{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:27:27Z","timestamp":1740130047704,"version":"3.37.3"},"reference-count":14,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001136","name":"Australian and New Zealand College of Anaesthetists","doi-asserted-by":"publisher","award":["09\/013"],"award-info":[{"award-number":["09\/013"]}],"id":[{"id":"10.13039\/501100001136","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Massey University Research Fund"},{"DOI":"10.13039\/100012500","name":"Palmerston North Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bja.2018.05.051","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T23:57:05Z","timestamp":1529452625000},"page":"681-682","source":"Crossref","is-referenced-by-count":2,"title":["A genetic mystery in malignant hyperthermia \u2018solved\u2019?"],"prefix":"10.1016","volume":"121","author":[{"given":"A.H.","family":"Schiemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.","family":"Bjorksten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.L.","family":"Gillies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.M.","family":"Hockey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bulger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Stowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.bja.2018.05.051_bib1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/0310057X0703501s05","article-title":"Unravelling the mystery of malignant hyperthermia","volume":"35","author":"Ball","year":"2007","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.bja.2018.05.051_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0140-6736(60)92690-8","article-title":"Anaesthetic deaths in a family","volume":"2","author":"Denborough","year":"1960","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2018.05.051_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/bja\/34.6.395","article-title":"Anaesthetic deaths in a family","volume":"34","author":"Denborough","year":"1962","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.05.051_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0140-6736(72)92854-1","article-title":"Inheritance of malignant hyperpyrexia","volume":"1","author":"King","year":"1972","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2018.05.051_bib5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/bja\/aev225","article-title":"European Malignant Hyperthermia Group guidelines for investigation of malignant hyperthermia susceptibility","volume":"115","author":"Hopkins","year":"2015","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.05.051_bib6","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/BF03006711","article-title":"The caffeine test of isolated human muscle in relation to malignant hyperthermia","volume":"24","author":"Kalow","year":"1977","journal-title":"Can Anaesth Soc J"},{"key":"10.1016\/j.bja.2018.05.051_bib7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00000542-198204000-00005","article-title":"Dantrolene in human malignant hyperthermia a multicenter study","volume":"56","author":"Kolb","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.05.051_bib8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/343559a0","article-title":"Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia","volume":"343","author":"MacLennan","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.bja.2018.05.051_bib9","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/343562a0","article-title":"Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2","volume":"343","author":"McCarthy","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.bja.2018.05.051_bib10","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1097\/ALN.0b013e3182a8a998","article-title":"Exome sequencing reveals novel rare variants in the ryanodine receptor and calcium channel genes in malignant hyperthermia families","volume":"119","author":"Kim","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.05.051_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ceca.2014.07.004","article-title":"Functional characterisation of the R2452W ryanodine receptor variant associated with malignant hyperthermia susceptibility","volume":"56","author":"Roesl","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bja.2018.05.051_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/ALN.0b013e31828cebfe","article-title":"Skeletal muscle ryanodine receptor mutations associated with malignant hyperthermia showed enhanced intensity and sensitivity to triggering drugs when expressed in human embryonic kidney cells","volume":"119","author":"Sato","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.05.051_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature14063","article-title":"Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution","volume":"517","author":"Yan","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bja.2018.05.051_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091218304446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091218304446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T15:45:44Z","timestamp":1569167144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091218304446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0007091218304446"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2018.05.051","relation":{},"ISSN":["0007-0912"],"issn-type":[{"type":"print","value":"0007-0912"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}