{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:45:16Z","timestamp":1782765916644,"version":"3.54.5"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J01241"],"award-info":[{"award-number":["2021J01241"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J02035"],"award-info":[{"award-number":["2021J02035"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020J01947"],"award-info":[{"award-number":["2020J01947"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J01528"],"award-info":[{"award-number":["2024J01528"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2021CXA019"],"award-info":[{"award-number":["2021CXA019"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Journal"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bj.2025.100908","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T06:37:28Z","timestamp":1755931048000},"page":"100908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["In vitro axotomy models regulated by ROCK inhibitor for studying neuroregeneration and growth cone morphology"],"prefix":"10.1016","volume":"49","author":[{"given":"Fang","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bj.2025.100908_bib1","article-title":"Research hotspots and trends of peripheral nerve injuries based on web of science from 2017 to 2021: a bibliometric analysis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Neurol"},{"issue":"4","key":"10.1016\/j.bj.2025.100908_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3390\/gels7040152","article-title":"Repair of peripheral nerve injury using hydrogels based on self-assembled peptides","volume":"7","author":"Zhang","year":"2021","journal-title":"Gels"},{"issue":"3","key":"10.1016\/j.bj.2025.100908_bib3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.4103\/1673-5374.202927","article-title":"Combination therapy using evening primrose oil and electrical stimulation to improve nerve function following a crush injury of sciatic nerve in Male rats","volume":"12","author":"Badri","year":"2017","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.bj.2025.100908_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.757906","article-title":"Effect of electrical and electromechanical stimulation on PC12 cell proliferation and axon outgrowth","volume":"9","author":"Xu","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"10.1016\/j.bj.2025.100908_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.7150\/ijbs.35653","article-title":"Current status of therapeutic approaches against peripheral nerve injuries: a detailed story from injury to recovery","volume":"16","author":"Hussain","year":"2020","journal-title":"Int J Biol Sci"},{"issue":"1","key":"10.1016\/j.bj.2025.100908_bib6","first-page":"100","article-title":"Neurobiology of peripheral nerve injury, regeneration, and functional recovery: from bench top research to bedside application","volume":"13","author":"Sulaiman","year":"2013","journal-title":"Ochsner J"},{"key":"10.1016\/j.bj.2025.100908_bib7","first-page":"337","article-title":"Emerging polymeric biomaterials and manufacturing-based tissue engineering approaches for neuro regeneration-A critical review on recent effective approaches","volume":"4","author":"Amna","year":"2023","journal-title":"Smart Mater Med"},{"issue":"16","key":"10.1016\/j.bj.2025.100908_bib8","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1523\/JNEUROSCI.3481-16.2017","article-title":"STAT3 controls the long-term survival and phenotype of repair schwann cells during nerve regeneration","volume":"37","author":"Benito","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.bj.2025.100908_bib9","doi-asserted-by":"crossref","first-page":"e62232","DOI":"10.7554\/eLife.62232","article-title":"Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring schwann cell c-Jun","volume":"10","author":"Wagstaff","year":"2021","journal-title":"ELife"},{"issue":"2","key":"10.1016\/j.bj.2025.100908_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nprot.2009.202","article-title":"Regenerating cortical connections in a dish: the entorhino-hippocampal organotypic slice co-culture as tool for pharmacological screening of molecules promoting axon regeneration","volume":"5","author":"del R\u00edo","year":"2010","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bj.2025.100908_bib11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.expneurol.2014.09.012","article-title":"Inhibition of rho-kinase differentially affects axon regeneration of peripheral motor and sensory nerves","volume":"263","author":"Joshi","year":"2015","journal-title":"Exp Neurol"},{"issue":"2","key":"10.1016\/j.bj.2025.100908_bib12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2174\/1570159X19666210407155543","article-title":"In vitro, in vivo and Ex vivo models for peripheral nerve injury and regeneration","volume":"20","author":"Li","year":"2022","journal-title":"Curr Neuropharmacol"},{"issue":"5","key":"10.1016\/j.bj.2025.100908_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0285897","article-title":"In vitro myelination using explant culture of dorsal root ganglia: an efficient tool for analyzing peripheral nerve differentiation and disease modeling","volume":"18","author":"Numata-Uematasu","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.bj.2025.100908_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/srep16763","article-title":"High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord","volume":"5","author":"Beaudet","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.bj.2025.100908_bib15","first-page":"57569","article-title":"Dorsal root ganglia isolation and primary culture to study neurotransmitter release","volume":"140","author":"Lin","year":"2018","journal-title":"J Vis Exp"},{"issue":"3","key":"10.1016\/j.bj.2025.100908_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrn3176","article-title":"Assembly of a new growth cone after axotomy: the precursor to axon regeneration","volume":"13","author":"Bradke","year":"2012","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"10.1016\/j.bj.2025.100908_bib17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tins.2011.11.002","article-title":"Growing the growth cone: remodeling the cytoskeleton to promote axon regeneration","volume":"35","author":"Hur","year":"2012","journal-title":"Trends Neurosci"},{"issue":"15","key":"10.1016\/j.bj.2025.100908_bib18","doi-asserted-by":"crossref","first-page":"8344","DOI":"10.3390\/ijms22158344","article-title":"Unraveling axon guidance during axotomy and regeneration","volume":"22","author":"Dom\u00ednguez-Romero","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.bj.2025.100908_bib19","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/s41467-024-45825-8","article-title":"Identification of the growth cone as a probe and driver of neuronal migration in the injured brain","volume":"15","author":"Nakajima","year":"2024","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.bj.2025.100908_bib20","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s42255-020-0252-3","article-title":"AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury","volume":"2","author":"Kong","year":"2020","journal-title":"Nat Metab"},{"issue":"4","key":"10.1016\/j.bj.2025.100908_bib21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/jnen\/nlz008","article-title":"Axotomy induces phasic alterations in Luman\/CREB3 expression and nuclear localization in injured and contralateral uninjured sensory neurons: correlation with intrinsic axon growth capacity","volume":"78","author":"Hasmatali","year":"2019","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.bj.2025.100908_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146864","article-title":"Intra-axonal mechanisms driving axon regeneration","volume":"1740","author":"Smith","year":"2020","journal-title":"Brain Res"},{"issue":"4 Suppl","key":"10.1016\/j.bj.2025.100908_bib23","doi-asserted-by":"crossref","first-page":"A74","DOI":"10.1227\/01.NEU.0000352378.26755.C3","article-title":"Responses of the nerve cell body to axotomy","volume":"65","author":"Richardson","year":"2009","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.bj.2025.100908_bib24","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.expneurol.2008.04.023","article-title":"Activated RHOA and peripheral axon regeneration","volume":"212","author":"Cheng","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bj.2025.100908_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1368630","article-title":"Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration","volume":"18","author":"Izhiman","year":"2024","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.bj.2025.100908_bib26","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1038\/ncomms3690","article-title":"PI3K-GSK3 signalling regulates Mammalian axon regeneration by inducing the expression of Smad1","volume":"4","author":"Saijilafu","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.bj.2025.100908_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-0716-1437-2_14","article-title":"Isolation and culture of dorsal root ganglia (DRG) from rodents","volume":"2311","author":"Shekarabi","year":"2021","journal-title":"Methods Mol Biol"},{"issue":"4","key":"10.1016\/j.bj.2025.100908_bib28","first-page":"319","article-title":"Purification and culture of spinal motor neurons from rat embryos","author":"Graber","year":"20132013","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.bj.2025.100908_bib29","first-page":"55609","article-title":"Anatomically inspired three-dimensional micro-tissue engineered neural networks for nervous system reconstruction, modulation, and modeling","volume":"123","author":"Struzyna","year":"2017","journal-title":"J Vis Exp"},{"issue":"6","key":"10.1016\/j.bj.2025.100908_bib30","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1111\/j.1471-4159.2010.06726.x","article-title":"Neurites regrowth of cortical neurons by GSK3beta inhibition independently of nogo receptor 1","volume":"113","author":"Seira","year":"2010","journal-title":"J Neurochem"},{"issue":"2","key":"10.1016\/j.bj.2025.100908_bib31","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/02688690701772413","article-title":"In vitro models of neurotrauma","volume":"22","author":"Kumaria","year":"2008","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.bj.2025.100908_bib32","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.expneurol.2014.10.012","article-title":"An in vitro assay to study induction of the regenerative state in sensory neurons","volume":"263","author":"Frey","year":"2015","journal-title":"Exp Neurol"},{"issue":"Pt 3","key":"10.1016\/j.bj.2025.100908_bib33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.expneurol.2016.01.020","article-title":"In vitro models of axon regeneration","volume":"287","author":"Al-Ali","year":"2017","journal-title":"Exp Neurol"},{"issue":"15","key":"10.1016\/j.bj.2025.100908_bib34","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1096\/fj.04-1805fje","article-title":"Acute physiological response of Mammalian central neurons to axotomy: ionic regulation and electrical activity","volume":"18","author":"Mandolesi","year":"2004","journal-title":"FASEB J"},{"issue":"4","key":"10.1016\/j.bj.2025.100908_bib35","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1227\/01.NEU.0000298896.31355.80","article-title":"In vivo use of a nanoknife for axon microsurgery","volume":"61","author":"Chang","year":"2007","journal-title":"Neurosurgery"},{"issue":"12","key":"10.1016\/j.bj.2025.100908_bib36","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1046\/j.1460-9568.2002.02027.x","article-title":"Involvement of cajal-retzius cells in robust and layer-specific regeneration of the entorhino-hippocampal pathways","volume":"15","author":"del R\u00edo","year":"2002","journal-title":"Eur J Neurosci"},{"issue":"1","key":"10.1016\/j.bj.2025.100908_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0014-4886(03)00108-0","article-title":"Localization of alpha-, beta-, and gamma-synuclein during neuronal development and alterations associated with the neuronal response to axonal trauma","volume":"182","author":"Quilty","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bj.2025.100908_bib38","first-page":"113","article-title":"Mechanisms of laser cellular microsurgery","volume":"82","author":"Quinto-Su","year":"2007","journal-title":"Methods Cell Biol"},{"issue":"11","key":"10.1016\/j.bj.2025.100908_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080722","article-title":"Probing functional properties of nociceptive axons using a microfluidic culture system","volume":"8","author":"Tsantoulas","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bj.2025.100908_bib40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12640-010-9152-8","article-title":"Wallerian-like degeneration of central neurons after synchronized and geometrically registered mass axotomy in a three-compartmental microfluidic chip","volume":"19","author":"Kilinc","year":"2011","journal-title":"Neurotox Res"},{"issue":"12","key":"10.1016\/j.bj.2025.100908_bib41","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.3390\/biomedicines10123186","article-title":"Axonal regeneration: underlying molecular mechanisms and potential therapeutic targets","volume":"10","author":"Akram","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bj.2025.100908_bib42","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-neuro-061010-113723","article-title":"Neuronal intrinsic mechanisms of axon regeneration","volume":"34","author":"Liu","year":"2011","journal-title":"Annu Rev Neurosci"},{"issue":"21","key":"10.1016\/j.bj.2025.100908_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2021.08.014","article-title":"RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury","volume":"109","author":"Stern","year":"2021","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.bj.2025.100908_bib44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/iovs.63.1.4","article-title":"Axonal protection by netarsudil, a ROCK inhibitor, is linked to an AMPK-autophagy pathway in TNF-induced optic nerve degeneration","volume":"63","author":"Kitaoka","year":"2022","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.bj.2025.100908_bib45","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jtos.2021.08.011","article-title":"The effect of rho kinase inhibition on corneal nerve regeneration in vitro and in vivo","volume":"22","author":"Mertsch","year":"2021","journal-title":"Ocul Surf"},{"issue":"4","key":"10.1016\/j.bj.2025.100908_bib46","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4103\/1673-5374.205080","article-title":"RhoA as a target to promote neuronal survival and axon regeneration","volume":"12","author":"Hu","year":"2017","journal-title":"Neural Regen Res"},{"issue":"4","key":"10.1016\/j.bj.2025.100908_bib47","first-page":"3395","article-title":"ROCK inhibitor Y-27632 protects rats against cerebral ischemia\/reperfusion-induced behavioral deficits and hippocampal damage","volume":"20","author":"Li","year":"2019","journal-title":"Mol Med Rep"},{"issue":"3","key":"10.1016\/j.bj.2025.100908_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107907","article-title":"Axon growth of CNS neurons in three dimensions is amoeboid and independent of adhesions","volume":"32","author":"Santos","year":"2020","journal-title":"Cell Rep"},{"issue":"10","key":"10.1016\/j.bj.2025.100908_bib49","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/ar.23843","article-title":"Expression of regeneration-associated proteins in primary sensory neurons and regenerating axons after nerve Injury-An overview","volume":"301","author":"Dubov\u00fd","year":"2018","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.bj.2025.100908_bib50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2014.09.027","article-title":"The neuroimmunology of degeneration and regeneration in the peripheral nervous system","volume":"302","author":"DeFrancesco-Lisowitz","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bj.2025.100908_bib51","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.pneurobio.2018.12.001","article-title":"Macrophage biology in the peripheral nervous system after injury","volume":"173","author":"Zigmond","year":"2019","journal-title":"Prog Neurobiol"},{"issue":"5","key":"10.1016\/j.bj.2025.100908_bib52","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1089\/neu.2012.2562","article-title":"A novel in vitro injury model based on microcontact printing demonstrates negative effects of hydrogen peroxide on axonal regeneration both in absence and presence of glia","volume":"30","author":"Yaka","year":"2013","journal-title":"J Neurotrauma"},{"issue":"1","key":"10.1016\/j.bj.2025.100908_bib53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archneur.1973.00490250071008","article-title":"Axon outgrowth enhanced by a previous nerve injury","volume":"29","author":"McQuarrie","year":"1973","journal-title":"Arch Neurol"}],"container-title":["Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417025000824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417025000824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:00:03Z","timestamp":1782763203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2319417025000824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2319417025000824"],"URL":"https:\/\/doi.org\/10.1016\/j.bj.2025.100908","relation":{},"ISSN":["2319-4170"],"issn-type":[{"value":"2319-4170","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro axotomy models regulated by ROCK inhibitor for studying neuroregeneration and growth cone morphology","name":"articletitle","label":"Article Title"},{"value":"Biomedical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bj.2025.100908","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chang Gung University.","name":"copyright","label":"Copyright"}],"article-number":"100908"}}