{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:32:05Z","timestamp":1790555525902,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.bja.2018.03.003","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T18:42:21Z","timestamp":1523644941000},"page":"8-12","source":"Crossref","is-referenced-by-count":65,"title":["Sugammadex-induced bradycardia and asystole: how great is the risk?"],"prefix":"10.1016","volume":"121","author":[{"given":"J.M.","family":"Hunter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Naguib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2018.03.003_bib1","first-page":"266","article-title":"A\u00a0novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host","volume":"41","author":"Bom","year":"2002","journal-title":"Angew Chem"},{"key":"10.1016\/j.bja.2018.03.003_bib2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/bjaceaccp\/mks030","article-title":"Neuromuscular physiology and pharmacology: an update","volume":"12","author":"Khirwadkar","year":"2012","journal-title":"Cont Educ Anaesth Crit Care Pain"},{"key":"10.1016\/j.bja.2018.03.003_bib3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1213\/01.ane.0000244594.63318.fc","article-title":"Sugammadex: another milestone in clinical neuromuscular pharmacology","volume":"104","author":"Naguib","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2018.03.003_bib4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1213\/01.ane.0000260135.46070.c3","article-title":"A\u00a0randomized, dose-finding, phase II study of the selective relaxant binding drug, sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block","volume":"104","author":"Groudine","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2018.03.003_bib5","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1097\/ALN.0b013e31819dabb0","article-title":"Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine","volume":"110","author":"Lee","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.03.003_bib6","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/446975a","article-title":"When good drugs go bad","volume":"446","author":"Giacomini","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bja.2018.03.003_bib7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/bja\/aes137","article-title":"Three cases of suspected sugammadex-induced hypersensitivity reactions","volume":"109","author":"Godai","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.03.003_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2044.2010.06611.x","article-title":"Allergy to low dose sugammadex","volume":"66","author":"Menendez-Ozcoidi","year":"2011","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2018.03.003_bib9","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1056\/NEJM198706253162603","article-title":"Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis","volume":"316","author":"Schwartz","year":"1987","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bja.2018.03.003_bib10","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1073\/pnas.87.10.3811","article-title":"Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family","volume":"87","author":"Vanderslice","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bja.2018.03.003_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jaci.2004.04.008","article-title":"Effect of sex and haplotype on plasma tryptase levels in healthy adults","volume":"114","author":"Min","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.bja.2018.03.003_bib12","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1172\/JCI118337","article-title":"The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis","volume":"96","author":"Schwartz","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.bja.2018.03.003_bib13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1365-2044.2004.03757.x","article-title":"Mast cell tryptase: a review of its physiology and clinical significance","volume":"59","author":"Payne","year":"2004","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2018.03.003_bib14","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/bja\/aeh203","article-title":"Anaphylaxis and anaesthesia\u2014all clear now?","volume":"93","author":"Axon","year":"2004","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.03.003_bib15","doi-asserted-by":"crossref","DOI":"10.1213\/ANE.0000000000002562","article-title":"Incidence of anaphylaxis associated with sugammadex","author":"Miyazaki","year":"2018","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2018.03.003_bib16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.5455\/ijmsph.2013.251220131","article-title":"Sugammadex associated persistent bradycardia","volume":"3","author":"Bilgi","year":"2015","journal-title":"Int J Med Sci Public Health"},{"key":"10.1016\/j.bja.2018.03.003_bib17","first-page":"641","article-title":"Transient third-degree AV block following sugammadex","volume":"29","author":"Saito","year":"2015","journal-title":"J\u00a0Anesth"},{"key":"10.1016\/j.bja.2018.03.003_bib18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jclinane.2017.11.003","article-title":"Cardiac arrest following anaphylaxis induced by sugammadex in a regional hospital","volume":"44","author":"Obara","year":"2018","journal-title":"J\u00a0Clin Anesth"},{"key":"10.1016\/j.bja.2018.03.003_bib19","first-page":"378","article-title":"Bradycardia in a pediatric heart transplant recipient: is it the sugammadex?","volume":"22","author":"King","year":"2017","journal-title":"J\u00a0Pediatr Pharmacol Ther"},{"key":"10.1016\/j.bja.2018.03.003_bib20","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4097\/kjae.2016.69.5.514","article-title":"Cardiac arrest after sugammadex administration in a patient with variant angina: a case report","volume":"69","author":"Ko","year":"2016","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.bja.2018.03.003_bib21","unstructured":"BRIDION: highlights of prescribing information. Available from: https:\/\/www.merck.com\/product\/usa\/pi_circulars\/b\/bridion\/bridion_pi.pdf (accessed 6 February 2018)"},{"key":"10.1016\/j.bja.2018.03.003_bib22","unstructured":"NDA 22225: sugammadex injection. Anesthetic and analgesic drug products advisory committee (AC) meeting November 6, 2015 sugammadex AC briefing document. Available from: https:\/\/www.fdanews.com\/ext\/resources\/files\/11-15\/110615-merck.pdf?1515434323 (accessed 8 February 2018)"},{"key":"10.1016\/j.bja.2018.03.003_bib23","unstructured":"FDA adverse event reporting system (FAERS). Available from: https:\/\/www.fda.gov\/Drugs\/InformationOnDrugs\/ucm135151.htm (accessed 21 February 2018)"},{"key":"10.1016\/j.bja.2018.03.003_bib24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/ALN.0b013e31817f5bc7","article-title":"Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial","volume":"109","author":"Puhringer","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.03.003_bib25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/bja\/aem402","article-title":"Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers","volume":"100","author":"Cammu","year":"2008","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.03.003_bib26","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1053\/euhj.2000.2249","article-title":"The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology","volume":"21","author":"Haverkamp","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.bja.2018.03.003_bib27","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1001\/jama.287.17.2215","article-title":"Timing of new black box warnings and withdrawals for prescription medications","volume":"287","author":"Lasser","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2018.03.003_bib28","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00000542-200604000-00009","article-title":"Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study","volume":"104","author":"Sorgenfrei","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.03.003_bib29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00228-011-1196-z","article-title":"Suspected unexpected adverse effect of sugammadex: hypotension","volume":"68","author":"Kokki","year":"2012","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.bja.2018.03.003_bib30","first-page":"Cd012763","article-title":"Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults","volume":"8","author":"Hristovska","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bja.2018.03.003_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bja.2018.02.036","article-title":"Severe bradycardia and asystole after sugammadex: a report of 2 cases","volume":"121","author":"Bhavani","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.03.003_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.yrtph.2009.11.006","article-title":"Prediction of drug-related cardiac adverse effects in humans\u2014a: creation of a database of effects and identification of factors affecting their occurrence","volume":"56","author":"Matthews","year":"2010","journal-title":"Regul Toxicol Pharmacol"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709121830182X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709121830182X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T20:58:14Z","timestamp":1561928294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000709121830182X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S000709121830182X"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2018.03.003","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}