{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:14:15Z","timestamp":1788318855518,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22005265"],"award-info":[{"award-number":["22005265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970781"],"award-info":[{"award-number":["81970781"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LBY21E030002"],"award-info":[{"award-number":["LBY21E030002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Journal"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bj.2023.03.005","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T15:47:53Z","timestamp":1680277673000},"page":"100592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Targeted dexamethasone nano-prodrug for corneal neovascularization management"],"prefix":"10.1016","volume":"47","author":[{"given":"Qichuan","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sifan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchao","family":"Shentu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bj.2023.03.005_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40662-017-0094-6","article-title":"Therapeutic approaches for corneal neovascularization","volume":"4","author":"Feizi","year":"2017","journal-title":"Eye Vis (Lond)"},{"issue":"3","key":"10.1016\/j.bj.2023.03.005_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav1281","article-title":"Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels","volume":"5","author":"Shirzaei Sani","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.bj.2023.03.005_bib3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ejpb.2020.08.022","article-title":"In vivo biocompatibility and efficacy of dexamethasone-loaded PLGA-PEG-PLGA thermogel in an alkali-burn induced corneal neovascularization disease model","volume":"155","author":"Chan","year":"2020","journal-title":"Eur J Pharm Biopharm"},{"issue":"4","key":"10.1016\/j.bj.2023.03.005_bib4","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jtos.2018.06.004","article-title":"Current and emerging therapies for corneal neovascularization","volume":"16","author":"Roshandel","year":"2018","journal-title":"Ocul Surf"},{"key":"10.1016\/j.bj.2023.03.005_bib5","doi-asserted-by":"crossref","first-page":"114770","DOI":"10.1016\/j.addr.2023.114770","article-title":"Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives","volume":"196","author":"Han","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"10.1016\/j.bj.2023.03.005_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10276","article-title":"Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis","volume":"7","author":"Wang","year":"2022","journal-title":"Bioeng Transl Med"},{"key":"10.1016\/j.bj.2023.03.005_bib7","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2147\/IJN.S179118","article-title":"High drug payload nanoparticles formed from dexamethasone-peptide conjugates for the treatment of endotoxin-induced uveitis in rabbit","volume":"14","author":"Yu","year":"2019","journal-title":"Int J Nanomed"},{"issue":"17","key":"10.1016\/j.bj.2023.03.005_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202200435","article-title":"Anti-oxidative and anti-inflammatory micelles: break the dry eye vicious cycle","volume":"9","author":"Li","year":"2022","journal-title":"Adv Sci"},{"issue":"5","key":"10.1016\/j.bj.2023.03.005_bib9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.bj.2022.05.002","article-title":"Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases","volume":"45","author":"Bhatti","year":"2022","journal-title":"Biomed J"},{"issue":"2","key":"10.1016\/j.bj.2023.03.005_bib10","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1021\/acsnano.6b05541","article-title":"Dual enzymatic reaction-assisted gemcitabine delivery systems for programmed pancreatic cancer therapy","volume":"11","author":"Han","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.bj.2023.03.005_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jconrel.2019.02.043","article-title":"Theranostic iRGD peptide containing cisplatin prodrug: dual-cargo tumor penetration for improved imaging and therapy","volume":"300","author":"Cho","year":"2019","journal-title":"J Contr Release"},{"issue":"6","key":"10.1016\/j.bj.2023.03.005_bib12","first-page":"595","article-title":"The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems","volume":"14","author":"Lu","year":"2019","journal-title":"Asian J Pharm Sci"},{"key":"10.1016\/j.bj.2023.03.005_bib13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jconrel.2021.08.044","article-title":"Nanoparticles modified with vasculature-homing peptides for targeted cancer therapy and angiogenesis imaging","volume":"338","author":"Seyyednia","year":"2021","journal-title":"J Contr Release"},{"issue":"4","key":"10.1016\/j.bj.2023.03.005_bib14","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/15569527.2020.1823406","article-title":"APRPG-modified nanoliposome loaded with miR-146a-5p inhibitor suppressed choroidal neovascularization by targeting endothelial cells","volume":"39","author":"Li","year":"2020","journal-title":"Cutan Ocul Toxicol"},{"key":"10.1016\/j.bj.2023.03.005_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2021.109778","article-title":"In vivo preclinical assessment of novel (68)Ga-labelled peptides for imaging of tumor associated angiogenesis using positron emission tomography imaging","volume":"174","author":"Denes","year":"2021","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.bj.2023.03.005_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110737","article-title":"Triptolide-nanoliposome-APRPG, a novel sustained-release drug delivery system targeting vascular endothelial cells, enhances the inhibitory effects of triptolide on laser-induced choroidal neovascularization","volume":"131","author":"Lai","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"17","key":"10.1016\/j.bj.2023.03.005_bib17","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1038\/sj.onc.1205347","article-title":"Anti-neovascular therapy using novel peptides homing to angiogenic vessels","volume":"21","author":"Oku","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.bj.2023.03.005_bib18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.addr.2016.06.015","article-title":"Peptide-drug conjugates as effective prodrug strategies for targeted delivery","volume":"110\u2013111","author":"Wang","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bj.2023.03.005_bib19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jconrel.2018.12.025","article-title":"Cartilage-targeting dexamethasone prodrugs increase the efficacy of dexamethasone","volume":"295","author":"Formica","year":"2019","journal-title":"J Contr Release"},{"issue":"10","key":"10.1016\/j.bj.2023.03.005_bib20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.tips.2019.08.003","article-title":"Drug delivery with designed peptide assemblies","volume":"40","author":"Sis","year":"2019","journal-title":"Trends Pharmacol Sci"},{"issue":"10","key":"10.1016\/j.bj.2023.03.005_bib21","doi-asserted-by":"crossref","first-page":"9966","DOI":"10.1021\/acsnano.8b04143","article-title":"Tandem enzymatic self-assembly and slow release of dexamethasone enhances its antihepatic fibrosis effect","volume":"12","author":"Tang","year":"2018","journal-title":"ACS Nano"},{"issue":"43","key":"10.1016\/j.bj.2023.03.005_bib22","doi-asserted-by":"crossref","first-page":"6759","DOI":"10.1039\/C9TB01066A","article-title":"Cytocompatible cerium oxide-mediated antioxidative stress in inhibiting ocular inflammation-associated corneal neovascularization","volume":"7","author":"Zheng","year":"2019","journal-title":"J Mater Chem B"},{"issue":"10","key":"10.1016\/j.bj.2023.03.005_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1167\/iovs.62.10.25","article-title":"Exploring the mechanism of the miRNA-145\/paxillin Axis in cell metabolism during VEGF-A-induced corneal angiogenesis","volume":"62","author":"Yang","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"14","key":"10.1016\/j.bj.2023.03.005_bib24","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1039\/C6CS00636A","article-title":"Cellular uptake of nanoparticles: journey inside the cell","volume":"46","author":"Behzadi","year":"2017","journal-title":"Chem Soc Rev"},{"issue":"23","key":"10.1016\/j.bj.2023.03.005_bib25","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1039\/D0TB00874E","article-title":"Development of mucoadhesive cationic polypeptide micelles for sustained cabozantinib release and inhibition of corneal neovascularization","volume":"8","author":"Han","year":"2020","journal-title":"J Mater Chem B"},{"issue":"1","key":"10.1016\/j.bj.2023.03.005_bib26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1021\/acs.jmedchem.0c01530","article-title":"Peptide-drug conjugates with different linkers for cancer therapy","volume":"64","author":"Alas","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bj.2023.03.005_bib27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.addr.2015.12.001","article-title":"Advancement in integrin facilitated drug delivery","volume":"97","author":"Arosio","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"issue":"13","key":"10.1016\/j.bj.2023.03.005_bib28","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.1167\/iovs.17-22904","article-title":"Photodynamic therapy leads to time-dependent regression of pathologic corneal (lymph) angiogenesis and promotes high-risk corneal allograft survival","volume":"58","author":"Hou","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.bj.2023.03.005_bib29","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bj.2023.03.005_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112274","article-title":"Inhibiting corneal neovascularization by sustainably releasing anti-VEGF and anti-inflammation drugs from silica-thermogel nanohybrids","volume":"128","author":"Lyu","year":"2021","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"11","key":"10.1016\/j.bj.2023.03.005_bib31","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.3390\/jcm8111925","article-title":"Bevacizumab induces upregulation of keratin 3 and VEGFA in human limbal epithelial cells in vitro","volume":"8","author":"Notara","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.bj.2023.03.005_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.nano.2019.01.001","article-title":"Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization","volume":"17","author":"Wang","year":"2019","journal-title":"Nanomedicine"},{"key":"10.1016\/j.bj.2023.03.005_bib33","article-title":"Association of inflammatory and angiogenic biomarkers in maternal plasma with retinopathy of prematurity in preterm infants","volume":"15","author":"Song","year":"2022","journal-title":"Eye"},{"issue":"11","key":"10.1016\/j.bj.2023.03.005_bib34","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.2217\/nnm-2018-0501","article-title":"Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy","volume":"14","author":"Meka","year":"2019","journal-title":"Nanomedicine"},{"issue":"15","key":"10.1016\/j.bj.2023.03.005_bib35","volume":"9","author":"Tang","year":"2022","journal-title":"Ocular Nanomedicine. Adv Sci (Weinh)"},{"key":"10.1016\/j.bj.2023.03.005_bib36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.addr.2018.02.010","article-title":"Limiting angiogenesis to modulate scar formation","volume":"146","author":"Korntner","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bj.2023.03.005_bib37","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.2147\/OPTH.S118409","article-title":"Systemic side effects of eye drops: a pharmacokinetic perspective","volume":"10","author":"Farkouh","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.bj.2023.03.005_bib38","article-title":"From eye drops to ICU, a case report of three side effects of ophthalmic timolol maleate in the same patient","volume":"2015","author":"Rana","year":"2015","journal-title":"Case Rep Crit Care"},{"key":"10.1016\/j.bj.2023.03.005_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121493","article-title":"Topical instillation of cell-penetrating peptide-conjugated melphalan blocks metastases of retinoblastoma","volume":"284","author":"Jiang","year":"2022","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bj.2023.03.005_bib40","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1038\/s41467-018-06981-w","article-title":"Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery","volume":"9","author":"Than","year":"2018","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.bj.2023.03.005_bib41","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4103\/ijo.IJO_1091_18","article-title":"Systemic toxicity of topical corticosteroids","volume":"67","author":"Jinagal","year":"2019","journal-title":"Indian J Ophthalmol"}],"container-title":["Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S231941702300029X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S231941702300029X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:15:43Z","timestamp":1762420543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S231941702300029X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S231941702300029X"],"URL":"https:\/\/doi.org\/10.1016\/j.bj.2023.03.005","relation":{},"ISSN":["2319-4170"],"issn-type":[{"value":"2319-4170","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted dexamethasone nano-prodrug for corneal neovascularization management","name":"articletitle","label":"Article Title"},{"value":"Biomedical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bj.2023.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Chang Gung University.","name":"copyright","label":"Copyright"}],"article-number":"100592"}}