{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:23:12Z","timestamp":1792754592368,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T00:00:00Z","timestamp":1712448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Journal"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bj.2024.100724","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T02:21:03Z","timestamp":1712974863000},"page":"100724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mesenchymal stem cell transplantation may be able to induce immunological tolerance in systemic lupus erythematosus"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-5179","authenticated-orcid":false,"given":"Julia","family":"Barbado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bj.2024.100724_bib1","doi-asserted-by":"crossref","first-page":"A277","DOI":"10.1016\/j.autrev.2009.12.008","article-title":"The geoepidemiology of systemic lupus erythematosus","volume":"9","author":"Borchers","year":"2010","journal-title":"Autoimmun Rev"},{"issue":"2","key":"10.1016\/j.bj.2024.100724_bib2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/BOR.0000000000000480","article-title":"Epidemiology of systemic lupus erythematosus: an update","volume":"30","author":"Stojan","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.bj.2024.100724_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8142368","article-title":"Biologics in the Treatment of Lupus Erythematosus: A Critical Literature Review","volume":"2019","author":"Samotij","year":"2019","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.bj.2024.100724_bib4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s13075-015-0819-7","article-title":"Update on mesenchymal stem cell-based therapy in lupus and scleroderma","volume":"17","author":"Cras","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.bj.2024.100724_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7515346","article-title":"Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus","volume":"2019","author":"Yang","year":"2019","journal-title":"J Immunol Res"},{"issue":"12","key":"10.1016\/j.bj.2024.100724_bib6","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"10.1016\/j.bj.2024.100724_bib7","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/art.10264","article-title":"Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus","volume":"46","author":"Girschick","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bj.2024.100724_bib8","doi-asserted-by":"crossref","first-page":"102979","DOI":"10.1016\/j.jaut.2022.102979","article-title":"The complement system and human autoimmune diseases","volume":"137","author":"Coss","year":"2023","journal-title":"J Autoimmun"},{"issue":"11","key":"10.1016\/j.bj.2024.100724_bib9","doi-asserted-by":"crossref","first-page":"102668","DOI":"10.1016\/j.autrev.2020.102668","article-title":"Phoenix from the flames: rediscovering the role of the CD40-CD40L pathway in systemic lupus erythematosus and lupus nephritis","volume":"19","author":"Ramanujam","year":"2020","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.bj.2024.100724_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2018.11.001","article-title":"Systemic lupus erythematosus: diagnosis and clinical management","volume":"96","author":"Fava","year":"2019","journal-title":"J Autoimmun"},{"issue":"11","key":"10.1016\/j.bj.2024.100724_bib11","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1093\/intimm\/dxh160","article-title":"Phenotypic and functional deficiencies of monocyte-derived dendritic cells in systemic lupus erythematosus (SLE) patients","volume":"16","author":"K\u00f6ller","year":"2004","journal-title":"Int Immunol"},{"issue":"6","key":"10.1016\/j.bj.2024.100724_bib12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1191\/0961203303lu423oa","article-title":"Apoptosis of CD34+ cells after incubation with sera of leukopenic patients with systemic lupus erythematosus","volume":"12","author":"Tiefenthaler","year":"2003","journal-title":"Lupus"},{"issue":"10","key":"10.1016\/j.bj.2024.100724_bib13","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/eji.200636416","article-title":"Immunoregulatory function of mesenchymal stem cells","volume":"36","author":"Uccelli","year":"2006","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.bj.2024.100724_bib14","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/bmt.2012.184","article-title":"Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus","volume":"48","author":"Li","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bj.2024.100724_bib15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/5584_2018_212","article-title":"Therapeutic applications of mesenchymal stem cells for systemic Lupus Erythematosus","volume":"1089","author":"Xu","year":"2018","journal-title":"Adv Exp Med Biol"},{"issue":"9","key":"10.1016\/j.bj.2024.100724_bib16","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/cdd.2012.26","article-title":"Mesenchymal stem cells: a double-edged sword in regulating immune responses","volume":"19","author":"Li","year":"2012","journal-title":"Cell Death Differ"},{"issue":"5","key":"10.1016\/j.bj.2024.100724_bib17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nri3209","article-title":"Multipotent mesenchymal stromal cells and the innate immune system","volume":"12","author":"Le Blanc","year":"2012","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"10.1016\/j.bj.2024.100724_bib18","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1002\/art.27560","article-title":"Interferon-\u03b3-dependent inhibition of B cell activation by bone marrow-derived mesenchymal stem cells in a murine model of systemic lupus erythematosus","volume":"62","author":"Schena","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.bj.2024.100724_bib19","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1182\/blood-2005-07-2657","article-title":"Human mesenchymal stem cells modulate B-cell functions","volume":"107","author":"Corcione","year":"2006","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bj.2024.100724_bib20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3390\/jcm9020445","article-title":"Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use","volume":"9","author":"Jimenez-Puerta","year":"2020","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.bj.2024.100724_bib21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.clim.2015.07.011","article-title":"Sun Y,et al. Mesenchymal stem cells promote CD206 expression and phagocytic activity of macrophages through IL-6 in systemic lupus erythematosus","volume":"161","author":"Deng","year":"2015","journal-title":"Clin Immunol"},{"issue":"10","key":"10.1016\/j.bj.2024.100724_bib22","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1182\/blood-2004-02-0586","article-title":"Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells","volume":"105","author":"Jiang","year":"2005","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bj.2024.100724_bib23","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1038\/s41467-019-10491-8","article-title":"Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients","volume":"10","author":"Yuan","year":"2019","journal-title":"Nat Commun"},{"issue":"17","key":"10.1016\/j.bj.2024.100724_bib24","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.3390\/ijms231710023","article-title":"Immunomodulatory Mechanisms of Mesenchymal Stem Cells and Their Potential Clinical Applications","volume":"23","author":"Huang","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.bj.2024.100724_bib25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13287-022-02777-4","article-title":"Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications","volume":"13","author":"Abbasi","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"10.1016\/j.bj.2024.100724_bib26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/1756-185X.12531","article-title":"Mesenchymal stem cells transplantation for systemic lupus erythematosus","volume":"18","author":"Liang","year":"2015","journal-title":"Int J Rheum Dis"},{"issue":"11","key":"10.1016\/j.bj.2024.100724_bib27","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","article-title":"Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing","volume":"25","author":"Chamberlain","year":"2007","journal-title":"Stem Cells"},{"issue":"3","key":"10.1016\/j.bj.2024.100724_bib28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/0961203309348983","article-title":"Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients","volume":"19","author":"Carrion","year":"2010","journal-title":"Lupus"},{"issue":"1","key":"10.1016\/j.bj.2024.100724_bib29","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s13287-018-1053-4","article-title":"Safety analysis in patients with autoimmune disease receiving allogeneic mesenchymal stem cells infusion: a long-term retrospective study","volume":"9","author":"Liang","year":"2018","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.bj.2024.100724_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.clim.2006.02.004","article-title":"The induction and maintenance of T cell anergy","volume":"120","author":"Powell","year":"2006","journal-title":"Clin Immunol"},{"issue":"1","key":"10.1016\/j.bj.2024.100724_bib31","first-page":"38","article-title":"T-cell activation, alterations in systemic lupus erythematosus: A narrative review","volume":"25","author":"T\u00e9llez","year":"2018","journal-title":"Rev Colomb Reumatol"},{"issue":"3","key":"10.1016\/j.bj.2024.100724_bib32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-4800(03)00072-8","article-title":"Function of CD80 and CD86 on monocyte- and stem cell-derived dendritic cells","volume":"75","author":"Dilioglou","year":"2003","journal-title":"Exp Mol Pathol"},{"issue":"9","key":"10.1016\/j.bj.2024.100724_bib33","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/rheumatology\/kel061","article-title":"Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus","volume":"45","author":"Decker","year":"2006","journal-title":"Rheumatology"},{"issue":"6029","key":"10.1016\/j.bj.2024.100724_bib34","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.1202947","article-title":"Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4","volume":"332","author":"Qureshi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bj.2024.100724_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fimmu.2012.00051","article-title":"Molecular mechanisms of treg-mediated T cell suppression","volume":"3","author":"Schmidt","year":"2012","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.bj.2024.100724_bib36","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/ni1003","article-title":"Modulation of tryptophan catabolism by regulatory T cells","volume":"4","author":"Fallarino","year":"2003","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.bj.2024.100724_bib37","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.178.4.2579","article-title":"Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus","volume":"178","author":"Valencia","year":"2007","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.bj.2024.100724_bib38","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1177\/0961203308090028","article-title":"T-regulatory cells in systemic lupus erythematosus","volume":"17","author":"La Cava","year":"2008","journal-title":"Lupus"},{"key":"10.1016\/j.bj.2024.100724_bib39","doi-asserted-by":"crossref","first-page":"102870","DOI":"10.1016\/j.jaut.2022.102870","article-title":"Abnormalities of T cells in systemic lupus erythematosus: new insights in pathogenesis and therapeutic strategies","volume":"132","author":"Li","year":"2022","journal-title":"J Autoimmun"},{"issue":"2","key":"10.1016\/j.bj.2024.100724_bib40","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1182\/blood-2010-07-294249","article-title":"Characterization of a rare IL-10\u2013competent B-cell subset in humans that parallels mouse regulatory B10 cells","volume":"117","author":"Iwata","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bj.2024.100724_bib41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.immuni.2009.11.009","article-title":"CD19+CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients","volume":"32","author":"Blair","year":"2010","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.bj.2024.100724_bib42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3109\/08820139.2014.917096","article-title":"Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis","volume":"43","author":"Zheng","year":"2014","journal-title":"Immunol Invest"},{"issue":"4","key":"10.1016\/j.bj.2024.100724_bib43","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3109\/03009742.2015.1126346","article-title":"Decreased IL-10 + regulatory B cells (Bregs) in lupus nephritis patients","volume":"45","author":"Heinemann","year":"2016","journal-title":"Scand J Rheumatol"},{"issue":"6","key":"10.1016\/j.bj.2024.100724_bib44","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.semarthrit.2018.10.007","article-title":"Regulatory B cells: New players in inflammatory and autoimmune rheumatic diseases","volume":"48","author":"Sakkas","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.bj.2024.100724_bib45","doi-asserted-by":"crossref","first-page":"609544","DOI":"10.3389\/fimmu.2021.609544","article-title":"Mesenchymal Stromal Cells Rapidly Suppress TCR Signaling-Mediated Cytokine Transcription in Activated T Cells Through the ICAM-1\/CD43 Interaction","volume":"12","author":"Zheng","year":"2021","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.bj.2024.100724_bib46","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","article-title":"Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases","volume":"14","author":"Shi","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.bj.2024.100724_bib47","article-title":"The immunomodulatory properties of mesenchymal stem cells play a critical role in inducing immune tolerance after liver transplantation","volume":"2021","author":"Wei","year":"2021","journal-title":"Stem Cell Int"},{"issue":"9","key":"10.1016\/j.bj.2024.100724_bib48","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/sj.leu.2403871","article-title":"Mesenchymal stem cells induce apoptosis of activated T cells","volume":"19","author":"Plumas","year":"2005","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.bj.2024.100724_bib49","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm.3554","article-title":"Interleukin-35 induces regulatory B cells that suppress autoimmune disease","volume":"20","author":"Wang","year":"2014","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.bj.2024.100724_bib50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.trim.2014.06.005","article-title":"Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with rapamycin","volume":"31","author":"Wang","year":"2014","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.bj.2024.100724_bib51","doi-asserted-by":"crossref","first-page":"957797","DOI":"10.3389\/fimmu.2022.957797","article-title":"Mesenchymal stromal cells induced regulatory B cells are enriched in extracellular matrix genes and IL-10 independent modulators","volume":"13","author":"Garcia","year":"2022","journal-title":"Front Immunol"},{"issue":"42","key":"10.1016\/j.bj.2024.100724_bib52","doi-asserted-by":"crossref","first-page":"17384","DOI":"10.1073\/pnas.1103650108","article-title":"Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells","volume":"108","author":"Chiesa","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.bj.2024.100724_bib53","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1182\/blood-2008-04-154138","article-title":"Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2\u2013dependent regulatory dendritic cell population","volume":"113","author":"Zhang","year":"2009","journal-title":"Blood"}],"container-title":["Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417024000271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417024000271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T21:40:18Z","timestamp":1724881218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2319417024000271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2319417024000271"],"URL":"https:\/\/doi.org\/10.1016\/j.bj.2024.100724","relation":{},"ISSN":["2319-4170"],"issn-type":[{"value":"2319-4170","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stem cell transplantation may be able to induce immunological tolerance in systemic lupus erythematosus","name":"articletitle","label":"Article Title"},{"value":"Biomedical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bj.2024.100724","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chang Gung University.","name":"copyright","label":"Copyright"}],"article-number":"100724"}}