{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:13:39Z","timestamp":1792206819486,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cientifico e Tecnologico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Journal"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.bj.2022.05.004","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T23:46:45Z","timestamp":1653004005000},"page":"100539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Female Wistar rats present particular glucose flux when submitted to classic protocols of experimental diabetes"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-6183","authenticated-orcid":false,"given":"Debora Santos","family":"Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiza Von","family":"Dentz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Felipe Argenta","family":"Model","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everton Lopes","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Ohlweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Vieira","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir Khal","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"Kucharski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bj.2022.05.004_bib1","first-page":"607","article-title":"Epidemiology of type 1 diabetes and its complications","volume":"68","author":"Briet","year":"2018","journal-title":"Rev Prat"},{"issue":"9680","key":"10.1016\/j.bj.2022.05.004_bib2","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/S0140-6736(09)60568-7","article-title":"Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study","volume":"373","author":"Patterson","year":"2009","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bj.2022.05.004_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2337\/dc06-1837","article-title":"Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth","volume":"30","author":"Vehik","year":"2007","journal-title":"Diabetes Care"},{"issue":"8","key":"10.1016\/j.bj.2022.05.004_bib4","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1007\/s00125-012-2571-8","article-title":"Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase","volume":"55","author":"Patterson","year":"2012","journal-title":"Diabetologia"},{"issue":"11","key":"10.1016\/j.bj.2022.05.004_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11892-017-0932-x","article-title":"Emerging concepts on disease-modifying therapies in type 1 diabetes","volume":"17","author":"Greenbaum","year":"2017","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.bj.2022.05.004_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-70178-3_1","article-title":"Epidemiology of gender differences in diabetes and obesity","volume":"1043","author":"Mauvais-Jarvis","year":"2017","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"10.1016\/j.bj.2022.05.004_bib7","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1464-5491.2007.02362.x","article-title":"Differences in height explain gender differences in the response to the oral glucose tolerance test- the AusDiab study","volume":"25","author":"Sicree","year":"2008","journal-title":"Diabet Med"},{"issue":"6","key":"10.1016\/j.bj.2022.05.004_bib8","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.2337\/diabetes.50.6.1344","article-title":"Decreased susceptibility to fatty acid-induced peripheral tissue insulin resistance in women","volume":"50","author":"Frias","year":"2001","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.bj.2022.05.004_bib9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jdiacomp.2014.11.011","article-title":"Elucidating sex and gender differences in diabetes: a necessary step toward personalized medicine","volume":"29","author":"Mauvais-Jarvis","year":"2015","journal-title":"J Diabetes Complications"},{"issue":"3","key":"10.1016\/j.bj.2022.05.004_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cmet.2011.08.005","article-title":"Estrogen receptors and the metabolic network","volume":"14","author":"Barros","year":"2011","journal-title":"Cell Metab"},{"issue":"24","key":"10.1016\/j.bj.2022.05.004_bib11","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1073\/pnas.0602956103","article-title":"Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice","volume":"103","author":"Le May","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.bj.2022.05.004_bib12","doi-asserted-by":"crossref","first-page":"E1296","DOI":"10.1152\/ajpendo.00131.2018","article-title":"Estrogen replacement enhances insulin-induced as160 activation and improves insulin sensitivity in ovariectomized rats","volume":"315","author":"Kawakami","year":"2018","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.bj.2022.05.004_bib13","doi-asserted-by":"crossref","first-page":"E908","DOI":"10.1152\/ajpendo.00466.2018","article-title":"Estrogen and voluntary exercise attenuate cardiometabolic syndrome and hepatic steatosis in ovariectomized rats fed a high-fat high-fructose diet","volume":"316","author":"Buniam","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.bj.2022.05.004_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1258\/la.2010.010090","article-title":"Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models","volume":"45","author":"Deeds","year":"2011","journal-title":"Lab Anim"},{"key":"10.1016\/j.bj.2022.05.004_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbi.2015.11.032","article-title":"Challenges and issues with streptozotocin-induced diabetes - a clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics","volume":"244","author":"Goyal","year":"2016","journal-title":"Chem Biol Interact"},{"issue":"6","key":"10.1016\/j.bj.2022.05.004_bib16","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1210\/endo.135.6.7988458","article-title":"Gender differences in the metabolic response to graded numbers of transplanted islets of Langerhans","volume":"135","author":"Bell","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.bj.2022.05.004_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-94-024-1079-2_26","article-title":"Perinatal taurine supplementation prevents metabolic and cardiovascular effects of maternal diabetes in adult rat offspring","volume":"975","author":"Thaeomor","year":"2017","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.bj.2022.05.004_bib18","first-page":"255","article-title":"Gender-effect on the contractile properties of skeletal muscle in streptozotocin-induced diabetic rats","volume":"18","author":"Virgen-Ortiz","year":"2018","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"1","key":"10.1016\/j.bj.2022.05.004_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2337\/diab.37.1.21","article-title":"Low-dose streptozocin-induced diabetes in mice. Electron microscopy reveals single-cell insulitis before diabetes onset","volume":"37","author":"Kolb-Bachofen","year":"1988","journal-title":"Diabetes"},{"issue":"4251","key":"10.1016\/j.bj.2022.05.004_bib20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.180605","article-title":"Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus","volume":"193","author":"Like","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.bj.2022.05.004_bib21","doi-asserted-by":"crossref","first-page":"118490","DOI":"10.1016\/j.lfs.2020.118490","article-title":"Protective effects of acarbose against insulitis in multiple low-dose streptozotocin-induced diabetic mice","volume":"263","author":"Zhao","year":"2020","journal-title":"Life Sci"},{"issue":"7","key":"10.1016\/j.bj.2022.05.004_bib22","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.4049\/jimmunol.178.7.4623","article-title":"The chemokine binding protein M3 prevents diabetes induced by multiple low doses of Streptozotocin","volume":"178","author":"Martin","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.bj.2022.05.004_bib23","series-title":"Guide for the care and use of laboratory animals","author":"Council","year":"2011"},{"key":"10.1016\/j.bj.2022.05.004_bib24","first-page":"631","article-title":"Ontogenetic study of glucose and lactate utilisation by rat cerebellum slices","volume":"22","author":"Bueno","year":"1994","journal-title":"Med Sci Res"},{"issue":"1","key":"10.1016\/j.bj.2022.05.004_bib25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.bj.2022.05.004_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31258-z","article-title":"Corticosterone levels reflect variation in metabolic rate, independent of \u2018stress","volume":"8","author":"Jimeno","year":"2018","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.bj.2022.05.004_bib27","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1681\/ASN.V124779","article-title":"Functional, molecular, and biochemical characterization of streptozotocin-induced diabetes","volume":"12","author":"Ward","year":"2001","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.bj.2022.05.004_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/cs0980021","article-title":"Time course of changes in serum glucose, insulin, lipids and tissue lipase activities in macrosomic offspring of rats with streptozotocin-induced diabetes","volume":"98","author":"Merzouk","year":"2000","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.1016\/j.bj.2022.05.004_bib29","first-page":"273","article-title":"Effects of xenoestrogens on streptozotocin-induced diabetic mice","volume":"65","author":"Kang","year":"2014","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.bj.2022.05.004_bib30","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.biopha.2018.05.132","article-title":"Effect of yerba mate (Ilex paraguariensis) extract on the metabolism of diabetic rats","volume":"105","author":"Rocha","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bj.2022.05.004_bib31","series-title":"Diabetes mellitus type 1","author":"Lucier","year":"2019"},{"issue":"5","key":"10.1016\/j.bj.2022.05.004_bib32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1081\/DDC-100104322","article-title":"A brief report on some physiological parameters of streptozocin-diabetic rat","volume":"27","author":"Al-Achi","year":"2001","journal-title":"Drug Dev Ind Pharm"},{"issue":"4","key":"10.1016\/j.bj.2022.05.004_bib33","first-page":"341","article-title":"Effect of leaf extract of Aegle marmelose (L.) Correa ex Roxb. on histological and ultrastructural changes in tissues of streptozotocin induced diabetic rats","volume":"34","author":"Das","year":"1996","journal-title":"Indian J Exp Biol"},{"issue":"6","key":"10.1016\/j.bj.2022.05.004_bib34","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1172\/JCI79895","article-title":"Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis","volume":"126","author":"Winnick","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bj.2022.05.004_bib35","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ijbiomac.2019.01.186","article-title":"Glycogen structure in type 1 diabetic mice: towards understanding the origin of diabetic glycogen molecular fragility","volume":"128","author":"Hu","year":"2019","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"10.1016\/j.bj.2022.05.004_bib36","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2337\/diabetes.55.03.06.db05-0849","article-title":"Role of hepatic glycogen breakdown in defective counterregulation of hypoglycemia in intensively treated type 1 diabetes","volume":"55","author":"Kishore","year":"2006","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.bj.2022.05.004_bib37","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.2337\/db15-0640","article-title":"Measurements of gluconeogenesis and glycogenolysis: a methodological review","volume":"64","author":"Chung","year":"2015","journal-title":"Diabetes"},{"issue":"1-2","key":"10.1016\/j.bj.2022.05.004_bib38","first-page":"65","article-title":"Rates of gluconeogenesis in perfused liver of alloxan-diabetic fed rats","volume":"107","author":"Akimoto","year":"2000","journal-title":"Res Commun Mol Pathol Pharmacol"},{"issue":"3","key":"10.1016\/j.bj.2022.05.004_bib39","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0021-9258(17)33861-9","article-title":"Alanine and glutamine synthesis and release from skeletal muscle. III. Dietary and hormonal regulation","volume":"251","author":"Karl","year":"1976","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.bj.2022.05.004_bib40","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.2337\/diab.43.11.1326","article-title":"STZ transport and cytotoxicity. specific enhancement in GLUT2-expressing cells","volume":"43","author":"Schnedl","year":"1994","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.bj.2022.05.004_bib41","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0002-9343(97)89464-8","article-title":"Current views on obesity","volume":"100","author":"Stunkard","year":"1996","journal-title":"Am J Med"},{"issue":"1","key":"10.1016\/j.bj.2022.05.004_bib42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJM199201023260104","article-title":"Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance","volume":"326","author":"Mitrakou","year":"1992","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.bj.2022.05.004_bib43","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1139\/apnm-2017-0559","article-title":"Sex-related differences in fuel utilization and hormonal response to exercise: implications for individuals with type 1 diabetes","volume":"43","author":"Brockman","year":"2018","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.bj.2022.05.004_bib44","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.biopha.2018.05.132","article-title":"Effect of yerba mate (Ilex paraguariensis) extract on the metabolism of diabetic rats","volume":"105","author":"Rocha","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.bj.2022.05.004_bib45","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1677\/joe.1.06596","article-title":"Sexual dimorphism in insulin sensitivity and susceptibility to develop diabetes in rats","volume":"190","author":"Vital","year":"2006","journal-title":"J Endocrinol"},{"issue":"11","key":"10.1016\/j.bj.2022.05.004_bib46","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1002\/ar.23641","article-title":"Changes in the pancreas in experimental diabetes and the effect of lycopene on these changes: proliferating, apoptotic, and estrogen receptor \u03b1 positive cells","volume":"300","author":"Sandikci","year":"2017","journal-title":"Anat Rec (Hoboken)"},{"issue":"2","key":"10.1016\/j.bj.2022.05.004_bib47","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1073\/pnas.79.2.630","article-title":"Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: influence of inbred background, sex, and thymus","volume":"79","author":"Leiter","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 2","key":"10.1016\/j.bj.2022.05.004_bib48","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1042\/BST0330354","article-title":"Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes","volume":"33","author":"Bj\u00f6rnholm","year":"2005","journal-title":"Biochem Soc Trans"},{"issue":"5","key":"10.1016\/j.bj.2022.05.004_bib49","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF00281829","article-title":"Role of ovarian hormones in the long-term control of glucose homeostasis. Effects of insulin secretion","volume":"19","author":"Bailey","year":"1980","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.bj.2022.05.004_bib50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1172\/JCI5479","article-title":"The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects","volume":"103","author":"Chen","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bj.2022.05.004_bib51","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.redox.2017.04.012","article-title":"Sex matters: the effects of biological sex on adipose tissue biology and energy metabolism","volume":"12","author":"Valencak","year":"2017","journal-title":"Redox Biol"},{"issue":"12","key":"10.1016\/j.bj.2022.05.004_bib52","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.biochi.2003.10.022","article-title":"Glyceroneogenesis revisited","volume":"85","author":"Hanson","year":"2003","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.bj.2022.05.004_bib53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5213\/inj.1836116.058","article-title":"High estradiol differentially affects the expression of the glucose transporter type 4 in pelvic floor muscles of rats","volume":"22","author":"Carrasco-Ruiz","year":"2018","journal-title":"Int Neurourol J"}],"container-title":["Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417022000774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417022000774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:13:38Z","timestamp":1762420418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2319417022000774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2319417022000774"],"URL":"https:\/\/doi.org\/10.1016\/j.bj.2022.05.004","relation":{},"ISSN":["2319-4170"],"issn-type":[{"value":"2319-4170","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Female Wistar rats present particular glucose flux when submitted to classic protocols of experimental diabetes","name":"articletitle","label":"Article Title"},{"value":"Biomedical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bj.2022.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V. on behalf of Chang Gung University.","name":"copyright","label":"Copyright"}],"article-number":"100539"}}