{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:41:43Z","timestamp":1790818903467,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T00:00:00Z","timestamp":1481155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Journal"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.bj.2017.01.001","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T21:19:13Z","timestamp":1490303953000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-337X","authenticated-orcid":false,"given":"Perle","family":"Latr\u00e9 de Lat\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Harnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Harnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1853-1494","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Besteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Langsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bj.2017.01.001_bib1","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.4161\/auto.25832","article-title":"Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation","volume":"9","author":"Tomlins","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bj.2017.01.001_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00682-16","article-title":"Overexpression of Plasmodium berghei ATG8 by liver forms leads to cumulative defects in organelle dynamics and to generation of noninfectious merozoites","volume":"7","author":"Voss","year":"2016","journal-title":"MBio"},{"issue":"Pt 4","key":"10.1016\/j.bj.2017.01.001_bib3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1017\/S0031182000065951","article-title":"The entry of Theileria parva merozoites into bovine erythrocytes occurs by a process similar to sporozoite invasion of lymphocytes","volume":"111","author":"Shaw","year":"1995","journal-title":"Parasitology"},{"key":"10.1016\/j.bj.2017.01.001_bib4","doi-asserted-by":"crossref","first-page":"33891","DOI":"10.1038\/srep33891","article-title":"Genome-wide association analysis identifies genetic loci associated with resistance to multiple antimalarials in Plasmodium falciparum from China-Myanmar border","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.bj.2017.01.001_bib5","doi-asserted-by":"crossref","first-page":"e79059","DOI":"10.1371\/journal.pone.0079059","article-title":"A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum","volume":"8","author":"Gaviria","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bj.2017.01.001_bib6","doi-asserted-by":"crossref","first-page":"e42977","DOI":"10.1371\/journal.pone.0042977","article-title":"Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum","volume":"7","author":"Kitamura","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bj.2017.01.001_bib7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4161\/auto.23689","article-title":"Features of autophagic cell death in Plasmodium liver-stage parasites","volume":"9","author":"Eickel","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bj.2017.01.001_bib8","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1111\/febs.12116","article-title":"Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic","volume":"280","author":"Raiborg","year":"2013","journal-title":"FEBS J"},{"key":"10.1016\/j.bj.2017.01.001_bib9","doi-asserted-by":"crossref","first-page":"11499","DOI":"10.1074\/jbc.M610974200","article-title":"Traffic to the malaria parasite food vacuole: a novel pathway involving a phosphatidylinositol 3-phosphate-binding protein","volume":"282","author":"McIntosh","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bj.2017.01.001_bib10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/auto.26743","article-title":"The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum","volume":"10","author":"Cervantes","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.bj.2017.01.001_bib11","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1038\/srep05829","article-title":"Starvation-response may not involve Atg1-dependent autophagy induction in non-unikont parasites","volume":"4","author":"Foldvari-Nagy","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.bj.2017.01.001_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4161\/auto.2.2.2350","article-title":"Multivesicular bodies and autophagy in erythrocyte maturation","volume":"2","author":"Fader","year":"2006","journal-title":"Autophagy"},{"key":"10.1016\/j.bj.2017.01.001_bib13","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1080\/15548627.2015.1067361","article-title":"Long-term live imaging reveals cytosolic immune responses of host hepatocytes against Plasmodium infection and parasite escape mechanisms","volume":"11","author":"Prado","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bj.2017.01.001_bib14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/cmi.12524","article-title":"Host cell autophagy contributes to Plasmodium liver development","volume":"18","author":"Thieleke-Matos","year":"2016","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.bj.2017.01.001_bib15","doi-asserted-by":"crossref","first-page":"E3519","DOI":"10.1073\/pnas.1525606113","article-title":"LAP-like process as an immune mechanism downstream of IFN-gamma in control of the human malaria Plasmodium vivax liver stage","volume":"113","author":"Boonhok","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bj.2017.01.001_bib16","doi-asserted-by":"crossref","first-page":"e1002416","DOI":"10.1371\/journal.ppat.1002416","article-title":"Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites","volume":"7","author":"Besteiro","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bj.2017.01.001_bib17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1462-5822.2011.01745.x","article-title":"Autophagy is a cell death mechanism in Toxoplasma gondii","volume":"14","author":"Ghosh","year":"2012","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.bj.2017.01.001_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12712","article-title":"Toxoplasma gondii autophagy-related protein ATG9 is crucial for the survival of parasites in their host","author":"Nguyen","year":"2017","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.bj.2017.01.001_bib19","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.4161\/auto.25189","article-title":"Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii","volume":"9","author":"Kong-Hap","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bj.2017.01.001_bib20","doi-asserted-by":"crossref","first-page":"e42107","DOI":"10.1371\/journal.pone.0042107","article-title":"Analysis of monensin sensitivity in Toxoplasma gondii reveals autophagy as a mechanism for drug induced death","volume":"7","author":"Lavine","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bj.2017.01.001_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01446-15","article-title":"Autophagy-related protein ATG8 has a noncanonical function for apicoplast inheritance in Toxoplasma gondii","volume":"6","author":"L\u00e9v\u00eaque","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.bj.2017.01.001_bib22","doi-asserted-by":"crossref","first-page":"e1197447","DOI":"10.1080\/19420889.2016.1197447","article-title":"Repurposing of conserved autophagy-related protein ATG8 in a divergent eukaryote","volume":"9","author":"L\u00e9v\u00eaque","year":"2016","journal-title":"Commun Integr Biol"},{"key":"10.1016\/j.bj.2017.01.001_bib23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.molcel.2014.03.009","article-title":"Autophagy in antimicrobial immunity","volume":"54","author":"Gomes Ligia","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.bj.2017.01.001_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/cells1030396","article-title":"LC3-Associated phagocytosis (LAP): connections with host autophagy","volume":"1","author":"Lai","year":"2012","journal-title":"Cells"},{"key":"10.1016\/j.bj.2017.01.001_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nri3598","article-title":"Innate immunity to Toxoplasma gondii infection","volume":"14","author":"Yarovinsky","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bj.2017.01.001_bib26","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1371\/journal.ppat.0010024","article-title":"Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases","volume":"1","author":"Martens","year":"2005","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bj.2017.01.001_bib27","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1084\/jem.20061318","article-title":"Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages","volume":"203","author":"Ling","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.bj.2017.01.001_bib28","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.chom.2008.10.003","article-title":"Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens","volume":"4","author":"Zhao","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bj.2017.01.001_bib29","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1080\/15548627.2016.1178447","article-title":"Targeting by AutophaGy proteins (TAG): targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy","volume":"12","author":"Park","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.bj.2017.01.001_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21541248.2016.1213090","article-title":"Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy","author":"Choi","year":"2016","journal-title":"Small GTPases"},{"key":"10.1016\/j.bj.2017.01.001_bib31","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.4049\/jimmunol.1302822","article-title":"Role of mouse and human autophagy proteins in IFN-gamma-induced cell-autonomous responses against Toxoplasma gondii","volume":"192","author":"Ohshima","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.bj.2017.01.001_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01157-15","article-title":"A noncanonical autophagy Pathway restricts Toxoplasma gondii growth in a strain-specific manner in IFN-\u03b3-activated human cells","volume":"6","author":"Selleck","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.bj.2017.01.001_bib33","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1172\/JCI28796","article-title":"CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes","volume":"116","author":"Andrade","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bj.2017.01.001_bib34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.micinf.2014.12.008","article-title":"Atg5 but not Atg7 in dendritic cells enhances IL-2 and IFN-\u03b3 production by Toxoplasma gondii-reactive CD4+ T cells","volume":"17","author":"Liu","year":"2015","journal-title":"Microbes Infect"},{"key":"10.1016\/j.bj.2017.01.001_bib35","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1128\/IAI.00101-16","article-title":"Identification of signaling pathways by which CD40 stimulates autophagy and antimicrobial activity against Toxoplasma gondii in macrophages","volume":"84","author":"Liu","year":"2016","journal-title":"Infect Immun"},{"key":"10.1016\/j.bj.2017.01.001_bib36","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1128\/IAI.01145-12","article-title":"CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteins","volume":"81","author":"Van Grol","year":"2013","journal-title":"Infect Immun"},{"key":"10.1016\/j.bj.2017.01.001_bib37","doi-asserted-by":"crossref","first-page":"e1003809","DOI":"10.1371\/journal.ppat.1003809","article-title":"Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite","volume":"9","author":"Muniz-Feliciano","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bj.2017.01.001_bib38","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1074\/jbc.M807890200","article-title":"Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth","volume":"284","author":"Wang","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bj.2017.01.001_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.micro.53.1.1","article-title":"Transformation of leukocytes by Theileria parva and T. annulata","volume":"53","author":"Dobbelaere","year":"1999","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.bj.2017.01.001_bib40","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1471-4922(02)00015-6","article-title":"Cell invasion by Theileria sporozoites","volume":"19","author":"Shaw","year":"2003","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.bj.2017.01.001_bib41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4161\/auto.7.2.13310","article-title":"Autophagy in protists","volume":"7","author":"Duszenko","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.bj.2017.01.001_bib42","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/cmi.12218","article-title":"The level of H(2)O(2) type oxidative stress regulates virulence of Theileria-transformed leukocytes","volume":"16","author":"Metheni","year":"2014","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.bj.2017.01.001_bib43","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.molmed.2013.04.005","article-title":"Autophagy: shaping the tumor microenvironment and therapeutic response","volume":"19","author":"Maes","year":"2013","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.bj.2017.01.001_bib44","doi-asserted-by":"crossref","first-page":"e1003222","DOI":"10.1371\/journal.ppat.1003222","article-title":"OncomiR addiction is generated by a miR-155 feedback loop in Theileria-transformed leukocytes","volume":"9","author":"Marsolier","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bj.2017.01.001_bib45","doi-asserted-by":"crossref","first-page":"e1003697","DOI":"10.1371\/journal.ppat.1003697","article-title":"MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb","volume":"9","author":"Wang","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bj.2017.01.001_bib46","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.joca.2016.01.005","article-title":"MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins","volume":"24","author":"D'Adamo","year":"2016","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.bj.2017.01.001_bib47","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3892\/etm.2014.1752","article-title":"miR-155 mediates drug resistance in osteosarcoma cells via inducing autophagy","volume":"8","author":"Chen","year":"2014","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.bj.2017.01.001_bib48","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s10495-006-7702-6","article-title":"A PKA survival pathway inhibited by DPT-PKI, a new specific cell permeable PKA inhibitor, is induced by T. annulata in parasitized B-lymphocytes","volume":"11","author":"Guergnon","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.bj.2017.01.001_bib49","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1083\/jcb.201002108","article-title":"Regulation of the autophagy\u00a0protein LC3 by phosphorylation","volume":"190","author":"Cherra","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bj.2017.01.001_bib50","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molcel.2004.05.021","article-title":"The Ras\/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus","volume":"15","author":"Chang","year":"2004","journal-title":"Mol cell"},{"key":"10.1016\/j.bj.2017.01.001_bib51","doi-asserted-by":"crossref","first-page":"13933","DOI":"10.1073\/pnas.0501046102","article-title":"An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase","volume":"102","author":"Budovskaya","year":"2005","journal-title":"Proc Natl Acad Sci U. S. A"},{"key":"10.1016\/j.bj.2017.01.001_bib52","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/15548627.2015.1055440","article-title":"Feedback regulation between autophagy and PKA","volume":"11","author":"Torres-Quiroz","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bj.2017.01.001_bib53","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1073\/pnas.94.10.5119","article-title":"Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva","volume":"94","author":"Galley","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bj.2017.01.001_bib54","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0166-6851(98)00070-X","article-title":"Upregulation of Jun and Fos family members and permanent JNK activity lead to constitutive AP-1 activation in Theileria-transformed leukocytes","volume":"94","author":"Chaussepied","year":"1998","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.bj.2017.01.001_bib55","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ni.3130","article-title":"The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation","volume":"16","author":"Zhang","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.bj.2017.01.001_bib56","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-3024.1986.tb00834.x","article-title":"Identification of infection-associated antigens in Theileria annulata transformed cells","volume":"8","author":"Shiels","year":"1986","journal-title":"Parasite Immunol"}],"container-title":["Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417016303262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417016303262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T23:59:26Z","timestamp":1568937566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2319417016303262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S2319417016303262"],"URL":"https:\/\/doi.org\/10.1016\/j.bj.2017.01.001","relation":{},"ISSN":["2319-4170"],"issn-type":[{"value":"2319-4170","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells","name":"articletitle","label":"Article Title"},{"value":"Biomedical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bj.2017.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Chang Gung University. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}