{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:43:31Z","timestamp":1789497811375,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.bja.2020.01.016","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T07:52:47Z","timestamp":1583135567000},"page":"553-561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"title":["Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery"],"prefix":"10.1016","volume":"124","author":[{"given":"Brandon M.","family":"Togioka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Yanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna R.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Tekkali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam M.","family":"Treggiari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2020.01.016_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0140-6736(08)60878-8","article-title":"An estimation of the global volume of surgery: a modelling strategy based on available data","volume":"372","author":"Weiser","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2020.01.016_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S2213-2600(18)30294-7","article-title":"Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study","volume":"7","author":"Kirmeier","year":"2019","journal-title":"Lancet Resp Med"},{"key":"10.1016\/j.bja.2020.01.016_bib3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/ALN.0000000000001279","article-title":"Nondepolarizing neuromuscular blocking agents, reversal, and risk of postoperative pneumonia","volume":"125","author":"Bulka","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib4","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e6329","article-title":"Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study","volume":"345","author":"Grosse-Sundrup","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.bja.2020.01.016_bib5","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1097\/ALN.0b013e3181fc6e0a","article-title":"Prediction of postoperative pulmonary complications in a population-based surgical cohort","volume":"113","author":"Canet","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jamcollsurg.2004.05.276","article-title":"Hospital costs associated with surgical complications: a report from the private-sector national surgical quality improvement program","volume":"199","author":"Dimick","year":"2004","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.bja.2020.01.016_bib7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1213\/ane.0b013e31816d1268","article-title":"Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit","volume":"107","author":"Murphy","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2020.01.016_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1213\/01.ANE.0000095040.36648.F7","article-title":"Postanesthesia care unit recovery times and neuromuscular blocking drugs: a prospective study of orthopedic surgical patients randomized to receive pancuronium or rocuronium","volume":"98","author":"Murphy","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2020.01.016_bib9","first-page":"735","article-title":"Prospective study of residual neuromuscular block and postoperative respiratory complications in patients reversed with neostigmine versus sugammadex","volume":"82","author":"Martinez-Ubieto","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.bja.2020.01.016_bib10","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1399-6576.1997.tb04851.x","article-title":"Residual neuromuscular block is a risk factor for postoperative pulmonary complications. A prospective, randomised, and blinded study of postoperative pulmonary complications after atracurium, vecuronium and pancuronium","volume":"41","author":"Berg","year":"1997","journal-title":"Acta Anaesth Scand"},{"key":"10.1016\/j.bja.2020.01.016_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bja.2019.08.023","article-title":"Use of a train-of-four ratio of 0.95 versus 0.9 for tracheal extubation: an exploratory analysis of POPULAR data","volume":"124","author":"Blobner","year":"2020","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/00000542-200004000-00014","article-title":"The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium","volume":"92","author":"Sundman","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib13","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/00000542-199711000-00005","article-title":"Functional assessment of the pharynx at rest and during swallowing in partially paralyzed humans: simultaneous videomanometry and mechanomyography of awake human volunteers","volume":"87","author":"Eriksson","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib14","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1097\/ALN.0b013e31819faa71","article-title":"Impaired upper airway integrity by residual neuromuscular blockade: increased airway collapsibility and blunted genioglossus muscle activity in response to negative pharyngeal pressure","volume":"110","author":"Herbstreit","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1164\/rccm.200512-1862OC","article-title":"The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade","volume":"175","author":"Eikermann","year":"2007","journal-title":"Am J Resp Crit Care"},{"key":"10.1016\/j.bja.2020.01.016_bib16","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/ALN.0000000000002711","article-title":"Reversal of partial neuromuscular block and the ventilatory response to hypoxia: a randomized controlled trial in healthy volunteers","volume":"131","author":"Broens","year":"2019","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bja.2018.03.029","article-title":"Management of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine","volume":"121","author":"Thilen","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib18","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1213\/ANE.0000000000000757","article-title":"The RECITE study: a Canadian prospective, multicenter study of the incidence and severity of residual neuromuscular blockade","volume":"121","author":"Fortier","year":"2015","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2020.01.016_bib19","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/anae.14386","article-title":"Therapeutic doses of neostigmine, depolarising neuromuscular blockade and muscle weakness in awake volunteers: a double-blind, placebo-controlled, randomised volunteer study","volume":"73","author":"Kent","year":"2018","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2020.01.016_bib20","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1097\/ALN.0b013e3181f70f3d","article-title":"Neostigmine\/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure","volume":"113","author":"Herbstreit","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib21","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1365-2044.2012.07197.x","article-title":"A\u00a0randomised controlled trial comparing sugammadex and neostigmine at different depths of neuromuscular blockade in patients undergoing laparoscopic surgery","volume":"67","author":"Geldner","year":"2012","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2020.01.016_bib22","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/ALN.0b013e31818a3fee","article-title":"Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine","volume":"109","author":"Jones","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib23","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1213\/01.ANE.0000130616.57678.80","article-title":"Tactile assessment for the reversibility of rocuronium-induced neuromuscular blockade during propofol or sevoflurane anesthesia","volume":"99","author":"Kim","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2020.01.016_bib24","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/bja\/aen176","article-title":"Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing","volume":"101","author":"Eikermann","year":"2008","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/bja\/aev104","article-title":"Effects of sugammadex on incidence of postoperative residual neuromuscular blockade: a randomized, controlled study","volume":"115","author":"Brueckmann","year":"2015","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib26","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/bja\/aen037","article-title":"Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine","volume":"100","author":"Flockton","year":"2008","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/bja\/aer330","article-title":"Randomized comparison of sugammadex and neostigmine for reversal of rocuronium-induced muscle relaxation in morbidly obese undergoing general anaesthesia","volume":"108","author":"Gaszynski","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/ALN.0b013e31817f5bc7","article-title":"Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial","volume":"109","author":"Puhringer","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/ALN.0b013e3181a51cb0","article-title":"Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia","volume":"111","author":"Rex","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2020.01.016_bib31","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1007\/s12630-019-01419-3","article-title":"Effects of neuromuscular block reversal with sugammadex versus neostigmine on postoperative respiratory outcomes after major abdominal surgery: a randomized-controlled trial","volume":"66","author":"Alday","year":"2019","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib32","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/anae.13277","article-title":"A\u00a0systematic review of sugammadex vs neostigmine for reversal of neuromuscular blockade","volume":"70","author":"Abad-Gurumeta","year":"2015","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2020.01.016_bib33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.kjms.2016.01.009","article-title":"Comparison of sugammadex and neostigmine-atropine on intraocular pressure and postoperative effects","volume":"32","author":"Hakimoglu","year":"2016","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.bja.2020.01.016_bib34","first-page":"CD012763","article-title":"Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults","volume":"8","author":"Hristovska","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bja.2020.01.016_bib35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/0019-5049.108562","article-title":"Introduction of sugammadex as standard reversal agent: impact on the incidence of residual neuromuscular blockade and postoperative patient outcome","volume":"57","author":"Ledowski","year":"2013","journal-title":"Indian J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5152\/TJAR.2015.35682","article-title":"Comparison of sugammadex versus neostigmine costs and respiratory complications in patients with obstructive sleep apnoea","volume":"43","author":"Unal","year":"2015","journal-title":"Turk J Anaesthesiol Reanim"},{"key":"10.1016\/j.bja.2020.01.016_bib37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/EJA.0000000000000543","article-title":"Diaphragmatic and intercostal electromyographic activity during neostigmine, sugammadex and neostigmine-sugammadex-enhanced recovery after neuromuscular blockade: a randomised controlled volunteer study","volume":"34","author":"Cammu","year":"2017","journal-title":"Eur J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib38","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bja.2018.11.028","article-title":"Retrospective analysis of 30-day unplanned readmission after major abdominal surgery with reversal by sugammadex or neostigmine","volume":"122","author":"Oh","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib39","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/bja\/aex240","article-title":"Association between intraoperative non-depolarising neuromuscular blocking agent dose and 30-day readmission after abdominal surgery","volume":"119","author":"Thevathasan","year":"2017","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2020.01.016_bib40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bja.2018.12.015","article-title":"Does reversal of neuromuscular block with sugammadex reduce readmission rate after surgery?","volume":"122","author":"Bose","year":"2019","journal-title":"Br J Anaesth"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091220300714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091220300714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:55:46Z","timestamp":1757789746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091220300714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0007091220300714"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2020.01.016","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737501295.793572409","asserted-by":"object"}]},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2020.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}