{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:16:51Z","timestamp":1786634211321,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","award":["2010B0797"],"award-info":[{"award-number":["2010B0797"]}],"id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013330","name":"Society of Cardiovascular Anesthesiologists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011924","name":"European Society of Anaesthesiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.bja.2018.07.037","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T01:39:19Z","timestamp":1536197959000},"page":"1298-1307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sevoflurane based anaesthesia does not affect already impaired cerebral autoregulation in patients with type 2 diabetes mellitus"],"prefix":"10.1016","volume":"121","author":[{"given":"N.H.","family":"Sperna Weiland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hermanides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.J.P.","family":"van der Ster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Hollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Preckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.J.","family":"Stok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"van Lieshout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.V.","family":"Immink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2018.07.037_bib1","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1088\/1361-6579\/aa6782","article-title":"An introduction into autonomic nervous function","volume":"38","author":"Karemaker","year":"2017","journal-title":"Physiol Meas"},{"key":"10.1016\/j.bja.2018.07.037_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.RES.24.1.109","article-title":"Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity","volume":"24","author":"Smyth","year":"1969","journal-title":"Circ Res"},{"key":"10.1016\/j.bja.2018.07.037_bib3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2337\/diab.28.4.313","article-title":"Impaired cardiovascular responses to graded exercise in diabetic autonomic neuropathy","volume":"28","author":"Hilsted","year":"1979","journal-title":"Diabetes"},{"key":"10.1016\/j.bja.2018.07.037_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2337\/diacare.9.4.389","article-title":"Decreased exercise heart rate and blood pressure response in diabetic subjects with cardiac autonomic neuropathy","volume":"9","author":"Kahn","year":"1986","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bja.2018.07.037_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1076\/apab.109.3.215.11589","article-title":"Blood pressure response to standing in the diagnosis of autonomic neuropathy: the EURODIAB IDDM Complications Study","volume":"109","author":"Kempler","year":"2001","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.bja.2018.07.037_bib6","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1046\/j.1464-5491.2002.00821.x","article-title":"Autonomic neuropathy is associated with increased cardiovascular risk factors: the EURODIAB IDDM Complications Study","volume":"19","author":"Kempler","year":"2002","journal-title":"Diabet Med"},{"key":"10.1016\/j.bja.2018.07.037_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s10286-007-1001-3","article-title":"Prevalence of orthostatic hypotension","volume":"18","author":"Low","year":"2008","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.bja.2018.07.037_bib8","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1464-5491.2008.02567.x","article-title":"Cardiovascular autonomic dysfunction predicts acute ischaemic stroke in patients with Type 2 diabetes mellitus: a 7-year follow-up study","volume":"25","author":"Ko","year":"2008","journal-title":"Diabet Med"},{"key":"10.1016\/j.bja.2018.07.037_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.autneu.2003.07.001","article-title":"Diabetic autonomic neuropathy is associated with an increased incidence of strokes","volume":"108","author":"Cohen","year":"2003","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.bja.2018.07.037_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.RES.34.4.435","article-title":"Upper limit of autoregulation of cerebral blood flow in the baboon","volume":"34","author":"Strandgaard","year":"1974","journal-title":"Circ Res"},{"key":"10.1016\/j.bja.2018.07.037_bib11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1152\/physrev.1959.39.2.183","article-title":"Cerebral blood flow and oxygen consumption in man","volume":"39","author":"Lassen","year":"1959","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bja.2018.07.037_bib12","first-page":"1182","article-title":"Cerebral dysautoregulation and the risk of ischemic events in occlusive carotid artery disease","volume":"255","author":"Reinhard","year":"2008","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.bja.2018.07.037_bib13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/bja\/aes148","article-title":"Risks for impaired cerebral autoregulation during cardiopulmonary bypass and postoperative stroke","volume":"109","author":"Ono","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.037_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1464-5491.2003.00885.x","article-title":"Impairment of cerebral autoregulation in diabetic patients with cardiovascular autonomic neuropathy and orthostatic hypotension","volume":"20","author":"Mankovsky","year":"2003","journal-title":"Diabet Med"},{"key":"10.1016\/j.bja.2018.07.037_bib15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/CS20070458","article-title":"Dynamic cerebral autoregulatory capacity is affected early in Type 2 diabetes","volume":"115","author":"Kim","year":"2008","journal-title":"Clin Sci"},{"key":"10.1016\/j.bja.2018.07.037_bib16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00000542-199507000-00011","article-title":"Neurocirculatory responses to sevoflurane in humans. A comparison to desflurane","volume":"83","author":"Ebert","year":"1995","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.037_bib17","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00000542-199205000-00010","article-title":"Sympathetic responses to induction of anesthesia in humans with propofol or etomidate","volume":"76","author":"Ebert","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.037_bib18","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/bja\/82.3.350","article-title":"Arterial baroreflex function in humans anaesthetized with sevoflurane","volume":"82","author":"Tanaka","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.037_bib19","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/00000542-199610000-00010","article-title":"Effects of sevoflurane with and without nitrous oxide on human cerebral circulation. Transcranial Doppler study","volume":"85","author":"Cho","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.037_bib20","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/bja\/aex333","article-title":"Novel method for intraoperative assessment of cerebral autoregulation by paced breathing","volume":"119","author":"Sperna Weiland","year":"2017","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.037_bib21","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1097\/ALN.0b013e31824f94ed","article-title":"Noninvasive continuous arterial blood pressure monitoring with Nexfin\u00ae","volume":"116","author":"Martina","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.037_bib22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/bja\/aew268","article-title":"Validation of non-invasive arterial pressure monitoring during carotid endarterectomy","volume":"117","author":"Heusdens","year":"2016","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.037_bib23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1113\/expphysiol.2005.030262","article-title":"Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger","volume":"90","author":"Bogert","year":"2005","journal-title":"Exp Physiol"},{"key":"10.1016\/j.bja.2018.07.037_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/bja\/76.2.179","article-title":"Effect of age on MAC in humans: a meta-analysis","volume":"76","author":"Mapleson","year":"1996","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.037_bib25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/bja\/aeg132","article-title":"Age-related iso-MAC charts for isoflurane, sevoflurane and desflurane in man","volume":"91","author":"Nickalls","year":"2003","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2018.07.037_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jns.2017.03.044","article-title":"Decreased baroreflex sensitivity in Parkinson\u2019s disease is associated with orthostatic hypotension","volume":"377","author":"Blaho","year":"2017","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.bja.2018.07.037_bib27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/CIRCULATIONAHA.106.634949","article-title":"Diabetic cardiovascular autonomic neuropathy","volume":"115","author":"Vinik","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.bja.2018.07.037_bib28","doi-asserted-by":"crossref","DOI":"10.1161\/01.HYP.3.6_Pt_2.II-134","article-title":"Baroreceptor reflex sensitivity index derived from Phase 4 of the Valsalva maneuver","volume":"3","author":"Palmero","year":"1981","journal-title":"Hypertension"},{"key":"10.1016\/j.bja.2018.07.037_bib29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/01.CIR.66.2.432","article-title":"Comparison of techniques for measuring baroreflex sensitivity in man","volume":"66","author":"Goldstein","year":"1982","journal-title":"Circulation"},{"key":"10.1016\/j.bja.2018.07.037_bib30","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1007\/s00125-011-2164-y","article-title":"Deep breathing improves blunted baroreflex sensitivity even after 30 years of type 1 diabetes","volume":"54","author":"Roseng\u00e5rd-B\u00e4rlund","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.bja.2018.07.037_bib31","first-page":"413","article-title":"On the motion of a pendulum suspended from two points","volume":"3","author":"Bowditch","year":"1815","journal-title":"Mem Am Acad Arts Sci"},{"key":"10.1016\/j.bja.2018.07.037_bib32","series-title":"M\u00e9moire sur l'\u00e9tude optique des mouvements vibratoires","year":"1857"},{"key":"10.1016\/j.bja.2018.07.037_bib33","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1097\/01.hjh.0000125439.28861.ed","article-title":"Time-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set","volume":"22","author":"Westerhof","year":"2004","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.bja.2018.07.037_bib34","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/00000539-200111000-00012","article-title":"The recovery profile of baroreflex control of heart rate after isoflurane or sevoflurane anesthesia in humans","volume":"93","author":"Nagasaki","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2018.07.037_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1161\/01.STR.20.1.45","article-title":"Cerebral autoregulation dynamics in humans","volume":"20","author":"Aaslid","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.bja.2018.07.037_bib36","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1227\/00006123-199009000-00004","article-title":"The frequency-dependent behaviour of cerebral autoregulation","volume":"27","author":"Giller","year":"1990","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bja.2018.07.037_bib37","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1161\/01.CIR.0000144472.08647.40","article-title":"Impaired cerebral autoregulation in patients with malignant hypertension","volume":"110","author":"Immink","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bja.2018.07.037_bib38","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1161\/01.STR.0000189624.06836.03","article-title":"Dynamic cerebral autoregulation in acute lacunar and middle cerebral artery territory ischemic stroke","volume":"36","author":"Immink","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.bja.2018.07.037_bib39","first-page":"881","article-title":"\u00dcber periodische Th\u00e4tigkeits-\u00c4usserungen des vasomotorischen und Hemmungs-Nervencentrums","volume":"3","author":"Traube","year":"1865","journal-title":"Zentralblatt f\u00fcr die medizinischen Wissenschaften"},{"key":"10.1016\/j.bja.2018.07.037_bib40","first-page":"281","article-title":"Studien zur Physiologie des Herzens und der Blutgef\u00e4sse. V. \u00dcber spontane Blutdruck schwankungen","volume":"74","author":"Mayer","year":"1876","journal-title":"Sitzungsberichte Akad der Wissenschaften Wien"},{"key":"10.1016\/j.bja.2018.07.037_bib41","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1213\/01.ane.0000189056.96273.48","article-title":"The effect of sevoflurane on dynamic cerebral blood flow autoregulation assessed by spectral and transfer function analysis","volume":"102","author":"Ogawa","year":"2006","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2018.07.037_bib42","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1090\/S0025-5718-1965-0178586-1","article-title":"An algorithm for the machine computation of the complex Fourier series","volume":"19","author":"Cooley","year":"1965","journal-title":"Math Comput"},{"key":"10.1016\/j.bja.2018.07.037_bib43","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/jappl.1970.29.5.665","article-title":"Effects of general anesthesia on autoregulation of cerebral blood flow in man","volume":"29","author":"Smith","year":"1970","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.bja.2018.07.037_bib44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00000542-199507000-00008","article-title":"Dynamic and static cerebral autoregulation during isoflurane, desflurane, and propofol anesthesia","volume":"83","author":"Strebel","year":"1995","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.037_bib45","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/01.STR.26.6.1014","article-title":"Comparison of static and dynamic cerebral autoregulation measurements","volume":"26","author":"Tiecks","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.bja.2018.07.037_bib46","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/00000542-199511000-00011","article-title":"Direct cerebrovasodilatory effects of halothane, isoflurane, and desflurane during propofol-induced isoelectric electroencephalogram in humans","volume":"83","author":"Matta","year":"1995","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2018.07.037_bib47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10877-015-9754-z","article-title":"Monitoring of cerebral blood flow autoregulation in adults undergoing sevoflurane anesthesia: a prospective cohort study of two age groups","volume":"30","author":"Goettel","year":"2016","journal-title":"J\u00a0Clin Monit Comput"},{"key":"10.1016\/j.bja.2018.07.037_bib48","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1399-6576.2010.02324.x","article-title":"The effects of sevoflurane on cerebral blood flow autoregulation and flow-metabolism coupling during cardiopulmonary bypass","volume":"55","author":"Reinsfelt","year":"2011","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.bja.2018.07.037_bib49","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/01.STR.17.5.913","article-title":"Transcranial Doppler measurement of middle cerebral artery blood flow velocity: a validation study","volume":"17","author":"Bishop","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.bja.2018.07.037_bib50","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1097\/00004647-199611000-00021","article-title":"Relationship of 133Xe cerebral blood flow to middle cerebral arterial flow velocity in men at rest","volume":"16","author":"Clark","year":"1996","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.bja.2018.07.037_bib51","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1152\/japplphysiol.00271.2007","article-title":"Influence of noninvasive peripheral arterial blood pressure measurements on assessment of dynamic cerebral autoregulation","volume":"103","author":"Sammons","year":"2007","journal-title":"J\u00a0Appl Physiol"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091218306342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091218306342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:13:19Z","timestamp":1762103599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091218306342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0007091218306342"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2018.07.037","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sevoflurane based anaesthesia does not affect already impaired cerebral autoregulation in patients with type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2018.07.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd on behalf of British Journal of Anaesthesia.","name":"copyright","label":"Copyright"}]}}