{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:45:18Z","timestamp":1792665918425,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis, Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["2P01 AR-05235"],"award-info":[{"award-number":["2P01 AR-05235"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis, Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["1R01AR068897-01A1"],"award-info":[{"award-number":["1R01AR068897-01A1"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N002407\/1"],"award-info":[{"award-number":["MR\/N002407\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bja.2018.07.008","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T22:54:08Z","timestamp":1533941648000},"page":"953-961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1"],"prefix":"10.1016","volume":"121","author":[{"given":"J.R.","family":"Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.P.","family":"Diggle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.D.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2018.07.008_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/bja\/aer132","article-title":"Malignant hyperthermia: pharmacology of triggering","volume":"107","author":"Hopkins","year":"2011","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.008_bib2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/ALN.0000000000001878","article-title":"Malignant hyperthermia in the post-genomics era: new perspectives on an old concept","volume":"128","author":"Riazi","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.008_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/(SICI)1097-4598(200001)23:1<4::AID-MUS3>3.0.CO;2-D","article-title":"Genetics and pathogenesis of malignant hyperthermia","volume":"23","author":"Jurkat-Rott","year":"2000","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bja.2018.07.008_bib4","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/ALN.0b013e3182320068","article-title":"Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families","volume":"115","author":"Groom","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.008_bib5","first-page":"1493","article-title":"Skeletal muscle channelopathies","volume":"249","author":"Jurkat-Rott","year":"2002","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.bja.2018.07.008_bib6","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1001\/jama.293.23.2918","article-title":"Malignant hyperthermia: update on susceptibility testing","volume":"293","author":"Litman","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2018.07.008_bib7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/humu.20356","article-title":"Mutations in RYR1 in malignant hyperthermia and central core disease","volume":"27","author":"Robinson","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.bja.2018.07.008_bib8","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1213\/ane.0b013e3181ac1548","article-title":"Prevalence of malignant hyperthermia due to anesthesia in New York State, 2001\u20132005","volume":"109","author":"Brady","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2018.07.008_bib9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/bja\/aev225","article-title":"The European Malignant Hyperthermia Group guidelines for the investigation of malignant hyperthermia susceptibility","volume":"115","author":"Hopkins","year":"2015","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.008_bib10","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1213\/ANE.0b013e3181b5ae2d","article-title":"Core myopathies and the risk of malignant hyperthermia","volume":"109","author":"Klingler","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2018.07.008_bib11","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/00000542-200612000-00016","article-title":"Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse","volume":"105","author":"Yang","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.008_bib12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1096\/fj.05-4497fje","article-title":"Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse","volume":"20","author":"Chelu","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.bja.2018.07.008_bib13","doi-asserted-by":"crossref","first-page":"20813","DOI":"10.1074\/jbc.M801944200","article-title":"Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia","volume":"283","author":"Jiang","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.bja.2018.07.008_bib14","first-page":"85","article-title":"[Ca2+]i in muscles of malignant hyperthermia susceptible pigs determined in\u00a0vivo with Ca2+ selective microelectrodes","volume":"9","author":"Lopez","year":"1986","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bja.2018.07.008_bib15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/mus.880110113","article-title":"Myoplasmic free [Ca2+] during a malignant hyperthermia episode in swine","volume":"11","author":"Lopez","year":"1988","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bja.2018.07.008_bib16","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1096\/fj.11-197582","article-title":"Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage","volume":"26","author":"Yuen","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.bja.2018.07.008_bib17","doi-asserted-by":"crossref","first-page":"16725","DOI":"10.1073\/pnas.012688999","article-title":"Topology of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (RyR1)","volume":"99","author":"Du","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bja.2018.07.008_bib18","doi-asserted-by":"crossref","first-page":"C1591","DOI":"10.1152\/ajpcell.00133.2006","article-title":"Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR","volume":"292","author":"Yang","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bja.2018.07.008_bib19","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1074\/jbc.M111.307926","article-title":"Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle","volume":"287","author":"Barrientos","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.bja.2018.07.008_bib20","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.1073\/pnas.1119207109","article-title":"Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor","volume":"109","author":"Eltit","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bja.2018.07.008_bib21","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.bja.2018.06.028","article-title":"Genetic epidemiology of malignant hyperthermia in the United Kingdom","volume":"121","author":"Miller","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.008_bib22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/bja\/aep204","article-title":"Genetic variation in RYR1 and malignant hyperthermia phenotypes","volume":"103","author":"Carpenter","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.008_bib23","doi-asserted-by":"crossref","first-page":"19180","DOI":"10.1074\/jbc.M114.550764","article-title":"Ca2+ influx via the Na+\/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle","volume":"289","author":"Altamirano","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.bja.2018.07.008_bib24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00000542-197304000-00013","article-title":"Halothane and methoxyflurane concentrations in end-tidal gas, arterial blood, and lumbar cerebrospinal fluid","volume":"38","author":"Stoelting","year":"1973","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.008_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-3495(83)84316-1","article-title":"Determination of ionic calcium in frog skeletal muscle fibers","volume":"43","author":"Lopez","year":"1983","journal-title":"Biophys J"},{"key":"10.1016\/j.bja.2018.07.008_bib26","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1096\/fj.12-218354","article-title":"Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia","volume":"27","author":"Eltit","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.bja.2018.07.008_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ceca.2016.02.005","article-title":"Calcium signaling in skeletal muscle development, maintenance and regeneration","volume":"59","author":"Tu","year":"2016","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bja.2018.07.008_bib28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/mus.880080502","article-title":"Intracellular ionized calcium concentration in muscles from humans with malignant hyperthermia","volume":"8","author":"Lopez","year":"1985","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bja.2018.07.008_bib29","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1365-2044.1986.tb13122.x","article-title":"The work of the Leeds malignant hyperpyrexia unit, 1971\u201384","volume":"41","author":"Ellis","year":"1986","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2018.07.008_bib30","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.nmd.2013.03.008","article-title":"Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis","volume":"23","author":"Dlamini","year":"2013","journal-title":"Neuromus Disord"},{"key":"10.1016\/j.bja.2018.07.008_bib31","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/sj.ejhg.5200964","article-title":"Recent advances in the diagnosis of malignant hyperthermia susceptibility: how confident can we be of genetic testing?","volume":"11","author":"Robinson","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.bja.2018.07.008_bib32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1046\/j.1469-1809.2000.6440307.x","article-title":"Multiple interacting gene products may influence susceptibility to malignant hyperthermia","volume":"64","author":"Robinson","year":"2000","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.bja.2018.07.008_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00439-002-0864-6","article-title":"Several interacting genes influence the malignant hyperthermia phenotype","volume":"112","author":"Robinson","year":"2003","journal-title":"Hum Genet"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091218305804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091218305804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T23:59:49Z","timestamp":1717199989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091218305804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0007091218305804"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2018.07.008","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2018.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}