{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:17:46Z","timestamp":1790201866209,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG8J0722"],"award-info":[{"award-number":["CMRPG8J0722"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG8J0723"],"award-info":[{"award-number":["CMRPG8J0723"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Journal"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.bj.2021.06.008","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T11:28:13Z","timestamp":1625311693000},"page":"491-503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["High fructose induced osteogenic differentiation of human valve interstitial cells via activating PI3K\/AKT\/mitochondria signaling"],"prefix":"10.1016","volume":"45","author":[{"given":"Hsiao-Huang","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ying","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chung","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Li","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-6788","authenticated-orcid":false,"given":"Kay L.H.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bj.2021.06.008_bib1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006339","article-title":"Valve interstitial cells: the key to understanding the pathophysiology of heart valve calcification","volume":"6","author":"Rutkovskiy","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.bj.2021.06.008_bib2","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/j.jacc.2005.12.073","article-title":"Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis","volume":"47","author":"Briand","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.bj.2021.06.008_bib3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2337\/db08-1515","article-title":"Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA) [published correction appears in Diabetes. 2009;58:1937]","volume":"58","author":"Katz","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bj.2021.06.008_bib4","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1161\/CIRCULATIONAHA.105.598086","article-title":"Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis","volume":"113","author":"Katz","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bj.2021.06.008_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/obr.12229","article-title":"Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies","volume":"16","author":"O'Neill","year":"2015","journal-title":"Obes Rev"},{"key":"10.1016\/j.bj.2021.06.008_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pneurobio.2006.06.003","article-title":"Insulin signaling in the central nervous system: learning to survive","volume":"79","author":"van der Heide","year":"2006","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bj.2021.06.008_bib7","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.2337\/db06-0391","article-title":"Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin","volume":"55","author":"Draznin","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.bj.2021.06.008_bib8","first-page":"1855","article-title":"Mechanical strain promotes osteogenic differentiation of bone mesenchymal stem cells from ovariectomized rats via the phosphoinositide 3kinase\/Akt signaling pathway","volume":"17","author":"Ouyang","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.bj.2021.06.008_bib9","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1242\/jcs.042770","article-title":"Akt promotes BMP2-mediated osteoblast differentiation and bone development","volume":"122","author":"Mukherjee","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bj.2021.06.008_bib10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yjmcc.2019.04.006","article-title":"Drp1\/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy","volume":"130","author":"Haileselassie","year":"2019","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.bj.2021.06.008_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.freeradbiomed.2013.01.013","article-title":"PI3K\/AKT signaling regulates bioenergetics in immortalized hepatocytes","volume":"60","author":"Li","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.bj.2021.06.008_bib12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bbabio.2010.03.024","article-title":"The fateful encounter of mitochondria with calcium: how did it happen?","volume":"1797","author":"Carafoli","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bj.2021.06.008_bib13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s13238-017-0385-7","article-title":"The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells","volume":"8","author":"Li","year":"2017","journal-title":"Protein Cell"},{"key":"10.1016\/j.bj.2021.06.008_bib14","doi-asserted-by":"crossref","first-page":"16019","DOI":"10.1074\/jbc.RA118.004102","article-title":"Active mitochondria support osteogenic differentiation by stimulating beta-catenin acetylation","volume":"293","author":"Shares","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bj.2021.06.008_bib15","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1242\/jcs.070490","article-title":"New insights into the role of mitochondria in aging: mitochondrial dynamics and more","volume":"123","author":"Seo","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bj.2021.06.008_bib16","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physrev.00030.2008","article-title":"Mitochondrial dynamics in mammalian health and disease","volume":"89","author":"Liesa","year":"2009","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bj.2021.06.008_bib17","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbamcr.2010.09.019","article-title":"Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network","volume":"1813","author":"Scarpulla","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bj.2021.06.008_bib18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/cvr\/cvn098","article-title":"Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha","volume":"79","author":"Ventura-Clapier","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.bj.2021.06.008_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.bj.2021.06.008_bib20","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1083\/jcb.201008084","article-title":"Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL","volume":"191","author":"Jin","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bj.2021.06.008_bib21","doi-asserted-by":"crossref","first-page":"1263S","DOI":"10.3945\/jn.108.098020","article-title":"Dietary fructose and metabolic syndrome and diabetes","volume":"139","author":"Bantle","year":"2009","journal-title":"J Nutr"},{"key":"10.1016\/j.bj.2021.06.008_bib22","doi-asserted-by":"crossref","first-page":"682673","DOI":"10.1155\/2013\/682673","article-title":"Fructose: a key factor in the development of metabolic syndrome and hypertension","volume":"2013","author":"Khitan","year":"2013","journal-title":"J Nutr Metab"},{"key":"10.1016\/j.bj.2021.06.008_bib23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/MOG.0b013e3282f3f4c4","article-title":"Dietary fructose and the metabolic syndrome","volume":"24","author":"Miller","year":"2008","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.bj.2021.06.008_bib24","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1161\/HYPERTENSIONAHA.114.03777","article-title":"Role of nitric oxide synthase uncoupling at rostral ventrolateral medulla in redox-sensitive hypertension associated with metabolic syndrome","volume":"64","author":"Wu","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.bj.2021.06.008_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jnutbio.2019.03.014","article-title":"High fructose diet induces early mortality via autophagy factors accumulation in the rostral ventrolateral medulla as ameliorated by pioglitazone","volume":"69","author":"Lin","year":"2019","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.bj.2021.06.008_bib26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3390\/nu9040323","article-title":"Fructose-rich diet affects mitochondrial DNA damage and repair in rats","volume":"9","author":"Cioffi","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.bj.2021.06.008_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1743-7075-2-5","article-title":"Fructose, insulin resistance, and metabolic dyslipidemia","volume":"2","author":"Basciano","year":"2005","journal-title":"Nutr Metab (Lond)"},{"key":"10.1016\/j.bj.2021.06.008_bib28","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ijo.2009.259","article-title":"Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response","volume":"34","author":"Perez-Pozo","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.bj.2021.06.008_bib29","doi-asserted-by":"crossref","first-page":"17835","DOI":"10.1038\/s41598-018-36388-y","article-title":"Experimental metabolic syndrome model associated with mechanical and structural degenerative changes of the aortic valve","volume":"8","author":"Go","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.bj.2021.06.008_bib30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ijcard.2017.06.104","article-title":"Influence of metabolic syndrome and diabetes on progression of calcific aortic valve stenosis","volume":"244","author":"Testuz","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.bj.2021.06.008_bib31","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2353\/ajpath.2007.070251","article-title":"The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology","volume":"171","author":"Liu","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bj.2021.06.008_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1357-2725(02)00100-0","article-title":"The cardiac valve interstitial cell","volume":"35","author":"Taylor","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.bj.2021.06.008_bib33","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.amjcard.2004.08.013","article-title":"Mechanisms of aortic valve calcification","volume":"94","author":"Mohler","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.bj.2021.06.008_bib34","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.athoracsur.2004.06.033","article-title":"Calcification of tissue heart valve substitutes: progress toward understanding and prevention","volume":"79","author":"Schoen","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bj.2021.06.008_bib35","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/MPA.0b013e3181a7c6e5","article-title":"Direct spectrophotometric determination of serum fructose in pancreatic cancer patients","volume":"38","author":"Hui","year":"2009","journal-title":"Pancreas"},{"key":"10.1016\/j.bj.2021.06.008_bib36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tibs.2004.11.003","article-title":"Restraining PI3K: mTOR signalling goes back to the membrane","volume":"30","author":"Harrington","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.bj.2021.06.008_bib37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/B978-0-12-801415-8.00016-3","article-title":"Analysis and interpretation of microplate-based oxygen consumption and pH data","volume":"547","author":"Divakaruni","year":"2014","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.bj.2021.06.008_bib38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.bj.2021.06.008_bib39","doi-asserted-by":"crossref","first-page":"E622","DOI":"10.1152\/ajpendo.00408.2018","article-title":"Pioglitazone reversed the fructose-programmed astrocytic glycolysis and oxidative phosphorylation of female rat offspring","volume":"316","author":"Wu","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.bj.2021.06.008_bib40","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/ars.2012.4609","article-title":"Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress","volume":"20","author":"Schulz","year":"2014","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.bj.2021.06.008_bib41","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bj.2021.06.008_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem J"},{"key":"10.1016\/j.bj.2021.06.008_bib43","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.bbabio.2016.04.002","article-title":"Bioenergetic roles of mitochondrial fusion","volume":"1857","author":"Silva Ramos","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bj.2021.06.008_bib44","doi-asserted-by":"crossref","first-page":"5298483","DOI":"10.1155\/2020\/5298483","article-title":"Melatonin attenuates calcium deposition from vascular smooth muscle cells by activating mitochondrial fusion and mitophagy via an AMPK\/OPA1 signaling pathway","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.bj.2021.06.008_bib45","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1242\/jcs.093849","article-title":"PINK1- and Parkin-mediated mitophagy at a glance","volume":"125","author":"Jin","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bj.2021.06.008_bib46","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/ATVBAHA.107.156752","article-title":"Calcific aortic stenosis: lessons learned from experimental and clinical studies","volume":"29","author":"Rajamannan","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.bj.2021.06.008_bib47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/07315724.2000.10718911","article-title":"The interaction between dietary fructose and magnesium adversely affects macromineral homeostasis in men","volume":"19","author":"Milne","year":"2000","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.bj.2021.06.008_bib48","first-page":"449","article-title":"Can valvular interstitial cells become true osteoblasts? A side-by-side comparison","volume":"20","author":"Monzack","year":"2011","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.bj.2021.06.008_bib49","doi-asserted-by":"crossref","first-page":"F712","DOI":"10.1152\/ajprenal.00433.2009","article-title":"Dietary fructose causes tubulointerstitial injury in the normal rat kidney","volume":"298","author":"Nakayama","year":"2010","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.bj.2021.06.008_bib50","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF02632049","article-title":"Fructose-induced enhanced mitogenicity of diploid human cells: possible relationship with cell differentiation","volume":"30A","author":"Wolfrom","year":"1994","journal-title":"In\u00a0Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.bj.2021.06.008_bib51","doi-asserted-by":"crossref","first-page":"12934","DOI":"10.1038\/s41598-019-49016-0","article-title":"Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties","volume":"9","author":"Bogdanova","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.bj.2021.06.008_bib52","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1002\/jemt.23369","article-title":"Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K\/Akt\/NF-kappaB signaling pathway","volume":"82","author":"He","year":"2019","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.bj.2021.06.008_bib53","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/10799893.2019.1625061","article-title":"Dexamethasone suppresses osteogenesis of osteoblast via the PI3K\/Akt signaling pathway in\u00a0vitro and in\u00a0vivo","volume":"39","author":"Pan","year":"2019","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1016\/j.bj.2021.06.008_bib54","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1111\/jcmm.14915","article-title":"Imperatorin promotes osteogenesis and suppresses osteoclast by activating AKT\/GSK3 beta\/beta-catenin pathways","volume":"24","author":"Yan","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.bj.2021.06.008_bib55","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1016\/j.bbadis.2019.05.019","article-title":"Impact of hyperinsulinemia and hyperglycemia on valvular interstitial cells - a link between aortic heart valve degeneration and type 2 diabetes","volume":"1865","author":"Selig","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.bj.2021.06.008_bib56","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1016\/S0021-9258(19)73805-8","article-title":"Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation","volume":"237","author":"Vasington","year":"1962","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bj.2021.06.008_bib57","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0005-2728(98)00120-0","article-title":"Role of mitochondria in oxidative stress and ageing","volume":"1366","author":"Lenaz","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bj.2021.06.008_bib58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3233\/JPD-160989","article-title":"PINK1, parkin, and mitochondrial quality control: what can we learn about Parkinson's disease pathobiology?","volume":"7","author":"Truban","year":"2017","journal-title":"J Parkinsons Dis"},{"key":"10.1016\/j.bj.2021.06.008_bib59","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cellsig.2019.03.006","article-title":"Lactate accelerates calcification in VSMCs through suppression of BNIP3-mediated mitophagy","volume":"58","author":"Zhu","year":"2019","journal-title":"Cell Signal"}],"container-title":["Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S231941702100086X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S231941702100086X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:12:55Z","timestamp":1762420375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S231941702100086X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S231941702100086X"],"URL":"https:\/\/doi.org\/10.1016\/j.bj.2021.06.008","relation":{},"ISSN":["2319-4170"],"issn-type":[{"value":"2319-4170","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High fructose induced osteogenic differentiation of human valve interstitial cells via activating PI3K\/AKT\/mitochondria signaling","name":"articletitle","label":"Article Title"},{"value":"Biomedical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bj.2021.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Chang Gung University. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}