{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:40:17Z","timestamp":1787956817499,"version":"build-2784847793"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Journal"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bj.2024.100713","type":"journal-article","created":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T23:05:33Z","timestamp":1709507133000},"page":"100713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis"],"prefix":"10.1016","volume":"47","author":[{"given":"Maria Luiza","family":"Thorstenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique Daiane Andrade","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia Ferreira","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Macedo L.V.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo R.C.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique M. Gualberto","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Eduardo Baggio","family":"Savio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson","family":"Coutinho-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-6036","authenticated-orcid":false,"given":"Claudia Lucia Martins","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bj.2024.100713_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.actatropica.2013.12.001","article-title":"Health Metrics for helminth infections","volume":"141","author":"King","year":"2015","journal-title":"Acta Trop"},{"issue":"5","key":"10.1016\/j.bj.2024.100713_bib2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nri1601","article-title":"A worm\u2019s eye view of the immune system: consequences for evolution of human autoimmune disease","volume":"5","author":"Dunne","year":"2005","journal-title":"Nature Rev Immunol"},{"issue":"3","key":"10.1016\/j.bj.2024.100713_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1095-6433(98)10041-7","article-title":"Increased reactivity to 5-hydroxytryptamine of portal veins from mice infected with Schistosoma mansoni","volume":"120","author":"Silva","year":"1998","journal-title":"Comp Biochem Physiol Mol Integr Physiol"},{"key":"10.1016\/j.bj.2024.100713_bib4","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.3389\/fimmu.2018.03042","article-title":"Schistosoma egg migration: mechanisms, pathogenesis and host immune responses","volume":"9","author":"Costain","year":"2018","journal-title":"Frontiers Immunol"},{"issue":"9","key":"10.1016\/j.bj.2024.100713_bib5","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.4049\/jimmunol.163.9.4976","article-title":"Nitric oxide and the Th2 response combine to prevent severe hepatic damage during Schistosoma mansoni infection","volume":"163","author":"Brunet","year":"1999","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.bj.2024.100713_bib6","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1002\/eji.201141869","article-title":"Macrophage activation governs schistosomiasis-induced inflammation and fibrosis","volume":"41","author":"Barron","year":"2011","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.bj.2024.100713_bib7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1096\/fj.11-190934","article-title":"Adenosine promotes alternative macrophage activation via A2A and A2B receptors","volume":"26","author":"Cs\u00f3ka","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.bj.2024.100713_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fphar.2018.00052","article-title":"The P2X7 receptor in inflammatory diseases: Angel or Demon?","volume":"9","author":"Savio","year":"2018","journal-title":"Frontiers Pharmacol"},{"issue":"1","key":"10.1016\/j.bj.2024.100713_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11302-015-9483-2","article-title":"Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release","volume":"12","author":"Zimmermann","year":"2016","journal-title":"Purinergic Signal"},{"issue":"Suppl 1","key":"10.1016\/j.bj.2024.100713_bib10","first-page":"S27","article-title":"The concise guide to pharmacology 2021\/22: G protein-coupled receptors","volume":"176","author":"Alexander","year":"2021","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.bj.2024.100713_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2019.03.011","article-title":"Intercellular Calcium signaling induced by ATP potentiates macrophage phagocytosis","volume":"27","author":"Zumerle","year":"2019","journal-title":"Cell Rep"},{"issue":"1\u20132","key":"10.1016\/j.bj.2024.100713_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imbio.2010.03.010","article-title":"Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages","volume":"216","author":"Marques-da-Silva","year":"2011","journal-title":"Immunobiology"},{"issue":"3","key":"10.1016\/j.bj.2024.100713_bib13","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.4049\/jimmunol.159.3.1451","article-title":"Extracellular ATP triggers IL-1b release by activating the purinergic P2Z receptor of human macrophages","volume":"159","author":"Ferrari","year":"1997","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.bj.2024.100713_bib14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00284-021-02718-z","article-title":"Pathogenicity of salmonella during Schistosoma-Salmonella co-infections and the importance of the gut microbiota","volume":"79","author":"Bajinka","year":"2022","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.bj.2024.100713_bib15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13104-015-1030-2","article-title":"Salmonella Typhi meningitis in a 9-year old boy with urinary schistosomiasis: a case report","volume":"8","author":"Chacha","year":"2015","journal-title":"BMC Res Notes"},{"issue":"1","key":"10.1016\/j.bj.2024.100713_bib16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1086\/509808","article-title":"Influence of helminth infections on the clinical course of immune response to Leishmania braziliensis cutaneous Leishmaniasis","volume":"195","author":"O\u2019Neal","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bj.2024.100713_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/134974","article-title":"Macrophage P2X7 receptor function is reduced during schistosomiasis: putative role of TGF- \u03b21","volume":"2014","author":"Oliveira","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.bj.2024.100713_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2545682","article-title":"P2Y2 receptor induces L. Amazonensis infection control in a mechanism dependent on Caspase-1 activation and IL-1\u03b2 secretion","author":"Thorstenberg","year":"2020","journal-title":"Mediators Inflamm"},{"issue":"4","key":"10.1016\/j.bj.2024.100713_bib19","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jhep.2017.05.021","article-title":"CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury","volume":"67","author":"Savio","year":"2017","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.bj.2024.100713_bib20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0003-2697(86)90640-8","article-title":"A direct colorimetric assay for Ca2+ -stimulated ATPase activity","volume":"157","author":"Chan","year":"1986","journal-title":"Anal Biochem"},{"issue":"3","key":"10.1016\/j.bj.2024.100713_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006125","article-title":"Tegumentary leishmaniasis and coinfections other than HIV","volume":"12","author":"Mart\u00ednez","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"10.1016\/j.bj.2024.100713_bib22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.chom.2014.07.014","article-title":"What lies within: coinfections and immunity","volume":"16","author":"Damania","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.bj.2024.100713_bib23","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3390\/ijms19041222","article-title":"Mechanisms of ATP release by inflammatory cells","volume":"19","author":"Dosch","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.bj.2024.100713_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010064","article-title":"Schistosome immunomodulators","volume":"17","author":"Acharya","year":"2021","journal-title":"PLoS Pathog"},{"issue":"2","key":"10.1016\/j.bj.2024.100713_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11302-016-9544-1","article-title":"The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control","volume":"13","author":"Figliuolo","year":"2017","journal-title":"Purinergic Signal"},{"issue":"11","key":"10.1016\/j.bj.2024.100713_bib26","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.4049\/jimmunol.148.11.3578","article-title":"IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity","volume":"148","author":"Oswald","year":"1992","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.bj.2024.100713_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187186","article-title":"Arginase expression modulates nitric oxide production in Leishmania amazonensis","volume":"12","author":"Acu\u00f1a","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bj.2024.100713_bib28","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4049\/jimmunol.162.2.974","article-title":"Anti-TGF-\u03b2 treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production","volume":"162","author":"Li","year":"1999","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.bj.2024.100713_bib29","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2353\/ajpath.2006.051319","article-title":"The Schistosoma mansoni hepatic egg granuloma provides a favorable microenvironment for sustained growth of Leishmania donovani","volume":"169","author":"Hassan","year":"2006","journal-title":"Am J Pathol"},{"issue":"12","key":"10.1016\/j.bj.2024.100713_bib30","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.4049\/jimmunol.143.12.4208","article-title":"Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates","volume":"143","author":"James","year":"1989","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.bj.2024.100713_bib31","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bbadis.2017.01.006","article-title":"IL-6 promotes M2 macrophage polarization by modulating purinergic signaling and regulates the lethal release of nitric oxide during Trypanosoma cruzi infection","volume":"1863","author":"Sanmarco","year":"2017","journal-title":"Biochim Biophys Acta"},{"issue":"162","key":"10.1016\/j.bj.2024.100713_bib32","doi-asserted-by":"crossref","first-page":"ra12","DOI":"10.1126\/scisignal.2001270","article-title":"ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors","volume":"4","author":"Schenk","year":"2011","journal-title":"Sci Signal"},{"issue":"1","key":"10.1016\/j.bj.2024.100713_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004375","article-title":"The severity of visceral leishmaniasis Correlates with elevated levels of serum IL-6, IL-27 and sCD14","volume":"10","author":"Dos Santos","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"10.1016\/j.bj.2024.100713_bib34","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/eji.200939741","article-title":"NTPDase1 governs P2X7-dependent functions in murine macrophages","volume":"40","author":"L\u00e9vesque","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.bj.2024.100713_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.vph.2016.02.005","article-title":"Increased expression of NTPDases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through P2Y1 receptors","volume":"82","author":"Oliveira","year":"2016","journal-title":"Vascul Pharmacol"},{"issue":"1","key":"10.1016\/j.bj.2024.100713_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11302-012-9332-5","article-title":"Endothelial P2X7 receptors\u2019 expression is reduced by schistosomiasis","volume":"9","author":"Oliveira","year":"2013","journal-title":"Purinergic Signal"},{"issue":"4","key":"10.1016\/j.bj.2024.100713_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001011","article-title":"Characterization of schistosome tegumental alkaline phosphatase (SmAP)","volume":"5","author":"Bhardwaj","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"10.1016\/j.bj.2024.100713_bib38","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/ATVBAHA.111.226852","article-title":"Regulation of macrophage function by adenosine","volume":"32","author":"Hask\u00f3","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.bj.2024.100713_bib39","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.4049\/jimmunol.162.6.3607","article-title":"IFN-g up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation","volume":"162","author":"Xaus","year":"1999","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.bj.2024.100713_bib40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nri.2016.4","article-title":"Purinergic regulation of the immune system","volume":"16","author":"Cekic","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bj.2024.100713_bib41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cyto.2015.12.016","article-title":"Up regulation of A2B adenosine receptor on monocytes are crucially required for immune pathogenicity in Indian patients exposed to Leishmania donovani","volume":"79","author":"Vijayamahantesh","year":"2016","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.bj.2024.100713_bib42","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/sj.bjp.0705218","article-title":"Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation","volume":"139","author":"De Man","year":"2003","journal-title":"Br J Pharmacol"},{"issue":"9","key":"10.1016\/j.bj.2024.100713_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fphar.2018.00054","article-title":"The A2B adenosine receptor modulates the epithelial-mesenchymal transition through the balance of cAMP\/PKA and MAPK\/ERK pathway activation in human epithelial lung cells","author":"Giacomelli","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bj.2024.100713_bib44","doi-asserted-by":"crossref","first-page":"1254762","DOI":"10.3389\/fimmu.2023.1254762","article-title":"Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut-lung microbiome and reduced endoprotective Caveolin-1\/BMPR2 expression","volume":"14","author":"Marinho","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.bj.2024.100713_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2023.102738","article-title":"Pathological roles of macrophages in Leishmania infections","volume":"94","author":"Goto","year":"2023","journal-title":"Parasitol Int"}],"container-title":["Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417024000167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417024000167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T22:53:14Z","timestamp":1734130394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2319417024000167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S2319417024000167"],"URL":"https:\/\/doi.org\/10.1016\/j.bj.2024.100713","relation":{},"ISSN":["2319-4170"],"issn-type":[{"value":"2319-4170","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis","name":"articletitle","label":"Article Title"},{"value":"Biomedical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bj.2024.100713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chang Gung University.","name":"copyright","label":"Copyright"}],"article-number":"100713"}}