{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:46:18Z","timestamp":1792050378450,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC-114-2320-B-182-016"],"award-info":[{"award-number":["NSTC-114-2320-B-182-016"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["BMRP 278"],"award-info":[{"award-number":["BMRP 278"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Journal"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bj.2026.101054","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:29:36Z","timestamp":1791588576000},"page":"101054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Context-Dependent Associations of HO-1 Modulation with Ferroptosis-Associated Injury and Vascular Cell Functions In Vitro"],"prefix":"10.1016","author":[{"given":"Patrick Yan-Tyng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Shuo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8524-8253","authenticated-orcid":false,"given":"Horng-Heng","family":"Juang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bj.2026.101054_bib1","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.bj.2026.101054_bib2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.bj.2026.101054_bib3","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/CIRCRESAHA.115.306361","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"118","author":"Bennett","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.bj.2026.101054_bib4","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41419-023-06206-z","article-title":"Macrophage polarization and metabolism in atherosclerosis","volume":"14","author":"Hou","year":"2023","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bj.2026.101054_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116112","article-title":"The mechanisms of ferroptosis and its role in atherosclerosis","volume":"171","author":"Xu","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bj.2026.101054_bib6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/cvr\/cvae270","article-title":"Iron, lipid peroxidation, and ferroptosis play pathogenic roles in atherosclerosis","volume":"121","author":"Jinson","year":"2025","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.bj.2026.101054_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbagen.2011.07.014","article-title":"Non-transferrin-bound iron: A key role in iron overload and iron toxicity","volume":"1820","author":"Brissot","year":"2012","journal-title":"Biochim Bioph Acta"},{"key":"10.1016\/j.bj.2026.101054_bib8","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.3390\/molecules27061784","article-title":"The (bio)chemistry of non-transferrin-bound iron","volume":"27","author":"Silva","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bj.2026.101054_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/03630260701726871","article-title":"Can iron chelators influence the progression of atherosclerosis?","volume":"32","author":"Marx","year":"2008","journal-title":"Hemoglobin"},{"key":"10.1016\/j.bj.2026.101054_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-44122-6","article-title":"The effect of circulating iron on barrier integrity of primary human endothelial cells","volume":"13","author":"Madsen","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.bj.2026.101054_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101156","article-title":"Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNF\u03b1-mediated apoptosis","volume":"297","author":"Fisher","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bj.2026.101054_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11095-021-03006-y","article-title":"Increasing intracellular levels of iron with ferric ammonium citrate leads to reduced P-glycoprotein expression in human brain endothelial cells","volume":"38","author":"Newman","year":"2021","journal-title":"Pharm Res"},{"key":"10.1016\/j.bj.2026.101054_bib13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of non-apoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bj.2026.101054_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: Death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Bio"},{"key":"10.1016\/j.bj.2026.101054_bib15","article-title":"Heme oxygenase-1 inhibits HLA class I antibody-dependent endothelial cell activation","volume":"10","author":"Zilan","year":"2015","journal-title":"PLOS One"},{"key":"10.1016\/j.bj.2026.101054_bib16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/nu15030591","article-title":"Targeting iron metabolism and ferroptosis as novel therapeutic approaches in cardiovascular diseases","volume":"15","author":"Chen","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bj.2026.101054_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11883-024-01251-1","article-title":"The role of iron in atherosclerosis and its association with related diseases","volume":"27","author":"Gao","year":"2025","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.bj.2026.101054_bib18","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.3390\/nu17243921","article-title":"Haem oxygenase-1, ferroptosis and disorders\u2014a narrative review","volume":"17","author":"Pham","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.bj.2026.101054_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/ijms20010039","article-title":"A dual role of heme oxygenase-1 in cancer cells","volume":"20","author":"Chiang","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bj.2026.101054_bib20","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3390\/ijms22041514","article-title":"Heme oxygenase-1 deficiency and oxidative stress: A review of 9 independent human cases and animal models","volume":"22","author":"Yachie","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bj.2026.101054_bib21","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1182\/blood-2017-12-822619","article-title":"Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion","volume":"131","author":"Youssef","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.bj.2026.101054_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101971","article-title":"HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration","volume":"43","author":"Tang","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.bj.2026.101054_bib23","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3390\/antiox10050789","article-title":"Clinical significance of heme oxygenase 1 in tumor progression","volume":"10","author":"Nitti","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.bj.2026.101054_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2025.1585079","article-title":"Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia","volume":"18","author":"Zou","year":"2025","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.bj.2026.101054_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","article-title":"Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases","volume":"7","author":"Yu","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.bj.2026.101054_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12933-025-02614-x","article-title":"Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases","volume":"24","author":"Wang","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.bj.2026.101054_bib27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tranon.2019.10.008","article-title":"Antioxidation and antiapoptosis characteristics of heme oxygenase-1 enhance tumorigenesis of human prostate carcinoma cells","volume":"13","author":"Chiang","year":"2020","journal-title":"Transl Oncol"},{"key":"10.1016\/j.bj.2026.101054_bib28","doi-asserted-by":"crossref","first-page":"C557","DOI":"10.1152\/ajpcell.00230.2024","article-title":"Growth differentiation factor is a glucose downregulated gene acting as the cross talk between stroma and cancer cells of the human bladder","volume":"328","author":"Chang","year":"2025","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bj.2026.101054_bib29","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.3390\/nu14214506","article-title":"Ferroptosis of endothelial cells in vascular disease","volume":"14","author":"Zhang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bj.2026.101054_bib30","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jdiacomp.2015.05.017","article-title":"Non-transferrin-bound iron is associated with biomarkers of oxidative stress, inflammation and endothelial dysfunction in type 2 diabetes","volume":"29","author":"Aljwaid","year":"2015","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.bj.2026.101054_bib31","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/biom14060730","article-title":"Exogenous iron induces mitochondrial lipid peroxidation, lipofuscin accumulation, and ferroptosis in H9c2 cardiomyocytes","volume":"14","author":"Lyamzaev","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.bj.2026.101054_bib32","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/CIRCRESAHA.122.321667","article-title":"Iron metabolism in cardiovascular disease: physiology, mechanisms, and therapeutic targets","volume":"132","author":"Sawicki","year":"2023","journal-title":"Circ Res"},{"key":"10.1016\/j.bj.2026.101054_bib33","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.15419\/bmrat.v11i4.880","article-title":"Kaempferol rescues vascular endothelial ferroptosis by inhibiting lipid peroxidation","volume":"11","author":"Wen","year":"2024","journal-title":"Biomed Res Ther"},{"key":"10.1016\/j.bj.2026.101054_bib34","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.2174\/092986712800609706","article-title":"Iron chelators for the treatment of cancer","volume":"19","author":"Yu","year":"2012","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bj.2026.101054_bib35","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1158\/0008-5472.CAN-11-1218","article-title":"Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes","volume":"71","author":"Lovejoy","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.bj.2026.101054_bib36","article-title":"Oxidative stress induces mitochondrial iron overload and ferroptotic cell death","volume":"13","author":"Chen","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.bj.2026.101054_bib37","doi-asserted-by":"crossref","first-page":"17016","DOI":"10.1074\/jbc.M112.350470","article-title":"The iron chelators Dp44mT and DFO inhibit TGF-\u03b2-induced epithelial-mesenchymal transition via up-regulation of N-myc downstream-regulated gene 1 (NDRG1)","volume":"287","author":"Chen","year":"2012","journal-title":"J Bio Chem"},{"key":"10.1016\/j.bj.2026.101054_bib38","doi-asserted-by":"crossref","first-page":"C676","DOI":"10.1152\/ajpcell.00180.2011","article-title":"L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N- myc downstream regulated gene 1 in prostate carcinoma cells","volume":"302","author":"Chung","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bj.2026.101054_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/srep29417","article-title":"Identification of cyclins A1, E1, and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis","volume":"6","author":"Bauer","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.bj.2026.101054_bib40","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease","volume":"17","author":"Wang","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.bj.2026.101054_bib41","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/HYPERTENSIONAHA.107.098046","article-title":"Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program","volume":"51","author":"Frank","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.bj.2026.101054_bib42","first-page":"443","article-title":"Iron chelator-mediated alterations in gene expression: Identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1\u03b1 and p53","volume":"77","author":"Saletta","year":"2010","journal-title":"Mol Parmacol"},{"key":"10.1016\/j.bj.2026.101054_bib43","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3181\/00379727-216-44197","article-title":"Heme induces the expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in vascular endothelial cells","volume":"216","author":"Wagener","year":"1997","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.bj.2026.101054_bib44","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.4049\/jimmunol.172.6.3553","article-title":"Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation","volume":"172","author":"Soares","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.bj.2026.101054_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1615197","article-title":"Ferroptosis and bone metabolic diseases: the dual regulatory role of the Nrf2\/HO-1 signaling axis","volume":"13","author":"Nan","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.bj.2026.101054_bib46","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/biom11040589","article-title":"Heme oxygenase-1 signaling and redox homeostasis in physiopathological conditions","volume":"11","author":"Consoli","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bj.2026.101054_bib47","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bcp.2016.12.009","article-title":"Heme oxygenase (HO)-1 induction prevents endoplasmic reticulum stress-mediated endothelial cell death and impaired angiogenic capacity","volume":"127","author":"Maamoun","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bj.2026.101054_bib48","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/HYPERTENSIONAHA.111.173807","article-title":"Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contraction in the aorta of the spontaneously hypertensive rat","volume":"58","author":"Li","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.bj.2026.101054_bib49","doi-asserted-by":"crossref","first-page":"H709","DOI":"10.1152\/ajpheart.00543.2012","article-title":"Growth differentiation factor 15 impairs aortic contractile and relaxing function through altered caveolar signaling of the endothelium","volume":"304","author":"Mazagova","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.bj.2026.101054_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2026.102680","article-title":"WISP1 is the stromal-secreting oncoprotein via paracrine downregulation of NDRG1, KAI1, and Maspin in human bladder cancer cells","volume":"65","author":"Chen","year":"2026","journal-title":"Transl Oncol"}],"container-title":["Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417026001101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2319417026001101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:50:43Z","timestamp":1792047043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2319417026001101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":50,"alternative-id":["S2319417026001101"],"URL":"https:\/\/doi.org\/10.1016\/j.bj.2026.101054","relation":{},"ISSN":["2319-4170"],"issn-type":[{"value":"2319-4170","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Context-Dependent Associations of HO-1 Modulation with Ferroptosis-Associated Injury and Vascular Cell Functions In Vitro","name":"articletitle","label":"Article Title"},{"value":"Biomedical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bj.2026.101054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chang Gung University.","name":"copyright","label":"Copyright"}],"article-number":"101054"}}