances"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.biotechadv.2026.109018","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:26:33Z","timestamp":1787095593000},"page":"109018","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Interplay Between Base Editing and DNA repair: From Molecular Mechanisms to Clinical Translation"],"prefix":"10.1016","volume":"93","author":[{"given":"Rui","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biotechadv.2026.109018_bb0005","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ctrv.2009.12.006","article-title":"Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer","volume":"36","author":"Abbotts","year":"2010","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0010","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.dnarep.2007.01.009","article-title":"A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification","volume":"6","author":"Almeida","year":"2007","journal-title":"DNA Repair"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-019-1711-4","article-title":"Search-and-replace genome editing without double-strand breaks or donor DNA","volume":"576","author":"Anzalone","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0020","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41587-020-0561-9","article-title":"Genome editing with CRISPR\u2013cas nucleases, base editors, transposases and prime editors","volume":"38","author":"Anzalone","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2020.05.037","article-title":"Determinants of base editing outcomes from target library analysis and machine learning","volume":"182","author":"Arbab","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg6518","article-title":"Base editing rescue of spinal muscular atrophy in cells and in mice","volume":"380","author":"Arbab","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.dnarep.2009.11.002","article-title":"DNA polymerase \u03b2-dependent long patch base excision repair in living cells","volume":"9","author":"Asagoshi","year":"2010","journal-title":"DNA Repair"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0040","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/s41467-024-45763-5","article-title":"Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope","volume":"15","author":"Bamidele","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0045","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cell.2021.12.021","article-title":"Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins","volume":"185","author":"Banskota","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0050","doi-asserted-by":"crossref","first-page":"6824","DOI":"10.1074\/jbc.RA117.001074","article-title":"Activity and fidelity of human DNA polymerase \u03b1 depend on primer structure","volume":"293","author":"Baranovskiy","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0055","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1021\/cr0404904","article-title":"Structure and mechanism of DNA polymerase \u03b2","volume":"106","author":"Beard","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0060","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0735-1097(22)01944-1","article-title":"Sequential in vivo crispr base editing of the pcsk9 and angptl3 genes in non-human primates","volume":"79","author":"Bellinger","year":"2022","journal-title":"JACC"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0065","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/nature09196","article-title":"Structure and mechanism of human DNA polymerase \u03b7","volume":"465","author":"Biert\u00fcmpfel","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0070","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.molcel.2017.08.008","article-title":"CRISPR-mediated base editing enables efficient disruption of eukaryotic genes through induction of STOP codons","volume":"67","author":"Billon","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0075","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adj6779","article-title":"High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease","volume":"16","author":"Bzhilyanskaya","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41591-018-0326-x","article-title":"Identification of preexisting adaptive immunity to Cas9 proteins in humans","volume":"25","author":"Charlesworth","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0085","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau0766","article-title":"Minimal PAM specificity of a highly similar SpCas9 ortholog","volume":"4","author":"Chatterjee","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0090","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1016\/j.cell.2021.09.018","article-title":"Enhanced prime editing systems by manipulating cellular determinants of editing outcomes","volume":"184","author":"Chen","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0095","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/s41467-021-21559-9","article-title":"Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41589-022-01163-8","article-title":"Engineering a precise adenine base editor with minimal bystander editing","volume":"19","author":"Chen","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0105","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41587-022-01532-7","article-title":"Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing","volume":"41","author":"Chen","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0110","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41587-023-01821-9","article-title":"Adenine transversion editors enable precise, efficient a\u2022T-to-C\u2022G base editing in mammalian cells and embryos","volume":"42","author":"Chen","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0115","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1056\/NEJMoa2300709","article-title":"Base-edited CAR7 T cells for relapsed T-cell acute lymphoblastic leukemia","volume":"389","author":"Chiesa","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0120","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jmb.2010.09.015","article-title":"Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases \u03b1, \u03b4, \u03b7, \u03b9, \u03ba, and REV1","volume":"404","author":"Choi","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0125","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1038\/s41467-022-29490-3","article-title":"In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration","volume":"13","author":"Choi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0130","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.ymthe.2020.05.002","article-title":"Mutation-independent allele-specific editing by CRISPR-Cas9, a novel approach to treat autosomal dominant disease","volume":"28","author":"Christie","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0135","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/crispr.2020.0144","article-title":"Rationally designed base editors for precise editing of the sickle cell disease mutation","volume":"4","author":"Chu","year":"2021","journal-title":"CRISPR J."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0140","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ebiom.2019.09.020","article-title":"A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with huntington disease clinical outcomes","volume":"48","author":"Ciosi","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0145","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1073\/pnas.79.8.2523","article-title":"A DNA primase activity associated with DNA polymerase alpha from drosophila melanogaster embryos","volume":"79","author":"Conaway","year":"1982","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0150","doi-asserted-by":"crossref","first-page":"11041","DOI":"10.1016\/S0021-9258(18)82089-0","article-title":"Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis","volume":"268","author":"Copeland","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0155","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1074\/jbc.M310447200","article-title":"Lesion bypass by human DNA polymerase \u03bc reveals a template-dependent, sequence-independent nucleotidyl transferase activity *","volume":"279","author":"Covo","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0160","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1038\/s41467-018-05843-9","article-title":"Cas9 immunity creates challenges for CRISPR gene editing therapies","volume":"9","author":"Crudele","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41551-024-01235-1","article-title":"A base editor for the long-term restoration of auditory function in mice with recessive profound deafness","volume":"9","author":"Cui","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0170","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1021\/acssynbio.5b00299","article-title":"The impact of chromatin dynamics on Cas9-mediated genome editing in human cells","volume":"6","author":"Daer","year":"2017","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0175","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkae1254","article-title":"DNA polymerase zeta can efficiently replicate structures formed by AT\/TA repeat sequences and prevent their deletion","volume":"53","author":"Das","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0180","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nature05978","article-title":"Base-excision repair of oxidative DNA damage","volume":"447","author":"David","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0185","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41587-020-0414-6","article-title":"Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors","volume":"38","author":"Doman","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0190","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41586-020-1978-5","article-title":"The promise and challenge of therapeutic genome editing","volume":"578","author":"Doudna","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0195","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012682","article-title":"Translesion DNA synthesis and mutagenesis in prokaryotes","volume":"5","author":"Fuchs","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0200","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.omtn.2023.07.029","article-title":"Targeting duchenne muscular dystrophy by skipping DMD exon 45 with base editors","volume":"33","author":"Gapinske","year":"2023","journal-title":"Mol. Ther. - Nucleic Acids"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0205","doi-asserted-by":"crossref","first-page":"13184","DOI":"10.1074\/jbc.M111601200","article-title":"DNA polymerase \u03bb, a novel DNA repair enzyme in human cells\u2217","volume":"277","author":"Garc\u0131\u0301a-D\u0131\u0301az","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/bies.70092","article-title":"The double face of base excision repair: preventing and triggering double-strand breaks","volume":"48","author":"Gasser","year":"2026","journal-title":"BioEssays"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0215","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature24644","article-title":"Programmable base editing of a\u2022T to G\u2022C in genomic DNA without DNA cleavage","volume":"551","author":"Gaudelli","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0220","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/s41587-020-0491-6","article-title":"Directed evolution of adenine base editors with increased activity and therapeutic application","volume":"38","author":"Gaudelli","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0225","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1038\/s41375-021-01282-6","article-title":"Base-edited CAR T cells for combinational therapy against T cell malignancies","volume":"35","author":"Georgiadis","year":"2021","journal-title":"Leukemia"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814186","article-title":"Base excision repair: mechanisms and impact in biology, disease, and medicine","volume":"24","author":"Gohil","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0235","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a010363","article-title":"Translesion DNA polymerases","volume":"5","author":"Goodman","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0240","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41586-019-1161-z","article-title":"Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors","volume":"569","author":"Gr\u00fcnewald","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0245","article-title":"Base editors: expanding the types of DNA damage products harnessed for genome editing","volume":"1","author":"Gu","year":"2021","journal-title":"Gene Genome Ed."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0250","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/s41587-025-02802-w","article-title":"Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes","volume":"44","author":"Gupta","year":"2026","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0255","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/s41591-019-0500-9","article-title":"Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss","volume":"25","author":"Gy\u00f6rgy","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0260","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/s12276-022-00822-z","article-title":"8-oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification","volume":"54","author":"Hahm","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0265","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/78169","article-title":"Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase \u03b7","volume":"25","author":"Haracska","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0270","doi-asserted-by":"crossref","first-page":"14256","DOI":"10.1073\/pnas.261560798","article-title":"Targeting of human DNA polymerase \u03b9 to the replication machinery via interaction with PCNA","volume":"98","author":"Haracska","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0275","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1101\/gad.882301","article-title":"Roles of yeast DNA polymerases \u03b4 and \u03b6 and of Rev1 in the bypass of abasic sites","volume":"15","author":"Haracska","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0280","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.1074\/jbc.M008021200","article-title":"Inefficient bypass of an abasic site by DNA polymerase \u03b7*","volume":"276","author":"Haracska","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0285","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.molcel.2024.01.021","article-title":"Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing","volume":"84","author":"He","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0290","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/nmeth.4038","article-title":"Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells","volume":"13","author":"Hess","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0295","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1152\/physiol.00006.2023","article-title":"Tissue specificity of DNA damage and repair","volume":"38","author":"Hoch","year":"2023","journal-title":"Physiology"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0300","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0305","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nbt.2647","article-title":"DNA targeting specificity of RNA-guided Cas9 nucleases","volume":"31","author":"Hsu","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0310","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature26155","article-title":"Evolved Cas9 variants with broad PAM compatibility and high DNA specificity","volume":"556","author":"Hu","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0315","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41587-019-0134-y","article-title":"Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors","volume":"37","author":"Huang","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0320","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.1093\/nar\/gkn719","article-title":"The N-clasp of human DNA polymerase \u03ba promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions","volume":"36","author":"Jia","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0325","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-biophys-062215-010822","article-title":"CRISPR\u2013Cas9 structures and mechanisms","volume":"46","author":"Jiang","year":"2017","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0330","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1021\/acssynbio.1c00293","article-title":"Molecular mechanism of the cytosine CRISPR base editing process and the roles of translesion DNA polymerases","volume":"10","author":"Jiang","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0335","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.7150\/thno.70869","article-title":"Internally inlaid SaCas9 base editors enable window specific base editing","volume":"12","author":"Jiang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0340","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.tibtech.2025.03.001","article-title":"Improving plant C-to-G base editors with a cold-adapted glycosylase and TadA-8e variants","volume":"43","author":"Jiang","year":"2025","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0345","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.aaw7166","article-title":"Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice","volume":"364","author":"Jin","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0350","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1038\/s41467-020-18506-5","article-title":"Structural snapshots of human DNA polymerase \u03bc engaged on a DNA double-strand break","volume":"11","author":"Kaminski","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0355","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1038\/s41467-023-37465-1","article-title":"GalNAc-lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy","volume":"14","author":"Kasiewicz","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0360","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1002\/j.1460-2075.1996.tb00710.x","article-title":"Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase","volume":"15","author":"Kavli","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0365","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nsmb.2961","article-title":"Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase \u03b8","volume":"22","author":"Kent","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0370","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1021\/tx5002755","article-title":"Biochemical analysis of six genetic variants of error-prone human DNA polymerase \u03b9 involved in translesion DNA synthesis","volume":"27","author":"Kim","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0375","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nbt.3803","article-title":"Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions","volume":"35","author":"Kim","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0380","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nbt.3852","article-title":"Genome-wide target specificities of CRISPR RNA-guided programmable deaminases","volume":"35","author":"Kim","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0385","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41587-021-01009-z","article-title":"Efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs delivered by adeno-associated virus","volume":"40","author":"Kim","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0390","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41587-023-01792-x","article-title":"Deep learning models to predict the editing efficiencies and outcomes of diverse base editors","volume":"42","author":"Kim","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0395","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature14592","article-title":"Engineered CRISPR-Cas9 nucleases with altered PAM specificities","volume":"523","author":"Kleinstiver","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0400","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nature16526","article-title":"High-fidelity CRISPR\u2013Cas9 nucleases with no detectable genome-wide off-target effects","volume":"529","author":"Kleinstiver","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0405","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nbt.4172","article-title":"Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction","volume":"36","author":"Koblan","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0410","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/s41587-021-00938-z","article-title":"Efficient C\u2022G-to-G\u2022C base editors developed using CRISPRi screens, target-library analysis, and machine learning","volume":"39","author":"Koblan","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0415","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature17946","article-title":"Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage","volume":"533","author":"Komor","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0420","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aao4774","article-title":"Improved base excision repair inhibition and bacteriophage mu gam protein yields C:G-to-T:a base editors with higher efficiency and product purity","volume":"3","author":"Komor","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0425","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1021\/acschembio.7b00710","article-title":"Editing the genome without double-stranded DNA breaks","volume":"13","author":"Komor","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0430","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nbt.4192","article-title":"Repair of double-strand breaks induced by CRISPR\u2013Cas9 leads to large deletions and complex rearrangements","volume":"36","author":"Kosicki","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0435","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012583","article-title":"Base excision repair","volume":"5","author":"Krokan","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0440","doi-asserted-by":"crossref","first-page":"16002","DOI":"10.1074\/jbc.M414541200","article-title":"Crystal structure of tRNA adenosine deaminase (TadA) from aquifex aeolicus*","volume":"280","author":"Kuratani","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0445","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41587-020-0609-x","article-title":"CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells","volume":"39","author":"Kurt","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0450","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nmeth.4327","article-title":"CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations","volume":"14","author":"Kuscu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0455","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1074-5521(03)00077-2","article-title":"Rational engineering of a DNA glycosylase specific for an unnatural cytosine:pyrene base pair","volume":"10","author":"Kwon","year":"2003","journal-title":"Chem. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0460","first-page":"1","article-title":"Clinical application of base editing for treating \u03b2-thalassaemia","author":"Lai","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0465","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41587-022-01611-9","article-title":"Improved cytosine base editors generated from TadA variants","volume":"41","author":"Lam","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0470","doi-asserted-by":"crossref","first-page":"D862","DOI":"10.1093\/nar\/gkv1222","article-title":"ClinVar: public archive of interpretations of clinically relevant variants","volume":"44","author":"Landrum","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0475","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nrc2998","article-title":"DNA polymerases and cancer","volume":"11","author":"Lange","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0480","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1126\/science.abb1390","article-title":"DNA capture by a CRISPR-Cas9\u2013guided adenine base editor","volume":"369","author":"Lapinaite","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0485","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0092-8674(00)81755-9","article-title":"Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision","volume":"95","author":"Lau","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0490","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1001\/jamaneurol.2020.0299","article-title":"Huntingtin-lowering therapies for huntington disease: a review of the evidence of potential benefits and risks","volume":"77","author":"Leavitt","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0495","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1016-8478(23)13956-2","article-title":"PCNA modifications for regulation of post-replication repair pathways","volume":"26","author":"Lee","year":"2008","journal-title":"Mol. Cells"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0500","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41551-019-0501-5","article-title":"Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses","volume":"4","author":"Levy","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibtech.2026.02.014","article-title":"Harnessing TLS polymerases to direct nucleotide outcomes in base editing","author":"Li","year":"2026","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0510","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1038\/s41467-020-19730-9","article-title":"Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0515","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1038\/s41467-025-57269-9","article-title":"Structural basis of error-prone DNA synthesis by DNA polymerase \u03b8","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0520","article-title":"Optimized gGBE enables robust G-to-Y conversion in mammalian cells and zebrafish embryos","author":"Li","year":"2026","journal-title":"Zool. Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0525","series-title":"Development of B-to-a Base Editors by Leveraging Translesion Synthesis Polymerase","author":"Liang","year":"2025"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0530","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0535","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1021\/bi00769a018","article-title":"Rate of depurination of native deoxyribonucleic acid","volume":"11","author":"Lindahl","year":"1972","journal-title":"Biochemistry"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0540","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1126\/science.286.5446.1897","article-title":"Quality control by DNA repair","volume":"286","author":"Lindahl","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0545","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0092-8674(01)00515-3","article-title":"Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication","volume":"107","author":"Ling","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0550","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1097-2765(04)00101-7","article-title":"Snapshots of replication through an abasic lesion: structural basis for base substitutions and frameshifts","volume":"13","author":"Ling","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0555","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1080\/10717544.2018.1474964","article-title":"Delivering CRISPR: a review of the challenges and approaches","volume":"25","author":"Lino","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0560","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210307","article-title":"DNA glycosylases define the outcome of endogenous base modifications","volume":"24","author":"Lirussi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0565","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1038\/s41467-020-19690-0","article-title":"A cas-embedding strategy for minimizing off-target effects of DNA base editors","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0570","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.molcel.2007.01.018","article-title":"Human DNA polymerase \u03ba encircles DNA: implications for mismatch extension and lesion bypass","volume":"25","author":"Lone","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0575","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/nmeth.4027","article-title":"Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells","volume":"13","author":"Ma","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0580","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade7997","article-title":"Polymerase iota (pol \u03b9) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability","volume":"9","author":"Mansilla","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0585","doi-asserted-by":"crossref","first-page":"8348","DOI":"10.1093\/nar\/gkz705","article-title":"DNA polymerase \u03b6 in DNA replication and repair","volume":"47","author":"Martin","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0590","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2517556122","article-title":"DNA polymerase \u03b1-primase can function as a translesion DNA polymerase","volume":"122","author":"Mayle","year":"2025","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0595","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cr.2008.4","article-title":"The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases","volume":"18","author":"McCulloch","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0600","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41586-021-03534-y","article-title":"In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates","volume":"593","author":"Musunuru","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0605","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1126\/science.1116336","article-title":"Rev1 employs a novel mechanism of DNA synthesis using a protein template","volume":"309","author":"Nair","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0610","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.str.2009.02.015","article-title":"DNA synthesis across an abasic lesion by human DNA polymerase \u03b9","volume":"17","author":"Nair","year":"2009","journal-title":"Structure"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0615","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jmb.2010.12.016","article-title":"DNA synthesis across an abasic lesion by yeast Rev1 DNA polymerase","volume":"406","author":"Nair","year":"2011","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0620","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.molcel.2021.12.026","article-title":"CRISPR-based genome editing through the lens of DNA repair","volume":"82","author":"Nambiar","year":"2022","journal-title":"Mol. Cell, Focus on technology"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0625","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1038\/s41477-023-01548-0","article-title":"Split complementation of base editors reduces off-target edits","volume":"9","year":"2023","journal-title":"Nat. Plants"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0630","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/382729a0","article-title":"Deoxycytidyl transferase activity of yeast REV1 protein","volume":"382","author":"Nelson","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0635","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41587-022-01533-6","article-title":"Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity","volume":"41","author":"Neugebauer","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0640","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1016\/j.ymthe.2021.09.002","article-title":"In vivo somatic cell base editing and prime editing","volume":"29","author":"Newby","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0645","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41586-021-03609-w","article-title":"Base editing of haematopoietic stem cells rescues sickle cell disease in mice","volume":"595","author":"Newby","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0650","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1038\/s41467-020-18715-y","article-title":"Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing","volume":"11","author":"Nguyen Tran","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0655","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf8729","article-title":"Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems","volume":"353","author":"Nishida","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0660","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1126\/science.aas9129","article-title":"Engineered CRISPR-Cas9 nuclease with expanded targeting space","volume":"361","author":"Nishimasu","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0665","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nbt.3528","article-title":"Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch","volume":"34","author":"Oakes","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0670","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1073\/pnas.0711227105","article-title":"Mutational specificity and genetic control of replicative bypass of an abasic site in yeast","volume":"105","author":"Pag\u00e8s","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0675","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1093\/emboj\/17.17.5214","article-title":"Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA","volume":"17","author":"Parikh","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0680","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1056\/NEJMra1800729","article-title":"A new class of medicines through DNA editing","volume":"380","author":"Porteus","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0685","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.biochem.74.082803.133250","article-title":"Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function","volume":"74","author":"Prakash","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0690","doi-asserted-by":"crossref","first-page":"10824","DOI":"10.1093\/nar\/gkw869","article-title":"Rev1 is a base excision repair enzyme with 5\u2032-deoxyribose phosphate lyase activity","volume":"44","author":"Prasad","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0695","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1016\/j.cell.2022.03.045","article-title":"Therapeutic in vivo delivery of gene editing agents","volume":"185","author":"Raguram","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0700","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1601317","article-title":"Structure and mechanism of human PrimPol, a DNA polymerase with primase activity","volume":"2","author":"Rechkoblit","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0705","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41576-018-0059-1","article-title":"Base editing: precision chemistry on the genome and transcriptome of living cells","volume":"19","author":"Rees","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0710","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/s41587-020-0453-z","article-title":"Phage-assisted evolution of an adenine base editor with improved cas domain compatibility and activity","volume":"38","author":"Richter","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0715","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/s41587-021-00933-4","article-title":"In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels","volume":"39","author":"Rothgangl","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0720","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/nar\/gkx1199","article-title":"Improving CRISPR\u2013cas specificity with chemical modifications in single-guide RNAs","volume":"46","author":"Ryan","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0725","doi-asserted-by":"crossref","first-page":"31555","DOI":"10.1074\/jbc.M109.043927","article-title":"Translesion synthesis of abasic sites by yeast DNA polymerase \u03f5*","volume":"284","author":"Sabouri","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0730","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1021\/bi00288a026","article-title":"Insertion of nucleotides opposite apurinic apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides","volume":"22","author":"Sagher","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0735","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3289","article-title":"Y-family DNA polymerases and their role in tolerance of cellular DNA damage","volume":"13","author":"Sale","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0740","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","article-title":"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints","volume":"73","author":"Sancar","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0745","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1038\/sj.emboj.7600424","article-title":"High-efficiency bypass of DNA damage by human DNA polymerase Q","volume":"23","author":"Seki","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0750","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/emboj.2008.281","article-title":"Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals","volume":"28","author":"Shachar","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0755","doi-asserted-by":"crossref","first-page":"9153","DOI":"10.1038\/s41467-025-64203-6","article-title":"A motif preferred adenine base editor with minimal bystander and off-targets editing","volume":"16","author":"Shang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0760","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl1045","article-title":"High-fidelity, hyper-accurate, and evolved mutants rewire atomic-level communication in CRISPR-Cas9","volume":"10","author":"Skeens","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0765","doi-asserted-by":"crossref","first-page":"21203","DOI":"10.1074\/jbc.273.33.21203","article-title":"Mammalian abasic site base excision repair: identification of the reaction sequence and rate-determining steps *","volume":"273","author":"Srivastava","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0770","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba7365","article-title":"CRISPR-engineered T cells in patients with refractory cancer","volume":"367","author":"Stadtmauer","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0775","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.3390\/ijms25074107","article-title":"The catalytic activity of human REV1 on undamaged and damaged DNA","volume":"25","author":"Stolyarenko","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0780","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/bies.950130206","article-title":"The \u201ca rule\u201d of mutagen specificity: a consequence of DNA polymerase bypass of non-instructional lesions","volume":"13","author":"Strauss","year":"1991","journal-title":"BioEssays"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0785","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102647","article-title":"Scales and mechanisms of somatic mutation rate variation across the human genome","volume":"81","author":"Supek","year":"2019","journal-title":"DNA Repair"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0790","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2021.103052","article-title":"Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells","volume":"100","author":"Suzuki","year":"2021","journal-title":"DNA Repair"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0795","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1016\/S0021-9258(18)61093-2","article-title":"Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic\/apyrimidinic endonucleases","volume":"262","author":"Takeshita","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0800","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41467-018-08034-8","article-title":"Engineering of high-precision base editors for site-specific single nucleotide replacement","volume":"10","author":"Tan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0805","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.7150\/thno.125705","article-title":"Harnessing nucleotide metabolism to control glycosylase base editing outcomes","volume":"16","author":"Tao","year":"2026","journal-title":"Theranostics"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0810","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1007\/s00018-010-0486-4","article-title":"Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment","volume":"67","author":"Tell","year":"2010","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0815","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2020.102866","article-title":"New insights into abasic site repair and tolerance","volume":"90","author":"Thompson","year":"2020","journal-title":"DNA Repair"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0820","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/s41587-019-0193-0","article-title":"Continuous evolution of base editors with expanded target compatibility and improved activity","volume":"37","author":"Thuronyi","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0825","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/pbi.13841","article-title":"Efficient C-to-G editing in rice using an optimized base editor","volume":"20","author":"Tian","year":"2022","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0830","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1101\/gad.14.13.1642","article-title":"Pol\u03b9, a remarkably error-prone human DNA polymerase","volume":"14","author":"Tissier","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0835","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1101\/gad.14.13.1642","article-title":"Poliota, a remarkably error-prone human DNA polymerase","volume":"14","author":"Tissier","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0840","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwad143","article-title":"Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase","volume":"10","author":"Tong","year":"2023","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0845","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/s41587-022-01595-6","article-title":"Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase","volume":"41","author":"Tong","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0850","doi-asserted-by":"crossref","DOI":"10.1093\/lifemedi\/lnae005","article-title":"Programmable G-to-Y base editing using engineered DNA glycosylase","volume":"3","author":"Tong","year":"2024","journal-title":"Life Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0855","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1038\/s41467-024-49343-5","article-title":"Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase","volume":"15","author":"Tong","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0860","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/10409238.2017.1291576","article-title":"Translesion DNA polymerases in eukaryotes: what makes them tick?","volume":"52","author":"Vaisman","year":"2017","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0865","doi-asserted-by":"crossref","first-page":"18201","DOI":"10.1073\/pnas.0907280106","article-title":"An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase \u03bb","volume":"106","author":"van Loon","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0870","doi-asserted-by":"crossref","first-page":"32094","DOI":"10.1074\/jbc.M111.246611","article-title":"In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases \u03f5, \u03bb, and \u03b2*","volume":"286","author":"Villani","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0875","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/s41591-018-0209-1","article-title":"Treatment of a metabolic liver disease by in vivo genome base editing in adult mice","volume":"24","author":"Villiger","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0880","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/s41591-026-04254-4","article-title":"In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial","volume":"32","author":"Wan","year":"2026","journal-title":"Nat. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0885","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0890","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41392-019-0072-7","article-title":"BE-PIGS: a base-editing tool with deaminases inlaid into Cas9 PI domain significantly expanded the editing scope","volume":"4","author":"Wang","year":"2019","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0895","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41556-021-00671-4","article-title":"Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations","volume":"23","author":"Wang","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0900","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0092-8674(01)00613-4","article-title":"Yeast DNA polymerase \u03b7 utilizes an induced-fit mechanism of nucleotide incorporation","volume":"107","author":"Washington","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0905","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1038\/s41467-019-13007-6","article-title":"Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors","volume":"10","author":"Webber","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0910","doi-asserted-by":"crossref","first-page":"10660","DOI":"10.1073\/pnas.1812856115","article-title":"Bypassing a 8,5\u2032-cyclo-2\u2032-deoxyadenosine lesion by human DNA polymerase \u03b7 at atomic resolution","volume":"115","author":"Weng","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0915","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1534\/genetics.110.124172","article-title":"The DNA polymerase activity of saccharomyces cerevisiae Rev1 is biologically significant","volume":"187","author":"Wiltrout","year":"2011","journal-title":"Genetics"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0920","doi-asserted-by":"crossref","first-page":"325","DOI":"10.52601\/bpr.2023.230029","article-title":"Nucleoside deaminases: the key players in base editing toolkit","volume":"9","author":"Xiang","year":"2023","journal-title":"Biophys. Rep."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0925","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-biochem-062917-012405","article-title":"Translesion and repair DNA polymerases: diverse structure and mechanism","volume":"87","author":"Yang","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0930","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13330","article-title":"Engineering and optimising deaminase fusions for genome editing","volume":"7","author":"Yang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0935","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/s41587-023-02050-w","article-title":"Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells","volume":"42","author":"Ye","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0940","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay9101","article-title":"In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness","volume":"12","author":"Yeh","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0945","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1038\/s41467-024-50012-w","article-title":"Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase","volume":"15","author":"Yi","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0950","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nsmb.2993","article-title":"Human DNA polymerase \u03b8 grasps the primer terminus to mediate DNA repair","volume":"22","author":"Zahn","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0955","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41591-020-0790-y","article-title":"Therapeutic base editing of human hematopoietic stem cells","volume":"26","author":"Zeng","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0960","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1038\/s41467-023-41331-5","article-title":"A split and inducible adenine base editor for precise in vivo base editing","volume":"14","author":"Zeng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0965","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1093\/nar\/28.21.4138","article-title":"Error-free and error-prone lesion bypass by human DNA polymerase \u03ba in vitro","volume":"28","author":"Zhang","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0970","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/nar\/29.4.928","article-title":"Response of human DNA polymerase \u03b9 to DNA lesions","volume":"29","author":"Zhang","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0975","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1568-7864(02)00055-1","article-title":"Activities of human DNA polymerase \u03ba in response to the major benzo[a]pyrene DNA adduct: error-free lesion bypass and extension synthesis from opposite the lesion","volume":"1","author":"Zhang","year":"2002","journal-title":"DNA Repair"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0980","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41556-020-0518-8","article-title":"Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain","volume":"22","author":"Zhang","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0985","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/1389203723666220406132737","article-title":"Research progress in human AP endonuclease 1: structure, catalytic mechanism, and inhibitors","volume":"23","author":"Zhang","year":"2022","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.biotechadv.2026.109018_bb0990","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/genes8010024","article-title":"Translesion synthesis: insights into the selection and switching of DNA polymerases","volume":"8","author":"Zhao","year":"2017","journal-title":"Genes"},{"key":"10.1016\/j.biotechadv.2026.109018_bb0995","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41587-020-0592-2","article-title":"Glycosylase base editors enable C-to-a and C-to-G base changes","volume":"39","author":"Zhao","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb1000","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.1038\/s41467-023-41829-y","article-title":"PAM-flexible genome editing with an engineered chimeric Cas9","volume":"14","author":"Zhao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biotechadv.2026.109018_bb1005","first-page":"249","article-title":"Advances and applications of genome-edited animal models for severe combined immunodeficiency","volume":"46","author":"Zheng","year":"2024","journal-title":"Zool. Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb1010","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1093\/nar\/gkl465","article-title":"The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins","volume":"34","author":"Zhong","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biotechadv.2026.109018_bb1015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jgg.2024.10.006","article-title":"Improving precision base editing of the zebrafish genome by Rad51DBD-incorporated single-base editors","volume":"52","author":"Zhong","year":"2025","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.biotechadv.2026.109018_bb1020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41586-019-1314-0","article-title":"Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis","volume":"571","author":"Zhou","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.biotechadv.2026.109018_bb1025","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3748\/wjg.v9.i6.1165","article-title":"DNA polymerase &zeta;: new insight into eukaryotic mutagenesis and mammalian embryonic development","volume":"9","author":"Zhu","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biotechadv.2026.109018_bb1030","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1126\/science.aav9973","article-title":"Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos","volume":"364","author":"Zuo","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.biotechadv.2026.109018_bb1035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nbt.3081","article-title":"Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo","volume":"33","author":"Zuris","year":"2015","journal-title":"Nat. Biotechnol."}],"container-title":["Biotechnology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975026002247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0734975026002247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:17:05Z","timestamp":1790698625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0734975026002247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":207,"alternative-id":["S0734975026002247"],"URL":"https:\/\/doi.org\/10.1016\/j.biotechadv.2026.109018","relation":{},"ISSN":["0734-9750"],"issn-type":[{"value":"0734-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interplay Between Base Editing and DNA repair: From Molecular Mechanisms to Clinical Translation","name":"articletitle","label":"Article Title"},{"value":"Biotechnology Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biotechadv.2026.109018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109018"}}