{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:08:01Z","timestamp":1778249281680,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["32003B_169334"],"award-info":[{"award-number":["32003B_169334"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bja.2018.01.020","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:05:20Z","timestamp":1520467520000},"page":"918-927","source":"Crossref","is-referenced-by-count":13,"title":["Comparison between neurally-assisted, controlled, and physiologically variable ventilation in healthy rabbits"],"prefix":"10.1016","volume":"121","author":[{"given":"M.","family":"Walesa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Albu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Baudat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Petak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Habre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2018.01.020_bib1","doi-asserted-by":"crossref","first-page":"L678","DOI":"10.1152\/ajplung.00154.2002","article-title":"Ventilator-induced lung injury: in\u00a0vivo and in\u00a0vitro mechanisms","volume":"283","author":"Matthay","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.bja.2018.01.020_bib2","first-page":"980","article-title":"Ventilator-induced lung injury","volume":"370","author":"Slutsky","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bja.2018.01.020_bib3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00134-005-2817-8","article-title":"Ventilator-induced lung injury: from the bench to the bedside","volume":"32","author":"Tremblay","year":"2006","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/01.anes.0000296068.80921.10","article-title":"Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury","volume":"108","author":"Wolthuis","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.01.020_bib5","doi-asserted-by":"crossref","first-page":"e24527","DOI":"10.1371\/journal.pone.0024527","article-title":"Recurrent recruitment manoeuvres improve lung mechanics and minimize lung injury during mechanical ventilation of healthy mice","volume":"6","author":"Reiss","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bja.2018.01.020_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/ALN.0b013e318291c165","article-title":"Effect of positive end-expiratory pressure on regional ventilation distribution during mechanical ventilation after surfactant depletion","volume":"119","author":"Bayat","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.01.020_bib7","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1164\/ajrccm.149.5.8173774","article-title":"Tidal ventilation at low airway pressures can augment lung injury","volume":"149","author":"Muscedere","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib8","article-title":"The extent of ventilator-induced lung injury in mice partly depends on duration of mechanical ventilation","volume":"2013","author":"Hegeman","year":"2013","journal-title":"Crit Care Res Pract"},{"key":"10.1016\/j.bja.2018.01.020_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/MCC.0b013e32835c517d","article-title":"Nonconventional ventilation techniques","volume":"19","author":"Cordioli","year":"2013","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.bja.2018.01.020_bib10","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1097\/CCM.0B013E3181650592","article-title":"When mechanical ventilation mimics nature","volume":"36","author":"Vassilakopoulos","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/30130","article-title":"Life-support system benefits from noise","volume":"393","author":"Suki","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bja.2018.01.020_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1164\/ajrccm.165.3.2010155","article-title":"Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury","volume":"165","author":"Arold","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib13","doi-asserted-by":"crossref","first-page":"L370","DOI":"10.1152\/ajplung.00036.2003","article-title":"Variable ventilation induces endogenous surfactant release in normal guinea pigs","volume":"285","author":"Arold","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.bja.2018.01.020_bib14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.CCM.0000196208.01682.87","article-title":"Comparison of variable and conventional ventilation in a sheep saline lavage lung injury model","volume":"34","author":"Bellardine","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib15","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1164\/ajrccm.165.4.2108006","article-title":"Improved arterial oxygenation with biologically variable or fractal ventilation using low tidal volumes in a porcine model of acute respiratory distress syndrome","volume":"165","author":"Boker","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib16","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/00000542-200403000-00022","article-title":"Variable ventilation improves perioperative lung function in patients undergoing abdominal aortic aneurysmectomy","volume":"100","author":"Boker","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.01.020_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1465-9921-5-22","article-title":"A\u00a0comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injury","volume":"5","author":"Funk","year":"2004","journal-title":"Respir Res"},{"key":"10.1016\/j.bja.2018.01.020_bib18","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s12630-011-9517-3","article-title":"Resolution of pulmonary edema with variable mechanical ventilation in a porcine model of acute lung injury","volume":"58","author":"Graham","year":"2011","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.bja.2018.01.020_bib19","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/01.CCM.0000269039.61615.A1","article-title":"Biologically variable ventilation improves gas exchange and respiratory mechanics in a model of severe bronchospasm","volume":"35","author":"Mutch","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/oxfordjournals.bja.a013403","article-title":"Biologically variable ventilation prevents deterioration of gas exchange during prolonged anaesthesia","volume":"84","author":"Mutch","year":"2000","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.01.020_bib21","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1097\/00003246-200007000-00045","article-title":"Biologically variable ventilation increases arterial oxygenation over that seen with positive end-expiratory pressure alone in a porcine model of acute respiratory distress syndrome","volume":"28","author":"Mutch","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1164\/ajrccm.162.1.9903120","article-title":"Biologically variable or naturally noisy mechanical ventilation recruits atelectatic lung","volume":"162","author":"Mutch","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib23","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1164\/rccm.200806-975OC","article-title":"Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury","volume":"179","author":"Spieth","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"104","key":"10.1016\/j.bja.2018.01.020_bib24","first-page":"1329","article-title":"Design of a new variable-ventilation method optimized for lung recruitment in mice","volume":"2008","author":"Thammanomai","year":"1985","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.bja.2018.01.020_bib25","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/bja\/aew093","article-title":"Comparison of different degrees of variability in tidal volume to prevent deterioration of respiratory system elastance in experimental acute lung inflammation","volume":"116","author":"Kiss","year":"2016","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.01.020_bib26","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/cc13706","article-title":"Lung protection during non-invasive synchronized assist versus volume control in rabbits","volume":"18","author":"Mirabella","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2018.01.020_bib27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4187\/respcare.01021","article-title":"Proportional assist ventilation and neurally adjusted ventilatory assist","volume":"56","author":"Kacmarek","year":"2011","journal-title":"Respir Care"},{"key":"10.1016\/j.bja.2018.01.020_bib28","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1164\/ajrccm.154.5.8912782","article-title":"Improved arterial oxygenation after oleic acid lung injury in the pig using a computer-controlled mechanical ventilator","volume":"154","author":"Lefevre","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib29","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/01.CCM.0000299736.55039.3A","article-title":"Noisy pressure support ventilation: a pilot study on a new assisted ventilation mode in experimental lung injury","volume":"36","author":"Gama de Abreu","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1164\/rccm.200808-1211OC","article-title":"Methacholine and ovalbumin challenges assessed by forced oscillations and synchrotron lung imaging","volume":"180","author":"Bayat","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"72","key":"10.1016\/j.bja.2018.01.020_bib31","first-page":"168","article-title":"Input impedance and peripheral inhomogeneity of dog lungs","volume":"1992","author":"Hantos","year":"1985","journal-title":"J\u00a0Appl Physiol"},{"issue":"82","key":"10.1016\/j.bja.2018.01.020_bib32","first-page":"1479","article-title":"Methacholine-induced bronchoconstriction in rats: effects of intravenous vs. aerosol delivery","volume":"1997","author":"Petak","year":"1985","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.bja.2018.01.020_bib33","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.bja.2018.01.020_bib34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/EJA.0000000000000485","article-title":"Pressure-regulated volume control vs. volume control ventilation in healthy and injured rabbit lung: an experimental study","volume":"33","author":"Porra","year":"2016","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.bja.2018.01.020_bib35","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bpa.2015.08.004","article-title":"Mechanisms of ventilator-induced lung injury in healthy lungs","volume":"29","author":"Silva","year":"2015","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"10.1016\/j.bja.2018.01.020_bib36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/bja\/aep319","article-title":"Comparison of two ventilatory strategies in elderly patients undergoing major abdominal surgery","volume":"104","author":"Weingarten","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.01.020_bib37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1213\/ane.0b013e31818db6c7","article-title":"Alveolar recruitment and arterial desflurane concentration during bariatric surgery","volume":"108","author":"Sprung","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2018.01.020_bib38","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/bja\/aep084","article-title":"Effects of four intraoperative ventilatory strategies on respiratory compliance and gas exchange during laparoscopic gastric banding in obese patients","volume":"102","author":"Almarakbi","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.01.020_bib39","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/ajrccm.154.3.8810593","article-title":"Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome","volume":"154","author":"Goodman","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2018.01.020_bib40","doi-asserted-by":"crossref","DOI":"10.1378\/chest.116.suppl_1.103S","article-title":"Chemokines in lung injury: Thomas A. Neff Lecture","volume":"116","author":"Strieter","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.bja.2018.01.020_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000542-200407000-00002","article-title":"Mechanical ventilation-induced lung release of cytokines: a key for the future or pandora's box?","volume":"101","author":"Dreyfuss","year":"2004","journal-title":"Anesthesiology"},{"issue":"111","key":"10.1016\/j.bja.2018.01.020_bib42","first-page":"1296","article-title":"The \u201cother\u02ee respiratory effect of opioids: suppression of spontaneous augmented (\u201csigh\u02ee) breaths","volume":"2011","author":"Bell","year":"1985","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.bja.2018.01.020_bib43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.resp.2011.10.016","article-title":"Hypocapnia-dependent facilitation of augmented breaths: observations in awake vs. anesthetized rats","volume":"180","author":"Moore","year":"2012","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.bja.2018.01.020_bib44","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bja.2017.11.078","article-title":"Variable versus conventional lung protective mechanical ventilation during open abdominal surgery (PROVAR): a randomised controlled trial","volume":"120","author":"Spieth","year":"2018","journal-title":"Br J Anaesth"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091218300540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091218300540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T21:55:58Z","timestamp":1569880558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091218300540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0007091218300540"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2018.01.020","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]}}}